Digital Commons Network^™

The Pacifican December 2, 2010, University Of The Pacific

All Issues - Student Newspaper, The Pacifican, Pacific Weekly

No abstract provided.

2010-12-02 Faculty Senate Meeting Minutes, Morehead State University. Faculty Senate.

Faculty Senate Records

Faculty Senate Meeting Minutes for December 2, 2010.

The Shifting American Community And The Rise Of Social Media: Exploring Social Media In Grassroots Non-Profits, Casandra Fritzsche

Capstone Projects – Politics and Government

No abstract provided.

Nuncrackers: The Nunsense Christmas Musical, Parkland College Theatre

Parkland Theatre

Book, Music and Lyrics: Dan Goggin

Director: J.W. Morrissette
Musical Director: Tim Schirmer
Choreographer: Jean Ray Korder
Costume Designer: Sr. Mary Poly Ester
Scenic and Lighting Designer: Thomas V. Korder
Sound Designer: Robert Dagit<
Technical Director: David G. Dillman

December 1, 3, 4, 9, 10, 11, at 7:30 p.m.
December 11, 12 at 3 p.m.

Produced by special arrangement with Tams-Whitmark Music Library, Inc.

To view images from this production, visit Nuncrackers: The Nunsense Christmas Musical (2010).

A Case Study Of The Impact Of Filmmaker Decisions In The Construction Of A Documentary: Helen Whitney's (2007) The Mormons, Elizabeth Joy Mott

Theses and Dissertations

Informed by theories of media framing, exemplification, and non-fiction film production, this case study used as its sample for textual analysis the typed transcripts from the final cut of Helen Whitney's (2007) documentary film, The Mormons, and the interview transcripts of the 15 key commentators interviewed for the documentary. These theories suggest that (a) media producers condense topics in the media by selecting information that connects news stories to a larger context and imbues them with symbolic value; (b) verbal and visual examples have been shown to be more easily retrieved in memory than abstract ideas and are consequently …

Gene Flow And Dispersal Of The Flatworm, Polycelis Coronata: A Multiscale Analysis, Jeffrey N. Moore

Theses and Dissertations

We determined genetic variance and gene flow across multiple scales (reaches, headwater segments, and catchments) to examine the dispersal ability of the flatworm Polycelis coronata along the Wasatch Mountains of Utah. Multiple models predict patterns of genetic differentiation in stream invertebrates based on dispersal traits and the spatial connectivity of the habitat. The stream hierarchy model predicts genetic differentiation to be low and gene flow to be high between reaches nested in segments, moderate among segments within catchments, and differentiation to be highest and gene flow lowest among catchments, whereas the headwater model predicts the greatest differentiation between headwater segments. …

The Prospector, December 2, 2010, Utep Student Publications

The Prospector

Headline: 2010 Grads

Montana Kaimin, December 2, 2010, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Jefferson Kimmel Cancer Center Support Groups

Bodine Journal

Listing of Jefferson Kimmel Cancer Center Support Groups.

Research Department Of Radiation Oncology

Bodine Journal

Listing of Basic Research Studies/Grants and Clinical Research Studies/Grants.

Young Investigator Awards

Bodine Journal

Robert Den, MD, Laura Doyle, MS, Nitin Ohri, MD and Evan Wuthrick, MD

New Faculty Members

Bodine Journal

New faculty members: Voichita (Voika) Bar Ad, MD and Wenyin Shi, MD, PhD.

The Gucy2c Tumor Suppressor Is The Nexus Of A Paracrine Hormone Axis Preventing Radiotherapy-Induced Gastrointestinal (Gi) Toxicity, E. J. Wuthrick, P. Li, J. E. Lin, A. P. Dicker, D. Leeper, S. A. Waldman

Bodine Journal

Purpose/Objective: Radiation-induced GI toxicity is the primary dose limitation compromising therapy in cancer patients treated with radiation therapy. GUCY2C is the intestinal receptor for diarrheagenic bacterial enterotoxins and the endogenous paracrine hormones guanylin and uroguanylin. Following genomic insult, cyclic (c)GMP produced by ligand activation of GUCY2C enhances DNA damage sensing and repair in intestinal cells. Here, we show that the GUCY2C-cGMP axis mediates p53-dependent radioprotection of intestinal epithelial cells.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

Departmental Information-Thomas Jefferson University, Jefferson Medical College, Department Of Radiation Oncology

Bodine Journal

Directory of Attending Physicians, Division of Molecular Radiology, Division of Medical Physics, Radiation Oncology Residents, Medical Physics Residents/Research Staff and Administration.

Chart Rounds In The Digital Age: A Survey Of North American Institutions, M. A. Whiton, A. P. Dicker, E. J. Wuthrick, L. Doyle, A. S. Harrison, Y. R. Lawrence

Bodine Journal

Purpose/Objective(s): In light of public concerns regarding the quality of radiation treatment delivery, we surveyed the utilization of “chart rounds” or peer-review quality assurance meetings, within North American academic institutions.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

Potential For Dose-Escalation In The Post-Prostatectomy Setting With Intensitymodulated Radiation Therapy: A Dosimetric Study Using Eortc Consensus Guidelines For Target Volume Contours, M. Studenski, A. Harrison, S. Anamalayil, A. Harvey, E. Trabulsi, Y. Xiao, Y. Yu, A. P. Dicker, T. N. Showalter

Bodine Journal

Purpose: Radiation therapy (RT) is delivered after radical prostatectomy (RP) for prostate cancer (PC). Although intensity modulated radiation therapy (IMRT) has become standard in definitive RT for PC, dosimetric data in support of post-RP IMRT are limited. This study was designed to quantify benefits of IMRT versus 3D conformal RT (3DCRT) with respect to dose sparing of rectum and bladder and target volume coverage. Motivated by the desire to deliver higher radiation doses and to quantify the dosimetric impact of IMRT, we retrospectively analyzed images in order to: 1) identify a preferred IMRT beam arrangement; 2) evaluate the dosimetric advantages …

Costs Of Early Adjuvant Radiation Therapy After Radical Prostatectomy: A Decision Analysis, T. N. Showalter, K. A. Foley, E. Jutkowitz, C. Lallas, A. J. Harvey, E. J. Trabulsi, L. G. Gomella, A. P. Dicker, L. T. Pizzi

Bodine Journal

Purpose/Objective(s): Prospective, randomized trials support adjuvant radiation therapy (RT) for adverse pathologic features after radical prostatectomy (RP). However, adjuvant RT is not universally delivered in this setting. Criticisms of adjuvant RT include toxicity, financial costs, potential overtreatment, and effectiveness of salvage RT. The objective of this study was to construct a decision analytic model to estimate real world cost of RT vs. no RT within the context of the effectiveness of early adjuvant RT for prostate patients based on published clinical results of the Southwest Oncology Group prospective trial of adjuvant RT (SWOG 8794).

American Society for Therapeutic Radiation Oncology …

Intensity Modulated Radiation Therapy Compared With 3d Conformal Radiotherapy For Craniospinal Irradiation In Adults – Do We Gain Anything?, X. Shen, M. Studenski, A. Harrison, Y. Xiao, T. Biswas

Bodine Journal

Purpose: Craniospinal irradiation (CSI) remains one of the most technically challenging planning processes in radiation oncology due to its long shape especially in adults and complex target volume. In addition, CSI is associated with significant acute and late morbidities. We undertook a dosimetric analysis to determine if intensity modulated radiation therapy (IMRT) could improve target coverage while sparing normal tissue structures compared to classic 3D conformal radiation (3D‐CRT) planning.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

Mirab: An Image-Guided Multichannel Robot For Prostate Brachytherapy, T. Podder, I. Buzurovic, K. Huang, Y. Yu

Bodine Journal

Purpose: To date, twelve robotic systems have been developed worldwide for brachytherapy, especially for seed implantation. However, the only system that has provision for simultaneous insertion of multiple needles is the MIRAB system. This article reports the feasibility and efficacy of the MIRAB robot as ultrasound image-guided autonomous delivery of radioactive seeds for treating prostate cancers.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

Prophylactic Radiation Therapy Is Safe And Effective Treatment For The Prevention Of Recurrent Heterotopic Ossification In Elbow And Knee Joints, M. V. Mishra, L. Austin, J. Parvisi, M. Ramsey, T. N. Showalter

Bodine Journal

Background: Background Prophylactic radiation therapy (RT) is an established adjuvant therapy for heterotopic ossification (HO) of the hip when delivered in the immediate pre- or post-operative setting. Its role in prevention of recurrence after excision of HO is supported by randomized trials for HO of the hip, but there is scant evidence to support a similar approach in non-hip joints. In the current study, we evaluate radiologic and functional outcomes after prophylactic radiation therapy (RT) for prevention of HO of the knee and upper extremity [elbow and metacarpophalangeal (MCP) joints].

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting …

Reirradiation For Recurrent Meningioma, N. Ohri, A. Wojcieszynski, J. J. Evans, D. W. Andrews, M. Werner-Wasik

Bodine Journal

Purpose/Objective(s): Management options for meningioma include observation, surgical resection, and radiation therapy (RT). In cases of progressive or recurrent disease after RT, similar options exist. The control rate following a second course of RT is unknown.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

Evolving Role Of Vorinostat Combined With Radiation Therapy In The Treatment Of Brain Tumors, From The Lab To The Clinic, Y. R. Lawrence, P. Wachsberger, Y. Liu, B. Andersen, A. P. Dicker

Bodine Journal

Purpose/Objective(s): Radiation therapy (RT) is a critical element in the treatment of both brain metastases and glioblastoma (GBM). Temozolomide (TMZ) has an established role in the upfront treatment of GBM. Down-regulated mismatch repair (MMR) is a known mechanism of resistance to TMZ. Vorinostat (SAHA), an HDAC inhibitor, has successfully been combined with a number of cytotoxic agents, including ionizing radiation (IR). We performed a series of preclinical and clinical studies to examine the role of SAHA in the treatment of brain tumors.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

Substantial Dose-Response Relationship With Clinical Outcome For Lung Stereotactic Body Radiotherapy (Sbrt) Delivered Via Online Image Guidance, L. Kestin, I. Grills, M. Guckenberger, J. Belderbos, A. J. Hope, M. Werner-Wasik, J. J. Sonke, J. P. Bissonnette, Y. Xiao, D. Yan

Bodine Journal

Purpose: To examine potential tumor dose-response relationships with various non-small cell lung cancer (NSCLC) SBRT fractionation regimens delivered with online CT-based image guidance.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

Early Stage Testicular Seminoma: A Multicenter Review Of Treatment Outcomes And Patterns Of Recurrence, M. Kim, E. Wuthrick, A. Lin

Bodine Journal

Purpose/Objective(s): Although overall survival for early stage testicular seminoma is generally excellent, certain pathologic factors can increase recurrence risk for those undergoing observation, while radiation therapy (RT) can be associated with long-term morbidity. We sought to identify disease-related and treatment-related factors that influenced the outcomes, with particular emphasis on recurrence risk, patterns and timing of recurrence, as well as RT-induced malignancy.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

Poor Pulmonary Function Is Not Associated With Increased Rates Of Toxicity Or Decreased Overall Survival After Stereotactic Body Radiotherapy For Early Stage Non-Small Cell Lung Cancer: Results Of A Multi-Institutional Analysis, M. Guckenberger, J. Belderbos, A. Hope, L. L. Kestin, M. Werner-Wasik, J. J. Sonke, Y. Xiao, D. Yan, J. Wilbert, I. S. Grills

Bodine Journal

Purpose/Objective(s): Stereotactic body radiotherapy (SBRT) is considered as the treatment of choice for stage I non-small cell lung cancer (NSCLC) in medically inoperable patients. It was the purpose of this study to evaluate whether pretreatment pulmonary function is predictive for survival and toxicity after SBRT.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

A Multi-National Pooled Analysis Of 434 Cases Of Stage I Non-Small Cell Lung Cancer (Nsclc) Treated With Volumetrically Image-Guided Stereotactic Lung Radiotherapy: Results From The Elekta Collaborative Lung Research Group, I. S. Grills, A. J. Hope, M. Guckenberger, L. L. Kestin, M. Werner-Wasik, D. Yan, J. J. Sonke, J. P. Bissonnette, Y. Xiao, J. Belderbos

Bodine Journal

Background: Published lung SBRT outcomes/dose response data for inoperable NSCLC come from small phase I-II studies or larger datasets not requiring image-guided radiotherapy (IGRT) or volumetric prescriptions. This entire cohort of SBRT patients had daily online cone-beam CT.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

Toxicity Of Phase I Radiation Oncology Trials: Worldwide Experience, C. Glass, R. B. Den, A. P. Dicker, Y. R. Lawrence

Bodine Journal

Introduction: Informed consent involves understanding the risks and benefits of trial enrollment. This is challenging in the phase I setting since true quantitative information is never known. We therefore performed an analysis of published radiation oncology (RO) phase I trials emphasizing patient outcomes. To our knowledge, no such systemic analysis has previously been published.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

Pathologic Correlation Of Pet-Ct Based Auto Contouring For Radiation Planning In Lung Cancer, S. E. Fogh, A. Farach, C. Intenzo, R. Axelrod, P. Mccue, A. Harper, A. Nelson, M Werner-Wasik

Bodine Journal

Purpose/Objective(s): Radiation therapy in lung cancer relies on CT and functional imaging (FDG-PET) to delineate tumor volumes. Semi-automatic contouring tools have been developed for PET to improve on the inter-observer bias of manual contouring and intrinsic differences in imaging equipment. A common method involves using a threshold at a given percentage of the max activity, which may be less accurate with smaller tumors and tumors with low source to background ratio. To overcome this deficiency, a gradient algorithm, which detects changes in image counts at the border of the tumor, has been developed. Few studies have correlated these methods to …

Igrt After Prostatectomy: Evaluation Of Corrective Shifts And Toxicity Using Online Cone Beam Ct Vs. Weekly Port Films For Target Localization, H. B. Eldredge, M. Studenski, S. Keith, E. J. Trabulsi, A. Harvey, C. Lallas, L. Gomella, A. P. Dicker, T. N. Showalter

Bodine Journal

Purpose/Objective(s): Image guidance (IG) may permit higher radiotherapy (RT) doses (>65 Gy) after radical prostatectomy (RP) without increased toxicity, with improved accuracy and smaller margins. Conebeam (CBCT) allows IGRT with volumetric images. This study evaluated CBCT shifts and toxicity after conformal IGRT, compared to RT with port films.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA

Dosimetric Comparison Of Vmat, Imrt And Proton Therapy For Post- Prostatectomy Radiation Therapy For Prostate Cancer, L. A. Doyle, M. Studenski, A. Harvey, A. P. Dicker, Y. Xiao, Y. Yu, T. N. Showalter, A. Harrison

Bodine Journal

Purpose/Objectives: Radiation therapy (RT) for the treatment of prostate cancer after radical prostatectomy (RP) is widely accepted. With technological advances, radiation treatment technique and dosimetry may vary. The purpose of this study is to quantify dosimetric difference of proton therapy versus VMAT and IMRT focusing on bladder and rectal dose sparing and target coverage.

American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, CA