Digital Commons Network^™

Interactions Of Burkholderia Pseudomallei And Acanthamoeba Castellanii And Their Effects On Virulence In Human Monocytes, Emily Ann Moore

Theses and Dissertations

Burkholderia pseudomallei, the etiological agent of melioidosis, is a saprophytic bacterium existing endemically in the water and soil of SE Asia and Northern Australia. This organism has shown the ability to remain dormant in its host for decades. B. thailandensis is a closely related non-pathogenic near neighbor that is also found in these soils. It has been suggested that free-living amoeba could be natural reservoirs for these organisms. The interactions of Burkholderia species and Acanthamoeba castellanii, a species of free-living amoeba, were studied to better understand the natural ecology of these organisms and to determine the effects amoeba …

Ribosomal Synthesis Of N-Methylated Peptides, Sara Ahadi

Theses and Dissertations

Natural peptide products isolated from various organisms often contain N-methylated backbones. Such a modification of backbone of the peptide changes its conformational rigidity. This modification improves the biological properties of the peptide, such as improved target affinity, proteolytic stability or membrane permeability. Therefore synthesis of N-methylated peptide libraries is valuable in screening for drug-like peptides suitable for therapeutic uses. Protein synthesis using recombinant elements (PURE) and Flexizyme were used in order to reassign specific codons to N-methyl amino acids. mRNA-dependent translation system enable us to make our desired peptides with N-methyl amino acids. This technology is a convenient tool for …

Citations In Psychology Phd Theses: An Obsolescence Study, N. Zafrunnisha, V. Pulla Reddy

Library Philosophy and Practice (e-journal)

An obsolescence study is one of the main areas of bibliometrics in library and information science. The study attempts to discover the obsolescence rate of psychology literature cited in the 141 doctoral theses awarded by the S.V. University Tirupati, Osmania University, Hyderabad, and Andhra University, Visakhapattanam, from 1963-2005. Half-life of journal citations in psychology was found to be 14 years and 19 years for book citations.

Effect Of Mechanical Stimulation On Mesenchymal Stem Cell Seeded Cartilage Constructs, Karin Wartella

Theses and Dissertations

Cartilage tissue engineered constructs using mesenchymal stem cells were stimulated with 3 different stimulation algorithms to achieve characteristics mimicking the superficial tangential zone of articular cartilage. The stimulation algorithm of both compression and tension without an offset had the best properties out of all the evaluated groups.

The Daily Egyptian, July 27, 2010, Daily Egyptian Staff

July 2010

No abstract provided.

St-11 - Utah - 2010-07-27, Dorothy Horan

State Representatives

No abstract provided.

Reproductive Senescence In The Florida Scrub-Jay (Aphelocoma Coerulescens), Travis Eli Wilcoxen

Electronic Theses and Dissertations Archive

Analysis of twenty years of historical reproductive data from our study population of Florida Scrub-Jays reveals a quadratic relationship between breeder age and number of fledglings produced, with the youngest and oldest birds having the lowest reproductive success. Such a decrease in reproductive performance in older birds, despite the likely benefits of increased experience, is often attributed to senescence. My dissertation research considered reproductive endocrinology, stress physiology, immunology, egg hatchability, life history trade-offs, and parental behavior. The oldest and youngest females have greater rates of hatching failure than middle-aged females. Results also indicate that circulating levels of reproductive hormones decrease …

The Power Within: The Influence Of Spirituality On African American Female Adult Learners, Nakeisha Latoy Owens

Electronic Theses and Dissertations Archive

This interpretive, qualitative study investigated the influence of spirituality in the lives six African American female adult learners. The following questions guided the research study:1) What role has spirituality played in the pursuit of educational goals of African American female adult learners? and 2)What influence has spirituality had on the development of these adult learners?An examination of the influence of spirituality in the areas of motivation, barriers, and adult development among college students framed the scholarly review of existing literature. The data collection methods included interviews, timeline and song lyric elicitations, and field notes.The interviews were audio recorded and transcribed.An …

Methods For Inhibiting Tumor Cell Proliferation, James Turkson, Richard Jove, Jay W. Palmer, Heidi Kay, Hua Yu

USF Patents

The subject invention concerns methods for inhibition of STAT biological functions using platinum complexes.

Ship-Deficiency To Increase Megakaryocyte Progenitor Production, William G. Kerr, Caroline Desponts, Lia Elena Perez

USF Patents

The invention concerns a method for increasing megakaryocyte and megakaryocyte progenitor numbers in vitro or in vivo by suppressing SH2-containing inositol-5-phosphatase (SHIP) function in megakaryocytes or megakaryocyte progenitors expressing the SHIP gene. SHIP function can be suppressed by administering an interfering RNA, or other SHIP inhibitor, to the megakaryocytes or megakaryocyte progenitors in vitro or in vivo.

Piperazinone Compounds As Anti-Tumor And Anti-Cancer Agents And Methods Of Treatment, Andrew D. Hamilton, Said Sebti, Hairuo Peng

USF Patents

The present invention relates to piperazinone compounds, pharmaceutical compositions containing those compounds and methods of treating tumors and cancer, among other disease states and conditions in mammalian patients, especially including humans.

Genetic Polymorphisms Of Cyp2e1, Gstp1, Nqo1 And Mpo And The Risk Of Nasopharyngeal Carcinoma In A Han Chinese Population Of Southern China, Xiuchan Guo, Yi Zeng, Hong Deng, Jian Liao, Yuming Zheng, Ji Li, Bailey Kessing, Stephen J. O'Brien

Biology Faculty Articles

Background

Southern China is a major area for endemic nasopharyngeal carcinoma (NPC). Genetic factors as well as environmental factors play a role in development of NPC. To investigate the roles of previously described carcinogen metabolism gene variants for NPC susceptibility in a Han Chinese population, we conducted a case-control study in two independent study population groups afflicted with NPC in Guangdong and Guangxi Provinces of southern China.

Methods

Five single nucleotide polymorphisms (SNPs) of CYP2E1-rs2031920, CYP2E1-rs6413432, GSTP1-rs947894, MPO-rs2333227 and NQO1-rs1800566 were genotyped by PCR-based RFLP, sequencing and TaqMan assay in 358 NPC cases and 629 …

Evolutionary Relationships In Afro-Malagasy Schefflera (Araliaceae) Based On Nuclear And Plastid Markers, Morgan Gostel

Theses and Dissertations

The genus Schefflera is the largest in Araliaceae, with approximately 900 species. Recent studies have shown that Schefflera is polyphyletic and represents no fewer than five distinct clades, each corresponding to a specific geographic region including Asia, continental Africa and Madagascar, Melanesia, the Neotropics, and a small clade distributed throughout several islands in the insular Pacific Ocean. The Afro-Malagasy clade contains nearly 50 species distributed throughout tropical, sub-Saharan Africa, Madagascar, the Comoros, and the Seychelles islands. Previous studies have suggested that this group is monophyletic, identifying two smaller subclades within Afro-Malagasy Schefflera corresponding roughly to informal groups identified as “Meiopanax” …

Social Relationships And Mortality Risk: A Meta-Analytic Review, Timothy B. Smith, Julianne Holt-Lunstad, J. Bradley Layton

Faculty Publications

Background: The quality and quantity of individuals' social relationships has been linked not only to mental health but also to both morbidity and mortality. Objectives: This meta-analytic review was conducted to determine the extent to which social relationships influence risk for mortality, which aspects of social relationships are most highly predictive, and which factors may moderate the risk. Data Extraction: Data were extracted on several participant characteristics, including cause of mortality, initial health status, and pre-existing health conditions, as well as on study characteristics, including length of follow-up and type of assessment of social relationships. Results: Across 148 studies (308,849 …

Research News: 2010, No. 1, University Of Mississippi. School Of Pharmacy

Research News: Grants and Publications (2000-2014)

Grants, publications, technology transfer, special announcements

Human Induced Rotation And Reorganization Of The Brain Of Domestic Dogs, Taryn Roberts, Paul Mcgreevy, Michael Valenzuela

Anatomy Collection

Domestic dogs exhibit an extraordinary degree of morphological diversity. Such breed-to-breed variability applies equally to the canine skull, however little is known about whether this translates to systematic differences in cerebral organization. By looking at the paramedian sagittal magnetic resonance image slice of canine brains across a range of animals with different skull shapes (N = 13), we found that the relative reduction in skull length compared to width (measured by Cephalic Index) was significantly correlated to a progressive ventral pitching of the primary longitudinal brain axis (r = 0.83), as well as with a ventral shift in the position …

Human Induced Rotation And Reorganization Of The Brain Of Domestic Dogs, Taryn Roberts, Paul Mcgreevy, Michael Valenzuela

Morphology Collection

Domestic dogs exhibit an extraordinary degree of morphological diversity. Such breed-to-breed variability applies equally to the canine skull, however little is known about whether this translates to systematic differences in cerebral organization. By looking at the paramedian sagittal magnetic resonance image slice of canine brains across a range of animals with different skull shapes (N = 13), we found that the relative reduction in skull length compared to width (measured by Cephalic Index) was significantly correlated to a progressive ventral pitching of the primary longitudinal brain axis (r = 0.83), as well as with a ventral shift in the position …

Moral Identification: An Alternative Approach To Framing Second-Generation Immigrants' Ethnic Identity Ambivalence, Benjamin R. Brady

Theses and Dissertations

Contemporary sociological research on second-generation immigrants living in the United States is lined with questions of ethnic inclusion and transnational participation. Many scholars are interested in how the children of immigrants relate to their parents' ethnic identity while being raised in a new land. Noting that the majority of scholars in this field approach ethnic identity within a social constructionist perspective, in this study I explore the ways that identity ambivalence and ethnic belonging are framed. Specifically, I critically question the ways that an ethnic identity is assumed to be valued and asserted in a constructionist model. After presenting a …

Distorting The Sarcomere, Kenneth S. Campbell

Physiology Faculty Publications

No abstract provided.

The Effects Of Hydrology And Vegetation On Microbial Community Structure And Soil Function In The Sediments Of Freshwater Wetlands, Christine Prasse

Theses and Dissertations

In wetland soils, hydrology is considered to be one of the primary factors shaping wetland function and microbial community structure, but plant-soil interactions are also important mechanisms affecting microbial nutrient transformations. The research presented here considered the interactive effect to describe how hydrology and the presence of plants alter the soil profile, the development of the bacterial community, and their associated functions. To achieve this goal, plots were established in three hydrologically-distinct regimes (Wet, Intermediate, and Dry) within a non-tidal freshwater wetland along the James River (Charles City County, Virginia). Inside each main plot, ten subplots were cleared of all …

Monitor Newsletter July 26, 2010, Bowling Green State University

Monitor

Official Publication of Bowling Green State University for Faculty and Staff

The Relationship Among Maternal Infant Bonding, Spirituality, And Maternal Perception Of Childbirth Experience, Linda Bennington

Theses and Dissertations

The beginning of life is an intense experience for both mother and baby and sets the foundation for future interactions. Researchers have theorized that maternal infant bonding begins prenatally and continues on through the postnatal period. Mṻller (1996) examined that process to determine if prenatal bonding was related to postnatal bonding and discovered that there was only a modest correlation between the two. This led to speculation as to what variables, besides prenatal bonding, could influence postnatal bonding. Klaus & Kennell (1976) noted the detrimental effects of a lack of bonding in terms of abuse and attachment disorders and emphasized …

In Vitro Enabling Technologies For Use In The Aquatic Environment, Colm J. O'Dowd

Doctoral

O’Dowd, C., Mothersill, C.E., Cairns, M.T., Austin, B., Lyng, F.M., McClean, B. and Murphy, J.E.J. Assessing the mitochondrion as a biomarker of fish tissue damage using g radiation as a stress model in vitro.

There is an ever-increasing need for biomarkers to identify toxic stress in the aquatic environment. Such techniques need to be accurate, expeditious, ethical and economical. Typically, in vitro based platforms fit these criteria however many of these systems often undergo ‘assay drift’ and consequently do not fully represent the real-life situation.

In recent years, there has been growing interest in the mitochondrion and its (dys)function …

Medical School Watercooler Newsletter - July 25, 2010, Lindsey Lyle

Watercooler Newsletter

This is the July 25, 2010 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Ashley Turbeville & Charlene Jordan Earn Certification For Research Administrators
• Family Medicine Graduate Dr. Heather Cannon Joins USA Student Health Center
• Medical Student Research Day Set For Aug. 6 - Dr. Jane Reusch To Lecture
• High School Students Visit Medical School During Summer Scrubs Program
• USA College of Medicine Welcomes Dr. Juan G. Ochoa
• Mobile Medical Museum Newsletter - Read About Pioneering Female Physicians in Mobile

Let The Child Decide: Surgical Intervention After Parental Consent Should No Longer Be Considered The Best Option For Children With Intersex Conditions, Kaitlin O. Semler

Student Works

No abstract provided.

The Murray Ledger And Times, July 24, 2010, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

07-23-2010 High School Students Attend Swosu Science & Math Academy, Southwestern Oklahoma State University

THE BARK ARCHIVE 2010

Thirty high school students attended the Summer Science and Mathematics Academy July 11-23 at Southwestern Oklahoma State University in Weatherford.

Measurement Of Hono, Hnco, And Other Inorganic Acids By Negative-Ion Proton-Transfer Chemical-Ionization Mass Spectrometry (Ni-Pt-Cims): Application To Biomass Burning Emissions, J. M. Roberts, P. Veres, C. Warneke, J. A. Neuman, R. A. Washenfelder, S. S. Brown, M. Baasandorj, J. B. Burkholder, I. R. Burling, T. J. Johnson, Robert J. Yokelson, J. De Gouw

Chemistry and Biochemistry Faculty Publications

A negative-ion proton-transfer chemical ionization mass spectrometric technique (NI-PT-CIMS), using acetate as the reagent ion, was applied to the measurement of volatile inorganic acids of atmospheric interest: hydrochloric (HCl), nitrous (HONO), nitric (HNO(3)), and isocyanic (HNCO) acids. Gas phase calibrations through the sampling inlet showed the method to be intrinsically sensitive (6-16 cts/pptv), but prone to inlet effects for HNO(3) and HCl. The ion chemistry was found to be insensitive to water vapor concentrations, in agreement with previous studies of carboxylic acids. The inlet equilibration times for HNCO and HONO were 2 to 4s, allowing for measurement in biomass burning …

Phylotree – A Toolkit For Computing Experiments With Distance-Based Methods For Genome Coevolution, Elissaveta Arnaoudova, Jerzy W. Jaromczyk, Neil Moore, Christopher L. Schardl, Ruriko Yoshida

Computer Science Presentations

We have developed software called Phylotree as a toolkit for running experiments to study gene cophylogenies for genome evolution using distance-based methods. In particular, the toolkit has been instrumental in conducting processing-heavy experiments with the new “difference of means” statistical method. Phylotree was used to run experiments using simulated data as well as biological sequences of well known host and parasite species, and is distributed with data and configuration files allowing these experiments to be reproduced.

Ciszek V. Kootenai County Bd. Of Com'rs Augmentation Record Dckt. 37562

Idaho Supreme Court Records & Briefs, All

No abstract provided.