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2010

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Neural Activity In The Hippocampus And Perirhinal Cortex During Encoding Is Associated With The Durability Of Episodic Memory, V. A. Carr, Indre Viskontas, S. A. Engel, B. J. Knowlton Jan 2010

Neural Activity In The Hippocampus And Perirhinal Cortex During Encoding Is Associated With The Durability Of Episodic Memory, V. A. Carr, Indre Viskontas, S. A. Engel, B. J. Knowlton

Psychology

Studies examining medial temporal lobe (MTL) involvement in memory formation typically assess memory performance after a single, short delay. Thus, the relationship between MTL encoding activity and memory durability over time remains poorly characterized. To explore this relationship, we scanned participants using high-resolution functional imaging of the MTL as they encoded object pairs; using the remember/know paradigm, we then assessed memory performance for studied items both 10 min and 1 week later. Encoding trials were classified as either subsequently recollected across both delays, transiently recollected (i.e., recollected at 10 min but not after 1 week), consistently familiar, or consistently forgotten. …


A Model‐Data Intercomparison Of Co2 Exchange Across North America: Results From The North American Carbon Program Site Synthesis, Christopher R. Schwalm, Christopher A. Williams, Kevin Schaefer, Ryan S. Anderson, M. Altaf Arain, Ian Baker, Alan Barr, T. Andrew Black, Guangsheng Chen, Jing Ming Chen, Philippe Ciais, Kenneth J. Davis, Ankur R. Desai, Michael Dietze, Danilo Dragoni, Marc L. Fischer, Lawrence B. Flanagan, Robert Grant, Lianhong Gu, David Hollinger, R. Cesar Izaurralde, Chris Kucharik, Peter Lafleur, Beverly E. Law, Longhui Li, Zhengpeng Li, Shuguang Liu, Erandathie Lokupitiya, Yiqi Luo, Siyan Ma, Hank Margolis, Roser Matamala, Harry Mccaughey, Russell K. Monson, Walter C. Oechel, Changhui Peng, Benjamin Poulter, David T. Price, Dan M. Riciutto, William Riley, Alok Kumar Sahoo, Michael Sprintsin, Jianfeng Sun, Hanqin Tian, Christian Tonitto, Hans Verbeeck, Shashi B. Verma Jan 2010

A Model‐Data Intercomparison Of Co2 Exchange Across North America: Results From The North American Carbon Program Site Synthesis, Christopher R. Schwalm, Christopher A. Williams, Kevin Schaefer, Ryan S. Anderson, M. Altaf Arain, Ian Baker, Alan Barr, T. Andrew Black, Guangsheng Chen, Jing Ming Chen, Philippe Ciais, Kenneth J. Davis, Ankur R. Desai, Michael Dietze, Danilo Dragoni, Marc L. Fischer, Lawrence B. Flanagan, Robert Grant, Lianhong Gu, David Hollinger, R. Cesar Izaurralde, Chris Kucharik, Peter Lafleur, Beverly E. Law, Longhui Li, Zhengpeng Li, Shuguang Liu, Erandathie Lokupitiya, Yiqi Luo, Siyan Ma, Hank Margolis, Roser Matamala, Harry Mccaughey, Russell K. Monson, Walter C. Oechel, Changhui Peng, Benjamin Poulter, David T. Price, Dan M. Riciutto, William Riley, Alok Kumar Sahoo, Michael Sprintsin, Jianfeng Sun, Hanqin Tian, Christian Tonitto, Hans Verbeeck, Shashi B. Verma

School of Natural Resources: Faculty Publications

Our current understanding of terrestrial carbon processes is represented in various models used to integrate and scale measurements of CO2 exchange from remote sensing and other spatiotemporal data. Yet assessments are rarely conducted to determine how well models simulate carbon processes across vegetation types and environmental conditions. Using standardized data from the North American Carbon Program we compare observed and simulated monthly CO2 exchange from 44 eddy covariance flux towers in North America and 22 terrestrial biosphere models. The analysis period spans ~220 site‐years, 10 biomes, and includes two large‐scale drought events, providing a natural experiment to evaluate …


Translocation To A Fragmented Landscape: Survival, Movement, And Site Fidelity Of Northern Bobwhites, Theron M. Terhune, D. Clay Sisson, William E. Palmer, Brant C. Faircloth, H. Lee Stribling, John P. Carroll Jan 2010

Translocation To A Fragmented Landscape: Survival, Movement, And Site Fidelity Of Northern Bobwhites, Theron M. Terhune, D. Clay Sisson, William E. Palmer, Brant C. Faircloth, H. Lee Stribling, John P. Carroll

School of Natural Resources: Faculty Publications

Habitat fragmentation, degradation, and loss have taxed early-successional species including the Northern Bobwhite (Colinus virginianus) and numerous grassland obligate birds. Translocation is often applied to counteract the consequences of habitat fragmentation through the creation, reestablishment, or augmentation of wild populations for the purposes of conservation, biodiversity maintenance. However, the implementation of these techniques is often conducted without valid experimental designs and therefore lacks robust, empirical data needed to evaluate and advance the knowledge and application of translocation. Despite the increasing amount of habitat management applied to patches among fragmented landscapes, a paucity of source populations often limits natural …


Upwelling Couples Chemical And Biological Dynamics Across The Littoral And Pelagic Zones Of Lake Tanganyika, East Africa, Jessica R. Corman, P. B. Mcintyre, B. Kuboja, W. Mbemba, D. Fink, C. W. Wheeler, C. Gans, E. Michel, A. S. Flecker Jan 2010

Upwelling Couples Chemical And Biological Dynamics Across The Littoral And Pelagic Zones Of Lake Tanganyika, East Africa, Jessica R. Corman, P. B. Mcintyre, B. Kuboja, W. Mbemba, D. Fink, C. W. Wheeler, C. Gans, E. Michel, A. S. Flecker

School of Natural Resources: Faculty Publications

We studied the effects of upwelling on nutrient and phytoplankton dynamics in the pelagic and littoral zones of Lake Tanganyika near Kigoma, Tanzania. During the dry season of 2004, a rise in the thermocline and sudden drop in surface water temperatures indicated a substantial upwelling event. Increases in concentrations of nitrate, soluble reactive phosphorus, and silica in the surface waters occurred simultaneously after the temperature drop. Within days, chlorophyll a concentrations increased and remained elevated, while inorganic nutrient concentrations returned to preupwelling levels and organic nutrient concentrations peaked. We observed parallel temporal patterns of water temperature, nutrient concentrations, and phytoplankton …


Diurnal Fluctuations In Shallow Groundwater Levels And In Streamflow Rates And Their Interpretation: A Review, Zoltan Gribovszki, Jozsef Szilagyi, Peter Kalicz Jan 2010

Diurnal Fluctuations In Shallow Groundwater Levels And In Streamflow Rates And Their Interpretation: A Review, Zoltan Gribovszki, Jozsef Szilagyi, Peter Kalicz

School of Natural Resources: Faculty Publications

No abstract provided.


Introduction To The Basic Drivers Of Climate, Alison P. Stevens Jan 2010

Introduction To The Basic Drivers Of Climate, Alison P. Stevens

School of Natural Resources: Faculty Publications

Climates on Earth vary from the warm, wet tropics to the cold, dry Arctic and Antarctic. What drives this variation?

Every day, we note the weather: temperature, rain, cloud cover, wind and humidity. Climate is the long-term prevailing weather in an area and is largely determined by temperature and precipitation. The climate in a desert is hot and dry. The climate in the tropics is warm and wet. The climate of a particular area is the largest determinant to the life found there. Climate is a key focus in ecology. Variations in climate include daily and seasonal cycles. Climatic variation …


Albedo Estimates For Land Surface Models And Support For A New Paradigm Based On Foliage Nitrogen Concentration, David Y. Hollinger, S. V. Ollinger, A. D. Richardson, T. P. Meyers, D. B. Dail, M. E. Martin, N. A. Scott, T. J. Arkebauer, D. D. Baldocchi, K. L. Clark, P. S. Curtis, K. J. Davis, A. R. Desai, D. Dragoni, M. L. Goulden, L. Gu, G. G. Katul, S. G. Pallardy, K. T. Pawu, H. P. Schmid, P. C. Stoy, Andrew E. Suyker, Shashi Verma Jan 2010

Albedo Estimates For Land Surface Models And Support For A New Paradigm Based On Foliage Nitrogen Concentration, David Y. Hollinger, S. V. Ollinger, A. D. Richardson, T. P. Meyers, D. B. Dail, M. E. Martin, N. A. Scott, T. J. Arkebauer, D. D. Baldocchi, K. L. Clark, P. S. Curtis, K. J. Davis, A. R. Desai, D. Dragoni, M. L. Goulden, L. Gu, G. G. Katul, S. G. Pallardy, K. T. Pawu, H. P. Schmid, P. C. Stoy, Andrew E. Suyker, Shashi Verma

School of Natural Resources: Faculty Publications

Vegetation albedo is a critical component of the Earth’s climate system, yet efforts to evaluate and improve albedo parameterizations in climate models have lagged relative to other aspects of model development. Here, we calculated growing season albedos for deciduous and evergreen forests, crops, and grasslands based on over 40 site-years of data from the AmeriFlux network and compared them with estimates presently used in the land surface formulations of a variety of climate models. Generally, the albedo estimates used in land surface models agreed well with this data compilation. However, a variety of models using fixed seasonal estimates of albedo …


Non-Destructive Estimation Pigment Content Ripening Quality And Damage In Apple Fruit With Spectral Reflectance In The Visible Range, Alexei E. Solovchenko, Olga B. Chivkunova, Anatoly A. Gitelson, Mark N. Merzlyak Jan 2010

Non-Destructive Estimation Pigment Content Ripening Quality And Damage In Apple Fruit With Spectral Reflectance In The Visible Range, Alexei E. Solovchenko, Olga B. Chivkunova, Anatoly A. Gitelson, Mark N. Merzlyak

School of Natural Resources: Faculty Publications

Modern non-destructive optical-reflectance-based techniques for estimation of pigment (chlorophyll, carotenoid, anthocyanin, and flavonol) contents, the rate of on- and off-tree ripening as well as for detection of common physiological disorders, such as sunscald, superficial scald, and water core, and other damages to apple fruit are an emphasis on the methods developed by the authors. The basic spectral features of fruit reflectance in the visible and near infra-red are briefly considered together with their implications for the development of algorithms for non-destructive pigment content assessment. The use of reflectance spectroscopy for estimating chlorophyll and carotenoid content as well as carotenoid/chlorophyll ratio …


Long-Term Response Of Groundwater Nitrate Concentrations To Management Regulations In Nebraska’S Central Platte Valley, Mary Exner Spalding, Hugo Perea-Estrada, Roy F. Spalding Jan 2010

Long-Term Response Of Groundwater Nitrate Concentrations To Management Regulations In Nebraska’S Central Platte Valley, Mary Exner Spalding, Hugo Perea-Estrada, Roy F. Spalding

School of Natural Resources: Faculty Publications

The impact of 16 years (1988–2003) of management practices on high groundwater nitrate concentrations in Nebraska’s central Platte River valley was assessed in a 58,812-ha (145,215-ac) groundwater quality management area intensively cropped to irrigated corn (Zea mays L.). Crop production and groundwater nitrate data were obtained from ~23,800 producer reports. The terrace, comprising ~56% of the study area, is much more intensively cropped to irrigated corn than the bottomland. From 1987 to 2003, average groundwater nitrate concentrations in the primary aquifer beneath the bottomland remained static at ~8 mg N/l. During the same period, average groundwater nitrate concentrations in the …


Finding The Smoothest Path To Success: Model Complexity And The Consideration Of Nonlinear Patterns In Nest-Survival Data, Max Post Van Der Burg, Larkin A. Powell, Andrew J. Tyre Jan 2010

Finding The Smoothest Path To Success: Model Complexity And The Consideration Of Nonlinear Patterns In Nest-Survival Data, Max Post Van Der Burg, Larkin A. Powell, Andrew J. Tyre

School of Natural Resources: Faculty Publications

Quantifying patterns of nest survival is a first step toward understanding why birds decide when and where to breed. Most studies of nest survival have relied on generalized linear models (GLM) to explore these patterns. However, GLMs require assumptions about the models’ structure that might preclude finding nonlinear patterns in survival data. Generalized additive models (GAM) provide a flexible alternative to GLMs for estimating linear and nonlinear patterns in data. Here we present a comparison of GLMs and GAMs for explaining variation in nest-survival data. We used two different model-selection criteria, the Bayes (BIC) and Akaike (AIC) information criteria, to …


Assessment Of Hatchery-Reared Pallid Sturgeon Survival In The Lower Missouri River, Kirk D. Steffensen, Larkin A. Powell, Jeff D. Koch Jan 2010

Assessment Of Hatchery-Reared Pallid Sturgeon Survival In The Lower Missouri River, Kirk D. Steffensen, Larkin A. Powell, Jeff D. Koch

School of Natural Resources: Faculty Publications

The population of pallid sturgeon Scaphirhynchus albus in the lower Missouri River between Gavins Point Dam (river kilometer [rkm] 1,305.2) and the confluence with the Mississippi River (rkm 0.0) remains imperiled, little to no natural recruitment occurring. Artificial propagation and subsequent population augmentation (i.e., stocking) may be the only viable option for maintaining pallid sturgeon populations in the lower Missouri River in the near term. Because relatively little is known about the ability of hatchery-reared pallid sturgeon to survive, the objective of this study was to quantify survival estimates for hatchery-reared pallid sturgeon stocked into the lower Missouri River. We …


Finding The Smoothest Path To Success: Model Complexity And The Consideration Of Nonlinear Patterns In Nest-Survival Data Encontrando El Camino Mas Facil Hacia El Exito: Complejidad De Los Modelos Y Consideraci6n De Patrones No Lineales En Datos De Supervivencia De Nidos, Max Post Van Der Burg, Larkin A. Powell, Andrew J. Tyre Jan 2010

Finding The Smoothest Path To Success: Model Complexity And The Consideration Of Nonlinear Patterns In Nest-Survival Data Encontrando El Camino Mas Facil Hacia El Exito: Complejidad De Los Modelos Y Consideraci6n De Patrones No Lineales En Datos De Supervivencia De Nidos, Max Post Van Der Burg, Larkin A. Powell, Andrew J. Tyre

School of Natural Resources: Faculty Publications

Quantifying patterns of nest survival is a first step toward understanding why birds decide when and where to breed. Most studies of nest survival have relied on generalized linear models (GLM) to explore these patterns. However, GLMs require assumptions about the models' structure that might preclude finding nonlinear patterns in survival data. Generalized additive models (GAM) provide a flexible alternative to GLMs for estimating linear and nonlinear patterns in data. Here we present a comparison of GLMs and GAMs for explaining variation in nest-survival data. We used two different model-selection criteria, the Bayes (BIC) and Akaike (AIC) information criteria, to …


2010 Interior Least Tern And Piping Plover Monitoring, Research, Management, And Outreach Report For The Lower Platte River, Nebraska, Mary Bomberger Brown, Joel G. Jorgensen Jan 2010

2010 Interior Least Tern And Piping Plover Monitoring, Research, Management, And Outreach Report For The Lower Platte River, Nebraska, Mary Bomberger Brown, Joel G. Jorgensen

School of Natural Resources: Faculty Publications

This document reports on our monitoring, research, management, and outreach activities during the past 12 months (2010). We prepared it to inform our partners, cooperating agencies, funding sources, and other interested parties of our activities and to provide a preliminary summary of our results.

The Tern and Plover Conservation Partnership (TPCP), based at the University of Nebraska–School of Natural Resources, and the Nongame Bird Program (NBP), based at the Nebraska Game and Parks Commission (NGPC) work cooperatively on Interior Least Tern and Piping Plover monitoring, research, management, and outreach activities. While the focus of our work is the Lower Platte, …


Coupling Of Carbon Dioxide And Water Vapor Exchanges Of Irrigated And Rainfed Maize–Soybean Cropping Systems And Water Productivity, Andrew E. Suyker, Shashi B. Verma Jan 2010

Coupling Of Carbon Dioxide And Water Vapor Exchanges Of Irrigated And Rainfed Maize–Soybean Cropping Systems And Water Productivity, Andrew E. Suyker, Shashi B. Verma

School of Natural Resources: Faculty Publications

Continuous measurements of CO2 and water vapor exchanges made in three cropping systems (irrigated continuous maize, irrigated maize–soybean rotation, and rainfed maize–soybean rotation) in eastern Nebraska, USA during 6 years are discussed. Close coupling between seasonal distributions of gross primary production (GPP) and evapotranspiration (ET) were observed in each growing season. Mean growing season totals of GPP in irrigated maize and soybean were 1738 ± 114 and 996 ± 69 g C m−2, respectively (±standard deviation). Corresponding mean values of growing season ET totals were 545 ± 27 and 454 ± 23 mm, respectively. Irrigation affected GPP …


2009-2010 President's Report, Mardi Mileham, Laura Davis Jan 2010

2009-2010 President's Report, Mardi Mileham, Laura Davis

Presidential Reports

The Linfield College President's Annual Report is a collection of information about the year in review, including academics, student life and athletics, enrollment, finances, philanthropy, and leadership.


The Lion 2010, Langston University Jan 2010

The Lion 2010, Langston University

LU Yearbooks, 2010-

No abstract provided.


Stonehill Alumni Magazine Winter/Spring 2010, Stonehill College Office Of Communications And Media Relations Jan 2010

Stonehill Alumni Magazine Winter/Spring 2010, Stonehill College Office Of Communications And Media Relations

Stonehill Alumni Magazine

This issue of the magazine includes the following features:

  • Bad Grades, Gone Good: Sometimes receiving a poor grade can provide lasting direction. Alumni share stories of falling short of the mark from a grade perspective, but of learning a valuable life lesson along the way. By Maura King Scully
  • Make Yourself at Home SAM invites alumni and friends to spend the day at Stonehill as part of this year's "staycation." Story includes a map and sample itinerary, highlighting some new sites as well as a few favorite spots on campus.
  • Craig's List: It is easy to get caught up in …


2010 Annual Joint Report On Pre-Kindergarten Through Higher Education In Tennessee, Tennessee. State Board Of Education, Tennessee Higher Education Commission Jan 2010

2010 Annual Joint Report On Pre-Kindergarten Through Higher Education In Tennessee, Tennessee. State Board Of Education, Tennessee Higher Education Commission

Annual Joint Reports

This report includes, but is not limited to, a discussion of the following four areas: minimizing duplication, compatibility, state needs in education, and master plan fulfillment.


Tennessee Agriculture 2010, Tennessee. Department Of Agriculture Jan 2010

Tennessee Agriculture 2010, Tennessee. Department Of Agriculture

Annual Report & Statistical Summary

This annual report and statistical summary highlights the accomplishments done by the Tennessee Department of Agriculture.


Transforming Teenagers: Integrating Social Justice Into Catholic Youth Ministry Or Catholic Education, Arthur David Canales D. Min Jan 2010

Transforming Teenagers: Integrating Social Justice Into Catholic Youth Ministry Or Catholic Education, Arthur David Canales D. Min

Verbum Incarnatum: An Academic Journal of Social Justice

This article investigates transforming teenagers through the process on integrating and implementing social justice concepts and principles into Catholic youth ministry and Catholic secondary and higher education. The essay addresses four aspects concerning social justice and Catholic young people: (1) it briefly studies the ecclesial documents concerning social justice and young people, (2) it looks at integrating Christian social justice concepts and principles into Catholic ministry and academia, (3) it examines the benefits of social justicelearning initiatives, and (4) it discusses two types of social justice-learning initiatives that work well in Catholic youth ministry and Catholic education-- praxis-based education and …


Killing An Inconvenient Truth: Social Justice And Forms Of Oppression In Modern Society, Francis Musa Boakari Ph.D Jan 2010

Killing An Inconvenient Truth: Social Justice And Forms Of Oppression In Modern Society, Francis Musa Boakari Ph.D

Verbum Incarnatum: An Academic Journal of Social Justice

Considered different, (less than human?) - Some are hated for what they are - for what they have been changed into, and believed to be. Others oppressed for what they symbolize - discriminated against for what they remind people of. Many are excluded because their wants are the same as other persons’. Many others are not listened to; made voiceless and even invisible, resilient, they stay. All humans have the same needs – biological, psychological, social, and spiritual. Nobody is asking for preferential treatments - We do not present impossible choices. All we are saying is – in relating to …


Mid-Atlantic Ethics Committee Newsletter, Winter 2010 Jan 2010

Mid-Atlantic Ethics Committee Newsletter, Winter 2010

Mid-Atlantic Ethics Committee Newsletter

No abstract provided.


County Employment Of West Virginia Higher Education Graduates 2009, George Hammond, Adam Hoffer Jan 2010

County Employment Of West Virginia Higher Education Graduates 2009, George Hammond, Adam Hoffer

Bureau of Business & Economic Research

No abstract provided.


From Higher Education To Work In West Virginia 2008, George Hammond, Adam Hoffer Jan 2010

From Higher Education To Work In West Virginia 2008, George Hammond, Adam Hoffer

Bureau of Business & Economic Research

No abstract provided.


Myosin Light Chain Kinase Mediates Transcellular Intravasation Of Breast Cancer Cells Through The Underlying Endothelial Cells: A Three-Dimensional Fret Study, S. Khuon, L. Liang, R. W. Dettman, P. H. S. Sporn, R. B. Wysolmerski, T.-L. Chew Jan 2010

Myosin Light Chain Kinase Mediates Transcellular Intravasation Of Breast Cancer Cells Through The Underlying Endothelial Cells: A Three-Dimensional Fret Study, S. Khuon, L. Liang, R. W. Dettman, P. H. S. Sporn, R. B. Wysolmerski, T.-L. Chew

Faculty & Staff Scholarship

No abstract provided.


Sustainability Through Profitability: The Triple Bottom Line, Connie I. Reimers-Hild Jan 2010

Sustainability Through Profitability: The Triple Bottom Line, Connie I. Reimers-Hild

Kimmel Education and Research Center: Presentations and White Papers

Today’s highly competitive, globalized world requires organizations and businesses to think differently about how they are going to stay in business. Businesses can no longer afford to focus on profits as their sole purpose for existence. Organizations must instead think about the “Triple Bottom Line” and its implications for their ability to grow their brand, customer loyalty and profits.


The Invisible Woman: Availability And Culpability In Reproductive Health Jurisprudence, Beth Burkstrand-Reid Jan 2010

The Invisible Woman: Availability And Culpability In Reproductive Health Jurisprudence, Beth Burkstrand-Reid

Nebraska College of Law: Faculty Publications

Women's health is widely assumed to be a significant consideration in reproductive rights cases. Court decisions relating to contraception, abortion, and childbirth demonstrate that while this assumption may have historical validity, consideration of women's health is often truncated in recent reproductive rights jurisprudence. This occurs, in part, through the application of one or both of two recurring tools. First, judges regularly--and often inaccurately--cite the theoretical availability of alternative reproductive health services as proof that women's health will not suffer even if a law curtailing reproductive rights is upheld. I label this the "availability tool." Second, when alternatives are not available, …


Pre-Mortem Cryopreservation: Recognizing A Patient’S Right To Die In Order To Live, Ryan Sullivan Jan 2010

Pre-Mortem Cryopreservation: Recognizing A Patient’S Right To Die In Order To Live, Ryan Sullivan

Nebraska College of Law: Faculty Publications

I. Introduction

II. The Science of Cryonic Preservation ... A. History of Cryonics ... B. The Process ... C. Current Science ... 1. Cryobiology ... a. Successful Births with Once-Frozen Embryos ... b. If You Can Thaw a Frozen Dog ... c. Surgeries Performed during Suspended Animation ... d. Successful Revival after Three Hours of Clinical Death ... 2. Advancements in Nanotechnology ... 3. Obstacles to Overcome

III. Relevant Law ... A. Laws Governing Cryonics ... B. Right to Die and Assisted Suicide ... C. States’ Interests Are Not Compelling ... 1. Interest in Preserving Life and Preventing Suicide ... …


High Yield And Conversion Of Biodiesel From A Nonedible Feedstock (Pongamia Pinnata), Yogesh C. Sharma, Bhaskar Singh, John Korstad Jan 2010

High Yield And Conversion Of Biodiesel From A Nonedible Feedstock (Pongamia Pinnata), Yogesh C. Sharma, Bhaskar Singh, John Korstad

College of Science and Engineering Faculty Research and Scholarship

An efficient approach has been adopted for the synthesis of biodiesel developed from karanja, a nonedible oil feedstock. A two-step reaction was followed for synthesis of biodiesel. Karanja oil possessing a high free fatty acid content was esterified with sulfuric acid, and the product obtained was further converted to fatty acid alkyl esters (biodiesel) by transesterification reactions. A moderate molar ratio of 6:1 (methanol/oil) was efficient for acid esterification with 1.5% v/v H2SO4 and 1 h of reaction time at 60 ± 0.5 °C, which resulted in reduction of FFA from 19.88 to 1.86 mg of KOH/g. …


Centrally Administered Pertussis Toxin Inhibits Microglia Migration To The Spinal Cord And Prevents Dissemination Of Disease In An Eae Mouse Model, Junxiang Yin, Jiang Long Tu, Haojie Lin, Rulan Liu, Chong Bo Zhao, Stephen W. Coons, Sandra Kuniyoshi, Jiong Shi Jan 2010

Centrally Administered Pertussis Toxin Inhibits Microglia Migration To The Spinal Cord And Prevents Dissemination Of Disease In An Eae Mouse Model, Junxiang Yin, Jiang Long Tu, Haojie Lin, Rulan Liu, Chong Bo Zhao, Stephen W. Coons, Sandra Kuniyoshi, Jiong Shi

Neurology

Background: Experimental autoimmune encephalomyelitis (EAE) models are important vehicles for studying the effect of infectious elements such as Pertussis toxin (PTx) on disease processes related to acute demyelinating encephalomyelitis (ADEM) or multiple sclerosis (MS). PTx has pleotropic effects on the immune system. This study was designed to investigate the effects of PTx administered intracerebroventricularly (icv) in preventing downstream immune cell infiltration and demyelination of the spinal cord. Methods and Findings: EAE was induced in C57BL/6 mice with MOG 35-55 . PTx icv at seven days post MOG immunization resulted in mitigation of clinical motor symptoms, minimal T cell infiltration, and …