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2010

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Ecological Niche And Potential Geographic Distribution Of The Invasive Fruit Fly Bactrocera Invadens (Diptera, Tephritidae), M. De Meyer, M. P. Robertson, M. W. Mansell, S. Ekesi, K. Tsuruta, W. Mwaiko, J. F. Vayssières, A. T. Peterson Feb 2010

Ecological Niche And Potential Geographic Distribution Of The Invasive Fruit Fly Bactrocera Invadens (Diptera, Tephritidae), M. De Meyer, M. P. Robertson, M. W. Mansell, S. Ekesi, K. Tsuruta, W. Mwaiko, J. F. Vayssières, A. T. Peterson

All Peer-Reviewed Publications

Two correlative approaches to the challenge of ecological niche modeling (genetic algorithm, maximum entropy) were used to estimate the potential global distribution of the invasive fruit fly, Bactrocera invadens, based on associations between known occurrence records and a set of environmental predictor variables. The two models yielded similar estimates, largely corresponding to Equatorial climate classes with high levels of precipitation. The maximum entropy approach was somewhat more conservative in its evaluation of suitability, depending on thresholds for presence/absence that are selected, largely excluding areas with distinct dry seasons; the genetic algorithm models, in contrast, indicate that climate class as partly …


Extension Specialist Roles In Communities Of Interest And Place: An Example From The Agriculture-Wildlife Interface, Eileen M. Cullen [email protected] Feb 2010

Extension Specialist Roles In Communities Of Interest And Place: An Example From The Agriculture-Wildlife Interface, Eileen M. Cullen [email protected]

Journal of Extension

The role of land-grant university Extension specialist originates in a community of place, enters into communities of interest to leverage resources or partnership opportunities, and returns to the local level with more effective outcomes than possible by operating solely within the community of place. A case study describes synergistic specialist programming roles that moved Wisconsin farmers and communities of interest toward a common goal of protecting corn fields from sandhill crane damage. Outcomes reinforce the concept that specialists are most effective when they forge seamless relationships between communities of place and interest, as "honest brokers," to solve unique practical local …


Chlamydomonas Mutants Display Reversible Deficiencies In Flagellar Beating And Axonemal Assembly, Mei Wei, Priyanka Sivadas, Heather A. Owen, David R. Mitchell, Pinfen Yang Feb 2010

Chlamydomonas Mutants Display Reversible Deficiencies In Flagellar Beating And Axonemal Assembly, Mei Wei, Priyanka Sivadas, Heather A. Owen, David R. Mitchell, Pinfen Yang

Biological Sciences Faculty Research and Publications

Axonemal complexes in flagella are largely prepackaged in the cell body. As such, one mutation often results in the absence of the co-assembled components and permanent motility deficiencies. For example, a Chlamydomonas mutant defective in RSP4 in the radial spoke (RS), which is critical for bend propagation, has paralyzed flagella that also lack the paralogue RSP6 and three additional RS proteins. Intriguingly, recent studies showed that several mutant strains contain a mixed population of swimmers and paralyzed cells despite their identical genetic background. Here we report a cause underlying these variations. Two new mutants lacking RSP6 swim processively and other …


Prairie Wetland Complexes As Landscape Functional Units In A Changing Climate, Carter W. Johnson, Brett Werner, Glenn R. Guntenspergen, Richard A. Voldseth, Bruce Millett, David E. Naugle, Mirela Tulbure, Rosemary W. H. Carroll, John Tracy, Craig Olawsky Feb 2010

Prairie Wetland Complexes As Landscape Functional Units In A Changing Climate, Carter W. Johnson, Brett Werner, Glenn R. Guntenspergen, Richard A. Voldseth, Bruce Millett, David E. Naugle, Mirela Tulbure, Rosemary W. H. Carroll, John Tracy, Craig Olawsky

Wildlife Biology Faculty Publications

The wetland complex is the functional ecological unit of the prairie pothole region (PPR) of central North America. Diverse complexes of wetlands contribute high spatial and temporal environmental heterogeneity, productivity, and biodiversity to these glaciated prairie landscapes. Climate-warming simulations using the new model WETLANDSCAPE (WLS) project major reductions in water volume, shortening of hydroperiods, and less-dynamic vegetation for prairie wetland complexes. The WLS model portrays the future PPR as a much less resilient ecosystem: The western PPR will be too dry and the eastern PPR will have too few functional wetlands and nesting habitat to support historic levels of waterfowl …


Use Of Rpsl As A Counterselectable Marker In Borrelia Burgdorferi, Dan Drecktrah, Miles J. Douglas, D. Scott Samuels Feb 2010

Use Of Rpsl As A Counterselectable Marker In Borrelia Burgdorferi, Dan Drecktrah, Miles J. Douglas, D. Scott Samuels

Biological Sciences Faculty Publications

We have demonstrated that rpsL, encoding the S12 protein of the small ribosomal subunit, can be used as a counterselectable marker in Borrelia burgdorferi, the causative agent of Lyme disease. Mutations in rpsL confer streptomycin resistance. Streptomycin susceptibility is dominant in an rpsL merodiploid, and streptomycin selects for the loss of wild-type rpsL carried in trans. This is the first description of a counterselectable marker in B. burgdorferi.


Psc 334.01: International Security, Karen R. Adams Feb 2010

Psc 334.01: International Security, Karen R. Adams

University of Montana Course Syllabi

No abstract provided.


Psc 250e.01: Introduction To Political Theory, Ramona Grey Feb 2010

Psc 250e.01: Introduction To Political Theory, Ramona Grey

University of Montana Course Syllabi

No abstract provided.


Greenhouse Gas Regulation Under The Clean Air Act: Structure, Effects, And Implications Of A Knowable Pathway, Nathan D. Richardson, Arthur G. Fraas, Dallas Butraw Feb 2010

Greenhouse Gas Regulation Under The Clean Air Act: Structure, Effects, And Implications Of A Knowable Pathway, Nathan D. Richardson, Arthur G. Fraas, Dallas Butraw

Faculty Publications

It appears inevitable, absent legislative intervention, that regulation under the Clean Air Act (CAA) will move beyond mobile sources to the industrial and power facilities that emit most U.S. greenhouse gas (GHG) emissions. We analyze the mechanisms available to the EPA for regulating such sources, and identify one, New Source Performance Standards (NSPS) as the most predictable, likely, and practical, i.e. knowable, pathway. Based on the legal structure of the NSPS and the EPA’s traditional approach, we analyze a hypothetical GHG NSPS for one sector, coal electricity generation. This analysis indicates that efficiency improvements and perhaps biomass cofiring could be …


Dangers In Prescription Drugs: Filling A Private Law Gap In The Healthcare Debate, David G. Owen Feb 2010

Dangers In Prescription Drugs: Filling A Private Law Gap In The Healthcare Debate, David G. Owen

Faculty Publications

No abstract provided.


Differences In The Transcriptome Signatures Of Two Genetically Related Entamoeba Histolytica Cell Lines Derived From The Same Isolate With Different Pathogenic Properties, Laura Biller, Paul H. Davis, Manuela Tillack, Jenny Matthiesen, Hannelore Lotter, Samuel L. Stanley, Egbert Tannich, Iris Bruchhaus Feb 2010

Differences In The Transcriptome Signatures Of Two Genetically Related Entamoeba Histolytica Cell Lines Derived From The Same Isolate With Different Pathogenic Properties, Laura Biller, Paul H. Davis, Manuela Tillack, Jenny Matthiesen, Hannelore Lotter, Samuel L. Stanley, Egbert Tannich, Iris Bruchhaus

Biology Faculty Publications

Results: The availability of two genetically very similar cell lines (A and B) derived from the laboratory isolate Entamoeba histolytica HM-1:IMSS, which differ in their virulence properties, provides a powerful tool for identifying pathogenicity factors of the causative agent of human amoebiasis. Cell line A is incapable inducing liver abscesses in gerbils, whereas interaction with cell line B leads to considerable abscess formation. Phenotypic characterization of both cell lines revealed that trophozoites from the pathogenic cell line B have a larger cell size, an increased growth rate in vitro, an increased cysteine peptidase activity and higher resistance to nitric …


A Remote Markerless Human Gait Tracking For E-Healthcare Based On Content-Aware Wireless Multimedia Communications, Haiyan Luo, Song Ci, Dalei Wu, Nikolaos Stergiou, Ka-Chun Siu Feb 2010

A Remote Markerless Human Gait Tracking For E-Healthcare Based On Content-Aware Wireless Multimedia Communications, Haiyan Luo, Song Ci, Dalei Wu, Nikolaos Stergiou, Ka-Chun Siu

Journal Articles

Remote human motion tracking and gait analysis over wireless networks can be used for various e-healthcare systems for fast medical prognosis and diagnosis. However, most existing gait tracking systems rely on expensive equipment and take lengthy processes to collect gait data in a dedicated biomechanical environment, limiting their accessibility to small clinics located in remote areas. In this work we propose a new accurate and cost-effective e­ healthcare system for fast human gait tracking over wireless networks, where gait data can be collected by using advanced video content analysis techniques with low-cost cameras in a general clinic environment. Furthermore, based …


Robots, Gps/Gis, And Programming Technologies: The Power Of "Digital Manipulatives" In Youth Extension Experiences, Bradley S. Barker, Neal Grandgenett, Gwen Nugent, Viacheslav I. Adamchuk Feb 2010

Robots, Gps/Gis, And Programming Technologies: The Power Of "Digital Manipulatives" In Youth Extension Experiences, Bradley S. Barker, Neal Grandgenett, Gwen Nugent, Viacheslav I. Adamchuk

Teacher Education Faculty Publications

The study reported here examined the effectiveness of educational robotics combined with GPS/GIS technologies used as "digital manipulatives" in the teaching of concepts in science, engineering, and technology. Based on the success of previous summer camps, the study also examined a scaling-up of the intervention from 38 participants to 147. The 147 youth (ages 10-15) participated in one of six summer camps held in Nebraska during 2008. Results indicate that participants scored higher on the content posttest than the pretest. The study further examined the differential results. The article makes recommendations for further studies, while acknowledging the potential power of …


Spectrophotometric And Colorimetic Methodology To Detect And Quantify Hydrazide Based Chemotherapeutic Drugs, Ronald Bartzatt Feb 2010

Spectrophotometric And Colorimetic Methodology To Detect And Quantify Hydrazide Based Chemotherapeutic Drugs, Ronald Bartzatt

Chemistry Faculty Publications

Pharmaceuticals having the hydrazide functional group are an important division within anti-tuberculosis, anti-parasitic, anti-cancer, and anti-radiation chemotherapeutics. This work presents a colorimetric methodology to detect and quantify hydrazide based pharmaceuticals. Processes for rapid spot test, qualitative colorimetric assay, and spectrophotometric quantitative assay are presented. The reagent 2,6-dichloroquinon-4-chloroimine (Gibb's reagent) is utilized to accomplish the various analytical objectives. The rapid spot test and qualitative colorimetric assay enables a detection of hydrazide drugs to a level of 0.0037 grams per milliliter. Quantitative spectrophotometric detection of hydrazide drugs is sensitive to a level of 128.2 micrograms permilliliter. The molar absorptivity () is calculated …


Self-Study Report Appendix 15: Libraries Faculty Vitae Feb 2010

Self-Study Report Appendix 15: Libraries Faculty Vitae

University of Nebraska-Lincoln Libraries: White Papers

294 pages


Climate Change Consensus: Emerging International Law, Elizabeth Burleson Feb 2010

Climate Change Consensus: Emerging International Law, Elizabeth Burleson

William & Mary Environmental Law and Policy Review

No abstract provided.


A Lanthanide-Based Chemosensor For Bioavailable Fe3+ Using A Fluorescent Siderophore: An Assay Displacement Approach, Karen M. Orcutt, William Scott Jones, Andrea Mcdonald, David Schrock, Karl J. Wallace Feb 2010

A Lanthanide-Based Chemosensor For Bioavailable Fe3+ Using A Fluorescent Siderophore: An Assay Displacement Approach, Karen M. Orcutt, William Scott Jones, Andrea Mcdonald, David Schrock, Karl J. Wallace

Faculty Publications

The measurement of trace analytes in aqueous systems has become increasingly important for understanding ocean primary productivity. In oceanography, iron (Fe) is a key element in regulating ocean productivity, microplankton assemblages and has been identified as a causative element in the development of some harmful algal blooms. The chemosenor developed in this study is based on an indicator displacement approach that utilizes time-resolved fluorescence and fluorescence resonance energy transfer as the sensing mechanism to achieve detection of Fe3+ ions as low as 5 nM. This novel approach holds promise for the development of photoactive chemosensors for ocean deployment.


Carboxysomal Carbonic Anhydrases: Structure And Role In Microbial Co2 Fixation, Gordon C. Cannon, Sabine Heinhorst, Cheryl A. Kerfeld Feb 2010

Carboxysomal Carbonic Anhydrases: Structure And Role In Microbial Co2 Fixation, Gordon C. Cannon, Sabine Heinhorst, Cheryl A. Kerfeld

Faculty Publications

Cyanobacteria and some chemoautotrophic bacteria are able to grow in environments with limiting CO2 concentrations by employing a CO2-concentrating mechanism (CCM) that allows them to accumulate inorganic carbon in their cytoplasm to concentrations several orders of magnitude higher than that on the outside. The final step of this process takes place in polyhedral protein microcompartments known as carboxysomes, which contain the majority of the CO2-fixing enzyme, RubisCO. The efficiency of CO2 fixation by the sequestered RubisCO is enhanced by co-localization with a specialized carbonic anhydrase that catalyzes dehydration of the …


Effects Of Metal Compounds With Distinct Physicochemical Properties On Iron Homeostasis And Antibacterial Activity In The Lungs: Chromium And Vanadium, Mitchell D. Cohen, Maureen Sisco, Colleen Prophete, Kotaro Yoshida, Lung-Chi Chen, Judith T. Zelikoff, Jason Smee, Alvin A. Holder, Jacqueline Stormhuerner, Debbie C. Crans, Andrew J. Ghio Feb 2010

Effects Of Metal Compounds With Distinct Physicochemical Properties On Iron Homeostasis And Antibacterial Activity In The Lungs: Chromium And Vanadium, Mitchell D. Cohen, Maureen Sisco, Colleen Prophete, Kotaro Yoshida, Lung-Chi Chen, Judith T. Zelikoff, Jason Smee, Alvin A. Holder, Jacqueline Stormhuerner, Debbie C. Crans, Andrew J. Ghio

Faculty Publications

In situ reactions of metal ions or their compounds are important mechanisms by which particles alter lung immune responses. The authors hypothesized that major determinants of the immunomodulatory effect of any metal include its redox behavior/properties, oxidation state, and/or solubility, and that the toxicities arising from differences in physicochemical parameters are manifest, in part, via differential shifts in lung iron (Fe) homeostasis. To test the hypotheses, immunomodulatory potentials for both pentavalent vanadium (V(V); as soluble metavanadate or insoluble vanadium pentoxide) and hexavalent chromium (Cr(VI); as soluble sodium chromate or insoluble calcium chromate) were quantified in rats after inhalation (5 h/day …


Accountability For Mitigation Through Procedural Review: The Nepa Jurisprudence Of Judge Betty B. Fletcher, A Trustee Of The Environment And Woman Of Substance, Kenneth S. Weiner Feb 2010

Accountability For Mitigation Through Procedural Review: The Nepa Jurisprudence Of Judge Betty B. Fletcher, A Trustee Of The Environment And Woman Of Substance, Kenneth S. Weiner

Washington Law Review

In the past thirty years, as judges who first required compliance with the mandates of the National Environmental Policy Act of 1969 retired or died, the First and Ninth Circuits became the most stalwart keepers of NEPA’s flame. This article explores how, despite the procedural characterization of NEPA, Judge Betty B. Fletcher of the Ninth Circuit has been able to focus attention on NEPA’s substantive goal of achieving productive harmony between people and nature, while respecting the limits of judicial review of executive action. Judge Fletcher insists public officials answer a simple question: If you are not well-informed about whether …


Range Extension Parameters Of The Opportunistic Bivalve Corbicula Fluminea (Müller, 1774) In New Jersey, Katie Elizabeth Vazquez Feb 2010

Range Extension Parameters Of The Opportunistic Bivalve Corbicula Fluminea (Müller, 1774) In New Jersey, Katie Elizabeth Vazquez

Theses, Dissertations and Culminating Projects

The invasive freshwater bivalve Corbicula fluminea has gained notoriety as a macro-fouler of industrial waterways across the United States. Little is known about the specific habitat requirements that contribute to its successful colonization of riverine systems. Small, often immature clams (shell length <14 mm) passively drift downstream. Settlement in unsuitable habitat can limit burrowing, growth and reproduction, and lead to juvenile mortality. Settlement in suitable habitat however can result in population densities in excess of 10,000 ind./m . Sampling was conducted in diverse Northern New Jersey waterways between May and mid-October 2008 to assess the habitat conditions conducive to establishment of new populations. Within these sites there was a significant correlation between clam density and both dissolved oxygen level and Ambient Biological Monitoring Network EPT scores. There was no correlation between clam density and dominant grain size, substratum organic content or turbidity. It appears stochastic events largely governed the dispersal and settlement of juvenile and small mature Asian clams while microhabitat conditions can be associated with population density. Live specimens of C. fluminea were collected at 8 sites half of which appear to house stable reproducing populations of C. fluminea. The remaining sites could represent interim “stops” likely containing specimens that entered as a result of downstream drift. Anthropogenic disturbance regimes in New Jersey waterways may contribute to the successful invasion by the Asian clam. An understanding of the habitat and physicochemical characteristics associated with the spread of juvenile C. fluminea is crucial to predictive modeling of dispersal patterns.


Gender Autonomy, Transgender Identity And Substantive Due Process: Finding A Rational Basis For Lawrence V. Texas, Jillian T. Weiss Feb 2010

Gender Autonomy, Transgender Identity And Substantive Due Process: Finding A Rational Basis For Lawrence V. Texas, Jillian T. Weiss

Journal of Race, Gender, and Ethnicity

No abstract provided.


Lost In The Gender Maze: Placement Of Transgender Inmates In The Prison System, Benish A. Shah Feb 2010

Lost In The Gender Maze: Placement Of Transgender Inmates In The Prison System, Benish A. Shah

Journal of Race, Gender, and Ethnicity

No abstract provided.


Arabidopsis Rna-Dependent Rna Polymerases And Dicer-Like Proteins In Antiviral Defense And Small Interfering Rna Biogenesis During Turnip Mosaic Virus Infection, Hernan Garcia-Ruiz, Atsushi Takeda, Elisabeth J. Chapman, Christopher M. Sullivan, Noah Fahlgren, Katherine J. Brempelis, James C. Carrington Feb 2010

Arabidopsis Rna-Dependent Rna Polymerases And Dicer-Like Proteins In Antiviral Defense And Small Interfering Rna Biogenesis During Turnip Mosaic Virus Infection, Hernan Garcia-Ruiz, Atsushi Takeda, Elisabeth J. Chapman, Christopher M. Sullivan, Noah Fahlgren, Katherine J. Brempelis, James C. Carrington

Department of Plant Pathology: Faculty Publications

Plants respond to virus infections by activation of RNA-based silencing, which limits infection at both the single-cell and system levels. Viruses encode RNA silencing suppressor proteins that interfere with this response. Wild-type Arabidopsis thaliana is immune to silencing suppressor (HC-Pro)-deficient Turnip mosaic virus, but immunity was lost in the absence of DICER-LIKE proteins DCL4 and DCL2. Systematic analysis of susceptibility and small RNA formation in Arabidopsis mutants lacking combinations of RNA-dependent RNA polymerase (RDR) and DCL proteins revealed that the vast majority of virus derived small interfering RNAs (siRNAs) were dependent on DCL4 and RDR1, although full antiviral defense …


Climate Change Response Strategy, Anne Bennett Feb 2010

Climate Change Response Strategy, Anne Bennett

Bulletins 4000 -

Climate change and policies introduced to reduce emissions will affect the agricultural sector and will lead to social and economic outcomes.

In addressing the Western Australian Government's priority plan for the agriculture and food sector, the Department of Agriculture and Food, Western Australia has a number of roles it can play to assist industry to adapt and respond to climate change.

This document provides a balanced and coordinated strategic direction for climate change activities by identifying and prioritising key actions to be achieved over the next five years. The strategy is split into four chapters: emissions abatement, carbon sinks, adapting …


Ecologically Significant Invasive Species, A Monitoring Framework For Natural Resource Management Groups In Western Australia, Jan-Willem De Miliano, Andrew Woolnough, Andrew Reeves, Damian Shepherd Feb 2010

Ecologically Significant Invasive Species, A Monitoring Framework For Natural Resource Management Groups In Western Australia, Jan-Willem De Miliano, Andrew Woolnough, Andrew Reeves, Damian Shepherd

Bulletins 4000 -

This publication is the result of the project titled 'Resource Condition Monitoring for Ecologically Significant Species. The project identified and addressed key weaknesses in the State's capacity to monitor threat posed by ecologically significant species. The invasive species monitoring framework for Western Australia developed through this project, along with the rationales underpinning the deign, are presented in this report.


Multiple Roles: The Conflicted Realities Of Community College Mission Statements, Mark David Mrozinski Feb 2010

Multiple Roles: The Conflicted Realities Of Community College Mission Statements, Mark David Mrozinski

Dissertations

Questions of efficacy have always plagued the use of mission statement as a strategic planning tool. In most planning models, the mission statement serves to clarify goals and guide the formation of strategies. However, little empirical evidence exists validating that mission statements actually improve the performance of organizations, even though regional accrediting commissions in higher education include mission statement and affiliated processes as criterion for accreditation. For community colleges, the question is how can mission statements best be used to move the institution forward in a climate of change and challenges?

The purpose of this study is to explore the …


The Endurance Of National Constitutions, Tom Ginsburg, James Melton, Zachary Elkins Feb 2010

The Endurance Of National Constitutions, Tom Ginsburg, James Melton, Zachary Elkins

Coase-Sandor Institute for Law & Economics Research Paper Series

No abstract provided.


The Role Of Formins In Human Disease, Aaron D. Deward, Kathryn M. Eisenmann, Stephen F. Matheson, Arthur S. Alberts Feb 2010

The Role Of Formins In Human Disease, Aaron D. Deward, Kathryn M. Eisenmann, Stephen F. Matheson, Arthur S. Alberts

University Faculty Publications and Creative Works

Formins are a conserved family of proteins that play key roles in cytoskeletal remodeling. They nucleate and processively elongate non-branched actin filaments and also modulate microtubule dynamics. Despite their significant contributions to cell biology and development, few studies have directly implicated formins in disease pathogenesis. This review highlights the roles of formins in cell division, migration, immunity, and microvesicle formation in the context of human disease. In addition, we discuss the importance of controlling formin activity and protein expression to maintain cell homeostasis. © 2009 Elsevier B.V. All rights reserved.


Twin Screw Extrusion Of Ddgs-Based Aquaculture Feeds, S. Kannadhason, Kurt A. Rosentrater, K. Muthukumapappan, Michael L. Brown Feb 2010

Twin Screw Extrusion Of Ddgs-Based Aquaculture Feeds, S. Kannadhason, Kurt A. Rosentrater, K. Muthukumapappan, Michael L. Brown

Natural Resource Management Faculty Publications

Six isocaloric (3.65 kcal/g), isonitrogenous (35% dry-basis [db] protein), ingredient blends were prepared with 0, 17.5, 20, 22.5, 25, and 27.5% distiller’s dried grains with solubles (DDGS) and other ingredients (soybean meal, corn, fish meal, whey, soybean oil, vitamin and mineral mix). The blends were moisture balanced to 15% db, then extruded in a twin screw extruder using a 2 mm die at 190 rpm, and a 3 mm die at 348 rpm. Analyses of the extrudates included moisture content, expansion ratio, unit density, bulk density, sinking velocity, color (L*, a*, and b*), water absorption, water solubility, and pellet durability …


Vertebrate Lrig3-Erbb Interactions Occur In Vitro But Are Unlikely To Play A Role In Lrig3-Dependent Inner Ear Morphogenesis., Victoria E. Abraia, Takunori Satoh, Donna M. Fekete, Lisa V. Goodrich Feb 2010

Vertebrate Lrig3-Erbb Interactions Occur In Vitro But Are Unlikely To Play A Role In Lrig3-Dependent Inner Ear Morphogenesis., Victoria E. Abraia, Takunori Satoh, Donna M. Fekete, Lisa V. Goodrich

Department of Biological Sciences Faculty Publications

The Lrig genes encode a family of transmembrane proteins that have been implicated in tumorigenesis, psoriasis, neural crest development, and complex tissue morphogenesis. Whether these diverse phenotypes reflect a single underlying cellular mechanism is not known. However, Lrig proteins contain evolutionarily conserved ectodomains harboring both leucine-rich repeats and immunoglobulin domains, suggesting an ability to bind to common partners. Previous studies revealed that Lrig1 binds to and inhibits members of the ErbB family of receptor tyrosine kinases by inducing receptor internalization and degradation. In addition, other receptor tyrosine kinase binding partners have been identified for both Lrig1 and Lrig3, leaving open …