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Synthesis Of Bicyclic Pyrrolo[2,3-D]Pyrimidines, And Tricyclic Indeno[2,1-D]/[1,2-D]Pyrimidines As Receptor Tyrosine Kinase (Rtk) Inhibitors And Antimitotic Agents, Ying Zhao

Electronic Theses and Dissertations

The dissertation will give an introduction, background and our research progress in the areas of receptor tyrosine kinases inhibitors and antimitosis inhibitors. The design and syntheses of bicyclic pyrrolo[2,3-d]pyrimidines, and tricyclic indeno[2,1-d]- and [1,2-d]pyrimidines as receptor tyrosine kinase inhibitors and bicyclic pyrrolo[2,3-d]pyrimidines, and tricyclic indeno[2,1-d]pyrimidines as antimitotic inhibitors have been described. As a part of this study, a total of two hundred and eleven new compounds have been synthesized and characterized. Of these, ninety five final compounds were submitted for biological evaluation.

The Marketplace Metaphor And Commercial Speech Doctrine: Or How I Learned To Stop Worrying About And Love Citizens United, Darrel C. Menthe

UC Law Constitutional Quarterly

In this article, I place the Citizens United decision in historical and doctrinal context, and argue that the decision indicates a terminal stage of the development and application of the "marketplace of ideas" metaphor in First Amendment law. I argue that the "good news" about the Citizens United decision is that it sets the stage for the abolition of the commercial speech doctrine, which resulted in lower protection for commercial speech, as previously set forth in the 1980 Central Hudson decision. This is good news because the commercial speech doctrine has become a doctrinal anomaly that threatens to undermine the …

2010 Annual Reports And Resolutions, American Dental Association

ADA Transactions

This item is part of the Annual Reports and Resolutions subtitle of the ADA Transactions, a serial publication of the annual activities of the ADA House of Delegates (HOD)/Board of Trustees (BOT) made up of three separate subtitles: Annual Reports and Resolutions, Supplements, and Transactions. Generally, the ADA Transactions are published in multiple volumes throughout the year. Older versions include reports from all departments as subsections, while more recent versions include only those of councils, commissions, and committees.

Blue Carbon: The Role Of Healthy Oceans In Binding Carbon, Christian Nellemann, Emily Corcoran, Carlos M. Duarte, Cassandra De Young, Luciano E. Fonseca, Gabriel Grimsdith

Center for Coastal and Ocean Mapping

No abstract provided.

Interaction Between The Biotin Carboxyl Carrier Domain And The Biotin Carboxylase Domain In Pyruvate Carboxylase From Rhizobium Etli, Adam D. Lietzan, Ann L. Menefee, Tonya N. Zeczycki, Sudhanshu Kumar, Paul V. Attwood, John C. Wallace, W. Wallace Cleland, Martin St. Maurice

Biological Sciences Faculty Research and Publications

Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in mammalian tissues. To effect catalysis, the tethered biotin of PC must gain access to active sites in both the biotin carboxylase domain and the carboxyl transferase domain. Previous studies have demonstrated that a mutation of threonine 882 to alanine in PC from Rhizobium etli renders the carboxyl transferase domain inactive and favors the positioning of biotin in the biotin carboxylase domain. We report the 2.4 Å resolution X-ray crystal structure of the Rhizobium etli PC T882A mutant which reveals the first high-resolution description of …

Consumer Protection In Transnational Contexts, Jacques Delisle, Elizabeth Trujillo

Faculty Scholarship

This Article provides an overview of United States consumer protection law in the growing number cases with an international dimension that arise with economic globalization, expanding transnational corporations, worldwide production chains, manufacturing outsourcing and more efficient international communication. U.S. consumer protection law remains primarily state law, including tort and product liability law, contract and warranty law, and general and product-specific consumer protection statutes. (This refers to the private law remedies for consumer goods which are the substantive laws addressed in this article.) There is little treaty-based, constitutional or federal law except for federal regulatory law that largely adopts state law …

Unrooted Stem Cutting Physiology; Water Use And Leaf Gas Exchange Of Severed Stem Cuttings, Peter Alem

All Theses

Stem cuttings are one of the most frequently used and successful methods of vegetative plant propagation. The understanding of unrooted cutting physiology, especially gas exchange and water flux, is crucial for successful propagation of healthy plants. Prior to root initiation, water uptake is limited and leafy stem cuttings are most vulnerable to wilting.
Experiments were carried out in the greenhouse with poinsettia cuttings to determine water uptake, photosynthesis, transpiration and stomatal conductance from the time of severing to rooting, including time spent in storage. Water uptake through the severed stem was investigated in the laboratory and growth chamber. Cutting gas …

Trends In Body Fat, Body Mass Index And Physical Fitness Among Male And Female College Students, Peter Pribis, Carol A. Burtnack, Sonya O. Mckenzie, Jerome Thayer

Faculty Publications

There have been many publications in recent years reporting on the quantity of physical activity among college students using indirect indicators such as steps walked per day or time spent on physical activities. The purpose of this study was to describe the trends of physical fitness related to BMI and body fat among university students between 1996 and 2008. The results showed a significant decline in the average fitness levels measured as an estimation of VO2max for male and female students (p < 0.001 for both sexes). The linear trend for BMI by years was not significant for both sexes (p for males = 0.772, p for females = 0.253). On average, in the last 13 years, % body fat was increasing 0.513%/year for males and 0.654%/year for females. There is a significant indirect correlation between the student's VO2max levels and % body fat, r = -0.489; p < 0.001 for males; and r = -0.416, p < 0.001 for females. Approximately 23.9% of the variance in the VO2max levels in males and 17.3% in females can be explained by the variance in % body fat. The results support recent findings that physical fitness among college students is declining and body fatness is increasing. © 2010 by the authors.

Beliefs And Attitudes Toward Vegetarian Lifestyle Across Generations, Peter Pribis, Rose C. Pencak, Tevni Grajales

Faculty Publications

The objective of the study was to examine whether reasons to adopt vegetarian lifestyle differ significantly among generations. Using a Food Frequency Questionnaire (FFQ), we identified that 4% of the participants were vegans, 25% lacto-ovo-vegetarians, 4% pesco-vegetarians and 67% non-vegetarian. Younger people significantly agreed more with the moral reason and with the environmental reason. People ages 41-60 significantly agreed more with the health reason. There are significant differences across generations as to why people choose to live a vegetarian lifestyle. © 2010 by the authors; licensee MDPI, Basel, Switzerland.

Business As Usual: Immigration And The National Security Exception, Shoba S. Wadhia

Faculty Scholarship

Javaid Iqbal is a native and citizen of Pakistan and a Muslim. After moving to the United States, Iqbal worked as a cable television installer on Long Island. Iqbal was one among hundreds of men apprehended and detained by the United States Department of Justice in the weeks that followed the September 11, 2001 attacks. Iqbal was held in a federal prison in Brooklyn, New York called the Metropolitan Detention Center (MDC), for more than one year. In January 2002, Iqbal was transferred to the maximum security section of the jail known as the Administrative Maximum Special Housing Unit (ADMAX …

Honors Senior Project, Mustafa Husaini

Honors Projects

In the first section of a three part series looking at health care reform, this segment analyzes a brief history of healthcare, a comparison of selected health care systems in the world, and the ethical and moral basis for health care systems in the respective countries. After analyzing the health care systems in England, France, and Germany, the ethical basis for health care in America will be established.

It is important to analyze important paradigm shifts in healthcare as the latest is advent of employee sponsored healthcare. Without this advancement, it is very difficult for a majority of individuals to …

Variations In Synechococcus Cell Quotas Of Phosphorus, Sulfur, Manganese, Iron, Nickel, And Zinc Within Mesoscale Eddies In The Sargasso Sea, Benjamin S. Twining, Daliangelis Nunez-Milland, Stefan Vogt, Rodney S. Johnson, Peter N. Sedwick

OES Faculty Publications

The quotas of P, S, Mn, Fe, Ni, and Zn in individual Synechococcus cells collected from the surface and deep chlorophyll maximum (DCM) layer of three mesoscale eddies in the Sargasso Sea were measured using synchrotron X-ray fluorescence microscopy. Cells in a mode-water eddy had significantly higher P (57 +/- 10 amol) and Mn (28 +/- 7 zmol) cell quotas than cells collected from a cyclone (22 +/- 2 amol and 10 +/- 1 zmol, respectively) or anticyclone (25 +/- 3 amol and 18 +/- 3 zmol, respectively). Conversely, Ni and Zn quotas were significantly higher in the cells from …

Climate Change And Displacement: Multidisciplinary Perspectives, 2010, Edited By J. Mcadam, Benjamin J. Richardson

Articles & Book Chapters

No abstract provided.

A Biomechanical Comparison Of Locking Compression Plate Constructs With Plugs/Screws In Osteoporotic Bone Model, Krishna P. Desai

Browse all Theses and Dissertations

Locking compression plates are proven to be safe for use in open reduction and internal fixation (ORIF) especially in osteoporotic bones. Because of various combinations of holes, the system provides more options for clinicians to use either locking screws or non-locking screws. This clinical research introduces screw like plugs which can be used along with the screws in case of locking compression plates. Experimental work was performed to determine the effectiveness of the plugs. The results showed that there is not a significant difference between the groups which used plugs and did not use the plugs, both in case of …

Cellular And Molecular Dissection Of Pluripotent Adult Somatic Stem Cells In Planarians, Norito Shibata, Labib Rouhana, Kiyokazu Agata

Biological Sciences Faculty Publications

Freshwater planarians, Plathelminthes, have been an intriguing model animal of regeneration studies for more than 100 years. Their robust regenerative ability is one of asexual reproductive capacity, in which complete animals develop from tiny body fragments within a week. Pluripotent adult somatic stem cells, called neoblasts, assure this regenerative ability. Neoblasts give rise to not only all types of somatic cells, but also germline cells. During the last decade, several experimental techniques for the analysis of planarian neoblasts at the molecular level, such as in situ hybridization, RNAi and fluorescence activated cell sorting, have been established. Moreover, information about genes …

Socioeconomic And Environmental Causes For Respiratory Infection Death In Alaska Native Villages, Sarah Mcbeth

Master of Public Health Program Student Publications

Objectives. This ecological study evaluates the association between community characteristics and death rates from pneumonia/influenza, tuberculosis, and infectious diseases in 196 Alaska Native villages.

Methods. Ecological variables studied included percentage of Natives in the population, age distribution, latitude, average household size, socioeconomic status, percentage of homes with complete plumbing and/or kitchens, type of heating fuel used, community alcohol restrictions, level of healthcare access, and residence in specific regions of Alaska. These data come from the 2000 U.S. Census, the Alaska Alcohol Beverage Control Board, and the Alaska Native Tribal Health Consortium. A stepwise analysis of variance using the Proc GLM …

Montgomery County Breast Cancer Study: Demographic Analysis Of Breast Cancer In Montgomery County, Ohio, Danial Jilani

Master of Public Health Program Student Publications

Background: Disparities exist in cancer incidence and mortality between specific population groups in the United States. Breast cancer is the second most common form of cancer diagnosed in women. Breast cancer ranks as the second highest leading cause of death for women in the state of Ohio and in the United States. Perhaps more concerning, breast cancer is the leading cause of death for Hispanic women and ranks second for white, black, Asian, and Native American women. Specifically, women of low socioeconomic status (SES) have been shown to have lower rates of survival.

Methods: A descriptive study of …

Metabolizability Of Dried Distillers Grains Plus Solubles In Finishing Cattle Diets, R.H. Pritchard, J.W. Mccarthick, J. Knock, D.L. Boggs, C.J. Mueller

South Dakota Beef Report, 2010

The feeding value of dried distillers grains plus solubles (DDGS) is a combination of its contributions to protein nutrition as well as caloric intake of cattle. When DDGS is included in diets at levels where dietary CP has been met, the feeding value would primarily be a function of caloric density. A replicated 4 x 4 metabolism study was conducted to measure the caloric value of DDGS at high inclusion levels. Diets were formulated to contain 0, 12, 24, or 36% DDGS. These finishing diets were fed to yearling steers during a 21 d adaptation prior to total fecal and …

Effects Of Molybdenum Supplementation On Performance Of Forage‐Fed Steersreceiving High‐Sulfur Water, K.L. Kessler, K.C. Olson, C.L. Wright, K.J. Austin, P.S. Johnson, K.M. Cammack

South Dakota Beef Report, 2010

There has been on‐going research in the area of the consumption of high‐sulfur (S) water by steers grazing rangeland as well as forage‐fed steers in a feedlot setting. During the summer of 2009, a trial was conducted on the effects of high‐S water in finishing steers supplemented with molybdenum (Mo). The main purpose of the research was to gather data that may aid in the formulation of a supplement to counteract the negative effects of high‐S water consumed by ruminant livestock species in areas where sulfur concentration in water sources is a risk to animal health and performance. The specific …

2010 South Dakota Beef Report, Department Of Animal And Range Sciences, South Dakota State University, Agricultural Experiment Station, South Dakota State University, Cooperative Extension Service, South Dakota State University

South Dakota Beef Report, 2010

This is the 2010 South Dakota Beef Report produced by the SDSU Department of Animal Sciences in conjunction with the Agricultural Experiment Station , and the SDSU Cooperative Extension. The articles published in this report summarize many of the beef cattle research activities conducted at South Dakota State University during 2010. The articles in this report have many levels of application. Some information has immediate application for your farm, ranch, or agribusiness. The articles include information on nutrition,management, health, growth and development, and economics of the cattle and beef industry in South Dakota.

Mitigation/Adaptation And Health: Health Policymaking In The Global Response To Climate Change And Implications For Other Upstream Determinants, Lindsay Wiley

Scholarly Articles in Law Reviews & Journals

No abstract provided.

Adaptation To The Health Consequences Of Climate Change As A Potential Influence On Public Health Law And Policy: From Preparedness To Resilience, Lindsay Wiley

Scholarly Articles in Law Reviews & Journals

Because the health effects of climate change are likely to be significant and far-reaching, a key component of climate change adaptation will be our public health infrastructure. Perhaps counter-intuitively, recent emphasis in public health law on preparedness for extraordinary events may be to the detriment of our ability to cope with the health impacts of climate change. While existing emergency preparedness law will necessarily be an important backdrop for health-focused climate change adaptation efforts (especially with regard to natural disasters and infectious disease outbreaks), the focus on emergency preparedness in recent years does not necessarily situate us well for handling …

Confirmatory Factor Analysis Of The Child Feeding Questionnaire Among Low-Income African American Families Of Preschool Children, Richard E. Boles, Timothy D. Nelson, Leigh A. Chamberlin, Jessica M. Valenzuela, Susan N. Sherman, Susan L. Johnson, Scott W. Powers

Department of Psychology: Faculty Publications

This study examined the factor structure for three of the Child Feeding Questionnaire (CFQ) subscales, a widely used measure of parental feeding practices, among 296 low-income parents of African American preschool children. Confirmatory factor analysis showed an overall poor fit among CFQ subscales; Restriction, Pressure to Eat, and Concern about Child Weight, (χ2, (df = 87 = 300.249, CFI = 1.00, NNFI = 1.07, RMSEA = .091). Additionally, Cronbach’s Alpha coefficients for 2 of the three subscales were below acceptable recommendations (Restriction = 0.69; Pressure to Eat = 0.58). These results suggest further psychometric clarification is needed to understand commonly …

The Social Determinants Of ‘Health’ Of Embryos: Practices, Purposes, And Implications, Roxanne Mykitiuk, Jeff Nisker

Articles & Book Chapters

An increasing focus on the biomedical determinants of the health of embryos and fetuses is resulting from new technical possibilities, clinical considerations and research purposes (Nisker and White, 2005), but also from social factors, and for a variety of reasons. An exploration of the determinants of health of embryos, just as an exploration of the determinants of child or adult health, must take into consideration traditional social determinants, including those related to the consequences of poverty, such as poor nutrition and toxic environments (World Health Organization, 1948; Wilkinson and Marmot, 2003; Raphael, 2004), but also laws, policies and institutions, which …

Parent's Guide, 2010-2014, Illinois State University, Dean Of Students Office, Parent Services

Parent and Family Guide

Campus guide prepared by the Illinois State University Dean of Students Office's Parent Services Department

Effects Of Attention Allocation On Habituation To Food Cues In Normal Weight And Overweight Children, Vandana Aspen

All Theses and Dissertations (ETDs)

ABSTRACT OF THE DISSERTATION Effects of Attention Allocation on Habituation to Food Cues in Normal weight and Overweight Children by Vandana Passi Aspen Doctor of Philosophy in Psychology Washington University in St. Louis, 2010 Professor Denise Wilfley, Chairperson Despite the rising prevalence of pediatric overweight, minimal research has been conducted to understand the basic biological processes underlying overweight in children. The present study assesses changes in physiological response: i.e., salivation) to food over time. The primary aims were to examine whether salivation patterns in children vary based on weight status and/or allocating attention to a distracter task. It was hypothesized …

Health Check: Analyzing Trends In West Michigan, Grand Valley State University

Health Check: Analyzing Trends in West Michigan

No abstract provided.

Internal Displacement In Colombia: Violence, Resettlement, And Resistance, Juan Esteban Zea

Dissertations and Theses

The majority of the estimated four million internally displaced persons (IDPs) in Colombia who have fled from their lands and homes have migrated to urban centers. This study, performed in Bogotá, Colombia between April and September 2009, examines how IDPs cope with living in a new, urban environment after violent displacement. I held interviews with IDPs, the non-displaced public, and government workers; performed participant-observation in government offices and neighborhoods; and examined archival material. The work examines cultural anthropological topics of violence, migration, and resistance. A discussion of state and structural violence reveals the current hardships many rural Colombians face. Analysis …

Family Relationship Quality And Acculturation: Examination Of Their Relationship Among Latino Adolescent Sexual Offenders, Lindsey B. Patterson

Dissertations and Theses

Research on child sexual abuse (CSA), from the perspective of the perpetrator, has been conducted to better inform intervention and prevention programs. Although information from perpetrators can be beneficial for these programs, much of the research is limited by the diversity of sample populations of sex offenders. Moreover, potentially distinct variables relevant to specific populations (e.g., Latinos) have not been thoroughly studied in relation to CSA. To better understand the perpetration of CSA on variables that may be of particular concern to Latinos (i.e., relationship quality in familial supervision and acculturation strategies), the purpose of the present study was to …

Use Of Media Technologies By Native American Teens And Young Adults: Evaluating Their Utility For Designing Culturally-Appropriate Sexual Health Interventions Targeting Native Youth In The Pacific Northwest, Stephanie Nicole Craig Rushing

Dissertations and Theses

American Indian and Alaska Native (AI/AN) youth are disproportionally burdened by high rates of sexually transmitted infections and teen pregnancy, heightening their need for sexual health interventions that are aligned to their unique culture and social context. Media technologies, including the Internet, cell phones, and video games, offer new avenues for reaching adolescents on a wide range of sensitive health topics. While several studies have informed the development of technology-based interventions targeting mainstream youth, no such data have been reported for AI/AN youth. To fill this gap, I: a) quantified media technology use in a select group of AI/AN teens …