Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2010

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 5251 - 5259 of 5259

Full-Text Articles in Entire DC Network

Mechanisms Of Copper Deficiency In The Zebrafish Embryo, Erik Madsen Jan 2010

Mechanisms Of Copper Deficiency In The Zebrafish Embryo, Erik Madsen

All Theses and Dissertations (ETDs)

Proper maternal nutrition is critical for early embryonic development. Despite overwhelming epidemiologic data indicating the benefits nutrient supplementation for the developing organism we do not fully understand the genetics of predisposition to abnormal developmental phenotypes when faced with suboptimal nutrient levels. Copper is an essential nutrient required for critical biochemical processes. Severe defects in copper homeostasis lead to significant disease typified by the X-linked recessive disorder Menkes disease. Patients with Menkes disease have cutis laxa, bone deformities, hypopigmentation, arterial malformation, and neurodegeneration due to copper deficiency caused by loss-of-function mutations in ATP7A, a copper transport protein. Despite the critical requirement …

Go to article

Mitotic Cell Cycle Progression And Differentiation Of Germline Stem Cells In Caenorhabditis Elegans, Paul Fox Jan 2010

Mitotic Cell Cycle Progression And Differentiation Of Germline Stem Cells In Caenorhabditis Elegans, Paul Fox

All Theses and Dissertations (ETDs)

In the C. elegans germline, stem cells make a decision to retain the germline proliferative cell fate or differentiate by entering meiosis. Importantly, this decision must be coordinated with progression through the mitotic cell cycle. Previous work has shown that the conserved GLP-1/Notch signaling pathway promotes the proliferative fate while two downstream and redundant pathways are repressed by GLP-1 and promote entry into meiosis: the GLD-1 and GLD-2 pathways. To better understand how the switch to enter meiosis is coordinated with progression through the mitotic cell cycle, I investigated mitotic cell cycle progression among germline proliferative cells. Proliferative cells cycle …

Go to article

Mechanisms Of Copper-Dependent Notochord Formation In Zebrafish, John Gansner Jan 2010

Mechanisms Of Copper-Dependent Notochord Formation In Zebrafish, John Gansner

All Theses and Dissertations (ETDs)

The interplay of genes and nutrition during early development profoundly impacts fetal outcome. Copper is an essential nutrient required for the redox activity of many enzymes, and recent work in our laboratory has elucidated the phenotype of copper deficiency in zebrafish, which includes a strikingly distorted notochord. The studies described here establish the specific genetic etiology of this distortion and reveal a number of gene-gene and gene-nutrient interactions critical to notochord morphogenesis. We first demonstrate that the notochord distortion observed in copper-deficient zebrafish results from lysyl oxidase cuproenzyme inhibition. Four lysyl oxidase family members are expressed throughout the developing zebrafish …

Go to article

Hawthorn Extract - Viable Treatment For Cardiovascular Disease Or Unscrupulous Herbal Supplement?, Andrea Lowing, Frank Sylvester Jan 2010

Hawthorn Extract - Viable Treatment For Cardiovascular Disease Or Unscrupulous Herbal Supplement?, Andrea Lowing, Frank Sylvester

Student Summer Scholars Manuscripts

In the past Hawthorn leaves, berries and flowers have been used in Asia to treat hypertension (high blood pressure) and other cardiovascular diseases. It is hypothesized that the Hawthorn extract acts as a vasodilator increasing the size of the lumen of blood vessels by relaxing the smooth muscle. This occurs by decreasing the amount of calcium that is present in the cytosol by either increasing the effectiveness of the Ca2+ -ATPase pump or by altering the Na+ -Ca2+ antiport exchanger. With this decrease in cytosolic calcium the calcium unbinds from CaM causing the enzyme myosin phosphatase to …

Go to article

Family Relationship Quality And Acculturation: Examination Of Their Relationship Among Latino Adolescent Sexual Offenders, Lindsey B. Patterson Jan 2010

Family Relationship Quality And Acculturation: Examination Of Their Relationship Among Latino Adolescent Sexual Offenders, Lindsey B. Patterson

Dissertations and Theses

Research on child sexual abuse (CSA), from the perspective of the perpetrator, has been conducted to better inform intervention and prevention programs. Although information from perpetrators can be beneficial for these programs, much of the research is limited by the diversity of sample populations of sex offenders. Moreover, potentially distinct variables relevant to specific populations (e.g., Latinos) have not been thoroughly studied in relation to CSA. To better understand the perpetration of CSA on variables that may be of particular concern to Latinos (i.e., relationship quality in familial supervision and acculturation strategies), the purpose of the present study was to …

Go to article

Use Of Media Technologies By Native American Teens And Young Adults: Evaluating Their Utility For Designing Culturally-Appropriate Sexual Health Interventions Targeting Native Youth In The Pacific Northwest, Stephanie Nicole Craig Rushing Jan 2010

Use Of Media Technologies By Native American Teens And Young Adults: Evaluating Their Utility For Designing Culturally-Appropriate Sexual Health Interventions Targeting Native Youth In The Pacific Northwest, Stephanie Nicole Craig Rushing

Dissertations and Theses

American Indian and Alaska Native (AI/AN) youth are disproportionally burdened by high rates of sexually transmitted infections and teen pregnancy, heightening their need for sexual health interventions that are aligned to their unique culture and social context. Media technologies, including the Internet, cell phones, and video games, offer new avenues for reaching adolescents on a wide range of sensitive health topics. While several studies have informed the development of technology-based interventions targeting mainstream youth, no such data have been reported for AI/AN youth. To fill this gap, I: a) quantified media technology use in a select group of AI/AN teens …

Go to article

Internal Displacement In Colombia: Violence, Resettlement, And Resistance, Juan Esteban Zea Jan 2010

Internal Displacement In Colombia: Violence, Resettlement, And Resistance, Juan Esteban Zea

Dissertations and Theses

The majority of the estimated four million internally displaced persons (IDPs) in Colombia who have fled from their lands and homes have migrated to urban centers. This study, performed in Bogotá, Colombia between April and September 2009, examines how IDPs cope with living in a new, urban environment after violent displacement. I held interviews with IDPs, the non-displaced public, and government workers; performed participant-observation in government offices and neighborhoods; and examined archival material. The work examines cultural anthropological topics of violence, migration, and resistance. A discussion of state and structural violence reveals the current hardships many rural Colombians face. Analysis …

Go to article

The Dilemma Of Direct Democracy, Craig M. Burnett, Elizabeth Garrett, Mathew D. Mccubbins Jan 2010

The Dilemma Of Direct Democracy, Craig M. Burnett, Elizabeth Garrett, Mathew D. Mccubbins

Faculty Scholarship

The dilemma of direct democracy is that voters may not always be able to make welfare- improving decisions. Lupia’s seminal work has led us to believe that voters can substitute voting cues for substantive policy knowledge. Lupia, however, emphasized that cues were valuable under certain conditions and not others. In what follows, we present three main findings regarding voters and what they know about California’s Proposition 7. First, much like Lupia reported, we show voters who are able to recall endorsements for or against a ballot measure vote similarly to people who recall certain basic facts about the initiative. We …

Go to article

Welfare As Happiness, John Bronsteen, Christopher Buccafusco, Jonathan S. Masur Jan 2010

Welfare As Happiness, John Bronsteen, Christopher Buccafusco, Jonathan S. Masur

Faculty Scholarship

No abstract provided.

Go to article

First Prev