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2010

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The Effect Of Natural Antimicrobial Ingredients On The Quality Of Roast Beef And Oven Roasted Turkey, Ace F. Vandewalle Aug 2010

The Effect Of Natural Antimicrobial Ingredients On The Quality Of Roast Beef And Oven Roasted Turkey, Ace F. Vandewalle

Department of Animal Science: Dissertations, Theses, and Student Research

This research evaluates the use of a buffered vinegar and lemon juice concentrate (LV) solution on the quality of restructured beef and turkey rolls. Two studies were conducted to evaluate processing and ingredient concentration. Beef and turkey rolls were formulated with minimal ingredients. 1.5% sea salt, 0.5% turbinado sugar, with LV or no LV. Study one evaluated length of mixing time (2.5, 5, 10, 15, 20 minutes) on quality and sensory attributes with 2.5% LV or 0% LV (C). Study two was divided into four treatments, 0% (C), 1.5%, 2.5%, and 3.5% LV, used to evaluate the effects of three …


Information Outlook, July/August 2010, Special Libraries Association Aug 2010

Information Outlook, July/August 2010, Special Libraries Association

Information Outlook, 2010

Volume 14, Issue 5


Detection Methods For The Genus Lysobacter And The Species Lysobacter Enzymogenes, Hu Yin Aug 2010

Detection Methods For The Genus Lysobacter And The Species Lysobacter Enzymogenes, Hu Yin

School of Biological Sciences: Dissertations, Theses, and Student Research

Strains of Lysobacter enzymogenes, a bacterial species with biocontrol activity, have been detected via 16S rDNA sequences in soil in different parts of the world. In most instances, however, their occurrence could not be confirmed by isolation, presumably because the species occurred in low numbers relative to faster-growing species of Bacillus or Pseudomonas. In this study, we developed DNA-based detection and enrichment culturing methods for Lysobacter spp. and L. enzymogenes specifically. In the DNA-based method, a region of 16S rDNA conserved among Lysobacter spp. (L4: GAG CCG ACG TCG GAT TAG CTA GTT), was used as the forward …


Perceived Stigma Among Patients Receiving Antiretroviral Treatment: A Prospective Randomised Trial Comparing An M-Dot Strategy With Standard-Of-Care In Kenya, Susan Kaai, Sandra Bullock, Avina Sarna, Matthew Chersich, Stanley Luchters, Scott Geibel, Kishorchandra Mandaliya, Marleen Temmerman, Naomi Rutenberg Aug 2010

Perceived Stigma Among Patients Receiving Antiretroviral Treatment: A Prospective Randomised Trial Comparing An M-Dot Strategy With Standard-Of-Care In Kenya, Susan Kaai, Sandra Bullock, Avina Sarna, Matthew Chersich, Stanley Luchters, Scott Geibel, Kishorchandra Mandaliya, Marleen Temmerman, Naomi Rutenberg

Population Health, East Africa

HIV and AIDS remain highly stigmatised. Modified directly observed therapy (m-DOT) supports antiretroviral treatment (ART) adherence but little is known about its association with perceived stigma in resource-constrained settings. In 2003, 234 HIV-infected adults enrolled in a two-arm randomised trial comparing a health centre-based m-DOT strategy with standard self-administration of ART. Data on perceived stigma were collected using Berger's HIV stigma scale prior to starting ART and after 12 months. This was a secondary analysis to examine whether perceived stigma was related to treatment delivery. Perceived stigma scores declined after 12 months of treatment from a mean of 44.9 (sd=7.6) …


Relationships Of Developmental Traits In Young Alpaca Crias And Lambs, Sara Elizabeth Lewis Aug 2010

Relationships Of Developmental Traits In Young Alpaca Crias And Lambs, Sara Elizabeth Lewis

Graduate Theses, Dissertations, and Problem Reports (ETD)

Successful reproduction in alpacas is highly dependent upon postnatal survival, which in turn is dependent upon a pattern of continuous gain in weight as an indicator of health. Weighing alpacas is the primary method used to assess their general health. Unfortunately, the measurement of cria weight is not always a simple, routine, or easy determination. The purpose of this study was to determine if, as in other species such as cattle and horses, morphometric body measurements can be used to estimate weight. In this study, continuous weight and girth measurements were taken on 34 alpaca cria. Age and girth were …


Phosphorus Nutrition In Broilers, Staci Ann Loop Aug 2010

Phosphorus Nutrition In Broilers, Staci Ann Loop

Graduate Theses, Dissertations, and Problem Reports (ETD)

Due to depleting resources, high feed ingredient costs, and eutrophication, phosphorus nutrition in broilers has been a topic of concern for many years. The amount of damage being done to the environment by phosphorus runoff in some states has led to regulations that require broiler litter to have decreased phosphorous with the use of a phytase enzyme. There are many phytase products on the market, however, these enzymes are not all equally effective. Companies may rely only on feed manufacture retention data instead of conducting live bird performance research to test the actual efficacy of the enzyme. The first study …


Determining Efficacy Of A Thermally Processed Exogenous Enzyme Cocktail For Broilers, Kala Renea Beaman Aug 2010

Determining Efficacy Of A Thermally Processed Exogenous Enzyme Cocktail For Broilers, Kala Renea Beaman

Graduate Theses, Dissertations, and Problem Reports (ETD)

Feed ingredient price has influenced nutritionists to maximize diet nutrient availability through use of exogenous enzymes. Poultry are almost exclusively fed pelleted diets that entails feed being subjected to conditions of high moisture, temperature and pressure that could partially denature added enzymes. Exogenous enzyme efficacy may be decreased or completely lost if enzymes are not able to survive the pelleting process. The objective of the current studies was to properly assess the efficacy of a commercially available exogenous enzyme cocktail subjected to increasing steam conditioning temperatures during pelleting (82, 88, 93°C). Dietary treatments consisted of nutritionally adequate diets or Positive …


Dietary Cholesterol Effects On Learning, Memory And Amyloid Beta: Learning And Memory Effects On Brain Cholesterol And Sulfatide Levels, Deya S. Darwish Aug 2010

Dietary Cholesterol Effects On Learning, Memory And Amyloid Beta: Learning And Memory Effects On Brain Cholesterol And Sulfatide Levels, Deya S. Darwish

Graduate Theses, Dissertations, and Problem Reports (ETD)

Recent studies have revealed ambiguous findings on the effects of dietary cholesterol on learning. In one study by Schreurs and coworkers it was reported that a 2% cholesterol diet had a positive effect on learning. However, it was realized that metals, specifically copper, could potentially exacerbate the aggregation of amyloid beta (Abeta), a protein associated with Alzheimer's disease (AD) leading to the formation of Abeta plaques. In a subsequent publication by Sparks and Schreurs it was reported that a 2% cholesterol diet with the addition of 0.12 ppm copper had a detrimental effect on learning and resulted in the formation …


Effect Of Conjugated Linoleic Acid On The Regulation Of Feed Intake And Body Fat In The Short Term, Valerie J. Shelton Aug 2010

Effect Of Conjugated Linoleic Acid On The Regulation Of Feed Intake And Body Fat In The Short Term, Valerie J. Shelton

Graduate Theses, Dissertations, and Problem Reports (ETD)

Conjugated linoleic acid (CLA) is known to decrease feed intake and body fat in mice. Our objectives were to determine the incorporation of CLA into tissues and the effect on serum hormones and arcuate neuropeptides during the first 7 d of CLA consumption. Mice (n=150; 9-wk-old) were fed 0 (ad libitum or pair-fed to CLA-fed mice) or 2% CLA (ad libitum) for 1, 2, 3, 5, or 7 d. A body fat index was calculated; liver, adipose tissue, and brain were analyzed for fatty acid profiles; and serum insulin, leptin, and PYY were measured. CLA and pair-fed mice ate less …


Effect Of Nutritional Deficiency On Ruffed Grouse Condition And Reproductive Success, Aaron B. Proctor Aug 2010

Effect Of Nutritional Deficiency On Ruffed Grouse Condition And Reproductive Success, Aaron B. Proctor

Graduate Theses, Dissertations, and Problem Reports (ETD)

Maternal body fat condition (i.e., percent carcass fat) is often a focal point in determining reproductive success in female galliforms. Previous research has centered around habitat-related nutritional parameters affecting body condition and the influence on reproductive capacity. Past studies have shown that ruffed grouse (Bonasa umbellus) maintain higher mean body fat levels throughout the Appalachians and variation in body condition exceeds that found in northern grouse. In the Appalachians, ruffed grouse with diets devoid of energy-rich hard mast have lower body fat condition. It has been hypothesized that females in poorer condition will have lower productivity in the Appalachians. We …


Justifying Phytogenic Feed Additive Matrix Values In Conjunction With Exogenous Feed Enzymes, Laurel K. Shires Aug 2010

Justifying Phytogenic Feed Additive Matrix Values In Conjunction With Exogenous Feed Enzymes, Laurel K. Shires

Graduate Theses, Dissertations, and Problem Reports (ETD)

Phytogenic feed additives are purported to possess antimicrobial properties as well as nutrient sparing characteristics that may aid in alleviating high diet costs; however, in order for PFAs to assist nutritionists in decreasing diet cost, matrix values must be determined and implemented in feed formulation. Study 1 evaluated proposed matrix values for a commercially available PFA and assessed nutrient sparing when the product was combined with commercial phytase, carbohydrase and protease. The most remarkable proposed matrix values were 32.2 kcal/kg for metabolizable energy and 0.07% for both Ca and AP. The objective of Study 2 was to determine true amino …


Hypercholesterolemia And Microvascular Dysfunction: Altered Mechanisms And Interventional Strategies, Phoebe Stapleton Aug 2010

Hypercholesterolemia And Microvascular Dysfunction: Altered Mechanisms And Interventional Strategies, Phoebe Stapleton

Graduate Theses, Dissertations, and Problem Reports (ETD)

Cardiovascular disease has a number of risk factors and confounding variables associated with the development and progression of the condition. Hypercholesterolemia is one of the few independent risk factors of peripheral vascular disease (PVD) and coronary artery disease (CAD) with causes stemming from a genetic predisposition and lifestyle management. The primary symptom of these diseases can be described as an endothelial cell dysfunction, which hypercholesterolemia can exacerbate, leading to a pro-inflammatory state of elevated oxidant stress and significant reduction in nitric oxide (NO) bioavailability, a key mediator of endothelium-dependent dilation. This environment can culminate into an impairment of the vascular …


Quality Of Life In The Nursing Home: An Outcome That Matters, Carol Dumond Aug 2010

Quality Of Life In The Nursing Home: An Outcome That Matters, Carol Dumond

Education Doctoral

This quantitative study collected information to determine how elders living at the nursing home studied perceived their quality of life, determined if there are differences in quality of life among neighborhoods, and if there are differences experienced by those living in private rooms compared to shared rooms. A descriptive, correlational, and cross-sectional design was applied. An instrument that focused on enhanced quality of life, the Quality of Life Scales for Nursing Home Residents, was used to guide 155 structured interviews. Data collected provided information on eleven domains of quality of life including safety, physical comfort, food enjoyment, meaningful activities, relationships, …


Variants At Irf5-Tnpo3, 17q12-21 And Mmel1 Are Associated With Primary Biliary Cirrhosis, Gideon M. Hirschfield, Xiangdong Liu, Younghun Han, Ivan P. Gorlov, Yan Lu, Chun Xu, Yue Lu, Wei Chen, Brian D. Juran, Catalina Coltescu Aug 2010

Variants At Irf5-Tnpo3, 17q12-21 And Mmel1 Are Associated With Primary Biliary Cirrhosis, Gideon M. Hirschfield, Xiangdong Liu, Younghun Han, Ivan P. Gorlov, Yan Lu, Chun Xu, Yue Lu, Wei Chen, Brian D. Juran, Catalina Coltescu

Health & Biomedical Sciences Faculty Publications

We genotyped individuals with primary biliary cirrhosis and unaffected controls for suggestive risk loci (genome-wide association P < 1 × 10−4) identified in a previous genome-wide association study. Combined analysis of the genome-wide association and replication datasets identified IRF5-TNPO3 (combined P = 8.66 × 10−13), 7q12-21 (combined P = 3.50 × 10−13) and MMEL1 (combined P = 3.15 × 10−8) as new primary biliary cirrhosis susceptibility loci. Fine-mapping studies showed that a single variant accounts for the IRF5-TNPO3 association. As these loci are implicated in other autoimmune conditions, these findings confirm genetic overlap among such diseases.


The 71f Advantage: Applying Army Research Psychology For Health And Performance Gains, Paul T. Bartone, Ross H. Pastel, Mark A. Vaitkus Aug 2010

The 71f Advantage: Applying Army Research Psychology For Health And Performance Gains, Paul T. Bartone, Ross H. Pastel, Mark A. Vaitkus

Books

This book grew out of paper presentations and discussions at the Army Research Psychology Biennial Conference held April 24–25, 2008, in Bethesda, Maryland. It provides a snapshot of groundbreaking research currently being done by Army research psychologists around the globe. The book illuminates the many contributions of Army research psychologists to supporting Soldiers and their families, as well as enhancing their performance and wellbeing.


The Effects Of High Pressure Processing On Peanut Sauce Inoculated With Salmonella, Tara K. Stiles Aug 2010

The Effects Of High Pressure Processing On Peanut Sauce Inoculated With Salmonella, Tara K. Stiles

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Recent Salmonella outbreaks have prompted the need for new processing options for peanut products. Traditional heating kill-steps have shown to be ineffective in lipid-rich matrices such as peanut products. High pressure processing is one such option for peanut sauce because it has a high water activity, which has proved to be a large contributing factor in microbial lethality due to high pressure processing. Four different formulations of peanut sauce were inoculated with a five strain Salmonella cocktail and high pressure processed. Results indicate that increasing pressure or increasing hold time increases log10 reductions. The Weibull model was fitted to …


Letter To The Editor, Charlotte Johnston Molloy, Clare Corish, John Kearney, Noirin Hayes, Corina Glennon Slattery Aug 2010

Letter To The Editor, Charlotte Johnston Molloy, Clare Corish, John Kearney, Noirin Hayes, Corina Glennon Slattery

Articles

No abstract provided.


The Holiness And Other Stories, Leslie Michelle Nichols Aug 2010

The Holiness And Other Stories, Leslie Michelle Nichols

Dissertations

This dissertation is a collection of an introductory essay and ten original short stories written and submitted to fiction workshops in the PhD program at The University of Southern Mississippi’s Center for Writers.


Assessing Mississippians’ Preparedness For Disasters Using The Citizen Corps National Survey 2009, Carl Huston Mangum Ii Aug 2010

Assessing Mississippians’ Preparedness For Disasters Using The Citizen Corps National Survey 2009, Carl Huston Mangum Ii

Dissertations

Disaster preparedness, a shared responsibility of all citizens and disaster agencies, is the most critical component in minimizing risk and damage from disaster. Mississippi has been affected by some of the most devastating disasters in American history, both in terms of physical destruction and human life. The purpose of this study was to assess Mississippians’ disaster preparedness by replicating The 2009 Citizen Corps National Survey (CCNS). The 65 question 2009 CCNS was slightly modified to survey 678 randomly selected Mississippians about the Citizen Corps Personal Disaster Preparedness Model: Demographics, Volunteering, Drills/Exercises, Community Plan, Household Plan, Disaster Supplies, Prevention, Self-efficacy, Reliance, …


Drug Safety And Commercial Speech: Television Advertisements And Reprints On Off-Label Uses, Margaret Gilhooley Aug 2010

Drug Safety And Commercial Speech: Television Advertisements And Reprints On Off-Label Uses, Margaret Gilhooley

San Diego Law Review

This Article examines how the constitutional protections for commercial speech have limited the ability of Congress and FDA to regulate prescription drugs in ways that can affect safety. In Thompson v. Western States, the Supreme Court struck down a Congressional restriction on advertisements for unapproved “compound” drugs because a disclosure that FDA had not approved the compound was considered a constitutionally adequate alternative. While drug compounds are a relatively obscure category, the decision influenced Congress in deciding not to require a moratorium on television advertisements for newly approved drugs until the risks were better known. The Article also provides an …


Local Area Agency On Aging Supports In-Home Nutrition Education For High-Nutritional Risk Seniors, Shelly Johnson Aug 2010

Local Area Agency On Aging Supports In-Home Nutrition Education For High-Nutritional Risk Seniors, Shelly Johnson

Journal of Extension

Area Agency on Aging (AAA) and University of Idaho Extension created the Senior Extension Nutrition Program (SENP) to help high-nutritional risk seniors understand the importance of using food to better manage their health and/or health conditions. Paraprofessionals from Food Stamp Nutrition Education are funded using AAA funds and provide in-home visits to at risk seniors. Paraprofessionals receive oversight from UI faculty and a registered dietitian. A retrospective pre-test survey indicates behavior changes in fruit, vegetable, dairy, and water consumption and food frequency intake. The program gives these seniors an increase confidence in how to manage their health.


Precipitating Factors And The Outcome Of Hepatic Encephalopathy In Liver Cirrhosis, Khalid Mumtaz, Umair Syed Ahmed, Shahab Abid, Noshaba Baig, Saeed Hamid, Wasim Jafri Aug 2010

Precipitating Factors And The Outcome Of Hepatic Encephalopathy In Liver Cirrhosis, Khalid Mumtaz, Umair Syed Ahmed, Shahab Abid, Noshaba Baig, Saeed Hamid, Wasim Jafri

Section of Gastroenterology

Objective: To determine precipitants of hepatic encephalopathy (HE) and their impact on hospital stay and mortality.

Study Design: Cross-sectional, analytical study. Place and Duration of Study: The Aga Khan University Hospital, from January 2005 to December 2007.

Methodology: Consecutive patients admitted with different grades of HE were evaluated between January 2005 and December 2007. The precipitants of HE were correlated with the different grades of HE, and length of hospital stay and mortality. Chi-square test was used to compare the proportion of precipitating factors versus hospital stay and grade with significance at p < 0.05.

Results: Of the 404 patients 252 (62%) …


Quantification Of 99mTc-Duramycin Uptake Kinetics In The Area-At-Risk After Myocardial Ischemia And Reperfusion, Joseph Capacete Aug 2010

Quantification Of 99mTc-Duramycin Uptake Kinetics In The Area-At-Risk After Myocardial Ischemia And Reperfusion, Joseph Capacete

Master's Theses (2009 -)

Myocardial infarction (MI) is a condition in which blood supply to the heart is insufficient. MI is associated with two forms of cell death: apoptosis and necrosis. 99mTc-duramycin (99mTc-D) is a novel radiopharmaceutical that detects cell death by recognizing externalized phosphatidylethanolamine. The objective of this study was to develop a compartmental model for 99mTc-D uptake kinetics in normal and infarct myocardium, and utilize this model to compare the uptake kinetics of 99mTc-D in MI with that of another radiopharmaceutical, 99mTc-C2A-GST.

MI was induced in rats which were then injected (i.v.) with 99mTc-D. Rats …


Blastocystis Hominis And Dientamoeba Fragilis In Patients Fulfilling Irritable Bowel Syndrome Criteria., Javed Yakoob, Wasim Jafri, Mohammad Asim Beg,, Z Abbas, Shagufta Naz,, Muhammad Islam, Rustam Khan Aug 2010

Blastocystis Hominis And Dientamoeba Fragilis In Patients Fulfilling Irritable Bowel Syndrome Criteria., Javed Yakoob, Wasim Jafri, Mohammad Asim Beg,, Z Abbas, Shagufta Naz,, Muhammad Islam, Rustam Khan

Section of Gastroenterology

Studies have suggested a possible role for Blastocystis hominis and Dientamoeba fragilis in the etiology of irritable bowel syndrome (IBS). We studied the prevalence of B. hominis and D. fragilis in patients with IBS-diarrhea (IBS-D). Three hundred and thirty patients were enrolled, 171 (52%) with IBS-D and 159 (48%) were controls, respectively. Stool microscopy, culture, and polymerase chain reaction (PCR) for B. hominis and D. fragilis were done. B. hominis was positive by stool microscopy in 49% (83/171) of IBS compared to 24% (27/159) in control (p < 0.001). B. hominis culture was positive in 53% (90/171) in IBS compared to 16% (25/159) in control (p < 0.001). B. hominis PCR was positive in 44% (75/171) in IBS compared to 21% (33/159) in control (p < 0.001). D. fragilis microscopy was positive in 3.5% (6/171) in IBS-D compared to 0.6% (1/159) in control (p = 0.123). D. fragilis culture was positive in 4% (7/171) in IBS compared to 1.3% (2/159) in control (p = 0.176). D. fragilis PCR was positive in 4% (6/171) in IBS-D compared to 0% (0/159) in control (p = 0.030). B. hominis is common, while D. fragilis was less prevalent in our patients with IBS-D. B. hominis and D. fragilis culture had a better yield compared to stool microscopy and PCR.


The One-Pager: A Practical Policy Advocacy Tool For Translating Community-Based Participatory Research Into Action, Betty T. Izumi, Amy J. Schulz, Barbara A. Isreal, Angela G. Reyes, Jenifer Martin, Richard L. Lichtenstein, Christine Wilson, Sharon L. Sand Aug 2010

The One-Pager: A Practical Policy Advocacy Tool For Translating Community-Based Participatory Research Into Action, Betty T. Izumi, Amy J. Schulz, Barbara A. Isreal, Angela G. Reyes, Jenifer Martin, Richard L. Lichtenstein, Christine Wilson, Sharon L. Sand

Community Health Faculty Publications and Presentations

The multiple and diverse perspectives, skills, and experiences inherent in community–academic partnerships make them uniquely positioned to educate policy makers and advocate for health equity. Effective communication tools are critical to successfully engage in the policy-making process. Yet few resources emphasize the development and use of practical tools for translating community-based participatory research (CBPR) findings into action. The purpose of this article is to describe a CBPR process for developing and using a one-page summary, or “one-pager,” of research findings and their policy implications. This article draws on the experience of the Healthy Environments Partnership (HEP), a community–academic partnership in …


Summer Commencement Ceremonies, University Of North Florida Jul 2010

Summer Commencement Ceremonies, University Of North Florida

Commencement Printed Materials

Program for the Summer Commencement ceremonies.


Structural Characterization Of Hiv Gp41 With The Membrane-Proximal External Region, Wuxian Shi, Jen Bohon, Mark R. Chance Jul 2010

Structural Characterization Of Hiv Gp41 With The Membrane-Proximal External Region, Wuxian Shi, Jen Bohon, Mark R. Chance

Faculty Scholarship

Human immunodeficiency virus, type 1 (HIV-1) envelope glycoprotein (gp120/gp41) plays a critical role in virus infection and pathogenesis. Three of the six monoclonal antibodies considered to have broadly neutralizing activities (2F5, 4E10, and Z13e1) bind to the membrane-proximal external region (MPER) of gp41. This makes the MPER a desirable template for developing immunogens that can elicit antibodies with properties similar to these monoclonal antibodies, with a long term goal of developing antigens that could serve as novel HIV vaccines. In order to provide a structural basis for rational antigen design, an MPER construct, HR1-54Q, was generated for x-ray crystallographic and …


The Effects Of A Polynutrient Dietary Supplement On Physiological Measures And Mood State In Resistance Trained Men, Thomas Incledon Jul 2010

The Effects Of A Polynutrient Dietary Supplement On Physiological Measures And Mood State In Resistance Trained Men, Thomas Incledon

Open Access Dissertations

The purpose of the present study was to test the acute effects of a dietary supplement, having as its major ingredient an extract of ginseng, on grip strength, lower body power output, cardiovascular markers, metabolic markers, hormones, and mood state. Twelve experienced resistance-trained men (28.3 ± 5.7 yrs) were randomly administered placebo (P), single dose (SD) and double dose (DD) of the supplement on separate days. Diet and activity levels were kept constant across testing days. On each day, subjects began with the Profile of Mood States (POMSpre1), blood draws (BDpre1), blood pressure (BPpre1), and heart rate (HRpre1) assessments, then …


Blue Cross And Blue Shield Of Florida Partners With Jacksonville Jaguars In Naming Of Practice Fields, 7/29/2010, Blue Cross And Blue Shield Of Florida, Inc. Jul 2010

Blue Cross And Blue Shield Of Florida Partners With Jacksonville Jaguars In Naming Of Practice Fields, 7/29/2010, Blue Cross And Blue Shield Of Florida, Inc.

Florida Blue Archives Printed Materials

Blue Cross and Blue Shield of Florida partners with Jacksonville Jaguars in naming of practice fields, with attachment: Talking points- Jacksonville Jaguars Announce Partnerships with Blue Cross and Blue Shield of Florida in naming Practice Fields from July 29, 2010.


Function And Regulation Of Matrix Metalloproteinase-1 In Glioblastoma Multiforme, Monika Anand Jul 2010

Function And Regulation Of Matrix Metalloproteinase-1 In Glioblastoma Multiforme, Monika Anand

Theses and Dissertations

Glioblastoma Multiforme (GBM) is an aggressive and fatal cancer of the brain. It is characterized with augmented morbidity and elusion to therapies due in part to the incessant infiltration and spread of tumor cells in normal brain. We investigated the function of Matrix metalloproteinase-1, an important enzyme noted to be responsible for invasion in other cancers, in GBM and its regulation by epidermal growth factor receptor (EGFR) signaling. Previous studies from our laboratory demonstrated elevated levels of MMP-1 in GBM. Further studies indicated the involvement of MMP-1 in GBM invasion. The GBM cell lines T98G, U251MG and U87MG were used …