Digital Commons Network^™

2009 Annual Report, Thomas F. Turner

Annual Reports

No abstract provided.

Expanding Access To Hepatitis C Virus Treatment--Extension For Community Healthcare Outcomes (Echo) Project: Disruptive Innovation In Specialty Care, Sanjeev Arora, Summers Kalishman, Karla Thornton, Denise Dion, Glen Murata, Paulina Deming, Brooke Parish, John Brown, Miriam Komaromy, Kathleen Colleran, Arthur Bankhurst, Joanna Katzman, Michelle Harkins, Luis Curet, Ellen Cosgrove, Wesley Pak

Project ECHO Bibliography

The Extension for Community Healthcare Outcomes (ECHO) Model was developed by the University of New Mexico Health Sciences Center as a platform to deliver complex specialty medical care to underserved populations through an innovative educational model of team-based interdisciplinary development. Using state-of-the-art telehealth technology, best practice protocols, and case-based learning, ECHO trains and supports primary care providers to develop knowledge and self-efficacy on a variety of diseases. As a result, they can deliver best practice care for complex health conditions in communities where specialty care is unavailable. ECHO was first developed for the management of hepatitis C virus (HCV), optimal …

A Breeding Ground For Communicable Disease: What To Do About Public Health Hazards In New York Prisons, Claire Fortin

Buffalo Public Interest Law Journal

No abstract provided.

Hiv-1 Reactivation Induced By The Periodontal Pathogens Fusobacterium Nucleatum And Porphyromonas Gingivalis Involves Toll-Like Receptor 2 And 9 Activation In Monocytes/Macrophages, Octavio A. Gonzalez, Mengtao Li, Jeffrey L. Ebersole, Chifu B. Huang

Center for Oral Health Research Faculty Publications

Although oral coinfections (e.g., periodontal disease) are highly prevalent in human immunodeficiency virus type 1-positive (HIV-1⁺) patients and appear to positively correlate with viral load levels, the potential for oral bacteria to induce HIV-1 reactivation in latently infected cells has received little attention. We showed that HIV-1 long terminal repeat (LTR) promoter activation can be induced by periodontopathogens in monocytes/macrophages; nevertheless, the mechanisms involved in this response remain undetermined. Since Toll-like receptor 2 (TLR2), TLR4, and TLR9 activation have been involved in HIV-1 recrudescence, we sought to determine the role of these TLRs in HIV-1 reactivation induced by …

What's Happening: September, 2010, Maine Medical Center

What's Happening

No abstract provided.

The Herpes Simplex Virus Type 1 Ul20 Protein And The Amino Terminus Of Glycoprotein K (Gk) Physically Interact With Gb, Vladimir N. Chouljenko, Arun V. Iyer, Sona Chowdhury, Joohyun Kim, Konstantin G. Kousoulas

Faculty Publications

Herpes simplex virus type 1 (HSV-1) glycoprotein K (gK) and the UL20 protein (UL20p) are strictly required for virus-induced cell fusion, and mutations within either the gK or UL20 gene cause extensive cell fusion (syncytium formation). We have shown that gK forms a functional protein complex with UL20p, which is required for all gK and UL20p-associated functions in the HSV-1 life cycle. Recently, we showed that the amino-terminal 82 amino acids (aa) of gK (gKa) were required for the expression of the syncytial phenotype of the mutant virus gBΔ28 lacking the carboxyl-terminal 28 amino acids of gB (V. N. Chouljenko, …

Appropriate Responses Of Campus Security Forces, Donald Challis

Washington and Lee Journal of Civil Rights and Social Justice

No abstract provided.

Time Will Tell: Community Acceptability Of Hiv Vaccine Research Before And After The "Step Study" Vaccine Discontinuation, Paula M. Frew, Mark J. Mulligan, Su-I Hou, Kayshin Chan, Carlos Del Rio

Environmental & Global Health Faculty Research

Objective This study examines whether men-who-have-sex-with-men (MSM) and transgender (TG) persons’ attitudes, beliefs, and risk perceptions toward human immunodeficiency virus (HIV) vaccine research have been altered as a result of the negative findings from a phase 2B HIV vaccine study. Design We conducted a cross-sectional survey among MSM and TG persons (N = 176) recruited from community settings in Atlanta from 2007 to 2008. The first group was recruited during an active phase 2B HIV vaccine trial in which a candidate vaccine was being evaluated (the “Step Study”), and the second group was recruited after product futility was widely reported …

以病人模擬器及標準化病人進行針對日常例行醫療個案之跨領域團隊合作調練, 金洲 黃, 加璋 黃, 仁峰 梁, 鈴茹 黃, 雅琳 程, 幸榮 林, 肇文 陳

Journal of Medical Education

背景：良好的團隊合作是成功施行臨床醫療的基礎。團隊合作訓練最早起源於航空業，之後被應用在麻醉、急診及重症醫學等跨領域的臨床醫療上，一般內容包括上課、討論、及演練。本研究的目地，是希望能為日常例行醫療建立一套新的結合病人模擬器和標準化病人的跨領域團隊合作訓練課程。研究方法：自2010年4月起，我們開始針對日常例行醫療個案舉辦一系列的跨領域團隊合作訓練課程，內容包括醫學模擬操作、回饋和討論，將病人模擬器和標準化病人結合應用在課程之中；參加對象包括醫師、護理師、藥師、放射師、檢驗師及呼吸治療師等職系的老師和學員。在每次的課程結束之後，所有的參與者都需填寫評估問春。結果：總共51位參與者參加本訓練課程，問春的回收率達到100%。有47位(92.1%)參與者對課程感到滿意；教師和學生對課程的整體滿意度相近(P=0.437)，但教師認為此課程可幫助了解團隊合作重要性的滿意度高於學生(P=0.027)，教師對於學生在演練中表現的滿意度也高於學生自己的滿意度(P=0.002)；在不同職系間的整體滿意度並無差異（P=0.287）。結論：病人模擬器和標準化病人可成功的應用於日常例行醫療個案之跨領域團隊合作訓練課程。這是一種新的教學訓練模式，值得推廣。

The Virginia Gardasil Law: A Constitutional Analysis Of Mandated Protection For Schoolchildren Against The Human Papillomavirus, Christina O. Hud

Washington and Lee Journal of Civil Rights and Social Justice

No abstract provided.

The Body Soviet: Propaganda, Hygiene, And The Revolutionary State, Brian K. Lapierre

Faculty Publications

No abstract provided.

Conidia But Not Yeast Cells Of The Fungal Pathogen Histoplasma Capsulatum Trigger A Type I Interferon Innate Immune Response In Murine Macrophages, Diane O. Inglis, Charlotte A. Berkes, Davina R. Hocking Murray, Anita Sil

Biology Faculty Publications

Histoplasma capsulatum is the most common cause of fungal respiratory infections and can lead to progressive disseminated infections, particularly in immunocompromised patients. Infection occurs upon inhalation of the aerosolized spores, known as conidia. Once inside the host, conidia are phagocytosed by alveolar macrophages. The conidia subsequently germinate and produce a budding yeast-like form that colonizes host macrophages and can disseminate throughout host organs and tissues. Even though conidia are the predominant infectious particle for H. capsulatum and are the first cell type encountered by the host during infection, very little is known at a molecular level about conidia or about …

Genetic Variants In Nuclear-Encoded Mitochondrial Genes Influence Aids Progression, Sher L. Hendrickson, J. A. Lautenberger, Leslie Wei Chinn, Michael Malasky, Lawrence Kingsley, James J. Goedert, Gregory D. Kirk, Edward Gomperts, Susan Buchbinder, Jennifer L. Troyer, Stephen J. O'Brien

Biology Faculty Articles

Background: The human mitochondrial genome includes only 13 coding genes while nuclear-encoded genes account for 99% of proteins responsible for mitochondrial morphology, redox regulation, and energetics. Mitochondrial pathogenesis occurs in HIV patients and genetically, mitochondrial DNA haplogroups with presumed functional differences have been associated with differential AIDS progression.

Methodology/Principal Findings: Here we explore whether single nucleotide polymorphisms (SNPs) within 904 of the estimated 1,500 genes that specify nuclear-encoded mitochondrial proteins (NEMPs) influence AIDS progression among HIV-1 infected patients. We examined NEMPs for association with the rate of AIDS progression using genotypes generated by an Affymetrix 6.0 genotyping array of 1,455 …

Annual Report 2010, Tennessee. Department Of Correction.

Annual Report

No abstract provided.

Full Issue: Vol. 64, Issue 3

Sci-Tech News

No abstract provided.

Relationship Between Maternal Methadone Dose At Delivery And Neonatal Abstinence Syndrome., Neil S., Seligman, Christopher V. Almario, Edward J. Hayes, Kevin C. Dysart, Vincenzo Berghella, Jason K. Baxter

Department of Obstetrics and Gynecology Faculty Papers

OBJECTIVE: To estimate the relationship between maternal methadone dose and the incidence of neonatal abstinence syndrome (NAS).

STUDY DESIGN: We performed a retrospective cohort study of pregnant women treated with methadone for opiate addiction who delivered live-born neonates between 1996 and 2006. Four dose groups, on the basis of total daily methadone dose, were compared (160 mg/d). The primary outcome was treatment for NAS. Symptoms of NAS were objectively measured with the Finnegan scoring system, and treatment was initiated for a score>24 during the prior 24 hours.

RESULTS: A total of 330 women treated with methadone and their 388 …

Does Gender Still Matter?: Women Physicians’ Self-Reported Medical Education Experiences, Katherine M. Butler, Julia Mason

Student Summer Scholars Manuscripts

Objective: This study aims to provide a rich analysis of particular women’s medical education experiences.

Design: One-on-one interviews and self-administered questionnaires Participants: 25 practicing women physicians who had graduated from U.S. medical schools.

Results: The author identified the following themes: 1) societal gender role assumptions significantly impact women physicians’ experiences as medical students, in practice, and as primary care givers. 2) Marginalities in women’s health education exist in all levels of medical training. Curriculum specific to reproductive and psychiatric women’s health impacts physicians’ preparedness for treating female patients. 3) Physicians reported the existence of medical hierarchy during training and in …

Clinical Characteristics Of 74 Pandemic H1n1 Influenza Patients From Turkey. Risk Factors For Fatality, Emin E. Tutuncu, Baris Ozturk, Yunus Gurbuz, Asli Haykir, Irfan Sencan, Ferit Kuscu, Gulay Dede, Aysegul U. Kilic, Gonul C. Senturk

Saudi Medical Journal

OBJECTIVE: To evaluate the clinical characteristics and certain risk factors that may be associated with fatal outcome in patients with H1N1 influenza. METHODS: This retrospective study was conducted between October and December 2009 in the Department of Infectious Diseases and Clinical Microbiology, SB Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey. Data regarding the epidemiological and clinical characteristics of 74 hospitalized cases of confirmed pandemic H1N1 influenza were reviewed. RESULTS: The median age was 49 (18-83) years, and 34 (46%) were males. The most common symptom and signs on admission were cough (91.9%) and fever more than 38 degrees …

Distinct Macrophage Subpopulations Regulate Viral Encephalitis But Not Viral Clearance In The Cns, Christina D. Steel, Woong-Ki Kim, Larry Sanford, Laurie Wellman, Sandra Burnett, Nico Van Rooijen, Rochard P. Ciavarra

Biological Sciences Faculty Publications

Intranasal application of vesicular stomatitis virus (VSV) induces acute encephalitis characterized by a pronounced myeloid and T cell infiltrate. The role of distinct phagocytic populations on VSV encephalitis was therefore examined in this study. Ablation of peripheral macrophages did not impair VSV encephalitis or viral clearance from the brain, whereas, depletion of splenic marginal dendritic cells impaired this response and enhanced morbidity/mortality. Selective depletion of brain perivascular macrophages also suppressed this response without altering viral clearance. Thus, two anatomically distinct phagocytic populations regulate VSV encephalitis in a non-redundant fashion although neither population is essential for viral clearance in the CNS. …

“The Unspeakable Gift Of The Holy Ghost”, P. Scott Ferguson

Religious Educator: Perspectives on the Restored Gospel

No abstract provided.

Shared Understanding Or Consensus-Masked Disagreement? The Anti-Torture Framework In The Convention On The Rights Of Persons With Disabilities, Janet E. Lord

Loyola of Los Angeles International and Comparative Law Review

No abstract provided.

The Economic And Financial Policies To Fight Against Climate Change: The Case Of Maghreb, Nathalie Hilmi, Alain Safa

Topics in Middle Eastern and North African Economies

No abstract provided.

"We're Locking The Door": Family Histories In A Sample Of Homeless Youth, Shahid Alvi, Hannah Scott, Wendy Stanyon

The Qualitative Report

It is well known that the pathways to homelessness for young people are embedded in often ongoing negative childhood experiences. Many of these experiences are rooted in multiple and intersecting problems including, but not limited to: family conflict, abuse, addictions, and mental health issues. The authors draw upon qualitative interviews conducted with 15 homeless male and female youth between the ages of 16 and 24 in a suburban area of Southern Ontario, Canada. We describe these young people's perceptions of family experiences and find support for Elliott Currie's (2004) proposition that a broader ethos of individualism and intolerant parenting underpins …

Klebsiella Osteomyelitis Of The Right Humerus Involving The Right Shoulder Joint In An Infant, Maqbool Qadir, Syed Rehan Ali, Mumtaz Lakhani, Pervaiz Hashmi, Ahsen Amirali

Department of Paediatrics and Child Health

Osteomyelitis in newborn infants is a rare infection. Lower extremity joints are commonly affected. Most of the cases have a haematogenous spread. Aerobes are the common group of organism involved, of which Staphylococcus aureus is the commonest. Klebsiella osteomyelitis has been reported as a cause of Osteomyelitis. However, to the best of our knowledge, this is the first case report of Klebsiella pneumoniae associated osteomyelitis in an infant from Pakistan.

Common Vitamin And Mineral Deficiencies In Utah, Jeffery O. Hall, D. R. Zobell

All Current Publications

This publication discusses common vitamin and mineral deficiencies in animals around Utah.

Prevalences Of Giardia Lamblia And Cryptosporidium Parvum Infection In Adults Presenting With Chronic Diarrhoea, Javed Yakoob, Zaigham Abbas, M. Asim Beg, Shagufta Naz, Rustam Khan, Muhammad Islam, Wasim Jafri

Section of Gastroenterology

iardia lamblia and Cryptosporidium parvum are both waterborne pathogens associated with diarrhoea in developing countries. In a recent study based at the Aga Khan University in Karachi, 334 adults aged 16–83 years (178 patients with chronic diarrhoea and 156 diarrhoea-free volunteers who acted as controls) were checked for infection with these parasites, using stool microscopy and/or PCR. Overall, 21 (6.3%) and 29 (8.7%) of the subjects were found positive for G. lamblia by microscopy and PCR, respectively, while the corresponding values for C. parvum were 13 (3.9%) and 14 (4.2%). Although, compared with the diarrhoea-free controls, the patients with diarrhoea …

A Role For The Histone Deacetylase Hdac4 In The Life-Cycle Of Hiv-1-Based Vectors., Johanna A Smith, Jennifer Yeung, Gary D Kao, René Daniel

Department of Medicine Faculty Papers

HIV-1 integration is mediated by the HIV-1 integrase protein, which joins 3'-ends of viral DNA to host cell DNA. To complete the integration process, HIV-1 DNA has to be joined to host cell DNA also at the 5'-ends. This process is called post-integration repair (PIR). Integration and PIR involve a number of cellular co-factors. These proteins exhibit different degrees of involvement in integration and/or PIR. Some are required for efficient integration or PIR. On the other hand, some reduce the efficiency of integration. Finally, some are involved in integration site selection. We have studied the role of the histone deacetylase …

Today - August 27, 2010, Loma Linda University

TODAY

Inside this issue:

-- $2.1 million NIH grant will enable pharmacy professor to study HIV/AIDS prevention
-- Loma Linda University Medical Center sweeps its categories at Pacific Southwest Emmy Awards
-- The future of parking at LLU
-- Researchers at Loma Linda University School of Medicine and George Mason University find promising biomarker source in early detection of Alzheimer's
-- BMC administrator speaks out on the stigma of mental illness
-- LLU Medical Center boasts largest hyperbaric oxygen chamber on West Coast
-- Phil-Anne Krogman leaves the door open as she says farewell to FMO
-- Loma Linda University operators …

Sanders Gives All At Work And At Home, Tyler Greer

Browse All News

No abstract provided.

Utilizing Facebook Application For Disaster Relief: Social Network Analysis Of American Red Cross Cause Joiners, Jennie Wan Man Lai

USF Tampa Graduate Theses and Dissertations

With the exponential growth of Facebook users worldwide, this platform for social network online has become a powerful tool to connect individuals and share information with each other. This study explores the phenomenal trend of utilizing a Facebook application called Causes to help users organize into online communities for a specific cause and mobilize their resources for disaster relief during the Haiti earthquake disaster. Two separate samples of 100 joiners each from the American Red Cross (ARC) Cause on Facebook were randomly selected before and after the Haiti earthquake disaster to examine the differences of the composition (i.e., attributes) and …