Digital Commons Network^™

The Role Of Aerobic Glycolysis In The Resting Human Brain, Sanjeev Vaishnavi

All Theses and Dissertations (ETDs)

The human brain accounts for 2% of total body weight, though it consumes 20% of the body's energy supply. Most of this energy is provided by the complete oxidation of glucose to carbon dioxide and water, though some fraction of glucose undergoes aerobic glycolysis without concomitant oxidative phosphorylation. Elevation in neuronal activity increases aerobic glycolysis due to the disproportionate increase in blood flow and glucose utilization greater than oxygen consumption. Since aerobic glycolysis produces significantly less energy than complete oxidation of glucose, its role in cellular activities has been overlooked, though its presence in the resting brain has been known …

How Our Health Depends On Biodiversity, Eric Chivian M.D., Aaron Bernstein M.D., M.P.H.

Ecosystem Disruption & Climate Change

The eminent Harvard biology Professor Edward O.Wilson once said about ants, “We need them to survive, but they don’t need us at all.” The same, in fact, could be said about countless other insects, bacteria, fungi, plankton, plants, and other organisms. This fundamental truth, however, is largely lost to many of us. Rather, we humans often act as if we are totally independent of Nature, as if our driving thousands of other species to extinction and disrupting the life-giving services they provide will have no effect on us whatsoever.

This summary, using concrete examples from our award-winning Oxford University Press …

Minimizing Injuries And Enhancing Performance In Golf Through Training Programs, Erik P. Meira, Jason Brumitt

Faculty Publications - College of Physical Therapy

Context: Golf is a popular sport, particularly in older populations. Regardless of age and skill level, golfers risk injury to the back, shoulder, wrist and hand, elbow, and knee. Because of the unique compressive, shear, rotational, and lateral bending forces created in the lumbar region during the golf swing, the primary sport-related malady experienced by amateurs and professionals is low back pain. Extrinsic and intrinsic injury risk factors have been reported in the literature. A growing body of evidence supports the prescription of strength training routines to enhance performance and reduce the risk of injury.

Evidence Acquisition: Relevant studies were …

Begin The Adventure : How To Break The Light Barrier By A.D. 2079 (3rd Ed.), Florentin Smarandache, Homer B. Tilton

Branch Mathematics and Statistics Faculty and Staff Publications

This edition, the third, has undergone a subtle name change, going from "A.D. 2070" in the title to A.D. 2079 as the timeline is fine-tuned. Because of the almost universal failure to recognize the distinction between physical (reality-based, dynamical) and visual (appearance-based, kinematical) variables, a tremendous volume of mythology arose over the past 100 years centered around Einstein's reality view of the distortions of special relativity. To get a sense of it, we point the reader to Paul J. Nahin's heroic book, Time Machines, 2nd ed.,- to these Tech Notes in particular: TN#6. "A High-Speed Rocket Is a One-Way Time …

Personality Of Pain : A Look Into The Experience Of Pain As Well As The Psychological And Sociological Factors That Impact It, Desiree Perez

Honors Capstones

Within my research paper, my goal was to take an in depth look into the development, experience, and treatment of chronic pain. Information found in the paper includes (but is not limited to): the physiological breakdown of pain, causes, symptoms, statistics, views of pain through different medical models, treatment types, and sociological and psychological factors influencing pain. In order to research the topic, a variety of sources were used including: online periodicals and government websites, web pages, printed books, information taught in classes, and personal experience while working in a physical therapy clinic. My research has led me to many …

Acoustic Vowel Space Differences Between Cochlear Implant And Hearing Aid Users, Elizabeth Glyda

Honors Capstones

This study examines the acoustic vowel space of three children aged 4 to 5 years with varying levels of hearing. One of the children had cochlear implants with a profound unaided hearing loss. One child wore hearing aids with a mild unaided hearing loss. One child had normal hearing. Participants' production of isolated vowels, words, and a sentence were acoustically analyzed using the Speech Filing System program to determine the acoustic distinction between each child's vowels. It was hypothesized that the child with normal hearing would have the largest acoustic vowel space due to her ability to utilize auditory feedback …

Complexity And Human Gait, Leslie M. Decker, Fabien Cignetti, Nikolaos Stergiou

Journal Articles

Recently, the complexity of the human gait has become a topic of major interest within the field of human movement sciences. Indeed, while the complex fluctuations of the gait patterns were, for a long time, considered as resulting from random processes, the development of new techniques of analysis, so-called nonlinear techniques, has open new vistas for the understanding of such fluctuations. In particular, by connecting the notion of complexity to the one of chaos, new insights about gait adaptability, unhealthy states in gait and neural control of locomotion were provided. Through methods of evaluation of the complexity, experimental results obtained …

Nebraska Biomechanics Core Facilty 2009 Annual Report, Issue 8, Nebraska Biomechanics Core Facility

Biomechanics Annual Report

April 2009 - March 2010

This issue features Announcements, Featured News, Projects, Collaborations, Visitors, Awards, Publications, and Support.

Exomedicine Synthesis Paper, Rita Briggs

Robert "Bob" Twiggs STEM Education Collection

A report by Rita Briggs titled "Exomedicine Synthesis Paper" from 2010.

Retention Of Students In A Diploma Nursing Program In The Southern United States, Carol Ann Tingle

LSU Doctoral Dissertations

Registered Nurses comprise the largest group of healthcare professionals in the United States, and forecasts predict a nursing shortage of epic proportions on the horizon. Significant factors include approaching retirement of Baby Boomer RNs, increased demand for care for aging Baby Boomers in the population, approaching retirement of nurse educators, and rejection of qualified applicants secondary to enrollment restrictions in nursing programs. Nursing student attrition further contributes to the pending shortage. Successful retention programs promote best-practice utilization of scarce resources. Understanding student characteristics serves as a basis for effective selection and retention programs. This study described characteristics of nursing students …

Localized Mechanical Deformation And Dissolution Of 45s5 Bioglass, Ding Li

University of Kentucky Doctoral Dissertations

Bioactive glasses react with the human physiological solution in control of their biofunctionality. The stress state in bioactive glasses determines the chemomechanical reaction and their biofunctionality. Using the microindentation technique, the effect of the indentation deformation on the surface damage and material dissolution of 45S5 bioglass was investigated.

The indentation-induced residual stresses were calculated. Complete anelastic recoveries of the indentation depths and the impression marks were observed for the first time, which was likely driven by the stored strain energy over the anelastic deformation zone. The indentation-induced local surface damages were revealed before and after the immersion tests in phosphate …

Differences In Satiety Effects Of Alginate- And Whey Protein-Based Foods, Vicky A. Solah, Deborah A. Kerr, Cynthia D. Adikara, Xingqiong Meng, Colin W. Binns, Kun Zhu, Amanda Devine, Richard L. Prince

Research outputs pre 2011

Satiety is important in regulating food intake and has important public health significance in the control of obesity. Food containing protein and non-starch polysaccharides provides a satiety effect through various mechanisms but a comparison of the satiety effect on each has not previously been investigated. This study compared the satiety effect or reduction of hunger after consumption of (i) a whey proteinbased drink versus an alginate-based drink of the same viscosity where only the protein content differed, (ii) two alginate-based drinks differing in alginate type and viscosity, and (iii) a whey protein-based drink versus an alginate-based drink differing in protein …

Moral Markets: The Critical Role Of Values In The Economy By Paul J. Zak (Book Review), Jonathan B. Wight

Economics Faculty Publications

This volume contains the fruits of a two-year seminar on ethics and economics funded by the John Templeton Foundation and administered through the Gruter Institute for Law and Behavioral Research. Participants came from the social sciences, natural sciences, and humanities, and included Nobel Laureate Vernon Smith and other figures such as Frans de Waal, Herbert Gintis, Robert Frank, and Robert Solomon (for whom the book is dedicated in memoriam). The book’s editor, Paul Zak, is a pioneer in the emerging field of neuroeconomics, which uses medical technology to discover the physiological manifestations of cooperative and altruistic behavior. A theme of …

Values In Transition: The Chiricahua Apache From 1886-1914, John W. Ragsdale Jr

Faculty Works

No abstract provided.

Encountering God In Life And Mission: A Festschrift Honoring Jon Dybdahl, Rudolf Maier

All Books

No abstract provided.

The Meaning Of Pain In Cormac Mccarthy's Border Trilogy, Glenn Alton Jackson (Iii)

Graduate Student Theses, Dissertations, & Professional Papers

While the majority of McCarthy’s work graphically depicts brutal violence, it often avoids portrayals of subjective pain. Although his first four novels incorporate descriptions of subjective pain at crucial points in the narrative, in the Border Trilogy, McCarthy overtly elucidates the myriad ways we make meaning from pain. An analysis of the depictions of subjective pain in the Border Trilogy, this paper suggests, can aid in a more complete understanding of McCarthy’s entire oeuvre. This study approaches the problem of pain in McCarthy’s work from a perspective that joins medical science and the humanities to show how this nearly universal …

Values In Transition: The Chiricahua Apache From 1886-1914, John W. Ragsdale Jr.

American Indian Law Review

Law confirms but seldom determines the course of a society. Values and beliefs, instead, are the true polestars, incrementally implemented by the laws, customs, and policies. The Chiricahua Apache, a tribal society of hunters, gatherers, and raiders in the mountains and deserts of the Southwest, were squeezed between the growing populations and economies of the United States and Mexico. Raiding brought response, reprisal, and ultimately confinement at the loathsome San Carlos Reservation. Though most Chiricahua submitted to the beginnings of assimilation, a number of the hardiest and least malleable did not. Periodic breakouts, wild raids through New Mexico and Arizona, …

Fibroblast Growth Factor Receptors 1 And 2 In Keratinocytes Control The Epidermal Barrier And Cutaneous Homeostasis, Jingxuan Yang, Michael Meyer, Anna-Katharina Müller, Friederike Böhm, Richard Grose, Tina Dauwalder, Francois Verrey, Manfred Kopf, Juha Partanen, Wilhelm Bloch, David M. Ornitz, Sabine Werner

Open Access Publications

Fibroblast growth factors (FGFs) are master regulators of organogenesis and tissue homeostasis. In this study, we used different combinations of FGF receptor (FGFR)-deficient mice to unravel their functions in the skin. Loss of the IIIb splice variants of FGFR1 and FGFR2 in keratinocytes caused progressive loss of skin appendages, cutaneous inflammation, keratinocyte hyperproliferation, and acanthosis. We identified loss of FGF-induced expression of tight junction components with subsequent deficits in epidermal barrier function as the mechanism underlying the progressive inflammatory skin disease. The defective barrier causes activation of keratinocytes and epidermal gammadelta T cells, which produce interleukin-1 family member 8 and …

Characterization Of Tram, A Required Bacteroides Fragilis Conjugal Apparatus Protein That Interacts With The B. Fragilis Putative Coupling Protein Bcta And The B. Fragilis Relaxase Protein Bmph, Mai Thi Thanh Nguyen

Dissertations

Bacteroides spp. organisms, the most prominent bacteria of the human colon, are reservoirs of antibiotic resistance genes which promiscuously transfer within and from the genus via conjugation. The B. fragilis clinical isolate LV23 harbors a 37kb conjugative transposon, BTF-37. Two important conjugal apparatus proteins encoded by BTF-37 are BctA, a predicted coupling protein (CP) that powers DNA translocation, and ORF7 (TraM). In this study, we demonstrated that TraM exhibits characteristics of a required conjugal apparatus protein including 1) upregulated expression under conjugation conditions; 2) localization to the bacterial inner membrane; 3) interaction with the putative coupling protein BctA and the …

Automatic Generation Of Music For Inducing Emotive Response, Tony R. Martinez, Kristine Monteith, Dan A. Ventura

Faculty Publications

We present a system that generates original music designed to match a target emotion. It creates n-gram models, Hidden Markov Models, and other statistical distributions based on musical selections from a corpus representing a given emotion and uses these models to probabilistically generate new musical selections with similar emotional content. This system produces unique and often remarkably musical selections that tend to match a target emotion, performing this task at a level that approaches human competency for the same task.

Late Pleistocene-Early Holocene Colonization And Regionalization In Northern Perú: Fishtail And Paiján Complexes Of The Lower Jequetepeque Valley, Greg J. Maggard

University of Kentucky Doctoral Dissertations

Until relatively recently, the view of Late Pleistocene hunter-gatherers in the Americas was dominated by the “Clovis-first” paradigm. However, recent discoveries have challenged traditional views and forced reconsiderations of the timing, processes, and scales used in modeling the settlement of the Americas. Chief among these discoveries has been the recognition of a wide range of early cultural diversity throughout the Americas that is inconsistent with previously held notions of cultural homogeneity.

During the Late Pleistocene-Early Holocene, the development of widely varying economic, technological and mobility strategies in distinct environments is suggestive of a range of different adaptations and traditions.

It …

Development Of Novel Ahr Antagonists, Hyosung Lee

University of Kentucky Doctoral Dissertations

Aryl hydrocarbon receptor (AHR) is a sensor protein, activated by aromatic chemical species for transcriptionally regulating xenobiotic metabolizing enzymes. AHR is also known to be involved in a variety of pathogenesis such as cancer, diabetes mellitus, cirrhosis, asthma, etc. The AHR signaling induced by xenobiotics has been intensively studied whereas its physiological role in the absence of xenobiotics is poorly understood. Despite a number of ligands of AHR have been reported thus far, further applications are still hampered by the lack of specificity and/or the partially agonistic activity. Thus, a pure AHR antagonist is needed for deciphering the AHR cryptic …

Fabrication Of Receptor-Modified Microfluidic Surfaces For Applications In Glycoprotein Screening, Jennifer Macalindong De Guzman

LSU Doctoral Dissertations

Glycoproteins have long been identified to have a profound association with human pathological processes, and they are much sought after as potential biomarkers to aid in the early diagnosis and clinical prognosis of cancers and diseases. There is currently high demand for high-throughput and low–limit–of–detection techniques that can afford profiling of the glycoproteome. Micro-total analysis systems (µTAS) based on microfluidics have the potential to fulfill these requirements, but in order to reduce the complexity of the protein pool, the µTAS devices must contain a pre-isolation and enrichment component. The research project undertaken here involved derivatization of microfluidic …