Digital Commons Network^™

In Vivo Evidence For The Iron-Binding Activity Of An Iron-Sulfur Cluster Assembly Protein Isca In Escherichia Coli, Wu Wang, Hao Huang, Guoqiang Tan, Fan Si, Min Liu, Aaron P. Landry, Jianxin Lu, Huangen Ding

Faculty Publications

IscA is a key member of the iron-sulfur cluster assembly machinery in prokaryotic and eukaryotic organisms; however, the physiological function of IscA still remains elusive. In the present paper we report the in vivo evidence demonstrating the iron-binding activity of IscA in Escherichia coli cells. Supplement of exogenous iron (1 μM) in M9 minimal medium is sufficient to maximize the iron binding in IscA expressed in E. coli cells under aerobic growth conditions. In contrast, IscU, an iron-sulfur cluster assembly scaffold protein, or CyaY, a bacterial frataxin homologue, fails to bind any iron in E. coli cells under the same …

Golgi Cells Operate As State-Specific Temporal Filters At The Input Stage Of The Cerebellar Cortex, Shane A. Heine, Stephen M. Highstein, Pablo M. Blazquez

Open Access Publications

Cerebellar processing of incoming information begins at the synapse between mossy fibers and granule cells, a synapse that is strongly controlled through Golgi cell inhibition. Thus, Golgi cells are uniquely positioned to control the flow of information into the cerebellar cortex and understanding their responses during behavior is essential to understanding cerebellar function. Here we show, for the first time, that Golgi cells express a unique oculomotor-related signal that can be used to provide state- and time-specific filtering of granule cell activity. We used newly established criteria to identify the unique electrophysiological signature of Golgi cells and recorded these neurons …

Volume 48, Number 17: December 15, 2010, University Of North Dakota

University Letter Archive

No abstract provided.

Lost On Purpose, Matthew Mccain Martin

Electronic Theses and Dissertations Archive

In nine linked nonfiction essays and eight codas, the author seeks to understand the meaning of being lost and the importance of not knowing in an era of instantaneous and ubiquitous information. Through extensive interviews, research, and memoir, the author seeks out those who choose to live lost in order to understand his own penchant for escape. Framed by the mystery of antique maps, these essays find the author in several different locations, from Tasmania to Siberia to Utah. In each, the author meets and spends time with an ambassador of each place before finally attempting to become lost himself.

Improving The Emulsion Stability Of Sponge Cake By The Addition Of ?-Polyglutamic Acid, Yung-Shin Shyu, Wen-Chieh Sung

Journal of Marine Science and Technology–Taiwan

The batter properties of sponge cake with the addition of γ-polyglutamic acid (PGA) at different levels (0.05, 0.1, 0.5 gkg-1, w/w) was evaluated. The viscosity, emulsion stability and foam stability increased at the addition of 0.5 gkg-1 PGA level. PGA caused significant declines in the differential scanning calorimetry (DSC) enthalpy, onset and peak temperatures of ice-melting transition of sponge cake. Sponge cakes manufactured with 0.5 gkg-1 PGA addition were in general lighter on crumb color and white index than the control. Scanning electron microscopy showed that sponge cake with the addition of 0.1 and 0.5 gkg-1 PGA exhibited microstructures having …

Incorporating Feedback From Multiple Sensory Modalities Enhances Brain–Machine Interface Control, Aaron J. Suminski, Dennis C. Tkach, Andrew H. Fagg, Nicholas G. Hatsopoulos

Biomedical Engineering Faculty Research and Publications

The brain typically uses a rich supply of feedback from multiple sensory modalities to control movement in healthy individuals. In many individuals, these afferent pathways, as well as their efferent counterparts, are compromised by disease or injury resulting in significant impairments and reduced quality of life. Brain–machine interfaces (BMIs) offer the promise of recovered functionality to these individuals by allowing them to control a device using their thoughts. Most current BMI implementations use visual feedback for closed-loop control; however, it has been suggested that the inclusion of additional feedback modalities may lead to improvements in control. We demonstrate for the …

New Proquest Interface, Georgia Southern University, Zach S. Henderson Library

Library Publications (1999-2023)

• New ProQuest interface

Youth Alcohol Access, Consumption, And Consequences In Anchorage, Alaska: Identification Of Indicators, Marny Rivera, Jennifer Mcmullen

Reports

This report identifies indicators of underage drinking in Anchorage, Alaska, which can be used in assessing changes brought about by strategies designed to reduce underage access to alcohol and consequences associated with underage drinking. Indicators are addressed under the categories of underage access to alcohol, social norms and perceptions associated with underage drinking, alcohol consumption patterns, and consequences of underage drinking. Consequences examined include school-related consequences, risky behavior, and legal consequences of underage drinking. Alcohol abuse by people under 21 years of age requiring substance abuse treatment, health and safety consequences of underage drinking, and economic consequences of underage drinking …

Mortgage Servicing, Adam J. Levitin, Tara Twomey

Documents

No abstract provided.

The Antelope, University Of Nebraska At Kearney

The Antelope

No abstract provided.

Modeling Of Aortic Valve Anatomic Geometry From Clinical Multi Detector-Row Computed Tomography Images, Gregory A. Book

Master's Theses

Transcatheter aortic valve implantation (TAVI) is an emerging and viable alternative to surgical valve replacement. A TAVI procedure involves insertion of a catheter into the heart through an artery or transapically, and expanding valve stent in place. This procedure dramatically reduces the recovery time by eliminating the need for open heart surgery. Understanding the biomechanics of the stent-valve interaction is crucial for proper device deployment and function. In this study, we examine the extraction of valve geometries and creation of valve models from multi-detector row computed tomography (MDCT) images that may eventually be used to model stent expansion on a …

The Effect Of Passive Stretching And Isometric Contractions On Delayed Onset Muscle Soreness After A Typical Bout Of Exercise, John W. Gibson

Theses and Dissertations

Delayed Onset Muscle Soreness (DOMS) is a common response to activities involving lengthening contractions. Muscle inflammation is associated with DOMS and may play an integral role in protecting a muscle from damage and soreness in response to subsequent bouts of lengthening contractions. Research in animals has shown that prior exposure to passive stretching and isometric contractions of a muscle resulting in muscle inflammation attenuates the muscle inflammatory response following subsequent bouts of lengthening contractions. The purpose of this study was to determine whether passive stretching and isometric contractions in humans would reduce DOMS following a typical bout of resistance exercise. …

Midazolam Inhibits Hippocampal Long-Term Potentiation And Learning Through Dual Central And Peripheral Benzodiazepine Receptor Activation And Neurosteroidogenesis, Kazuhiro Tokuda, Kazuko A. O'Dell, Yukitoshi Izumi, Charles F. Zorumski

Open Access Publications

Benzodiazepines (BDZs) enhance GABA(A) receptor inhibition by direct actions on central BDZ receptors (CBRs). Although some BDZs also bind mitochondrial receptors [translocator protein (18 kDa) (TSPO)] and promote the synthesis of GABA-enhancing neurosteroids, the role of neurosteroids in the clinical effects of BDZs is unknown. In rat hippocampal slices, we compared midazolam, an anesthetic BDZ, with clonazepam, an anticonvulsant/anxiolytic BDZ that activates CBRs selectively. Midazolam, but not clonazepam, increased neurosteroid levels in CA1 pyramidal neurons without changing TSPO immunostaining. Midazolam, but not clonazepam, also augmented a form of spike inhibition after stimulation adjacent to the pyramidal cell layer and inhibited …

Intradermal Immunization Of Mice With Radiation-Attenuated Sporozoites Of Plasmodium Yoelii Induces Effective Protective Immunity, Tatiana Voza, Chahnaz Kebaier, Jerome P. Vanderberg

Publications and Research

Background Intravenous injection of mice with attenuated Plasmodium berghei sporozoites induces sterile immunity to challenge with viable sporozoites. Non-intravenous routes have been reported to yield poor immunity. Because intravenous immunization has been considered to be unacceptable for large scale vaccination of humans, assessment was made of the results of intradermal immunization of mice with Plasmodium yoelii, a rodent malaria parasite whose infectivity resembles that of human malaria. Methods Mice were immunized with two injections of isolated, radiation-attenuated P. yoelii sporozoites, either by intravenous (IV) or intradermal (ID) inoculation. In an attempt to enhance protective immunogenicity of ID-injections, one group of …

African American Women's Health: An Examination Of Resource Needs, Context, And Public Policy Over The Life Course, Cynthia Newbille

Theses and Dissertations

African American Women's Health: An Examination of Resource Needs, Context, and Public Policy over the Life Course

A Simple Method To Reduce Infection Of Ventriculoperitoneal Shunts Clinical Article, Atiq-Ur Rehman, Tausif-Ur Rehman, Hassaan H. Bashir, Vikas Gupta

Department of Medicine

Object: Postoperative shunt infection is the most common and feared complication of ventriculoperitoneal (VP) shunt placement for treatment of hydrocephalus. The rate of shunt infection is highest in the 1st postoperative month. The most common organisms responsible for shunt infection include coagulase-negative Staphylococcus and Staphylococcus aureus. This suggests a transfer of Patient's skin flora via the surgeons' glove as a possible means of infection. The authors conducted a study to determine if the rate of postoperative shunt infections could be reduced simply by changing gloves before handling the shunt catheter. Methods: A total of 111 neonates born with congenital hydrocephalus …

The Effects Of Chronic Ampk Activation On Hepatic Triglyceride Accumulation And Glycerol-3-Phosphate Acyltransferaseactivity With High Fat Feeding, Mary E. Curtis

Theses and Dissertations

High fat feeding increases hepatic fat accumulation and is associated with hepatic insulin resistance. AMP Activated Protein Kinase (AMPK) is thought to inhibit lipid synthesis by the acute inhibition of glycerol-3-phosphate acyltransferase (GPAT) activity and transcriptional regulation via SREBP-1c. The purpose of this study was to determine if chronic activation of AMPK prevented an increase in GPAT1 activity in rats fed a high fat diet. Rats were fed a control (C), or a high fat (HF) diet (60% fat) for 6 weeks and injected with saline or a daily AICAR dose of 0.5 mg/g body weight. Chronic AMPK activation by …

Measuring Awareness Of The Impacts Of Change In The Public Health Workforce: A Precursory Step In Promoting A Shared Vision Via Cross-Sectoral Collaboration, Anthony G. Robins, Dhitinut Ratnapradipa, Kadi R. Bliss

Online Journal for Workforce Education and Development

Public health is currently undergoing significant changes and becoming increasingly dependent on one another to achieve their missions. The restructuring is forcing public health stakeholders to reexamine their present and future roles. This case study examines a local health department’s staff and its awareness of the department’s epidemiology program as a practical framework for thinking about and implementing cross-sectoral collaboration. An OEB (Office of Epidemiology and Biostatistics) Awareness Survey was developed and administered to 492 participants at the Allegheny County Health Department. Cross-sectional analysis examined associations between demographics, behavioral and cultural factors, and help seeking (attempts at collaboration). Results indicate …

Glimpses Of Islam In Egypt., Madame Emilie Hyacinthe Loyson

The Open Court

No abstract provided.

Biomarkers Of Mild Cognitive Impairment And Alzheimer's Disease, Mark A. Lovell, Bert C. Lynn

Chemistry Faculty Patents

A method for quantifying a neurodegenerative disorder in a patient that includes obtaining a fluid sample from the subject; measuring a protein biomarker complex in said fluid sample and correlating the measurement with mild cognitive impairment or Alzheimer's disease status. The biomarkers include those that comprise at least one of a transthyretin protein and/or a prostaglandin-H2 D-isomerase protein, and at least one second, different protein selected from a transthyretin, prostaglandin-H2 D-isomerase, beta-2-microglobulin, cystatin C, superoxide dismutase [Cu—Zn], plasma retinol-binding protein, phosphatidylethanolamine-binding protein, carbonic anhydrase 2, prostaglandin-H2 D-isomerase, and/or serotransferrin protein.

The Effects Of A Single Session Of Dance/Movement Therapy With Adults In Crisis Stabilization: A Mixed Methods Study, Ashley Duquette

Creative Arts Therapies Theses

The purpose of this thesis is to identify the effects of a single session of dance/movement therapy (DMT) for crisis stabilization with adults in a short-term residential facility. Over the course of 14 weeks (14 sessions) surveys were administered before and after each session to participants who were new to the group. These surveys, along with the researcher’s observations and written notes about the group were collected in order to gain information about the participants’ experience of symptoms and wellbeing before and after the group. The change in symptoms and wellbeing was analyzed quantitatively and qualitatively through the use of …

Sr-10-11-15 Cc, Marshall University

Recommendations

No abstract provided.

Education, Politics And Opinions About Climate Change: Evidence For Interaction Effects, Lawrence C. Hamilton

Sociology

U.S. public opinion regarding climate change has become increasingly polarized in recent years, as partisan think tanks and others worked to recast an originally scientific topic into a political wedge issue. Nominally “scientific” arguments against taking anthropogenic climate change seriously have been publicized to reach informed but ideologically receptive audiences. Reflecting the success of such arguments, polls have noted that concern about climate change increased with education among Democrats, but decreased with education among Republicans. These observations lead to the hypothesis that there exist interaction (non-additive) effects between education or knowledge and political orientation, net of other background factors, in …

December 14, 2010: A Fundamental Rights Decision Masquerading As A Commerce Decision, Bruce Ledewitz

Hallowed Secularism

Blog post, “A Fundamental Rights Decision Masquerading as a Commerce Decision“ discusses politics, theology and the law in relation to religion and public life in the democratic United States of America.

A Study On Legal And Ethical Issues Surrounding Health Practitioner Pro Bono Services, Lori Khan Ms, Clt, Dpt

Journal of Health Ethics

The purpose of this paper is to explore the legal and ethical implications of pro bono health care services in the United States and abroad. The research regarding volunteer or pro bono health services has focused mainly on physician involvement in volunteer medical services, or pro bono health services, with research showing only 39% of physicians, compared to 30% of general public, taking part in volunteer services to patients and the community (Grande, D, and Armstrong, K, 2007). Historically, pro bono services were derived from the Canons of Professional Ethics in 1908 and evolved into the Model Code of Professional …

Dachau—Remembering The Unforgettable, Jennie Gunn Ph.D., Fnp, Carroll Gunn M.A.

Journal of Health Ethics

Ethical research provides great benefit to the public, but ethical research is not guaranteed. Research can go terribly wrong when research subjects are not protected. Egos of scientists and others in power can cause disastrous results, and that is what happened at the Dachau concentration camp in Germany. Because of incidents such as this, medical research at universities is now reviewed by Institutional Review Boards to protect subjects. But not so long ago, in the Dachau concentration camp, researchers were free to impose pain and death upon prisoners in the name of research. Prisoners were mistreated to glean knowledge; many …

Domestic Violence: Not My Job, Not My Problem, John Chapin, Grace Coleman, Erin Varner

Journal of Health Ethics

The study examines incidences of domestic violence in several communities, police statistics and attitudes of medical professionals. Findings suggest a fundamental ethical dilemma in services for victims of domestic violence: medical professionals view domestic violence as a law enforcement issue, while police view it as a health issue. Victims are confronted by multiple systems each with opposing beliefs and attitudes about their respective roles.

Informed Consent: Elective Abortion, Kaye Wilson-Anderson Dsn, Msn

Journal of Health Ethics

This article presents an overview of the history of informed consent, identifies the necessary elements of informed consent and provides a discussion of the controversy surrounding informed consent for an elective abortion. The most current scientific reports of risk and benefits of elective abortions are examined and essential information for informed consent for an elective abortion is identified.

Preventing Preventative Health, Clare Stride Bsc

Journal of Health Ethics

With the Earth’s human population estimated to exceed 10 billion by 2050, the now globalised community has some serious discussions involving the upcoming, necessary transition to sustainable habitation and preventative healthcare. This paper examines the social and economic structures preventing this transition at individual, national and multinational levels and their responsibilities to public health. Greater responsibility for ones individual health and consumption is essential and should be supported and encouraged by national governance that in turn has a responsibility to provide the environment in which healthy sustainable lifestyles are achievable and affordable. Multi-national corporations must also accept their responsibilities to …

Unfair Contribution And Consumption In Medicare: Results From The Medical Expenditure Panel Survey In 2006, Yi-Sheng Chao M.D., M.P.H.

Journal of Health Ethics

The imbalance of Medicare financing and cost sharing consumption is rooted in the Medicare tax collection and its main purpose to serve the aged population. The unfairness of Medicare tax collection includes its regressivity for all income levels and the incomplete tax collection among income groups. Those suffering from premature death, especially black males, lose the chance to enjoy longevity and the coverage of Medicare. The solution to the unfair redistribution posited is: alteration of Medicare enrollment age for different races and sexes, differential Medicare tax based on the population characteristics, and progressive taxation on all individuals to raise Medicare …