Digital Commons Network^™

Alternative Regulation Of The Alginate Algd Operon By An Activated Algb In Nonmucoid Pseudomonas Aeruginosa Is Dependent On Sigma 54, Jean Kim

Theses and Dissertations

Alginate overproduction by Pseudomonas aeruginosa, which causes a mucoid phenotype, is a major virulence factor associated with chronic pulmonary infections in cystic fibrosis patients. Expression of the algD operon for alginate biosynthesis requires three major regulators in association with the ECF sigma factor, σ22, in mucoid strains that are typically defective in anti-sigma factor, MucA. One such algD regulator is AlgB, a member of the NtrC family of two-component systems, which typically utilize σ54. However, neither σ54 nor the cognate sensor kinase (KinB) of AlgB are required for algD expression in such mucoid strains. I hypothesized that KinB-phosphorylated AlgB must …

Novel Cinnamic Acid-Based Dehydropolymers For Emphysema: In Vitro And In Vivo Assessment Of Their Activities, Bhawana Saluja

Theses and Dissertations

Pulmonary emphysema is a serious worldwide illness, causing progressive and irreversible alveolar wall loss and difficulty in breathing. It is caused mostly by cigarette smoking. However, its unresolved complex and multiple pathogenic mechanisms have left this disease without effective pharmacotherapy. This project hypothesized that cinnamic acid-based dehydropolymers (DHPs), originally discovered as novel anti-coagulants, protect against emphysema through their potent triple inhibitory actions against oxidative stress, inflammation and elastase, some of the pathogenic mechanisms associated with this disease. Three in vitro inhibitory activity assays for oxidative stress, lung inflammation and neutrophil elastase (NE) were developed and used to identify the most …

Cell-Cell Junction Signaling Regulating Dna Double-Strand Break Repair In Breast Cells, Sinduja Ethiraj

Theses and Dissertations

Genomic instability and acquisition of invasiveness through the basement membrane extracellular matrix (ECM) are two major processes for epithelial cell malignancy in breast cancer. DNA double-strand break repair (DSBR) is one of the processes that get misregulated during breast cancer progression. In addition, radiation induced breaks such as those induced during radiation therapy to treat breast cancer patients are repaired by DSBR, rendering this pathway relevant for therapy as well. DSBR can occur either by homologous recombination (HR) or non-homologous end-joining (NHEJ). HR is accepted as the more error-free pathway. HR is regulated by the cell cycle status such that …

The Role Of Synaptically Evoked Plateau Potentials In Retinogeniculate Development, Emily Dilger

Theses and Dissertations

We study the activity-dependent refinement of sensory systems by using the mouse retinogeniculate system as a model. Spontaneous retinal waves lead to robust excitatory post-synaptic activity in developing relay cells in the dorsal lateral geniculate nucleus (dLGN) of the thalamus and are reportedly needed to help guide the segregation of retinal inputs into eye-specific domains as well as for the pruning of extraneous retinal inputs onto single dLGN relay cells. The composition of retinally evoked post-synaptic activity activated by these retinal waves in dLGN is largely unknown, but based on our in vitro recordings, such activity seems well suited to …

Patient Ventilator Dyssynchrony: Types, Frequency And Patterns In Critically Ill Adults, Karen Mellott

Theses and Dissertations

Patient ventilator dyssynchrony (PVD) occurs frequently, but little is known about the types, frequency and patterns of PVD for longer than 30 minutes. Deeper levels of sedation are associated with PVD. Evaluation of ventilator graphics and the ability to identify PVD should assist clinicians to optimize patient ventilator interactions and promote earlier interventions. The purpose of this study was to identify the different types, frequency and patterns of PVD in critically ill adults and determine the effect of sedation level on PVD. Thirty medical and surgical ICU adult patients were enrolled; 27 were used for analysis. Pressure/time and flow/ time …

Contributions Of Neglect Subtypes And Family History In Dsm-Iv Disorders: Findings From The Ncs-R, Leanne Heaton

Theses and Dissertations

Despite the prevalence of neglect in the child welfare system, understanding of the etiology of neglect remains limited in scope. Limitations are driven by the frequent reliance on child protective services (CPS) data which consists of identified cases and consequently, the most serious of all cases, or through a few population based studies that operationalize neglect as a homogenous phenomenon rather than as distinct subtypes. Furthermore, most studies of neglect focus on maternal deficiencies while paternal factors are largely ignored. This study is meant to address these considerations by utilizing the National Comorbidity Survey Replication (NCS-R), a broad population based …

Generation Y And Vocal Fry, Paul Michael Valley

Theses and Dissertations

In this thesis, the author explores a vocal phenomenon called “vocal fry” and why this dysphonia has emerged as one of the primary means of communication for the population referred to as “Generation Y.” The first chapter defines what vocal fry is and why it is of modest value to the stage actor. The second chapter defines the physiological means by which the human body creates sound, what good sound is and how vocal fry is created. The third and fourth chapters define several generations as well as what defines Gen Y, and the communication physiologies associated with those generations. …

The Everyday In America, Janet Bruhn

Theses and Dissertations

Abstract: My vanilla, Grade A, white bread, run-of-the-mill, middle-of-the-road, threadbare, well-worn, moth-eaten, potato sack, butterscotch, grass stained America: Mundane American life is an existence clinging to the ordinary, where a quilt of mass- mediated preferences and ingrained traditions define many people, specifically from north to south and east to west. Yet, the tastes and dialects of people within the mundane are complex. Ideological preferences are rooted in immigrant history and political persuasion. Various modes of realism have been used by American painters such as The Ash Can School, Regionalists of the 1930’s, and Pop Art. The notion of the real …

The Adventures Of A Young Artist, And The Promise Of The Digital Culture In Art, Jonathan Marshall

Theses and Dissertations

An analysis and explanation of my reasons for working in video, painting and drawing, and sculpture, considering the technological developments of the past decade; the possibility to use the internet as a distribution tool for works of art, and to shift the decision-making balance of the art-world; the ways that this approach is a democratic format for output in the arts and within communities of artists; an explanation of my studio practice while a graduate student at Virginia Commonwealth University.

The Prognostic Potential Of The Epidermal Growth Factor Receptor And Nuclear Factor Kappa B Pathways And Associated Therapeutic Strategies In Patients With Squamous Cell Carcinoma Of The Head And Neck, Pamela Wirth

Theses and Dissertations

Little is known about the signaling pathways that contribute to treatment response in advanced stage head and neck tumors. Increased expression of epidermal growth factor receptor (EGFR) and downstream pathways such as nuclear factor kappa B (NFκB) are implicated in aggressive tumor phenotypes and limited response to therapy. This study explored the rationale for combining the proteasome inhibitor bortezomib with the EGFR inhibitor gefitinib in a subset of head and neck squamous cell carcinomas with high EGFR gene amplification. Drug responses of gefitinib and bortezomib as single agents and in combination within head and neck squamous cell carcinoma cell lines …

Executive Summaries

The Foundation Review

No abstract provided.

Demonstrating The Value Of Social Service Programs: A Simplified Approach To Calculating Return On Investment, Herbert M. Baum, Andrew H. Gluck, Bernice S. Smoot, William H. Wubbenhorst

The Foundation Review

· In 2008, as charitable giving dropped by $6.4 billion, 54 percent of human service programs saw an increase in the need for their services. Additionally, 74 percent of programs specifically serving children and youth reported being underfunded or severely underfunded.

· As government and foundation grantmakers transition from charitable giving to social investment, a Gates Foundation report on eight methodologies to assist measuring social value creation finds the methodologies are many years away from being suitable for both nonprofits and grantmakers.

· To better recognize and communicate the work of frontline practitioners, there is a need to change the …

Enrolling The Eligible: Lessons For Funders, Beth Stevens, Sheila Dunleavy Hoag, Judith Wooldridge

The Foundation Review

· Many social programs have a gap between the number of individuals eligible for services and the number enrolled.

· The Robert Wood Johnson Foundation implemented Covering Kids & Families to increase enrollment in Medicaid and the State Children’s Health Insurance Program.

· Grantees sought to increase enrollment by raising awareness among low-income families, simplifying the application process, and coordinating among programs.

· Funders are encouraged to consider the lifecycle of programs and organizations, the skills in coalition-building and working with public officials that are needed, and the need to fit political strategies with the local culture.

Foundation Evaluation Startup: A Pause For Reflection, Jill M. Yegian

The Foundation Review

· This article reports on the accomplishments, challenges, and lessons learned in creating a new Department of Research and Evaluation at the California HealthCare Foundation.

· Different tools were developed to address each of three key areas: performance assessment, organizational learning, and program evaluation.

· These new processes and tools have been wellreceived by both staff and the board, and have become increasingly important as resources become more scarce, making understanding and maximizing the impact of investments even more critical.

· Fostering a culture of evaluative inquiry in a fast-paced, payout-oriented environment is a significant challenge – program staff often …

Assessing Nonprofits’ Communications Capacity: An Online Self-Assessment Tool, Anne Reisinger Whatley, R. Christine Hershey, Julia Coffman, Andre Oliver

The Foundation Review

· Foundations increasingly recognize the importance of strategic and effective communications to advance their social-change goals. This article provides a framework that helps foundations to better understand the communications capacity of their grantee partners.

· Based on a detailed analysis of a survey of 529 foundations, universities and nonprofits, the authors created a six-point index that identifies the characteristics and practices of organizations that are ranked as highly effective at using communications to advance their goals.

· The six indicators are: Involvement of organization leadership in communications, communications planning and organization-wide planning, staffing and the use of outside expertise, donor …

Social Movements And Philanthropy: How Foundations Can Support Movement Building, Barbara Masters, Torie Osborn

The Foundation Review

· As foundations seek to catalyze broad-based social change, there is a need for greater understanding of what social movements are, how they evolve, and how foundations can support them.

· Movement building presents unique challenges to foundations. Because movements, by definition, must be driven by the people who are most affected, foundations cannot determine the goals and timetables of a movement.

· The authors identify five core elements to movement building: organizing an authentic base; leadership; vision and ideas; alliances; and advocacy infrastructure.

· A framework for evaluating movement building is proposed, which can help foundations identify measureable outcomes …

Editorial, Teresa R. Behrens

The Foundation Review

No abstract provided.

Building The Bridge For Diversity And Inclusion: Testing A Regional Strategy, Vicki Rosenberg, Lynn Perry Wooten, Mary Mcdonald, Kimberly Burton

The Foundation Review

· Transforming Michigan Philanthropy Through Diversity & Inclusion (TMP) is a six-year research and development effort of the Council of Michigan Foundations (CMF). A unique experiment, TMP is the only statewide, comprehensive effort to promote diversity and inclusiveness among foundations in the country.

· Organizational excellence through diversity and inclusion requires an organization to find a goal that resonates with its stakeholders and then create collaborative communities that focus on achieving that goal. This strategy positions an organization to use the full diversity of those stakeholders for tasks such as problem-solving, innovation, quality initiatives, and the acquisition of resources.

· …

“Decision Rules” And Kids: Clarifying The Vagueness Problems With Status Offense Statutes And School Disciplinary Rules, Martin R. Gardner

Nebraska Law Review

Because they are dependent and vulnerable, young people have long been the recipients of governmental policies and legal measures aimed at promoting their welfare and protecting them in circumstances of perceived need. Through its parens patriae power, the state routinely maintains a paternalistic posture in its interactions with minors in hopes of assisting their development into mature and responsible adulthood. In similar fashion, governmentally employed educators are often loosely deemed to act in loco parentis and thus are sometimes thought to assume a quasi-parental relationship with their students. Juveniles are thus the recipients of unique legal attention in a variety …

The Erosion Of Nebraska’S Free Exercise Protection: In Re Interest Of Anaya (Anaya Ii), 276 Neb. 825, 758 N.W.2d 10 (2008), Sara Lunsford Kohen

Nebraska Law Review

After the Nebraska Supreme Court’s holding in In re Interest of Anaya (“Anaya II”) in December of 2008, an individual whose religious liberty is burdened by a neutral, generally applicable law has no recourse under the Nebraska Constitution, no matter how extreme the burden is.

The plaintiffs in Anaya II challenged the state’s newborn screening statutes under the free exercise provision of article I, section four of the Nebraska Constitution (hereinafter “Section Four”), claiming that drawing blood from their infant under the newborn screening statutes violated their sincerely held religious beliefs. In so arguing, they cited Palmer v. …

Editorial, Teresa R. Behrens

The Foundation Review

No abstract provided.

Leveraging Grant-Making—Part 2: Aligning Programmatic Approaches With Complex System Dynamics, David Peter Stroh, Kathleen A. Zurcher

The Foundation Review

· The purpose of this two-part article is to enable foundations to increase the leverage of their grantmaking resources by working effectively with the dynamics of complex social systems.

· This article examines how foundations can align planning, implementation, and evaluation efforts with the behavior of the social systems they seek to improve.

· Asking powerful questions of staff, board, grantees, and other stakeholders helps to transform how they think about their goals and strategies.

· In addition to using the power of questioning, foundations function more systemically by suspending their assumptions about their effectiveness and what is possible, creating …

Speak Your Peace: A Communications Strategy For Changing Community Culture, Douglas Easterling, Holly C. Sampson, Beth Probst

The Foundation Review

· Strategic communications can play a crucial role in advancing tangible community-wide impacts.

· “Speak Your Peace: The Civility Project” (SYP) was developed by The Duluth Superior Area Community Foundation and the Millennium Group to improve the civility of public discourse, under the premise that this would strengthen community decision making, expand civic engagement, and increase residents’ interest in elected office.

· The SYP campaign promotes nine principles (or “tools”) adapted from Forni’s book Choosing Civility (e.g., pay attention, take responsibility, apologize, give constructive criticism).

· City councils, county commissions, and school boards in the region adopted the nine tools …

Mediation In Employment And Creeping Legalism: Implications For Dispute Systems Design, Lisa Blomgren Bingham, Susan S. Raines, Tim Hedeen, Lisa Marie Napoli

Faculty Articles

This article will explore the question of creeping legalism in mediation of statutory disputes arising out of employment. First, it will briefly review the issue of creeping legalism in arbitration. Second, it will introduce dispute systems design (DSD). Third, it will review the analogous debate on legalism in mediation in three design contexts: evaluative mediation of employment disputes in the court-connected setting, grievance mediation embedded in the collective bargaining agreement, and transformative mediation of employment disputes in the United States Postal Service's (USPS's) REDRESS program. Most employees do not face a choice among mediation models; instead, they choose among adjudicative …

"Your Results May Vary": Protecting Students And Taxpayers Through Tighter Regulation Of Proprietary School Representations, Aaron N. Taylor

All Faculty Scholarship

This article argues for stricter regulation of proprietary (for-profit) school advertising and recruitment practices and proffers specific proposals for effectuating this regulation. Proprietary schools play an important role in broadening access to higher education. They enroll a large number of students who are underserved by traditional, non-profit institutions. These students tend to be poorer, less educated, and older than students at traditional schools, and they tend to undertake higher education for very practical reasons. These characteristics make them particularly susceptible to deceptive marketing and unfounded promises of higher education providers. Unfortunately, some proprietary schools exploit the susceptibilities of their target …

African Americans Can't Win, Break Even, Or Get Out Of The System: The Persistence Of “Unequal Treatment ” In Nursing Home Care, Ruqaiijah A. Yearby

All Faculty Scholarship

Empirical data show that racial disparities in the quality of care provided by nursing homes are a common occurrence, not isolated to Illinois. Nine years after the publication of the groundbreaking Institute of Medicine Study (“IOM study”) Unequal Treatment: Confronting Racial and Ethnic Disparities in Healthcare, which acknowledged continued racial disparities in health care and provided suggestions for the elimination of these disparities, racial disparities still remain. One chief example of the continuation of racial disparities in health care is in the provision of nursing home care.

Decades of empirical research studies have shown that racial disparities in accessing quality …

Litigation, Integration, And Transformation: Using Medcaid To Address Racial Inequities In Health Care, Ruqaiijah A. Yearby

All Faculty Scholarship

Instances of racial discrimination in health care continue despite the enactment of civil rights laws, such as Title VI of the Civil Rights Act of 1964 *329 (Title VI). Title VI prohibited racial discrimination by health care entities receiving government funding such as Medicaid payments. The federal government focused its initial efforts on hospitals. Because hospitals relied on federal funding, the federal government was able to force hospitals to integrate without much resistance from the hospital industry. However, since this accomplishment the government has relied too heavily on assurances of compliance from other health care entities, such as nursing homes, …

Reducing Disparities Through Health Care Reform: Disability And Accessible Medical Equipment, Elizabeth Pendo

All Faculty Scholarship

People with disabilities face multiple barriers to adequate health care and report poorer health status than people without disabilities. Although health care institutions, offices, and programs are required to be accessible, people with disabilities are still receiving unequal and in many cases inadequate care. The 2009 report by the National Council on Disability, The Current State of Health Care for People with Disabilities, reaffirmed some of these findings, concluding that people with disabilities experience significant health disparities and barriers to health care; encounter a lack of coverage for necessary services, medications, equipment, and technologies; and are not included in the …

Race, Sex And Genes At Work: Uncovering The Lessons Of Norman-Bloodsaw, Elizabeth Pendo

All Faculty Scholarship

The Genetic Information Nondiscrimination Act of 2008 (“GINA”) is the first federal, uniform protection against the use of genetic information in both the workplace and health insurance. Signed into law on May 21, 2008, GINA prohibits an employer or health insurer from acquiring or using an individual’s genetic information, with some exceptions. One of the goals of GINA is to eradicate actual, or perceived, discrimination based on genetic information in the workplace and in health insurance. Although the threat of genetic discrimination is often discussed in universal terms - as something that could happen to any of us - the …

A Service Learning Project: Disability, Access And Health Care, Elizabeth Pendo

All Faculty Scholarship

Last summer, I was thinking about a public service project for my disability discrimination law course. I teach the course in fall, and try to incorporate a project each year. At the same time, I was working on a project looking at barriers to health care for people with disabilities. Some of the barriers are well known, such as lower average incomes, disproportionate poverty, and issues with insurance coverage, to name just a few. I was looking at barriers of a different type, however: those posed by physically inaccessible facilities and equipment. This was a new area for me. Like …