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Dopamine And Leptin Interactions In Rodent Models Of Obesity And Cocaine Abuse, Michael Michaelides

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Dopamine (DA) is a catecholamine neurotransmitter and along with its receptors plays a well-documented role in motivation and goal-directed behavior. Clinical studies have previously documented striatal DA D2 receptor (D2R) deficits in obese individuals and chronic cocaine users. These studies suggest that impaired DA-D2R signaling in the striatum may underlie deficits in goal-directed behaviors that can ultimately lead to obesity and drug addiction. However, such studies have not addressed the question of whether D2R deficits precede obesity and cocaine abuse or whether D2R decline in response to repeated overeating and cocaine use.This thesis aims to answer this question by further …

Engendering A Counter-Tradition: Jeff Wall, Photo-Conceptualism, And The Sexual Politics Of The Defeatured Landscape, Leah Modigliani

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This dissertation analyses the work of photographer Jeff Wall between the years of 1970 and 1979 in order to argue that the counter tradition he helped develop with other photo-conceptual artists in the Canadian city of Vancouver has included a gendered bifurcation of space since its earliest incarnation in 1970 as the"defeatured landscape." By analyzing the existence of eroticized images of women within the defeatured landscapes of Wall and his peers, the Vancouver counter-tradition of large-scale photography is shown to depend in part on the old modern trope of woman-as-nature. Rather than simply considering space as a particular place, space …

Spatial, Temporal And Reversible Regulation Of Endogenous Gene In Vivo Using Rna Interference, Prem K. Premsrirut

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

RNA interference is a powerful tool for controlling gene expression in mammalian systems; as such, it has become an effective alternative to conventional knockout approaches. RNAi has proven to be an efficient method to inhibit tumor suppressor gene function and yield insight into the important players in cancer biology. Still, the promise of regulatable RNAi transgenic mice has yet to be realized because the reproducible generation of these animals remains a significant technical limitation. By combining optimized fluorescence-coupled mir30-based shRNA technology with high efficiency ES cell targeting, I have developed a flexible and scalable pipeline for the rapid and reliable …

Effects Of Blood Glucose Elevation On The Structure And Function Of Microvascular Networks Of Skeletal Muscle In Mice, Melissa Katherine-Barrell Georgi

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Diabetes Mellitus and its precursor, pre-diabetes, are metabolic disorders that are characterized by high levels of elevated blood glucose. This work addresses the effects of these diseases on the microvasculature of the peripheral cardiovascular system including endothelial dysfunction and capillary rarefaction, which lead to circulation problems and secondary complications. The purpose of this study is to develop an understanding of the arteriolar network architecture and function in peripheral skeletal muscle in the normal mouse and to investigate the effects of alterations in blood glucose. We demonstrate that only two hours of elevated glucose concentration decreases dilatory responses in both endothelium …

Production And In Vitro Investigation Of Vitamin B12-Based Bioprobes, Amy Rabideau

Renée Crown University Honors Thesis Projects - All

Vitamin B₁₂ (B₁₂)-based bioprobes were produced and investigated in vitro for studying the B₁₂ uptake pathway in certain cancer cell lines and their target-specific capabilities as imaging and/or contrast agents in vivo. An intrinsic factor (IF)-bound B₁₂ conjugate (B₁₂-ReBQBA) was produced containing rhenium(I) for in vitro analysis of the cubilin-expressing placental choriocarcinoma cell line. B₁₂-ReBQBA has millimolar toxicity in vitro and excitation and emission wavelengths in the visible region, 488 nm and 560 nm, respectively. The rhenium metal in this bioprobe can be readily exchanged for the metastable radioactive metal technetium-99m …

Benchmarks 2010, May 14, The Rockefeller University

BenchMarks 2010

BenchMarks. Friday, May 14, 2010

The community newsletter of The Rockefeller University

BenchMarks is published monthly and is distributed on the campus of The Rockefeller University. It produced by the Office of Communications and Public Affairs

Raps Sheet, May 2010, Retirement Association Of Portland State

RAPS Sheet: Monthly Newsletter

No abstract provided.

An Investigation Of Dietary Supplementation As A Potential Source Of Nutrition Misinformation Hindering The Development Of Healthy Eating Habits In The College Population, Mary Dimmick

Undergraduate Honors Capstone Projects

Current dietary supplement legislation allows nutrition misinformation to flourish; misleading structure‐function and health‐claims now abound on supplement labels. Meanwhile, college students tend to be open to experimentation and exploration. Hence, this study’s objective was to discover if students at USU are being influenced by such claims to unjustifiably take dietary supplements in a manner which hinders the development of healthy eating habits. During August of 2009, 1,300 USU freshmen were invited to voluntarily participate in an on‐line survey concerning dietary patterns which included a section about dietary supplementation. Five‐hundred‐and‐twelve completed the survey after providing informed written consent to participate. The …

Parental Perspectives Of Play With Preschool Children, Danielle M. Jensen

Undergraduate Honors Capstone Projects

Research in child development has found that guided play can be a very effective teaching method for young children. Children obtain higher levels of play when parents have an understanding of play and its benefits to learning. This research is designed to assess how parents of children at the Adele and Dale Young Child Development Laboratory view play as a learning technique. Also, this study considered the relationship between parental opinions of play and other parenting roles. A total of 22 parents of children enrolled in the Child Development Laboratory completed the Parent As A Teacher (PAAT) inventory. Results showed …

Metastasis Suppression In Carcinoma And Melanoma Cells, Sherry Marie Baker

Undergraduate Honors Capstone Projects

No abstract provided.

Bracketing The Age Of The Great Gallery Rock Art Panel In Horseshoe Canyon, Utah By Osl Dating Of Associated Alluvial Terraces, Melissa S. Jackson

Undergraduate Honors Capstone Projects

Barrier Canyon Style rock art (BCS) is a unique rock art style indigenous to the middle Colorado Plateau that is of an unknown age and formed by a combination of wall preparation, rock pecking, and application of multiple pigments. It is characterized by broad-shouldered, mummy-like figures that commonly lack limbs and facial details but are accompanied by animated and realistic representations of animals. The age of BCS art remains unknown in spite of attempts to radiocarbon date accessory brush fibers in the mineral-based pigment. Yet a range of age hypotheses exist, from as young as 1600 AD to as old …

Invisible Abuse: Utah's Response To Emotional Child Abuse, Janae Sirrine

Undergraduate Honors Capstone Projects

The very nature of emotional child abuse makes it difficult to detect and report. Nevertheless, scholars and professionals in the field of child welfare have identified emotional abuse as being equally detrimental to children as physical abuse and neglect. Many states, including Utah, have unclear definitions of emotional child abuse. The purpose of this study is to interpret how Utah has used its statute on emotional abuse in the court system and whether the current definition of emotional child abuse has given Utah’s courts enough information and direction to prosecute those who emotionally abuse children. Data was collected by researching …

Drivers Of Plant Population Dynamics In Three Arid To Subhumid Ecosystems, Luke J. Zachmann

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Understanding the relative importance of density-dependent and density-independent factors in driving population dynamics is one of the oldest challenges in ecology, and may play a critical role in predicting the effects of climate change on populations. We used long-term observational data to describe patterns in plant population regulation for 57 forb and grass species from three different ecosystems (arid desert grassland, semiarid sagebrush steppe, and subhumid mixed-grass prairie). Using a hierarchical partitioning approach, we (i) quantified the relative influence of conspecific density, heterospecific composition, and climate on temporal variation in population growth rates, and (ii) asked how the relative importance …

Comparison Of Agricultural Area Source Ammonia Gas Concentration And Flux Measurements, Emyrei Reese

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This study was conducted in order to compare and evaluate a variety of ammonia (NH₃) measurement techniques for determination of ambient gas phase concentration and evaluation of system fluxes. This was accomplished by measuring NH3 emitted from area sources within two dairies, one located in south-central Idaho and another in central California. The measurement techniques utilized included: an array of passive diffusion samplers, a single annular denuder system, a single or paired Fourier transform infrared spectrometer(s) (FTIR), a paired (upwind and downwind) set of differential optical absorption spectrometers (DOAS), and a portable wind tunnel in conjunction with a …

Investigation Of The Toxicity And Toxicokinetics Of Selenium From The Accumulator Plant Symphyotrichum Spathulatum (Western Mountain Aster) In Sheep, Amanda Wilhelm

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This study was designed to observe the effects of selenium from plant material in sheep after a single, oral dose. Purified sodium selenite and selenomethionine were given as positive controls. The plant Symphyotrichum spathulatum (Western Mountain Aster) was collected, analyzed for selenium content, and administered orally to sheep at varying doses according to body weight. Clinical signs were observed for 7 days during which time whole blood, serum, and expired air were collected. Following euthanasia, tissues were collected for histopathological analysis and mineral analysis.

Clinical signs were less apparent than expected and included depression and mild dyspnea in sheep receiving …

Finding, Nurturing, And Instilling Hope In Family Therapy, Joseph Daniel Tschudy

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The development of a personal theory of therapy and change is an integral part of the training and educational philosophies of the Marriage and Family Therapy Program at Utah State University. This personal theory attempts to identify and explain each student's beliefs regarding the specific mechanisms by which change occurs, thus providing a therapeutic backbone from which one may integrate various interventions, ideas, concepts, and approaches to therapy. As one engages in the process of integration, it becomes critical for students to evaluate their performances. A thorough self-evaluation that includes the utilization of scientific methods leads to the development of …

Snowshoe Hare And Forest Structure Relationships In Western Wyoming, Nathan Daniel Berg

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Snowshoe hares (Lepus americanus) are a critically important prey species for Canada lynx (Lynx canadensis). Determination of snowshoe hare distribution and abundance is needed in western Wyoming for lynx conservation. We used linear regression to examine the correlations between snowshoe hare density, as determined by mark-recapture estimates, and fecal pellet plot counts on both uncleared and annually cleared plots on the Bridger-Teton National Forest, western Wyoming. We found significant correlations between hare density estimates and fecal pellet counts for both uncleared and annually cleared pellet counts; however the relationship was much stronger for annually cleared pellet …

Quantifying Legacy Effects Of Managed Disturbance On Sagebrush Steppe Resilience And Diversity, Julie Ripplinger

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Land-use legacies can affect landscapes for decades to millennia. A long history of shrub management exists in the sagebrush steppe of the Intermountain West where shrub-removal treatments, a type of managed disturbance, have been implemented for over 50 years to reduce sagebrush cover. The assumption behind managed disturbances is that they will increase forage for domestic livestock and improve wildlife habitat. However, the long-term effects of managed disturbance on plant community composition and diversity are not well understood. We investigated the legacy effects of three common types of managed disturbance (chemical, fire, and mechanical treatments) on plant community diversity and …

Our Mountain Home: The Oscar And Emma Swett Ranch, Carolyn Toone

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

In this thesis, I examined the lives of my great-grandparents, Oscar and Emma Swett. Oscar began a homestead in the Uinta Mountains in 1909, which he successfully ran for nearly sixty years. My grandmother was born on the ranch, and my own father spent much of his time there. I look at how land policy changed from encouraging ranching and farming in the early 1900's to tourism and recreation in the 1960's, with the coming of the Flaming Gorge Dam. The lives of my great-grandparents and their children were shaped by these changes and they felt the consequences of the …

"To Drink From Places": Uncovering A Rich Way Of Life Near The Grand Canyon's North Rim, Melinda Snow Rich

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The chapters of this thesis focus on the history and stories of the people who built and traveled down the highways--Highway 89A, Highway 89, and Highway 67--that branch out from the junction in front of Jacob Lake Inn, the Bowman/Rich family's 87-year-old lodge. The family's role in building roads, supporting and encouraging the growing tourist industry in Kanab and the North Rim of the Grand Canyon, and the converging effects of these choices have created the unique family culture and contributed to the history of the Grand Canyon region over time. Ultimately this thesis is about relationships, about the connections, …

Reproductive Ecology Of Astragalus Filipes, A Great Basin Restoration Legume, Kristal M. Watrous

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Astragalus filipes Torrey ex. A. Gray (Fabaceae) is being studied and propagated for use in rangeland restoration projects throughout the Great Basin. Restoration forbs often require sufficient pollination services for seed production and persistence in restoration sites. Knowledge of a plant's breeding biology is important in providing pollination for maximal seed set.

Reproductive output from four manual pollination treatments (autogamy, geitonogamy, xenogamy, and distant xenogamy) was examined in a common garden. Pod set, seed set, and seed germination were quantified for each of the treatments. Seed set from four wild populations was compared to that of an openly visited common …

Plastic And Genetic Determination Of Population, Community, And Ecosystem Properties In Freshwater Environments, Leigh C. Latta Iv

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The hierarchy of biological organization, from molecules to ecosystems, describes the relationships among various biological systems. Of particular interest is assessing how the factors that primarily determine the nature of one hierarchical level also have transcendent qualities that affect the ecology and evolution of higher hierarchical levels. The goal of this dissertation was to use a bottom-up approach to examine the transcendent effects of two factors that strongly determine the nature of their associated level of biological organization. The first, phenotypic plasticity, is a primary factor that determines the phenotype of an individual. The second factor, genetic diversity, largely determines …

Changes In Hybrid Poplar Endophytic Microbial Diversity In Response To Trichloroethylene Exposure, Jared S. Ervin

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Remediation of trichloroethylene (TCE) is a major priority for many contaminated sites all over the industrialized world including Hill Air Force Base, UT (HAFB). Phytoremediation as part of a cleanup strategy is an appealing option, and trees at HAFB have been studied to this end. Trees have also been used to delineate groundwater plumes because the passive uptake of organic contaminants by trees generally results in a direct relationship between tree and groundwater TCE concentrations if the trees are using the contaminated groundwater. However, the concentrations of plant-produced TCE metabolites can vary greatly. It was hypothesized that the endophytic microbial …

Maternal Effects In Transmission Of Self-Medicative Behavior From Mother To Offspring In Sheep, Udita Sanga

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Mammals begin learning food preferences in utero and maternally mediated influences early in life help offspring develop their feeding habits. Mammals also learn by individual experience to ingest medicinal compounds such as polyethylene glycol (PEG), which attenuates the negative post-ingestive effects of tannins, a group of potentially toxic plant secondary compounds. The objective of this study was to investigate the transmission of acquired self-medicative behavior from mother to offspring using polyethylene glycol (PEG) as a medicine to relieve malaise caused by tannins. I hypothesized that: 1) mothers trained to associate the beneficial effects of PEG while consuming tannins will pass …

Terrestrial Ecosystem Classification In The Rocky Mountains, Northern Utah, Antonin Kusbach

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Currently, there is no comprehensive terrestrial ecosystem classification for the central Rocky Mountains of the United States. A comprehensive classification of terrestrial ecosystems in a mountainous study area in northern Utah was developed incorporating direct gradient analysis, spatial hierarchy theory, the zonal concept, and concepts of diagnostic species and fidelity, together with the biogeoclimatic ecosystem classification approach used in British Columbia, Canada.

This classification was derived from vegetation and environmental sampling of both forest and non-forest ecosystems. The SNOwpack TELemetry (SNOTEL) and The National Weather Service (NWS) Cooperative Observer Program (COOP) weather station network were used to approximate climate of …

Parents As Partners In Kindergarten And Second Grade Literacy Instruction: A Qualitative Inquiry Into Student-Authored Traveling Books, Dorothy C. Little

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The purpose of this research was to study a sociocognitive “student/parent/peer authoring community” called Traveling Books (TBks) in kindergarten and second grade in a public elementary school setting. TBks are teacher-made vehicles for involving parents in peer-based literacy environments. The study was based on Epstein's theory that increasing overlap of students' spheres of influence, home, school, and community, creates a greater likelihood that children will learn what the parents want them to learn. The aim was to locate essential elements that triggered learning processes to occur and to discover research-based fundamentals still missing from TBks.

This qualitative inquiry incorporated the …

Ecology Of Isolated Greater Sage-Grouse Populations Inhabiting The Wildcat Knolls And Horn Mountain, Southcentral Utah, Christopher J. Perkins

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Greater sage-grouse (Centrocercus urophasianus) currently inhabit about 56% of pre-settlement distribution of potential habitat. In 2005, the Castle Country Adaptive Resources Management Local Working Group (CaCoARM) was formed to address concerns regarding local sage-grouse populations in Carbon and Emery counties. In 2006-2007, CaCoARM identified the Wildcat Knolls and Horn Mountain as areas of special concern for greater sage-grouse conservation. Both sites selected by the group were inhabited by what appeared to be small isolated sage-grouse populations. Factors limiting small isolated greater sage-grouse populations throughout its range are diverse and largely site-specific.

During 2008-2009, I captured, radio-collared, and monitored …

The Pursuit Of An Unequivocal Primary Representation, Delroy A. Brinkerhoff

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

A chief human characteristic is the desire and ability to change the world. Prior planning is crucial when those changes are complex and extensive, and require the cooperation of many people. To satisfy this need, many disciplines have developed specialized notations for representing the plans. Developers in one discipline, computer-based instruction, are burdened by the current need to use two separate notations. Instructional experts design the instruction and represent the design with a primary representation. The instruction described in a primary representation is easy to see, which makes the representation suitable for evaluation, communication, and enhancement. Programmers translate the primary …

Role Of Protein Kinase C Isotypes In 1,25-Dihydroxyvitamin D3 Mediated Signal Transduction Through The 1,25d3 Membrane Associated, Rapid Response Steroid Binding Receptors In Chick Intestinal Cells, Sakara Tunsophon

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

It is now accepted that 1,25(OH)2D3 mediates its rapid actions on the control of phosphate and calcium homeostasis through its membrane receptor termed the 1,25D3-MARRS (membrane associated rapid response steroid binding) protein. I determined the various PKC isotypes involved in the rapid regulation of phosphate uptake and calcium extrusion in chick intestinal cells. 1,25(OH)2D3-mediated phosphate uptake was stimulated within 1 min after addition of the hormone. Western blot analyses on isolated intestinal cells treated with steroid hormone resulted in dose-dependent increases in PKC alpha and PKC beta in postnuclear centrifugation fractions, but not in the low speed centrifugation fractions. The …

Language Brokering In Latino Families: Direct Observations Of Brokering Patterns, Parent-Child Interactions, And Relationship Quality, Kee J. E. Straits

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

With the growing percentage of immigrant families in the USA, language transition is a common immigrant experience and can occur rapidly from generation to generation within a family. Child language brokering appears to occur within minority language families as one way of negotiating language and cultural differences; however, the phenomenon of children translating or mediating language interactions for parents has previously been hypothesized to contribute to negative outcomes for children, such as role-reversals and parentification, emotional distancing and lack of communication, increased parent-child conflict, and increased internalizing/externalizing disorders. The current study used direct observations of 60 Spanish-speaking parent-child dyads (30 …