Digital Commons Network^™

Determination Of The Myogenic Potential Of Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells, Rory Coleman

Honors Scholar Theses

Human embryonic stem cells (hESCs) have the potential to

differentiate to all adult somatic cells. This property makes hESCs a very promising area of research for the treatment of disorders in which specific cell populations need to be restored. Despite this potential, research that focuses on producing mesodermally derived cell populations from hESCs is decidedly limited, notwithstanding the prevalence of disorders involving mesodermal tissues for which treatment options are limited. Skeletal muscle myoblasts are derivatives of mesodermal cells and are characterized by the expression of the MyoD gene. These cells are difficult to obtain from hESCs in a reproducible and …

Assessing The Phylogenetic Utility Of Dna Barcoding Using The New Zealand Cicada Genus Kikihia, Megan Ribak

Honors Scholar Theses

DNA Barcoding (Hebert et al. 2003) has the potential to revolutionize the process of identifying and cataloguing biodiversity; however, significant controversy surrounds some of the proposed applications. In the seven years since DNA barcoding was introduced, the Web of Science records more than 600 studies that have weighed the pros and cons of this procedure. Unfortunately, the scientific community has been unable to come to any consensus on what threshold to use to differentiate species or even whether the barcoding region provides enough information to serve as an accurate species identification tool. The purpose of my thesis is to analyze …

Changes In Mirna Expression In A Model Of Microcephaly, Shan Parikh

Honors Scholar Theses

miRNAs function to regulate gene expression through post-transcriptional mechanisms to potentially regulate multiple aspects of physiology and development. Whole transcriptome analysis has been conducted on the citron kinase mutant rat, a mutant that shows decreases in brain growth and development. The resulting differences in RNA between mutant and wild-type controls can be used to identify genetic pathways that may be regulated differentially in normal compared to abnormal neurogenesis. The goal of this thesis was to verify, with quantitative reverse transcriptase polymerase chain reaction (qRT-PCR), changes in miRNA expression in Cit-k mutants and wild types. In addition to confirming miRNA expression …

Conceptualizing Success In Therapeutic Wilderness Experiences: The Creation And Maintenance Of Instructor-Participant Relationships, Chelsea I. Ambrozaitis

Honors Scholar Theses

Researchers have noted that relationships created between instructors and clients in therapeutic wilderness experiences are unique (Russell, 2003; Russell & Phillips-Miller, 2001; Sklar, Anderson, & Autry, 2007; Taniguchi et al., 2009), but little research has been done to explore these relationships. The present study is an investigation of how instructors build and maintain relationships with participants, conceptualize these relationships, and define success in these tasks. Nine instructors from a wilderness program for at-risk youth participated in interviews. Data were analyzed using a line-by-line coding technique. Results of this study add to existing research on wilderness therapy and therapeutic wilderness experiences, …

Text As Resistance In Holocaust Literature: Struggles For Personhood In Wiesel, Levi, And Delbo, Gillian M. Mozer

Honors Scholar Theses

This thesis is an examination of the memoirs of three core Holocaust writers, Elie Wiesel (Night and Day), Primo Levi (If This is A Man), and Charlotte Delbo (Auschwitz and After), exploring the ways in which each of the three authors uses his or her memoir to simultaneously document and resist the dehumanizing influence of the concentration camp experience.

Characterization Of The Putative Xyloglucan Glycosyltransferase Gt14 In Arabidopsis Thaliana, Najam R. Syed

Honors Scholar Theses

Plant cell walls largely consist of matrix polysaccharides that are linked to cellulose microfibrils. Xyloglucan, the primary hemicellulose of the cell wall matrix, consists of a repeating glucose tetramer structure with xylose residues attached to the first three units ('XXXG'). In Arabidopsis thaliana, the core XXXG structure is further modified by enzymatic addition of galactose and fucose residues to the xylose side chains to produce XLXG, XXLG, XLLG and XLFG structures. GT14 is a putative glycosyltransferase in the GT47 gene family. Initial predictions of GT14's hydrophobic regions, based on its translated amino acid sequence, are almost identical to its Arabidopsis …

Development Of A 3d Game Engine, Nicholas Alexander Woodfield

Honors Scholar Theses

This paper presents the development history and specification of a 3D game engine titled "Spark Engine". The term "engine" is used to describe a complex graphics software suite that streamlines application development and provides efficient rendering functionality. A game engine specifically provides tools to simplify game development. Spark Engine is fully shader driven and is built on top of Microsoft's XNA Framework. It is a reusable and flexible platform that can be used to build any type of graphics application ranging from gaming to simulation. The engine was released as open source software under the New BSD License with an …

Investigating The Diversity Of Radial Glia Fates In The Rat Neocortex, Abraham William Aron

Honors Scholar Theses

Radial Glia (RG) are a mitotically active population of cells which reside within the ventricular zone at the lateral ventricle and give rise to the pyramidal neurons and astrocytes of the neocortex. Through cellular divisions, RG produce two daughter cells, one which resides in the ventricular zone and becomes another RG while the other is an immature progenitor which migrates away from the ventricle and populates the growing cortex. RG have been found to be a heterogeneous population of cells which express different surface antigens and genetic promoters which may influence the cellular fate of their progeny. In this study …

"An Attentive Ear, A Watchful Eye, And A Calm Judicious Pen": William Samuel Johnson, The Colonial Agents, And The Transformation Of The British Atlantic World, Allison Hopkins

Honors Scholar Theses

By looking at Great Britain and the American colonies in conjunction with the larger British Atlantic Empire, historians can better understand the political, social, and cultural transformations that occurred when transatlantic actors met. William Samuel Johnson is an example of an "ordinary" agent who nonetheless had extensive contacts with numerous British and American thinkers. While acting on Connecticut's behalf in London between 1767 and 1771, he sent reports back to Connecticut governors Jonathan Trumbull and William Pitkin on parliamentary proceedings while corresponding with the people who traveled around the Atlantic world during this critical period-merchants, seafarers, emigrants, soldiers, missionaries, radicals …

The Effect Of Heavy Metal Stress On Avian Proximal Tubule Urate Secretion, Carla L. Maffeo

Honors Scholar Theses

In both humans and birds, urate is an important antioxidant when maintained at normal plasma concentrations. Though human kidneys primarily reabsorb filtered urate, while those of birds perform mostly secretion, both maintain urate levels at ~300microM. The importance of maintaining urate levels within the homeostatic range was observed when the study of several prominent diseases revealed an association with hyperuricemia.

This study examined the effect of elevated zinc concentration on avian urate secretion. Here, acute exposure of chicken proximal tubule epithelial cells (cPTCs) to zinc stress had no effect on urate secretion, but prolonged zinc-induced cellular stress inhibited active transepithelial …

Alterations In The Cellular Composition Of The Mouse Bladder Following Ovariectomy, Partial Bladder Outlet Obstruction, And Aging, Diane Holly Smith

Honors Scholar Theses

Detrusor underactivity (DU) increases susceptibility to urinary retention and accordingly further complicates the management of urinary incontinence. Bladder muscle stretch, a lack of estrogen, and aging are 3 notable DU risk factors. The aim of this research is to better characterize the changes in cellular composition of the bladder that result from these 3 risk factors to gain a better understanding of DU pathogenesis and pathobiology. This research focuses on the effects of a lack of estrogen while also providing an outline for determining the effects of bladder muscle stretch and aging on the cellular composition of the bladder.

From Books To The Web: A Comparative Analysis Of Holocaust Denial In The Internet Age, Elise Nickerson

Honors Scholar Theses

An analysis of print Holocaust denial literature as it compares to internet Holocaust denial, with a focus on how the transition from print literature to the internet has affected Holocaust denial.

Executive Power And The People: Does The President Care What You Think?, James Ringold

Honors Scholar Theses

I sought to examine the relationship between public approval of the president and his subsequent behavior. Specifically, I looked at the relationship between public approval and signing statement usage along with their usage following the 2006 outcry against President Bush's use of them.

Alkylphenol Contamination In Homarus Americanus, Jennifer Renee Urban

Honors Scholar Theses

Alkylphenols are pollutants that are present in marine sediments and fishes. In earlier work it has been discovered that alkylphenols are present in the Homarus americanus, or the American lobster. Research suggests that alkylphenols could behave as endocrine disruptors as they have been found to affect juvenile hormone activity. It has been hypothesized that lobsters may be able to rid themselves of alkylphenol contamination through secreting these compounds into the environment or sequestering them in their tissues. In this study, I address the question of how lobsters may rid themselves of alkylphenols by analyzing hemolymph, muscle, gill, and shell samples …

Carbon Finance & Cattle Externalities In The Brazilian Amazon: Pricing Reforestation In Terms Of Restoration Ecology, Christian T. Hofer

Honors Scholar Theses

This paper evaluates land-use conflict between cattle pasture and tropical rainforest in the Brazilian Amazon and attempts to reconcile negative production externalities within the framework of carbon finance. Specifically, it analyzes the price per metric ton of CO2e that would make reforestation projects, in terms of restoration ecology, a viable land-use alternative. Regional information on opportunity, implementation, and transaction costs is used to develop a partial equilibrium cost-benefit analysis, in which carbon sequestration is the only benefit. Financing is employed through Kyoto’s Clean Development Mechanism and long-term certified emission reductions (lCERs) are the carbon financial instrument modeled. Results indicate that …

Alessandro Baricco: A Modern Homer / Alessandro Baricco: Omero Modern, Whitney Losapio

Honors Scholar Theses

Alessandro Baricco is an Italian author, pianist, journalist and music critic, among a wide range of many other talents. His novels have won great critical acclaim in Italy and France and are popular around the world. While generally considered among the postmodern writers, some critics have accused him of being a forerunner in a 1990s movement dubbed letteratura giovanile, that is juvenile literature that is simplistic, targets a young audience and is created for the sole purpose of making money. This criticism is unwarranted. Baricco is a multitalented author who pays strict attention to the quality of his work and …

Regulation Of Pannexin 1 Channels By Atp, Feng Qiu

Open Access Dissertations

Pannexins represent a recently discovered second family of gap junction proteins in vertebrates. However, instead of forming intercellular gap junction channels like connexins, pannexins operate as unpaired pannexons, allowing the flux of molecules from the cytoplasm to the extracellular space and vice versa. Pannexins appear to play a vital role in the local control loop of blood perfusion and oxygen delivery. The properties of Panx1 channels indicate that this protein is the most probable candidate for an ATP release channel and is involved in the propagation of intercellular calcium waves. It is also proposed to mediate the large pore formation …

South Dakota State University One Hundred-Twenty-Fourth Annual Commencement, May 8, 2010, Brookings, South Dakota, South Dakota State University

Commencement Programs

Please be advised that the names listed in the program do not constitute official confirmation of meeting the graduation requirements. The 124th Annual Commencement ceremony will commence with introductions by University President David L. Chicoine. Honorary marshals are Linda Nussbaumer, Professor and Program Coordinator of Interior Design, and E. Dennis Hinde, Associate Professor of Mass Communication. Brigadier General Mark A. Clark will deliver the commencement address titled "Life's Compass." Provost Laurie Nichols, Vice President for Academic Affairs, will extend recognition to student honors. The commissioning of Army and Air Force officers will be conducted by Major Kory L. Knight and …

Riparian Efformation, Laura C. Brodersen

Architecture Masters of Science Program: Theses

This thesis deals with two widespread issues facing contemporary society and the environment which it finds itself: 1. It is often assumed that what and where one calls home is straightforward, that our sense of home and identity are singularly rooted in a local place. Rather than being seen as an integral aspect of social life, mobility has been regarded as a special and temporary phenomenon classified under such headings as migration, refugee studies, and tourism. But increasingly, modern forms of dwelling, working, and playing involve circulating through a geographically extended network of social relations and a multiplicity of widely …

Dwellevator, Jacob A. Slobodnik

Architecture Masters of Science Program: Theses

dwellevator (dwel-uh-vey-ter) -noun 1. a rehabilitative response to homelessness 2. the rehabilitation of derelict grain elevators

rehabilitate (ree-hu-bil-i-teyt) -verb 1. to restore to a condition of good health, ability to work, or the like.

It is estimated that there are over 3 million homeless individuals in the United States at any given time. Today’s homeless are far different than those of the past. History would have it that many of the past homeless were vagabonds looking to escape the rigid constraints of society, in search of a life with no rules, no restrictions, and most importantly, no responsibilities. The majority …

Future Bionic, Ryan J. Huber

Architecture Masters of Science Program: Theses

Future Bionic is a study into how biological processes can be reinterpreted and applied to revolutionize the idea of performance in buildings. The term bionic refers to the combining of a natural system and a mechanical system or technology [bionics]. Biomimicry refers to the copying or imitation of a natural systems processes [biomimicry]. Future Bionic is a hybrid of both concepts, in which I am looking at how principles of bionics and biomimicry can be used to design a built environment that begins to blur the edges between the natural and man-made world. Both bionics and biomimicry can be used …

2010 - Howard University Commencement Program, Howard University

Howard University Commencement Programs

No abstract provided.

School Of Law Commencement: May 8, 2010, University Of North Dakota

UND Commencement Programs

School of Law Commencement program from May 8, 2010.

Resistance Training Increases The Expression Of Ampk, Mtor, And Glut4 In Previously Sedentary Subjects And Subjects With The Metabolic Syndrome., Andrew Steven Layne

Electronic Theses and Dissertations

Exercise has been considered a cornerstone of diabetes prevention and treatment for decades, but the benefits of resistance training are less clear. Nineteen non-diabetic subjects (10 metabolic syndrome, 9 sedentary controls) underwent 8 weeks of supervised resistance training. After training, strength and V̇ O_2max increased by 10% in both groups. Percent body fat decreased in subjects with the metabolic syndrome. Additionally, lean body mass increased in both groups (p<0.05). Expression of glucose transporter protein-4 (GLUT4), the principle insulin-responsive glucose transporter, increased significantly in both groups. 5-adenosine monophosphateactivated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) expression increased in both groups, indicating increased protein synthesis and mitochondrial biogenesis. Markers of insulin resistance measured by a euglycemic hyperinsulinemic clamp did not improve in subjects with the metabolic syndrome but increased significantly in control subjects (13%). Resistance training upregulates intracellular signaling pathways that may be beneficial for ameliorating the metabolic syndrome.

Morphisms., Samuel W. Crowe

Electronic Theses and Dissertations

I discuss my Master of Fine Arts exhibition, Morphisms, hosted by Slocomb Galleries on the campus of East Tennessee State University March 22 through March 26, 2010. The exhibit includes works created during the artist's three year study at East Tennessee State University.

The exhibition consists of works that address the projection of human qualities on domesticated animals and the projection of animal qualities onto mythological deities. Discussion also includes the process involved in creating the artwork as well as artistic influences in technical concepts.

Characteristics Of Nectar Production And Standing Crop In Campsis Radicans (Bignoniaceae)., Andrea Alexis Edge

Electronic Theses and Dissertations

We examined several aspects of nectar production in Campsis radicans to better understand how standing crop is affected and how production affects pollinator visitation. In all experiments, nectar and concentration of flowers were measured and total sugar was calculated. Flowers do not produce additional nectar unless nectar is removed, and it is not resorbed. Volume of standing crop and total sugar fluctuates throughout the day, whereas concentration remains constant. Age and time of day significantly affect regeneration of nectar and sugar. The number of removals did not significantly affect the amount of nectar or sugar regenerated; however, concentration declined significantly …

Hermit Thrush (Catharus Guttatus) And Veery (C. Fuscescens) Breeding Habitat Associations In Southern Appalachian High-Elevation Forests., Andrew J. Laughlin

Electronic Theses and Dissertations

The Hermit Thrush is a new breeding bird in the Southern Appalachian high-elevation mountains, having expanded its range southward over the last few decades. Here it is sympatric with the Veery, a congeneric breeding resident. In order to more fully understand why the range expansion took place and to understand more about the local ecology of the newly arrived bird, I measured several habitat variables in 30 Hermit Thrush and 24 Veery territories. Principal Components Analysis and Cluster Analysis brought to light several patterns of habitat preferences for these 2 species. Hermit Thrushes prefer territories with more leaf litter on …

A Re-Evaluation Of The Pleistocene Hellbender, Cryptobranchus Guildayi, And An Overview Of Cryptobranchus Remains From Appalachian Caves., Keila Elaine Bredehoeft

Electronic Theses and Dissertations

Cryptobranchus guildayi is described as an extinct species of large salamander that is closely related to the hellbender, Cryptobranchus alleganiensis. The validity of this extinct taxon has been questioned, so an expanded osteological sample of modern hellbenders was used for comparative purposes with the C. guildayi fossil material. Based on this analysis, all supposed distinguishing morphological characteristics used to define C. guildayi can be observed in specimens of C. alleganiensis, or are based on misidentifications. Therefore, Cryptobranchus guildayi is considered to be conspecific with C. alleganiensis and taxonomically should be considered a junior synonym of the latter. The …

Peter L. Berger's Early Conception Of Agency: Exposition And Evaluation., James Greene

Electronic Theses and Dissertations

Peter L. Berger's conception of agency in his earliest writings (c.1954-1960) is logically and empirically inadequate. At the root of this inadequacy is an idealism that prevents him from providing a compelling account of actual empirical agency. Chapter 1 asserts that Berger's earlier works warrant analysis. Chapter 2 discusses Berger's earliest influences, particularly Max Weber and The Swedish Lund School of motif research. Chapter 3 identifies a unique commitment to Christian Humanism at the base of Berger's conception of agency. Chapter 4 clarifies how Berger's Christian humanism interacts with his Weberian, and Parsonian-inspired functional analysis of the American religious establishment. …

Newfangled., John Daniel Simmons

Electronic Theses and Dissertations

This thesis paper supports the Master of Fine Arts exhibition at the B. Carroll Reece Museum, East Tennessee State University, from March 9th through April 22nd, 2010. The exhibit is comprised of 62 unique ceramic pieces, which are presented on pedestals and wall mounted shelves. The exhibition presents the artist's exploration of form and surface used to create functional pottery. Topics discussed are the influences, concepts, techniques, and methods used to create the work. Included are process images, detail images, and images of selected works from the exhibition.