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Executive Committee - Agenda, 5/11/2010, Academic Senate

Academic Senate Agendas

No abstract provided.

Method Of Using Electric Fields To Facilitate The Entry Of Molecules Into Cells In Vivo, Mark J. Jaroszeski, Richard Gilbert, Richard Heller

USF Patents

A method for facilitating a delivery of a molecule into an interior space of a cell includes the steps of introducing a molecule into a target tissue comprising a cell and applying a substantially continuous low-level electric field to the target tissue. The field is applied for a duration sufficient to effect a change in porosity the cell of the target tissue sufficient to facilitate an entry of a desired molecule into an interior of the cell.

Inhibition Of The Raf/Mek/P-Erk Pathway For Treating Cancer, Said M. Sebti

USF Patents

The invention disclosed herein provides for methods of treating cancer using inhibitors of the Raf/Mek/P-Erk 1/2 pathway. These inhibitors include B2AR agonists (such as ARA-211 (pirbuterol) and isoproterenol), adenylyl cyclase activators, cAMP analogs and Epac activators. The invention also provides methods for diagnosing cancer in an individual.

Control Of Nk Cell Function And Survival By Modulation Of Ship Activity, William G. Kerr

USF Patents

Inhibition of dendritic cell function in solid organ grafts or allogeneic bone marrow transplants prior to or during engraftment by blocking SH2-containing inositol phosphatase (SHIP) expression or function is taught as a method of abrogating immune rejection and thereby increasing the efficacy of engraftment of an allogeneic bone marrow transplant or solid organ allograft or xenograft. Also disclosed is a transgenic mouse having the genotype SHIP−/− which exhibits enhanced survival following mismatched allogeneic marrow grafts.

Acid-Sensing Ion Channels And Pain, Qihai Gu, Lu-Yuan Lee

Physiology Faculty Publications

Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury can all evoke pain, and each is accompanied by local acidosis. Acid sensing ion channels (ASICs) are proton-gated cation channels expressed in both central and peripheral nervous systems. Increasing evidence suggests that ASICs represent essential sensors for tissue acidosis-related pain. This review provides an update on the role of ASICs in pain sensation and discusses their therapeutic potential for pain management.

A Brain-Specific Cytochrome P450 Responsible For The Majority Of Deltamethrin Resistance In The Qtc279 Strain Of Tribolium Castaneum, Fang Zhu, R. Parthasarathy, Hua Bai, Katharina Woithe, Martin Kaussmann, Ralf Nauen, Douglas A. Harrison, Subba R. Palli

Entomology Faculty Publications

Cytochrome P450-mediated detoxification is one of the most important mechanisms involved in insecticide resistance. However, the molecular basis of this mechanism and the physiological functions of P450s associated with insecticide resistance remain largely unknown. Here, we exploited the functional genomics and reverse genetic approaches to identify and characterize a P450 gene responsible for the majority of deltamethrin resistance observed in the QTC279 strain of Tribolium castaneum. We used recently completed whole-genome sequence of T. castaneum to prepare custom microarrays and identified a P450 gene, CYP6BQ9, which showed more than a 200-fold higher expression in the deltamethrin-resistant QTC279 strain when compared …

Sweet Briar, 1800-1900: Palladian Plantation House, Italianate Villa, Aesthetic Retreat, Harriet Christian Carr

Theses and Dissertations

Sweet Briar House is one of the best documented sites in Virginia, with sources ranging from architectural drawings and extensive archives to original furnishings. Sweet Briar House was purchased by Elijah Fletcher, a prominent figure in Lynchburg, Virginia, in 1830. Thirty years later it passed into the possession of his daughter Indiana Fletcher Williams, and remained her home until her death in 1900. In her will, Williams left instructions for the founding of Sweet Briar Institute, an educational institution for women that exists today as Sweet Briar College. This dissertation examines Sweet Briar House in three distinct phases, while advancing …

Artificial Selection For Determinate Growth Habit In Soybean, Zhixi Tian, Xiaobo Wang, Rian Lee, Yinghui Li, James E. Specht, Randall L. Nelson, Phillip E. Mcclean, Lijuan Qiu, Jianxin Ma

Department of Agronomy and Horticulture: Faculty Publications

Determinacy is an agronomically important trait associated with the domestication in soybean (Glycine max). Most soybean cultivars are classifiable into indeterminate and determinate growth habit, whereas Glycine soja, the wild progenitor of soybean, is indeterminate. Indeterminate (Dt1/Dt1) and determinate (dt1/dt1) genotypes, when mated, produce progeny that segregate in a monogenic pattern. Here, we show evidence that Dt1 is a homolog (designated as GmTfl1) of Arabidopsis terminal flower 1 (TFL1), a regulatory gene encoding a signaling protein of shoot meristems. The transition from indeterminate to determinate phenotypes in soybean is associated …

Measurement Of Functional Residual Capacity Of The Lung By Nitrogen Washout/Wash-In In Mechanically Ventilated Icu Patients, Lara Brewer, Joseph Orr

Utah Space Grant Consortium

Background: We evaluated the functionality, feasibility of use at the bedside and repeatability of subsequent Functional Residual Capacity (FRC) measurements in mechanically ventilated ICU patients using a new system. The newly developed system had previously been assessed for accuracy in spontaneously breathing human volunteers.

Materials and Methods: We measured the FRC of the lungs of 20 mechanically ventilated ICU patients using the nitrogen washout/wash-in technique. Duplicate measures in each of the patients were analyzed for repeatability.

Results: The squared correlation coefficient for the linear regression between repeated measurements was r²=0.92 (n=39); y=0.99x +0.03. the bias +/- Standard Deviation …

High-Speed, Three-Dimensional Quantification Of Ladybug Flapping Wing Kinematics During Takeoff, Ryan B. George, Scott L. Thomson

Utah Space Grant Consortium

Ladybug wing and body kinematics during takeoff is explored using high-speed stereoscopic images acquired at a rate of 3000 frames per second. A direct linear transformation algorithm is used to quantify positions of selected locations on the body, forewings (elytra), and hindwings. Design and setup of instrumentation and analysis procedures are explained. Flapping frequency is reported. Significant motion of the forewing and other findings are presented and their applications are discussed.

Mustang Daily, May 10, 2010

Cal Poly Student Newspaper

Student newspaper of California Polytechnic State University, San Luis Obispo, CA.

A Hybrid Approach To The Valuation Of Climate Change Effects On Ecosystem Services: Evidence From The European Forests, Helen Ding, Silvia Silvestri, Aline Chiabai, Paulo A.L.D. Nunes

Fondazione Eni Enrico Mattei Working Papers

In this paper we present a systematic attempt to assess economic value of climate change impact on forest ecosystems and human welfare. In the present study, climate change impacts are downscaled to the different European countries, which in turn constitute the elements of our analysis. First, we anchor the valuation exercise in the Millennium Ecosystem Assessment (MEA) Approach and therefore the link between the different forest ecosystem goods and services, including provisioning, regulating and cultural services, human well-being and climate change. Second, climate change is operationalized by exploring the different storylines developed by the International Panel on Climate Change (IPCC) …

A History Of Violence: Testing The ‘Culture Of Honor’ In The Us South, Pauline Grosjean

Fondazione Eni Enrico Mattei Working Papers

Using historical data on early settlers to the United States, this paper tests and confirms the “Culture of Honor” hypothesis by socio-psychologists Dov Cohen and Richard Nisbett (1994, 1996). This hypothesis argues that the high prevalence of homicides in the US South stems from the fact that it was a frontier region settled by people whose economy was based on herding: the Scotch-Irish. Herding societies develop cultures of honors for reasons having to do with their precariousness: violence is a necessary condition to preserve a reputation for toughness and deter animal theft. Using historical census data on waves of settlers …

Columbia Chronicle (05/10/2010), Columbia College Chicago

Columbia Chronicle

Student newspaper from May 10, 2010 entitled The Columbia Chronicle. This issue is 44 pages and is listed as Volume 45, Number 30. Cover story: "Columbia celebrates rising stars" Editor-in-Chief: Bethany Reinhart

Ua12/2/1 Stress Busters, Wku Student Affairs

WKU Administration Documents

Special finals week edition of the College Heights Herald.

Oral History Transcript - Basilio David Villarreal Iv, Basilio David Villarreal Iv, Nancy Jasmine Serna

Community Historical Archaeology Project with Schools (CHAPS) Educational Resources

No abstract provided.

Oral History Transcript - Carrol Norquest, Jr., Carrol (Kelly) Norquest, Adrian Alonzo, Rogelio Paez Jr., Sergio Elizondo, Erica Rivera

Community Historical Archaeology Project with Schools (CHAPS) Educational Resources

No abstract provided.

Interview With Joe Cantu, Jr. And Sylvia Cantu Garcia, Joe Cantu Jr., Sylvia Cantu Garcia, Sandra Carrizales

Community Historical Archaeology Project with Schools (CHAPS) Educational Resources

No abstract provided.

Oral History Transcript - Dr. Lucas Hinojosa, Lucas Hinojosa, Baldemar Chavez, Vanessa Santillan, Katherine Tapia

Community Historical Archaeology Project with Schools (CHAPS) Educational Resources

No abstract provided.

Neuroprotective Effects Of Postinjury Lithium Treatment: Determining The Optimal Dosing Paradigm And Assessing Potential Mechanisms Of Action, Katharine Eakin

Theses and Dissertations

Traumatic brain injury (TBI) has a dramatic impact on our society in terms of mortality, morbidity, and inherently high financial costs. Formidable research efforts are being addressed to the identification of neuroprotective agents capable of ameliorating the neurological outcome after TBI. Preclinical studies have recently demonstrated lithium to be a promising neuroprotective agent for both acute ischemic brain injury and chronic neurodegenerative disease. In light of these encouraging data, we designed a lateral fluid-percussion injury (FPI) study aimed at investigating the role of early post-traumatic administration of lithium as a strategy for reducing TBI-induced motor and cognitive deficits. The optimal …

Awesome, Hannah Walsh

Theses and Dissertations

Opinions about Linguistics and Phonetics extrapolated to think about art and object-making, followed by an exposition of titles of recent work, including discussions about: stunting in All Star Cheerleading, rainbows, offset halo patterns, the common corn disease Crazy Top, failure, humility and the profound.

Pseudomonas Aeruginosa Evasion Of Phagocytosis Is Mediated By Loss Of Swimming Motility And Is Independent Of Flagellum Expression, Eyal Amiel, Rustin R. Lovewell, George A. O'Toole, Deborah A. Hogan, Brent Berwin

Dartmouth Scholarship

Pseudomonas aeruginosa is a pathogenic Gram-negative bacterium that causes severe opportunistic infections in immunocompromised individuals; in particular, severity of infection with P. aeruginosa positively correlates with poor prognosis in cystic fibrosis (CF) patients. Establishment of chronic infection by this pathogen is associated with downregulation of flagellar expression and of other genes that regulate P. aeruginosa motility. The current paradigm is that loss of flagellar expression enables immune evasion by the bacteria due to loss of engagement by phagocytic receptors that recognize flagellar components and loss of immune activation through flagellin-mediated Toll-like receptor (TLR) signaling. In this work, we employ bacterial …

Effect Of Hyaluronidase Treatment On The Structural Integrity Of The Endothelial Glycocalyx Layer, Kristin Simmons

Theses and Dissertations

The endothelial glycocalyx plays an important role as part of the permeability barrier between the blood and the interstitium. In this study, we used different sized fluorescently labeled dextran molecules to determine the size of the macromolecular exclusion zone in capillaries. The width of the exclusion zone was calculated as one half the difference between the anatomic luminal diameter, as determined by transillumination, and the width of a fluorescent dextran column. During the first hour after systemic injection of labeled dextrans, neither 70 kDa dextran (Dextran 70) nor 500 kDa dextran (Dextran 500) labeled with the anionic fluorescein isothiocyanate (FITC) …

Eighteen Hundred And Froze To Death, Cognets Nicholas Des

Theses and Dissertations

Essay to accompany MFA thesis exhibition for the Department of Sculpture and Extended Media.

Eternal September, Benjamin Jurgensen

Theses and Dissertations

A series of digitally inflected texts – September that never ends, some French belles, 1950/1986/1996, Ted Turner, being SO FUCKING FUTURE, The Gilmore Girls, Fic, FanFic, Sapphic, ctrl-c/v, “falsehood”, memes, Robert Gober, INTP, thought control, a “line of flight”, speed, and light refracting on all of it

Oral History Transcript - Guillermo Gonzalez - Part 01, Guillermo Gonzalez, Cristina M. Gonzalez

Community Historical Archaeology Project with Schools (CHAPS) Educational Resources

No abstract provided.

Cbd & D9-Thc - The Two Faces Of Cannabis, Zeissler, Cb Carroll, J Zajicek

Peninsula Medical School

Cannabidiol (CBD) and D9-tetrahydrocannabinol (D9-THC) are phytocannabinoids produced by the plant Cannabis sativa which have both shown promising therapeutic value as anti-inflammatory and neuroprotective agents in a variety of neurological disorders. However, the molecular mechanisms involved in their protective function are thought to be distinctly different probably due to their divergent receptor pharmacology. D9-THC is a potent agonist at the cannabinoid receptors 1 and 2 through which it is thought to modulate synaptic plasticity and inflammatory responses respectively. CBD on the other hand exhibits negligible affinity for both receptors prompting research into cannabinoid receptor independent mechanisms of action such as …

Medical School Watercooler Newsletter - April 9, 2010, Lindsey Lyle

Watercooler Newsletter

This is the May 9, 2010 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Alabama's 2005 Professor of the Year to Speak at COM
• COM Spring Faculty Assembly Meeting
• Commencement Exercises
• Family Medicine Center Implements EHR Software
• USA College of Medicine's Honors Convocation
• Library Art Exhibit Features Work of USA's Medical Illustrator

"My One Regret...": The Case For Cultural Immersion In Study Abroad Programs, Kevin Geyer

Honors Scholar Theses

Study abroad has been an established institution in US universities for almost a century, and hundreds of thousands of students travel to all corners of the world every year. While many list some degree of cultural immersion as a main goal, most students have a difficult time achieving this. Drawing from interviews with twenty-five UConn undergraduates that studied abroad, this study attempts to identify factors that hold students back from cultural encounters. The study also discusses the 'success stories' of undergrads that made significant connections abroad, and highlights the factors that can lead to this (e.g., homestays, jobs, internships).

Hole In The Head: A Play, Accompanied By A Conspectus Of Knowledge, Both Repressed And Researched, That Directly Influenced The Playwright In Her Development Of A New Work, Margaret Hunter Cook

Honors Scholar Theses

"Hole in the Head" is a play about a woman who wakes up. Maude wakes up in the first act, and in every subsequent scene she undergoes some form of physical or emotional awakening as characters walk in and out of her front door."Hole in the Head" is accompanied by an introduction that attempts to understand the interplay between creativity and academia through an analysis of theatre, feminist and queer theory, and science.