Digital Commons Network^™

Breast Cancer Dna Methylation Profiles Are Associated With Tumor Size And Alcohol And Folate Intake, Brock C. Christensen, Karl T. Kelsey, Shichun Zheng, E. Andres Houseman, Carmen J. Marsit, Margaret R. Wrensch, Joseph L. Wiemels, Heather H. Nelson, Margaret R. Karagas

Dartmouth Scholarship

Although tumor size and lymph node involvement are the current cornerstones of breast cancer prognosis, they have not been extensively explored in relation to tumor methylation attributes in conjunction with other tumor and patient dietary and hormonal characteristics. Using primary breast tumors from 162 (AJCC stage I-IV) women from the Kaiser Division of Research Pathways Study and the Illumina GoldenGate methylation bead-array platform, we measured 1,413 autosomal CpG loci associated with 773 cancer-related genes and validated select CpG loci with Sequenom EpiTYPER. Tumor grade, size, estrogen and progesterone receptor status, and triple negative status were significantly (Q-values <0.05) associated with altered methylation of 209, 74, 183, 69, and 130 loci, respectively. Unsupervised clustering, using a recursively partitioned mixture model (RPMM), of all autosomal CpG loci revealed eight distinct methylation classes. Methylation class membership was significantly associated with patient race (P<0.02) and tumor size (P<0.001) in univariate tests. Using multinomial logistic regression to adjust for potential confounders, patient age and tumor size, as well as known disease risk factors of alcohol intake and total dietary folate, were all significantly (P<0.0001) associated with methylation class membership. Breast cancer prognostic characteristics and risk-related exposures appear to be associated with gene-specific tumor methylation, as well as overall methylation patterns.

Essay: Constitutional Commitments And Religious Identity, Bernadette Meyler

Cornell Law Faculty Publications

This essay comments on Steve Shiffrin's The Religious Left and Church-State Relations. It contends, on the one hand, that Shiffrin has valuably brought to the fore various reasons why religious believers might resist close relations between church and state. On the other hand, it argues that no fundamental connection exists between the "religious Left" and a particular position on church-state relations and that religious liberals will not necessarily be more persuasive than secular liberals in arguing against positions espoused by religious conservatives.

Determining The Fate Of Hybridized Genomes In The Allopolyploid Brassica Napus, Tina Y. Wang

Master's Theses

Polyploidy is widely acknowledged as a widespread mechanism in the evolution and speciation of the majority of flowering plants. Allopolyploid forms through interspecific hybridization and whole genome duplication. While allopolyploids may display increased vigor relative to their progenitors, they can also face challenges to fertility following hybridization. Genetic changes in allopolyploids result from recombination between the hybridized subgenomes, which can influence phenotype and ultimately determine fitness of future generations. To study dynamic changes that follow allopolyploid formation, Brassica napus lineages were derived by hybridizing Brassica oleracea and Brassica rapa. Two lineages of B. napus were analyzed for genetic and phenotypic …

Ecology, Stable Isotopes, And Management Of Grassland Songbirds At National Park Service Properties On The Great Plains, Sarah E. Rehme

School of Natural Resources: Dissertations, Theses, and Student Research

Grassland ecosystems have been severely reduced and grassland bird populations have experienced consistent declines. National Park Service (NPS) properties on the Great Plains provide breeding habitat for grassland songbirds, though little is known about the quality of this habitat. A short-term study on songbirds at three NPS properties complemented current monitoring, providing an among park comparison addressing grassland bird productivity and fidelity relative to NPS property size. During 2008-2009, I assessed avian species richness, and estimated bird density and grassland songbird nest success. Bird species richness was greatest at small and medium sites, while number of nesting obligate species was …

Food Handling Practices, Knowledge And Beliefs Of Families With Young Children Based On The Health Belief Model, Adeline Lum

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

Objective: To determine current food handling practices, knowledge and beliefs of primary food handlers with children 10 years old and the relationship between these components.

Design: Surveys were developed based on FightBac!™ concepts and the Health Belief Model (HBM) construct.

Participants: The majority of participants (n= 503) were females (67%), Caucasians (80%), aged between 30 to 49 years old (83%), had one or two children (83%), prepared meals all or most of the time (76%) and consumed meals away from home three times or less per week (66%).

Analysis: Descriptive statistics and inferential statistics using Spearman’s rank correlation coefficient (rho) …

Holocarboxylase Synthetase-Dependent Biotinylation Of Histone H4, Luisa F. Rios Avila

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

Holocarboxylase synthetase (HCS) catalyzes the binding of biotin to lysine (K) residues in histones H3 and H4. Histone biotinylation marks play important roles in the repression of genes and retrotransposons. Preliminary studies suggested that K16 in histone H4 is a target for biotinylation by HCS. Here we demonstrated that H4K16bio is overrepresented in repeat regions {pericentromeric alpha satellite repeats; long terminal repeats (LTR)} compared with euchromatin promoters. H4K16bio was also enriched in the repressed interleukin-2 gene promoter. The enrichment at LTR22 and promoter 1 of the sodium-dependent multivitamin transporter (SMVT) depended on biotin supply; and was significantly lower in fibroblasts …

The Role Of Trust Protectors In American Trust Law, Richard C. Ausness

Law Faculty Scholarly Articles

“A trust is an arrangement whereby one person (the trustor) transfers property to another person or entity (the trustee) and directs the trustee to hold the property for the benefit of another person (the beneficiary).” These days, trustees often have significant discretionary and administrative powers. The increased use of institutional trustees, as well as the growing sophistication and complexity of modern trust asset management, have induced many settlors to give their trustees greater power and discretion. In addition, many states have enacted statutes, such as the Uniform Trustees’ Powers Act or the Uniform Trust Code (UTC), that confer broad powers …

Forum, Volume 34, No. 2, Summer 2010, Florida Humanities Council, Barbara O'Reilley

FORUM: The Magazine of Florida Humanities

Contents: Letter from the Director -- A Place for Writers -- General Fiction -- Florida Nonfiction -- Poetry -- Humanities Alive! -- The Many Faces of Michael Gannon's Life -- Popular Fiction -- Spanish Language -- Young Adult Literature -- Children Literature

Table Of Contents

The Journal of Law and Education

No abstract provided.

Bending Nature, Bending Law, David Owen

Faculty Publications

No abstract provided.

Cover Image, Matthew D. Hoffman

Reconstruction: Studies in Contemporary Culture

Cover with image for Reconstruction, Volume 10, Number 3.

Constructing The Shitting Citizen, Deanna Grant-Smith

Reconstruction: Studies in Contemporary Culture

Art activism uses visual and performance art to promote social and environmental agendas. In this paper, I explore attempts to raise awareness of sanitation issues at the global, local and personal level using scatological art. I focus on the successes of the open-air public art exhibition set up in the Brisbane (Queensland, Australia) central business district to celebrate World Toilet Day in 2008. The art in this exhibition featured included one hundred toilets decorated to raise awareness of global sanitation issues and the distribution of promotional materials featuring scatological images including postcards and stickers. Given the subject matter and intent, …

From Slacker To Revolutionary: Generation X And The Rise Of The Global Justice Movement, Benjamin Balthaser

Reconstruction: Studies in Contemporary Culture

[First paragraph]

Over a year now since Barack Obama ascended the stage with a politics of sincerity, many progressives are beginning to suspect that our motivational speaker-in-chief may have awakened the wrong giant within. Plagued with mobs from the UFO-wing of the Aryan Nation, Obama's genial retreat from principle has occasioned a great deal of hand-wringing, but little historical introspection regarding the movements of the previous decade. Part of this absence is a problem of definition. "Generation X" by its very name marks a non-event, something without a self-generative name. To make matters worse, if Generation X were ever useful …

Creative Tactics And Union Politics. Learning From The York University Strike, Roberta Buiani

Reconstruction: Studies in Contemporary Culture

[First paragraph]

The third-largest university in Canada, York University owes its fame to a long history of labor disputes. Historically, the neoliberal rhetoric and goals of York’s intransigent administration have always clashed with a radical body of graduate students and faculty, who not only deemed it politically and ethically necessary to challenge the employer and reclaim their rights, but also considered it a question of survival. Certified as a union since the mid-Seventies, York’s contract faculty and teaching assistants (then joined in 2001 by graduate assistants) [1] have been periodically engaged against the institution’s trend towards the progressive …

Edward Abbey's Bottle: An Essay On Trash And Treasure, Thomas Bowen

New Mexico Historical Review

No abstract provided.

Book Reviews

New Mexico Historical Review

No abstract provided.

Qubit, July 2010

Qubit (Cuban science fiction magazine)

The July 2010 issue of the Qubit.

A Trickle Of Cash For The River Of Grass: Federal Funding Of Comprehensive Everglades Restoration, A Critique And A Proposal, Kelly F. Taylor

University of Miami Law Review

No abstract provided.

The Effect Of Virtual Reality On Gait Variability, Dimitrios Kastavelis, Mukul Mukherjee, Leslie M. Decker, Nikolaos Stergiou

Journal Articles

Optic Flow (OF) plays an important role in human locomotion and manipulation of OF characteristics can cause changes in locomotion patterns. The purpose of the study was to investigate the effect of the velocity of optic flow on the amount and structure of gait variability. Each subject underwent four conditions of treadmill walking at their self-selected pace. In three conditions the subjects walked in an endless virtual corridor, while a fourth control condition was also included. The three virtual conditions differed in the speed of the optic flow displayed as follows – same speed (OFn), faster (OFf), and slower (OFs) …

New Intravenous Antibiotics: A Focused Pharmacotherapy Update, Kathryn A. Connor

Pharmacy Faculty/Staff Publications

Infections due to multidrug-resistant pathogens are increasing throughout the world, in particular due to the emergence of resistant Staphylococcus aureus, vancomycin-resistant enterococcus (VRE) penicillin-resistant Streptococcus pneumonia, multidrug-resistant (MDR) Pseudomonas and Acinetobacter spp, extended-spectrum β-lactamase- (ESBL) producing enteric organisms, etc. These serious pathogens are a major cause of severe hospital and community-acquired infections and are associated with high morbidity and mortality. Several new parenteral antibiotics have been approved in the past several years to help treat these infections, including telavancin, doripenem, tigecycline and daptomycin. This article reviews the pharmacology and limitations of these new antibiotics in treating infections in …

What Feminists Have To Lose In Same-Sex Marriage Litigation, Mary Anne Case

Public Law and Legal Theory Working Papers

This Article highlights both the rewards in accepting and the risks in rejecting a claim of sex discrimination as one constitutional basis for invalidating restrictions on marriage for same-sex couples. It argues that recognition of same-sex marriage and elimination of enforced sex roles are as inextricably intertwined as the duck is with the rabbit in the famous optical illusion. As the Article demonstrates, this has long been clear to opponents, from the pope to David Blankenhorn, but needs to become as clear to proponents and to judges deciding same-sex marriage cases if we are to preserve and extend the liberty …

The Eagleville Times,Volume 8, Issue 7, Debbie Ryan

Eagleville Times

No abstract provided.

Stealth Marketing And Antibranding: The Love That Dare Not Speak Its Name, Sonia K. Katyal

Buffalo Law Review

No abstract provided.

Consumer Counter-Advertising Law And Corporate Social Responsibility, Alberto R. Salazar V.

Buffalo Law Review

No abstract provided.

Annual Report Of Externally Funded Grants And Contracts, July 1, 2009 - June 30, 2010, Office Of Research And Sponsored Programs. Morehead State University.

Office of Research and Sponsored Programs Reports and Publications

Annual Report of Externally Funded Grants and Contracts from July 1, 2009 - June 30, 2010.

Re-Writing The Bhabhian “Mimic Man”: Akin, The Posthuman Other In Octavia Butler’S Adulthood Rites, Aparajita Nanda

English

Cultural critics have sought to define the term posthuman¹ as primarily a condition that does away with hierarchical forms of power and control. It recognizes a transformation of the human species into a subject position that moves from an oppositional politics of segregating the human “self” from the “other” to one of acknowledging the “other” as part of the human “self.” ² With the advent of the posthuman condition comes the need to re-define human rights in a posthuman context. Octavia Butler’s science fiction novel Adulthood Rites³ introduces us to Oankali, gene-trading aliens who travel through space. They …

Prey Selection By Young Green Crabs (Carcinus Maenas), Rock Crabs (Cancer Irroratus) And American Lobsters (Homarus Americanus) In The Gulf Of Maine, Joseph Sungail

All Theses And Dissertations

The intertidal zone in the Gulf of Maine supports large populations of three species of decapods. Young green crabs (Carcinus maenas), rock crabs (Cancer irroratus) and American lobsters (Homarus americanus) co-exist in close proximity and forage on similar prey species. Competition for prey resources could have major implications for the populations of these predators. This experimental study focuses on determining the potential for interspecific competition between these decapods for prey resources. Young green crabs (25 - 35 mm carapace width), rock crabs (25 - 35 mm carapace width) and American lobsters (25 - 35 mm carapace length), were collected along …

Orsp Research Newsletter - Fall 2010, Office Of Research And Sponsored Programs

ORSP Research Newsletter

No abstract provided.

Do Psychology Researchers Tell It Like It Is? A Microgenetic Analysis Of Research Strategies And Self-Report Accuracy, David F. Feldon

Instructional Technology and Learning Sciences Faculty Publications

Acquiring research skills is considered to be a highly challenging aspect of developing expertise in the social sciences. Because instruction and mentoring in these skills are typically grounded in the self-report of researchers, difficulties in learning the material may be due to the content and accuracy of these explanations. Using a mixed-method, microgenetic design, this study examines the explanations of problem-solving processes by researchers along a continuum of expertise during simulated experiment design and subsequent data analysis. Findings indicate that participants’ self-explanations are largely inaccurate. Further, frequency of inaccurate statements is positively associated with the frequency of abstract cognitive processes, …

Pharmaceutical Patent Bargains: The Brazilian Experience, Bruno Salama, Daniel Benoliel

Cardozo Journal of International and Comparative Law

In the backdrop of the strict patent regime flatly adopted by the World Trade Organization (WTO) for all countries, a few countries constantly challenge this system through aggressive patent bargains. Within the pharmaceutical sector, noticeably, some countries now threaten to issue or otherwise actually issue compulsory licenses that may sway large pharmaceutical companies into selling drugs with large discounts or into granting voluntary licenses domestically. That is conspicuously the negotiation strategy adopted by Brazil in its negotiations with big international pharmaceutical companies.

This paper explains Brazil's aggressive bargaining approach based on an analysis of two aspects of its political economy. …