Digital Commons Network^™

Academic Senate - Agenda, 1/20/2009, Academic Senate

Academic Senate Agendas

No abstract provided.

Systems-Level Interactions Between Insulin-Egf Networks Amplify Mitogenic Signaling., Nikolay Borisov, Edita Aksamitiene, Anatoly Kiyatkin, Stefan Legewie, Jan Berkhout, Thomas Maiwald, Nikolai P Kaimachnikov, Jens Timmer, Jan B Hoek, Boris N Kholodenko

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Crosstalk mechanisms have not been studied as thoroughly as individual signaling pathways. We exploit experimental and computational approaches to reveal how a concordant interplay between the insulin and epidermal growth factor (EGF) signaling networks can potentiate mitogenic signaling. In HEK293 cells, insulin is a poor activator of the Ras/ERK (extracellular signal-regulated kinase) cascade, yet it enhances ERK activation by low EGF doses. We find that major crosstalk mechanisms that amplify ERK signaling are localized upstream of Ras and at the Ras/Raf level. Computational modeling unveils how critical network nodes, the adaptor proteins GAB1 and insulin receptor substrate (IRS), Src kinase, …

The Collegian (2009-01-19), Linet Cisneros

UTB/TSC Archives - The Collegian [Newspaper]

Vol. 61, No. 17

Lanthorn, Vol. 43, No. 36, January 19, 2009, Grand Valley State University

Volume 43, July 10, 2008 - June 7, 2009

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

A Role For The Igh Intronic Enhancer E Mu In Enforcing Allelic Exclusion, Fubin Li, Laurel A. Eckhardt

Publications and Research

The intronic enhancer (E mu) of the immunoglobulin heavy chain (IgH) locus is critical for V region gene assembly. To determine E mu's subsequent functions, we created an Igh allele with assembled V(H) gene but with E mu removed. In mice homozygous for this E mu-deficient allele, B cell development was normal and indistinguishable from that of mice with the same V(H) knockin and E mu intact. In mice heterozygous for the E mu-deficient allele, however, allelic exclusion was severely compromised. Surprisingly, this was not a result of reduced suppression of V-DJ assembly on the second allele. Rather, the striking …

Gang Brooding In Canada Geese: Role Of Parental Condition And Experience, Michael R. Conover

Wildland Resources Faculty Publications

Some Canada Geese (Branta canadensis) raise their broods by themselves (two-parent families), while others raise them in gang broods, defined as two or more broods amalgamated into a single cohesive unit and shepherded by four or more parents. From 1984 to 2005, I individually marked Canada Geese in New Haven County, Connecticut, so that I could compare the characteristics of adults that raise their goslings in gang broods to those of adults that raised their goslings in two-parent families. I wanted to determine if a parent's decision to form a gang brood was influenced by its age or body mass, …

Face And Lip Tracking In Unconstrained Imagery For Improved Automatic Speech Recognition, Brandon Crow, Jane Zhang

Electrical Engineering

When combined with acoustical speech information, visual speech information (lip movement) significantly improves Automatic Speech Recognition (ASR) in acoustically noisy environments. Previous research has demonstrated that visual modality is a viable tool for identifying speech. However, the visual information has yet to become utilized in mainstream ASR systems due to the difficulty in accurately tracking lips in real-world conditions. This paper presents our current progress in tracking face and lips in visually challenging environments. Findings suggest the mean shift algorithm performs poorly for small regions, in this case the lips, but it achieves near 80% accuracy for facial tracking.

2009 Alaska’S Construction Spending Forecast, Oliver Scott Goldsmith, Mary Killorin

ISER Reports

Construction spending “on the street” in Alaska in 2009 will be $7.1 billion, down 3% from 2008.1,2,3 Lower construction spending, combined with higher material and labor costs, will result in a modest reduction in the level of construction employment in 2009. Although this will be the fourth year of decline, the level remains considerably above the long-term average. Excluding the oil and gas sector—which accounts for 43% of the total—construction spending will be $4.1 billion—down 1% from 2008. Private-sector construction spending will follow the slowdown in the Alaska economy. Excluding oil and gas, we expect private spending to be $1.3 …

Waste Generation, Incineration And Landfill Diversion. De-Coupling Trends, Socio-Economic Drivers And Policy Effectiveness In The Eu, Massimiliano Mazzanti, Roberto Zoboli

Fondazione Eni Enrico Mattei Working Papers

Waste generation and waste disposal are issues that are becoming increasingly prominent in the environmental arena both from a policy perspective and in the context of delinking analysis. Waste generation is still increasing proportionally with income, and economic and environmental costs associated to landfilling are also increasing. This paper provides a comprehensive analysis of waste generation, incineration, recycling and landfill dynamics based on panel data for the EU25, to assess the effects of different drivers (economic, structural, policy) and the eventual differences between western and eastern EU countries. We show that for waste generation there is still no Waste Kuznets …

The Tiger Vol. 103 Issue 1 2009-01-16, Clemson University

Tiger Newspapers

No abstract provided.

Central Florida Future, Vol. 41 No. 6, January 16, 2009

Central Florida Future

UnCover Fridays; A story with a bite; Plus: Heavy and light night; Brett Dennen gets social; Laser beam team shines; Definitions; Abolitionist urges action; The secret life of empty cans; Aluminum can history.

Gec1-Kappa Opioid Receptor Binding Involves Hydrophobic Interactions Gec1 Has Chaperone-Like Effect, Yong Chen, Chongguang Chen, Evangelia Kotsikorou, Diane L. Lynch, Patricia H. Reggio, Lee Yuan Liu-Chen

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

We demonstrated previously that the protein GEC1 (glandular epithelial cell 1) bound to the human κ opioid receptor (hKOPR) and promoted cell surface expression of the receptor by facilitating its trafficking along the secretory pathway. Here we showed that three hKOPR residues (Phe³⁴⁵, Pro³⁴⁶, and Met³⁵⁰) and seven GEC1 residues (Tyr⁴⁹, Val⁵¹, Leu⁵⁵, Thr⁵⁶, Val⁵⁷, Phe⁶⁰, and Ile⁶⁴) are indispensable for the interaction. Modeling studies revealed that the interaction was mediated via direct contacts between the kinked hydrophobic fragment in …

Inclusive Learning Environments: An Analysis Of Early Intervention Service Options For Preschoolers With Special Needs, Mimi L. Heath

Doctoral Dissertations and Projects

In the quest to restructure educational programming toward higher student outcomes for preschoolers with special needs, professional educators are continuously challenged to provide with integrity a free appropriate public education (FAPE) in the least restricted environment (LRE) as mandated by law. This study analyzed the effectiveness of an inclusive programming model for preschoolers with special needs by examining achievement gains in the developmental domains of adaptive, motor, and cognitive skills as assessed by the Battelle Developmental Inventory, Second Edition. Analysis of an inclusive learning environment for six preschoolers with special needs as guided by IEP committee recommendations occurred. In order …

Chimes: January 16, 2009, Calvin College

Chimes

Fieldhouse opens by Lerae Kroon and Chaz Amidon

Calvin ranks first in study abroad by Jasmine Wilson

Chaplain search narrowed to three by Griffin Jackson

Prospect of island domination draws student gamers by Griffin Jackson

Spoelhof Fieldhouse opens, offering state-of-the-art facilities, 'home' for athletes by Chaz Amidon

Both benefits and costs of new athletic building deserve reflection by Paul Chaplin

Knights edge Trine in overtime, end skid by Chaz Amidon

Exercise Bouts At Three Different Intensities Fail To Potentiate Concentric Power, Chad A. Cabrera†, Jacobo Morales‡, Felicia Greer‡, Robert W. Pettitt‡

International Journal of Exercise Science

Postactivation potentiation (PAP) has been hypothesized previously to occur during voluntary, concentric actions. We tested the hypothesis that one of at least three different intensities of conditioning exercises would evoke potentiation of power during the concentric, bench press throw (BPT). Twelve men (age = 22.9 &#; 2.7 years, bench press 1 repetition maximum (1RM) = 1.20 ± 0.12 kg•kg-1 body weight) completed five isotonic conditioning presses at ~55, 70, and 86% 1RM, in counterbalanced order, and on separate days. Average and peak power of the BPT using a load of 55% 1RM along with surface electromyography (EMG) of the triceps …

Influence Of Body Composition, Oral Contraceptive Use, And Physical Activity On Bone Mineral Density In Premenopausal Women, Vanessa D. Sherk†, Clint D. Howard†, Michael G. Bemben‡, Debra A. Bemben‡

International Journal of Exercise Science

In premenopausal women, low bone density may reflect attainment of a lower peak bone mass which can increase risk of osteoporosis after menopause. The purpose of this study was to examine the relationship between total body, lumbar spine, and proximal femur bone mineral density (BMD) and body composition and oral contraceptive (OC) use in 18-30 year old women. Sixty-five healthy women, split into groups of oral contraceptive users (OC, n = 36) and non oral contraceptive users (Non-OC, n = 29), completed Baecke physical activity, calcium intake, and menstrual history questionnaires. Total body, AP lumbar spine, and dual proximal femur …

Timing Carbohydrate Beverage Intake During Prolonged Moderate Intensity Exercise Does Not Affect Cycling Performance, George G. Schweitzer†, John D. Smith‡, James D. Lecheminant‡

International Journal of Exercise Science

Carbohydrate beverages consumed during long-term exercise have been shown to attenuate fatigue and improve performance; however, the optimal timing of ingestion is unclear. Therefore, the purpose of this study was to determine if timing the carbohydrate ingestion (front-loading (FL), continual loading (CL), and end-loading (EL)) during prolonged exercise influenced exercise performance in competitive cyclists. Ten well-trained cyclists completed three separate exercise bouts on a bicycle ergometer, each lasting 2 hours at an intensity of ~67% VO₂ max, followed by a 15-minute “all out” time trial. In the FL trial, participants ingested a carbohydrate beverage during the first hour and …

Commonwealth Times 2009-01-15

Commonwealth Times, 1969-

No abstract provided.

Testing Of Great Bay Oysters For Two Protozoan Pathogens, Douglas E. Grout

PREP Reports & Publications

Two protozoan pathogens, Haplosporidium nelsoni (MSX) and Perkinsus marinus (Dermo) are known to be present in Great Bay oysters. With funds provided by the Piscataqua Region Estuaries Partnership (PREP), the Marine Fisheries Division of New Hampshire Fish and Game Department, (NHF&G) continues to assess the presence and intensity of both disease conditions in oysters from the major beds within the Great Bay estuarine system. Histological examination of Great Bay oysters has also revealed other endoparasites.

The Effects Of The Acetic Acid “Pain” Test On Feeding, Swimming, And Respiratory Responses Of Rainbow Trout (Oncorhynchus Mykiss): A Critique On Newby And Stevens (2008), Lynne U. Sneddon

Experimentation Collection

Newby and Stevens’ (2008) paper ‘‘The effects of the acetic acid ‘pain’ test on feeding, swimming, and respiratory responses of rainbow trout (Oncorhynchus mykiss)’’ examines the effects of a noxious stimulus on the behaviour of trout in an attempt to replicate research conducted in my laboratory (Sneddon, 2003a; Sneddon, 2007; Sneddon et al., 2003a,b; Reilly et al., 2008). However, the authors used a different protocol to the one already published and I would like to respond to some of their points of discussion to provide scientific explanations for their results using data from my laboratory. The authors show that swimming …

Quantitative And Qualitative Assessment Of The Response Of Foals To The Presence Of An Unfamiliar Human, Michela Minero, Maria Vittoria Tosi, Elisabetta Canali, Françoise Wemelsfelder

Sentience Collection

This work aimed to apply a combined qualitative and quantitative approach to the interpretation of an on-farm behaviour test for horses, and to examine whether 1 month of handling would affect the response of yearlings to an unfamiliar stationary human in their home environment. Throughout a 1-month period, 14 Thoroughbred Yearlings (16 ± 0.22 months old) that had formerly experienced minimal contact with humans, were handled daily for about 45 min. The yearlings were tested twice, just before and just after the handling period. The behaviour of the horses during the tests was both video-recorded and directly recorded by the …

Are Animal Models Predictive For Humans?, Niall Shanks, Ray Greek, Jean Greek

Validation of Animal Experimentation Collection

It is one of the central aims of the philosophy of science to elucidate the meanings of scientific terms and also to think critically about their application. The focus of this essay is the scientific term predict and whether there is credible evidence that animal models, especially in toxicology and pathophysiology, can be used to predict human outcomes. Whether animals can be used to predict human response to drugs and other chemicals is apparently a contentious issue. However, when one empirically analyzes animal models using scientific tools they fall far short of being able to predict human responses. This is …

Randomization And In Vivo Selection Reveal A Ggrg Motif Essential For Packaging Human Immunodeficiency Virus Type 2 Rna, Tayyba T. Baig, Jean-Marc Lanchy, J. Stephen Lodmell

Biological Sciences Faculty Publications

The packaging signal (psi) of human immunodeficiency virus type 2 (HIV-2) is present in the 5' noncoding region of RNA and contains a 10-nucleotide palindrome (pal; 5'-392-GGAGUGCUCC) located upstream of the dimerization signal stem-loop 1 (SL1). pal has been shown to be functionally important in vitro and in vivo. We previously showed that the 3' side of pal (GCUCC-3') is involved in base-pairing interactions with a sequence downstream of SL1 to make an extended SL1, which is important for replication in vivo and the regulation of dimerization in vitro. However, the role of the 5' side of pal (5'-GGAGU) was …

Washington University Record, January 15, 2009

Washington University Record

No abstract provided.

The Daily Gamecock, Thursday, January 15, 2009, University Of South Carolina, Office Of Student Media

January

No abstract provided.

Mitostatin, A Putative Tumor Suppressor On Chromosome 12q24.1, Is Downregulated In Human Bladder And Breast Cancer., A Vecchione, M Fassan, V Anesti, A Morrione, S Goldoni, G Baldassarre, D Byrne, D D'Arca, J P Palazzo, J Lloyd, L Scorrano, L G Gomella, R V Iozzo, R Baffa

Department of Urology Faculty Papers

Allelic deletions on human chromosome 12q24 are frequently reported in a variety of malignant neoplasms, indicating the presence of a tumor suppressor gene(s) in this chromosomal region. However, no reasonable candidate has been identified so far. In this study, we report the cloning and functional characterization of a novel mitochondrial protein with tumor suppressor activity, henceforth designated MITOSTATIN. Human MITOSTATIN was found within a 3.2-kb transcript, which encoded a approximately 62 kDa, ubiquitously expressed protein with little homology to any known protein. We found homozygous deletions and mutations of MITOSTATIN gene in approximately 5 and approximately 11% of various cancer-derived …

The Bg News January 15, 2009, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. January 15, 2009. Volume 99-Issue 79.

Green Technology In Developing Countries: Creating Accessibility Through A Global Exchange Forum, Michael Hasper

Duke Law & Technology Review

As they pursue economic development, developing countries possess high demand for processes and technologies that have climate-friendly methods or alternatives. However, these nations currently face barriers to entry because of trade policies and intellectual property regulations that render procurement of these technologies cost-prohibitive. In light of the recent breakdown in negotiations at the United Nations climate conference in Bali to remove tariffs on green technology, a new approach to green technology diffusion should be considered in order to balance the demand among developing nations for fluid technology transfers with the profit-driven needs and intellectual property considerations of technology holders. A …

Mustang Daily, January 15, 2009

Cal Poly Student Newspaper

Student newspaper of California Polytechnic State University, San Luis Obispo, CA.

The George-Anne, Georgia Southern University

The George-Anne

• First Candidate for CLASS Dean Speaks at GSU
• Briefs
• Opinions
• Classifieds, Etc.
• Features
• Sports