Digital Commons Network^™

Micro Integrated Planar Optical Waveguide Type Spr Sensor., Hyoung Cho, Hyungseok Bang, Patrick Likamwa

UCF Patents

An integrated optical waveguide type surface plasmon resonance (SPR) sensor having an optical waveguide with a corresponding SPR sensing area, photodetectors, and wave-length tunable laser or any kind of external tunable laser source/coupler formed on a substrate. In an embodiment, the laser is a wavelength tunable laser and optionally, the integrated device may include a power source on the substrate for providing a electric power to the wavelength tunable laser and the photodetectors, or a circuit for signal processing, or a microfluidic structure for routing a target sample to the SPR sensor area. The microfluidic structure optionally includes a mixer …

Naloxone's Pentapeptide Binding Site On Filamin A Blocks Mu Opioid Receptor–Gs Coupling And Creb Activation Of Acute Morphine, Hoau-Yan Wang, Lindsay H. Burns

Publications and Research

Chronic morphine causes the mu opioid receptor (MOR) to switch its coupling from Gi/o to Gs, resulting in excitatory signaling via both Gαs and its Gβγ dimer. Ultra-low-dose naloxone (NLX) prevents this switch and attenuates opioid tolerance and dependence. This protective effect is mediated via a high-affinity interaction of NLX to a pentapeptide region in c-terminal filamin A (FLNA), a scaffolding protein interacting with MOR. In organotypic striatal slice cultures, we now show that acute morphine induces a dose-dependent Go-to-Gs coupling switch at 5 and 15 min that resolves by 1 hr. The acute Gs coupling induced by 100 µM …

Faculty Senate Summarized Minutes, 1/27/2009, Unm Faculty Senate

Faculty Senate Meeting Minutes, 1920 - 2013

No abstract provided.

The Current Volume 19: Issue 16, Nova Southeastern University

Student Newspapers

No abstract provided.

Daily Eastern News: January 27, 2009, Eastern Illinois University

January

No abstract provided.

Ras P27 Mouse Models And Uses Thereof, W. Jack Pledger, Rosalind J. Jackson, Jalila Adnane, Said M. Sebti

USF Patents

The subject invention pertains to a transgenic animal model for tumorigenesis having a genome comprising a ras transgene and which is heterozygous or homozygous for a null p27 gene, and methods of using such animal to screen compounds or evaluate treatments for oncogenic and antitumor activity. The subject invention further concerns a transgenic mouse comprising a ras transgene and which has a genome that is wild-type p27+/+, and wherein the mouse has an FVB/N and C57BL/6X 129 genetic background; and methods of using such transgenic mice to screen compounds or evaluate treatments for oncogenic or antitumor activity. Advantageously, the female …

Growth Factor-Binding Compounds And Methods Of Use, Said M. Sebti, Andrew D. Hamilton, Rishi Jain

USF Patents

Growth factor binding compounds having a plurality of acyclic isophthalic acid groups attached to a non-peptide organic scaffold and pharmaceutical compositions of the same are disclosed. Methods of administering and using the growth factor binding compounds or the growth factor binding compositions are also taught. These novel growth factor binding compounds are useful for treating angiogenesis, excessive cellular proliferation, tumor growth, and a combination thereof as well as inhibiting growth factor binding to cells and phosphorylation.

N-Thiolated 2-Oxazolidinone-Derived Antibiotics, Edward Turos, Rajesh Kumar Mishra

USF Patents

This invention describes the discovery and synthesis of N-thiolated 2-oxazolidinones as a new class of anti bacterial agents. These compounds can be synthesized from 2-oxazolidinones by Ndeprotection and N-sulfenylation. These new substances were found to exhibit potent anti-bacterial activity, including bacteriostatic properties against Staphylococcus spp., including methicillin resistant Staphylococcus aureus (MRSA), and Bacillus spp., including Bacillus anthracis.

Lecture Series Explores Journeys In Conservation, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Urban Ecology & Conservation Symposium 2009: 7th Annual -- Connecting Green Research, Lands And Partners (Abstracts), Urban Ecosystem Research Consortium Of Portland/Vancouver

Urban Ecosystem Research Consortium of Portland/Vancouver

The UERC is a consortium of people from various universities and colleges, state and federal agencies, local governments, non-profit organizations and independent professionals interested in supporting urban ecosystem research and creating an information-sharing network of people that collect and use ecological data in the Portland/Vancouver area.

UERC Mission Statement:

To advance the state of the science of urban ecosystems and improve our understanding of them, with a focus on the Portland/Vancouver metropolitan region, by fostering communication and collaboration among researchers, managers and citizens at academic institutions, public agencies, local governments, non-profit organizations, and other interested groups.

The principal organizers span …

Grand Valley Forum, Volume 033, Number 18, January 26, 2009, Grand Valley State University

2008-2009, Volume 33

Grand Valley Forum is Grand Valley State's faculty and staff newsletter, published from 1976 to the present.

The Chanticleer, 2009-01-26, Coastal Carolina University

The Chanticleer Student Newspaper

The editorially independent student produced weekly newspaper of Coastal Carolina University.

Commonwealth Times 2009-01-26

Commonwealth Times, 1969-

No abstract provided.

Glutathione Diminishes Tributyltin- And Dibutyltin-Induced Loss Of Lytic Function In Human Natural Killer Cells, Jeralyn J. Powell, Mclisa V. Davis, Margaret M. Whalen

Chemistry Faculty Research

This study investigated whether reduced glutathione (GSH) was able to alter the negative effects of tributyltin (TBT) or dibutyltin (DBT) on the lytic function of human natural killer (NK) cells. NK cells are an initial immune defense against the development of tumors or viral infections. TBT and DBT are widespread environmental contaminants, due to their various industrial applications. Both TBT and DBT have been shown to decrease the ability of NK cells to lyse tumor cells (lytic function). The results indicated that the presence of GSH during the exposure of NK cells to TBT or DBT diminished the negative effect …

2009 January 26 - Graduate Council Minutes, College Of Graduate And Continuing Studies, East Tennessee State University

Graduate Council Agendas and Minutes

No abstract provided.

Central Florida Future, Vol. 41 No. 9, January 26, 2009

Central Florida Future

Damage to Tower III caused by grease fire; UCF grads make it in N.Y.; 'Keep that heart if serving'; Alumna's short film premieres at Sundance.

Monitor Newsletter January 26, 2009, Bowling Green State University

Monitor

Official Publication of Bowling Green State University for Faculty and Staff

The Collegian (2009-01-26), Linet Cisneros

UTB/TSC Archives - The Collegian [Newspaper]

Vol. 61, No. 18

Today - January 26, 2009, Loma Linda University

TODAY

Inside this issue:

-- ‘Come Unto Me’ sculpture graces entrance to Loma Linda University Medical Center
-- Trustees approve new administrative appointment
-- Second careers benefit Children’s Hospital, volunteers
-- School of Public Health graduate receives prestigious award
-- Spiritual life,wholeness forum focuses on trauma
-- School, organizations bring cheer to LLUCH patients
-- School of Medicine plans dedication service for students
-- Kristen Cameron brings musical healing to patients with her harp
-- School of Pharmacy honors students for summer, autumn 2008 quarters
-- Trustees actions of December 10, 2008, outlined
-- Sports luncheon raises $39,835 for PossAbilities
-- …

January 26, 2009 Reporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Characterization And Synthesis Of Nanoscale Materials, Jinfeng Wang

Dissertations

This dissertation focuses on the systematic study of techniques for characterization and synthesis of nanoscale materials. We have achieved several goals. Firstly, high number density uniform zinc oxide nanostructure growth has been achieved using thermal evaporation, through control of experimental parameters that include source material temperature, substrate temperature, substrate material, gas flow rate, and choice of catalyst. Aligned zinc oxide nanowires, randomly oriented zinc oxide nanowires, zinc oxide container-shaped structures, and zinc oxide nanobelts have been synthesized with high yield. Secondly, using a one parameter family of lattice fringe geometry curves, we show how to examine the epitaxial relationship between …

Senior Project Ideas (2010 Cohort), Liz Markus

Blog Archive: River Reflections at the University of Dayton

In class on Friday we discussed ideas for our River Steward Senior Project. None of this is set in stone, but I volunteered to write a summary of our collective thoughts so Franz and Katie could see them and contribute, (as well as others if you would like)! Here it goes:

Mustang Daily, January 23, 2009

Cal Poly Student Newspaper

Student newspaper of California Polytechnic State University, San Luis Obispo, CA.

Nanotechnology For Molecular Recognition Of Biological Analytes, Robert C. Triulzi

Open Access Dissertations

Nanotechnology is a term used to describe nanometer scaled systems. This thesis presents various nanomaterials and systems for the investigation of biologically relevant analytes in general, and in particular for their detection, decontamination, or destruction. The validation of short peptide fragments as models for protein aggregation is initially discussed through applying spectroscopic and microscopic techniques to Langmuir monolayer surface chemistry. Following this validation, the use of nanogold as a photoablative material for the destruction of aggregated protein is investigated. Subsequently, the versatility of nanotechnology is shown by investigating a different form of nanogold; namely, gold quantum dots and the interesting …

Cross-Talk In The Gut, Jennifer E. Dinalo, David A. Relman

United States Department of Veterans Affairs: Publications

Modulation of host signaling by the products of microbial activity in the gut may affect weight gain and fat formation.

The relationship between humans and the population of indigenous microorganisms in their intestines (the gut microbiota) is ancient and important. In a recent survey exploring the relationship between mammals and their microbiota it was found that individuals of the same species were more likely to have a similar gut microbiota than mammals of different species [1]. This observation held true regardless of the geographic separation between the two hosts. These results indicate that the composition of the microbiota is dependent …

Incompatibility With Formin Cdc12p Prevents Human Profilin From Substituting For Fission Yeast Profilin: Insights From Crystal Structures Of Fission Yeast Profilin., Obidimma Ezezika, Noah S Younger, Jia Lu, Donald A Kaiser, Zachary A Corbin, Bradley J Nolen, David R Kovar, Thomas D Pollard

Health Studies Publications

Expression of human profilin-I does not complement the temperature-sensitive cdc3-124 mutation of the single profilin gene in fission yeast Schizosaccharomyces pombe, resulting in death from cytokinesis defects. Human profilin-I and S. pombe profilin have similar affinities for actin monomers, the FH1 domain of fission yeast formin Cdc12p and poly-L-proline (Lu, J., and Pollard, T. D. (2001) Mol. Biol. Cell 12, 1161-1175), but human profilin-I does not stimulate actin filament elongation by formin Cdc12p like S. pombe profilin. Two crystal structures of S. pombe profilin and homology models of S. pombe profilin bound to actin show how the two profilins bind …

The Murray State News, January 23, 2009, The Murray State News

Murray State University Collection

No abstract provided.

Faculty Senate Meeting Minutes Jan 23, 2009, A-State Faculty Senate

Faculty Senate Minutes

No abstract provided.

Dietary Resistant Starch Increases Hypothalamic Pomc Expression In Rats, Li Shen, Michael J. Keenan, Roy J. Martin, Richard T. Tulley, Anne M. Raggio, Kathleen L. Mccutcheon, Jun Zhou

Faculty Publications

Resistant starch (RS) is fermentable dietary fiber. Inclusion of RS in the diet causes decreased body fat accumulation and altered gut hormone profile. This study investigates the effect of feeding RS on the neuropeptide messenger RNA (mRNA) expressions in the arcuate nucleus (ARC) of the hypothalamus and whether vagal afferent nerves are involved. The rats were injected intraperitoneally with capsaicin to destroy unmyelinated small vagal afferent nerve fibers. The cholecystokinin (CCK) food suppression test was performed to validate the effectiveness of the capsaicin treatment. Then, capsaicin-treated rats and vehicle-treated rats were subdivided into a control diet or a RS diet …

Daily Eastern News: January 23, 2009, Eastern Illinois University

January

No abstract provided.