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Ionic Selectivity In L-Type Calcium Channels By Electrostatics And Hard-Core Repulsion, Dezso Boda, Douglas Henderson, Monika Valisko, Bob Eisenberg, Dirk Gillespie

Faculty Publications

A physical model of selective "ion binding" in the L-type calcium channel is constructed, and consequences of the model are compared with experimental data. This reduced model treats only ions and the carboxylate oxygens of the EEEE locus explicitly and restricts interactions to hard-core repulsion and ion–ion and ion–dielectric electrostatic forces. The structural atoms provide a flexible environment for passing cations, thus resulting in a self-organized induced-fit model of the selectivity filter. Experimental conditions involving binary mixtures of alkali and/or alkaline earth metal ions are computed using equilibrium Monte Carlo simulations in the grand canonical ensemble. The model pore rejects …

A Mathematical Model For Anti-Malarial Drug Resistance, Amanda Matthews

Theses and Dissertations

Despite the array of medical advances of our modern day society, infectious diseases still plague millions of people worldwide. Malaria, in particular, causes substantial suffering and death throughout both developed and developing countries. Aside from the socioeconomic challenges presented by the disease's prevalence in impoverished nations, one of the major difficulties scientists have encountered while attempting to eradicate the disease is the parasite's ability to become resistant to new drugs and methods of treatment. In an effort to better understand the dynamics of malaria, we analyze a mathematical model that accounts for both the treatment aspect as well as the …

Meta-Analysis: Racial Disparities In Prostate Cancer Survival And Case-Control Study: Association Between Family History Of Cancers, Obesity And Prostate Cancer, Gayathri Sridhar

Theses and Dissertations

This is a compilation of 3 abstracts for the three manuscripts included in this dissertation. I. Meta-Analysis: Racial Disparities in Prostate Cancer Survival: Prostate cancer is the second leading cause of cancer-related mortality in men. Previous studies have drawn inconsistent conclusions on racial differences in prostate cancer survival. This meta-analysis was conducted to investigate the relationship between race and survival from prostate cancer. A systematic review of published articles from 1968 to 2007 assessing survival from prostate cancer among African American and White men was conducted. The search yielded 20 eligible published manuscripts. Analysis of unadjusted studies showed African American …

The Bg News April 27, 2009, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. April 27, 2009. Volume 99-Issue 143.

Cancer In The Florida Hispanic Diverse Populations, Paulo S. Pinheiro

Open Access Dissertations

Cancer afflicts 1.4 million people in the United States annually. In 2007, 45.5 million Hispanics were the largest and fastest growing minority in the US. Although treated as a homogeneous group, Hispanics are different from cultural, socioeconomic and genetic perspectives. The cancer experience of Hispanic subpopulations has, thus far, been poorly described. The present dissertation focused on the descriptive epidemiology of Cancer in Hispanics in the US. We created and validated an algorithm, the Hispanic Origin Identification Algorithm (HOIA), to improve the assignment of ethnicity and Hispanic subpopulation. We applied the HOIA to the Florida incident cancer data of the …

Cancer In The Florida Hispanic Diverse Populations, Paulo S. Pinheiro

Open Access Dissertations

Cancer afflicts 1.4 million people in the United States annually. In 2007, 45.5 million Hispanics were the largest and fastest growing minority in the US. Although treated as a homogeneous group, Hispanics are different from cultural, socioeconomic and genetic perspectives. The cancer experience of Hispanic subpopulations has, thus far, been poorly described. The present dissertation focused on the descriptive epidemiology of Cancer in Hispanics in the US. We created and validated an algorithm, the Hispanic Origin Identification Algorithm (HOIA), to improve the assignment of ethnicity and Hispanic subpopulation. We applied the HOIA to the Florida incident cancer data of the …

Interval Estimation For The Difference In Paired Areas Under The Roc Curves In The Absence Of A Gold Standard Test, Hsin-Neng Hsieh, Hsiu-Yuan Su, Xiao-Hua Zhou

UW Biostatistics Working Paper Series

Receiver operating characteristic (ROC) curves can be used to assess the accuracy of tests measured on ordinal or continuous scales. The most commonly used measure for the overall diagnostic accuracy of diagnostic tests is the area under the ROC curve (AUC). A gold standard test on the true disease status is required to estimate the AUC. However, a gold standard test may sometimes be too expensive or infeasible. Therefore, in many medical research studies, the true disease status of the subjects may remain unknown. Under the normality assumption on test results from each disease group of subjects, using the expectation-maximization …

Ucc Minutes April 23, 2009, Kutztown University Curriculum Committee

UCC Minutes

No abstract provided.

Sitehound-Web: A Server For Ligand Binding Site Identification In Protein Structures, Marylens Hernandez, Dario Ghersi, Roberto Sanchez

Interdisciplinary Informatics Faculty Publications

SITEHOUND-web (http://sitehound.sanchezlab.org) is a binding-site identification server powered by the SITEHOUND program. Given a protein structure in PDB format SITEHOUND-web will identify regions of the protein characterized by favorable interactions with a probe molecule. These regions correspond to putative ligand binding sites. Depending on the probe used in the calculation, sites with preference for different ligands will be identified. Currently, a carbon probe for identification of binding sites for drug-like molecules, and a phosphate probe for phosphorylated ligands (ATP, phoshopeptides, etc.) have been implemented. SITEHOUND-web will display the results in HTML pages including an interactive 3D representation of …

American Society Of Parasitologists Newsletter, V. 31, No. 1, April 26, 2009, Scott Lyell Gardner

American Society of Parasitologists: Newsletter

An issue of the American Society of Parasitologists' quarterly newsletter, also called the Journal of Parasitology Newsletter.

2008-2009 Lindenwood University Honors Convocation, Lindenwood University

Honors Convocation Programs

2008-2009 Lindenwood University Honors Convocation

Gold Series Choral Collage: April 26, 2009, School Of Music

School of Music Programs

This is the one hundred and ninety-fifth program of the 2008-2009 season.

Center for the Performing Arts

April 26, 2009

Sunday Evening

7:00 p.m.

Hotline Press Newspaper- April 26,2005 Vol 22 No 40, Hotline Press Newspaper

Hotline Press Newspaper 2005

No abstract provided.

Attractors In Dynamics With Choice, Sanja Zivanovic

Open Access Dissertations

Dynamics with choice is a generalization of discrete-time dynamics where instead of the same evolution operator at every time step there is a choice of operators to transform the current state of the system. Many real life processes studied in chemical physics, engineering, biology and medicine, from autocatalytic reaction systems to switched systems to cellular biochemical processes to malaria transmission in urban environments, exhibit the properties described by dynamics with choice. We study the long-term behavior in dynamics with choice. We prove very general results on the existence and properties of global compact attractors in dynamics with choice. In addition, …

The Role Of Spatiotemporal Heterogeneity In Water And Nutrient Pools In Everglades Plant Community Diversity And Function, Amartya K. Saha

Open Access Dissertations

Spatial and temporal heterogeneity of water and nutrient pools is closely associated with the existence of different plant communities in hydrologically-controlled ecosystems such as the Everglades. These various communities differ in their flooding and fire tolerances as well as nutrient requirements. Upland plant communities are of particular ecological significance since they have high biodiversity and provide habitat to terrestrial fauna, yet comprise less than 10 % of the total area. Restoration and maintenance of such communities requires an understanding of their water and nutrient requirements. Chapter 2 compares water source utilization in hammocks and pine rocklands on the Miami Rock …

Spokane Intercollegiate Research Conference 2009, Whitworth University

SIRC Event Programs

No abstract provided.

Accelerated Oxidation Of Epinephrine By Silica Nanoparticles, Zhimin Tao, Gang Wang, Jerry Goodisman, Tewodros Asefa

Chemistry - All Scholarship

We have measured the influence of mesoporous silica (MCM-41 and SBA-15) nanoparticles and dense silica nanoparticles on epinephrine oxidation, a pH-dependent reaction, whose rate is small in acidic or neutral solutions but much greater at higher pH. The reaction was measured by monitoring adrenochrome at 480 nm, the product of epinephrine oxidation. In distilled water (dH ₂O) with no particles present, the oxidation of epinephrine occurs slowly but more rapidly at higher pH. The presence of MCM-41 or silica spheres does not accelerate the oxidation, but SBA-15 does, showing that the difference in the structures of nanomaterials leads to …

Marshall University Music Department Presents The University Chorus, Spring Concert, Robert Wray, Conductor, Robert Wray

All Performances

No abstract provided.

Ultrasonic Drug Delivery To Tumors Via Stealth Liposomes, Peter Jones, Ghaleb A. Husseini, William G. Pitt, Beverly L. Roeder

Faculty Publications

Our research develops ultrasonically-controlled drug delivery systems. Previous micellar drug carriers released the drug upon ultrasonication. We have developed a liposomal drug carrier that is even more effective upon insonation in reducing tumors.

Booklet, Altrusa International District Three Conference Information, Tampa, April 23-25, 2009, Altrusa International

Altrusa International of Tampa Bay, Inc. - Records

An information packet for the Altrusa International Inc. District Three Conference held at Hilton Tampa Airport Westshore Hotel in Tampa, taking place April 23-25, 2009.

Pengaruh Suhu Dan Lama Proses Menggoreng (Deep Frying) Terhadap Pembentukan Asam Lemak Trans, Ratu Ayu Dewi Sartika

Makara Journal of Science

Influencing of Deep Frying in Forming of Trans Fatty Acid. Frying process is one of the cooking’s techniques using vegetable oil. This process is commonly used in food industry, restaurants, food services, food retail and household scale. This is a laboratory experimental study which performed in laboratory of Public Health Nutrition FKM-UI and Integrated Laboratory IPB, Bogor from December 2005 until March 2006. It was conducted by two (2) type of treatment (used cooking oil ex cassava and meat) with 4 (four) times for each treatment. The objective of this study is to know the influence of frying by using …

Kandungan Senyawa Kimia, Uji Toksisitas (Brine Shrimp Lethality Test) Dan Antioksidan (1,1-Diphenyl-2-Pikrilhydrazyl) Dari Ekstrak Daun Saga (Abrus Precatorius L.), Juniarti Juniarti, Delvi Osmeli, Yuhernita Yuhernita

Makara Journal of Science

Chemical Compound Gynecology, ToxinTest (Brine Shrimp Lethality Test) and Antioxidants (1,1-Diphenyl-2- Pikrilhydrazyl) from Saga Leaf Extract (Abrus Precatorius L.). Cytotoxicity effects and antioxidant activities of saga (Abrus precatorius L.) extract were studied by using Brine Shrimp Lethality Test and 1,1-diphenyl-2-pikrilhydrazyl assays. Saga was extracted with different solvents i.e n-hexane, ethyl acetate and methanol. Result showed that the methanolic extract of saga had been potential to be cytotoxic againts Brine Shrimp with LC50 value of 606.736 ppm. However, all the extract of saga did not have antioxidant activities.

Isolasi Bakteri Selulolitik Dan Karakterisasi Enzimnya, Anja Meryandini, Wahyu Widosari, Besty Maranatha, Titi Candra Sunarti, Nisa Rachmania, Hasrul Satria

Makara Journal of Science

Isolation of Cellulolytic Bacteria and Characterization of the Enzyme. Four of cellulolitic bacteria isolates had been characterized. The determination of cellulase activity was conducted at the highest production time, using crude enzymes with the modification of Miller methods (1959) on pure cellulose substrates such as CMC (Carboxymethyl cellulose), Avicel and Filter paper Whatman No. 1 as well as agriculture waste such as rice straw, corn cob and banana peel. Cellulase from C4-4, C5-1, C5-3 and C11-1 showed optimum activity at pH 5, 70°C, pH 3.5, 90°C, pH 5, 80°C and pH 8, 70°C, respectively. Avicel is a appropriate substrate for …

Keanekaragaman Jenis Ekhinodermata Di Perairan Teluk Kuta, Nusa Tenggara Barat, Eddy Yusron

Makara Journal of Science

Biodiversity of Echinoderms at Kuta Bay, West Nusa Tenggara. Observation on echinoderms diversity was carried out at coastal waters of Kuta bay in the Nusa Tenggara Barat, Nopember 2005. A total of 21 species of echinoderms, consist of 4 species Holothuroidea, 7 species Echinoidea, 5 species Asteroidea and 5 species Ophiuroidea have been found in the Kuta of Nusa Tenggara Barat. The Echinoidea were relatively common in the sea gras zone. On the basis of population density, Echinoidea was the dominant group and relatively highest in the individual density. In general the number of species of echinoderm fauna is smaller …

Peningkatan Mutu Sari Buah Nanas Dengan Memanfaatkan Sistem Filtrasi Aliran Dead-End Dari Membran Selulosa Asetat, Jajang Juansah, Kiagus Kiagus, Farida Huriati

Makara Journal of Science

Quality Improvement of Pineapple Juice using Filtration System of Dead-end Flow from Selulosa Asetate Membrane. The main idea of this research is determination of alternating food technology using acetate cellulose membrane. The Cellulose acetate membrane can be used to filter several solution like extract of pineapple. Filtration technique of dead-end flow system was used to improve the quality of pineapple extract. The filtration system was condition in a state of under pressure energy, gravity force and squealer velocity variation. Flux of membrane for all process treat to experience of degradation increasedly it time filtrasi. Assess got highest flux to process …

Senyawa Triterpenoid Dari Ekstrak N-Heksana Kulit Batang Tanaman Garcinia Benthami, Berna Elya1, Soleh Kosela, Muhammad Muhammad

Makara Journal of Science

Triterpenoids compounds from N-hexane extract of the stem bark of Garcinia benthami. Two triperpenoids compounds, i.e. friedelin (1) and 3β-hydroxy-lanosta-9(11),24-dien-26-oic acid (2) were isolated from the n-hexane extract of the stem bark of Garcinia benthami. The structures of these compounds were elucidated by IR, MS,1 H-NMR and 13C-NMR spectroscopy and by comparison of their spectroscopic data with those reported data from the literature.

Kondisi Oseanografi Fisika Perairan Barat Sumatera (Pulau Simeulue Dan Sekitarnya) Pada Bulan Agustus 2007 Pasca Tsunami Desember 2004, Dewi Surinati

Makara Journal of Science

Physical Oceanographic Condition of the Western Waters of Sumatera (Simeulue Island Water) on August 2007 Pasca Tsunami December 2004. The physical oceanographic condition of the western waters of Sumatera was observed in August 2007 after tsunami disaster using the RV Baruna Jaya VII. The tenth CTD stations were observed for measuring the temperature and salinity. The temperature and salinity conditions after two years and seven months of the disaster have been normal as a usual condition. The temperature of 28 – 30o C gradually increased from north to south and salinity of 32.8 to 34 PSU gradually increased from the …

Biodegradasi Fenantren Oleh Bakteri Laut Pseudomonas Sp Kalp3b22 Asal Kumai Kalimantan Tengah, Tutik Murniasih, Yopi Yopi, Budiawan Budiawan

Makara Journal of Science

The Biodegradation of Phenanthren by Marine Bacteria Pseudomonas sp KalP3b22 from Kumai Central Borneo. The study of the potential marine bacteria that degrade Polycyclic Aromatic Hydrocarbons (PAHs) was already done among several marine bacterium isolated from the contaminated sea water collected in Kumai Port area. The biodegradation rate of phenanthrene by selected bacteria Pseudomonas sp Kalp-3b22 was 59,5% after 29 days cultivation. The structural determination of degradation product was deduced as 1-naphtalenol.

Screening Bakteri Penghambat Untuk Bakteri Penyebab Penyakit Pada Budidaya Ikan Kerapu Dari Perairan Banten Dan Lampung, Ariani Hatmanti, Ruyitno Nuchsin, Julinasari Dewi

Makara Journal of Science

Screening for Inhibitor Bakteri for Pathogenic Bacteria in Groupers Culture in Banten and Lampung Waters. A research about screening of inhibitor bacteria for pathogenic bacteria in grouper culture was done during 2005 in Marine Microbiology Laboratory, Research Center for Oceanography LIPI. Inhibition test was done using paper disc method for three isolates of pathogenic bacteria in his research, they were: Vibrio harveyii, 9.2/Luka/TSA and 8.2/Luka/TSA. The result shows that from 39 isolates of inhibitor bacteria from Banten and 27 isolates of inhibitor bacteria from Lampung only two isolates showed inhibition effect to the growth of three isolates of pathogenic bacteria. …

Komposisi Keberadaan Krustasea Di Mangrove Delta Mahakam Kalimantan Timur, Rianta Pratiwi

Makara Journal of Science

Crustacean composition on mangrove Mahakam Delta, East Kalimantan. The research was conducted in Mangrove area, Mahakam Delta, East Kalimantan. The aim of this research was to analyze the diversity and the richness of crustacean. The research was done in the locations where dense area (Muara Ilu I), moderate area (Muara Ilu II, P. Tunu) and rare area of mangroves Muara Pantuan (P. Lagenting Luar). The transect research method was used stand upright line of the seashore for mangrove and crustacean. The result of environment parameter shows relative in good condition for living mangrove and crustacean organisms. Total founded crustacean were …