Digital Commons Network^™

Breast Carcinoma Grading, Estimation Of Tumor Size, Axillary Lymph Node Status, Staging, And Nottingham Prognostic Index Scoring On Mastectomy Specimens., Zubair Ahmad, Amna Khurshid, Asim Qureshi, Romana Idress, Nasira Asghar, Naila Kayani Naila Kayani

Department of Pathology and Laboratory Medicine

Introduction: Breast carcinoma is the most common malignant tumor and the leading cause of cancer death in women. In western countries, a sharp increase in the detection of breast carcinoma, largely due to widespread use of mammography, has recently led to a fall in breast cancer mortality. This, however, is not true for less developed countries, in which mortality continues to rise.
Objective:The aim of this study was to acquire information about the extent and spread of breast carcinoma in our Patients by grading the tumors, determining the tumor size, and axillary lymph node status, staging of the tumors …

Frances Burke Leftwich

Virginia Journal of Science

Obituary for Dr. Francis Burke Leftwich, 1933-2010.

Winners Of Undergraduate Research Funds 2009-2010

Virginia Journal of Science

Listing of undergraduate award winners for poster presentations held on October 24, 2009.

Sacred Heart University Magazine, Fall 2009, Sacred Heart University

Sacred Heart University Magazine

No abstract provided.

Accounting For Differences Among Patients In The Fda Approval Process, Mark Van Der Laan, Anup Malani, Oliver Van Der Bembom

Public Law and Legal Theory Working Papers

The FDA employs an average-patient standard when reviewing drugs: it approves a drug only if the average patient (in clinical trials) does better on the drug than on control. It is common, however, for different patients to respond differently to a drug. Therefore, the average-patient standard can result in approval of a drug with significant negative effects for certain patient subgroups (false positives) and disapproval of drugs with significant positive effects for other patient subgroups (false negatives). Drug companies have a financial incentive to avoid false negatives. After their clinical trials reveal that their drug does not benefit the average …

Lipid-Protein Interactions Probed By Electron Crystallography, Steve L. Reichow, Tamir Gonen

Chemistry Faculty Publications and Presentations

Electron crystallography is arguably the only electron cryomicroscopy (cryoEM) technique able to deliver an atomic-resolution structure of membrane proteins embedded in the lipid-bilayer. In the electron crystallographic structures of the light driven ion pump, bacteriorhodopsin, and the water channel, aquaporin-0, sufficiently high resolution was obtained and both lipid and protein were visualized, modeled and described in detail. An extensive network of lipid-protein interactions mimicking native membranes is established and maintained in two-dimensional (2D) crystalline vesicles used for structural analysis by electron crystallography. Lipids are tightly integrated into the protein's architecture where they can affect the function, structure, quaternary assembly and …

Fixing A Hole: Will Generic Biologics Find A Niche Within The Hatch-Waxman Act?, Elysa B. Goldberg

Fordham Intellectual Property, Media and Entertainment Law Journal

No abstract provided.

Focus, 2009, Fall, Andrews University

Focus

FOCUS (ISSN 1077-9345) is published quarterly, free of charge, for alumni and friends of Andrews University, an institution owned and operated by the Seventh-day Adventist Church.

2009 October/November-Newsletter, Nancy Rockey

Life Renewal Archive

No abstract provided.

Ccl3l1 And Hiv/Aids Susceptibility, Thomas J. Urban, Amy C. Weintrob, Jacques Fellay, Sara Colombo, Kevin V. Shianna, Curtis Gumbs, Margalida Rotger, Kimberly Pelak, Kristen K. Dang, Roger Detels, Jeremy J. Martinson, Stephen J. O'Brien, Norman L. Letvin, Andrew J. Mcmichael, Barton F. Haynes, Mary Carrington, Amalio Telenti, Nelson L. Michael, David B. Goldstein

Biology Faculty Articles

No abstract provided.

Expanding Access To Hiv Testing In Northern Minas Gerais, Brazil, Julia Elinor Roberts, Kimberly Marie Jones, Luçandra Ramos Espirito Santos Espirito Santos, Mauro Jose Guedes Roque, Marise Fagundes Silveira, Amaro Sérgio Marques

Southern Anthropologist

[2009 Undergraduate Prize Winner]

Brazil serves as a potent example of a nation striving to meet the public healthcare needs of a complex and diverse society. To evaluate how a public hospital in Montes Claros, Brazil has attempted to reconcile HIV/AIDS outcome gaps, this study examined aspects of the demographic profi les of public health clients receiving HIV exams in the largest city in Northern Minas Gerais at two respective sites. Age, sex, and residential neighborhood for clients tested for HIV during an eight month period in 2007-2008 at HUCF and CTA were statistically compared. In comparison to CTA, the …

A Biomechanical Comparison Of Locked Plate Fixation With Percutaneous Insertion Capability Versus The Angled Blade Plate In A Subtrochanteric Fracture Gap Model, Brett D. Crist, Afshin Khalafi, Scott J. Hazelwood, Mark A. Lee

Biomedical Engineering

Objectives: The angled blade plate has been the historical standard in fixed-angle extramedullary subtrochanteric femur fracture fixation, but it requires an extensile lateral approach to the femur. Little formal evaluation exists for specifically designed percutaneous extramedullary implants. The purpose of this study was to compare 3 locked plating constructs, all with percutaneous insertion capability, with the standard 95-degree angled blade plate to determine whether specifically designed fixed-angle extramedullary implants for subtrochanteric femur fractures were biomechanically comparable to the angled blade plate.

Methods: Forty composite adult femurs were divided into 4 equal groups. The constructs evaluated included a 95-degree angled blade …

Sex-Specific Variation In The Interaction Between Distichlis Spicata (Poaceae) And Mycorrhizal Fungi, Sarah M. Eppley, Charlene Ashley Mercer, Christian Haaning, Camille Brianne Graves

Biology Faculty Publications and Presentations

Associations between mycorrhizal fungi and plants can influence intraspecific competition and shape plant population structure. While variation in plant genotypes is known to affect mycorrhizal colonization in crop systems, little is known about how genotypes affect colonization in natural plant populations or how plant sex might influence colonization with mycorrhizal fungi in plant species with dimorphic sexual systems. In this study, we analyzed mycorrhizal colonization in males and females of the wetland dioecious grass Distichlis spicata, which has spatially segregated sexes. Our results suggest that D. spicata males and females interact with mycorrhizal fungi differently. We discuss the implications for …

Athletics & Recreation Master Plan Sub‐Committee Final Report, Charlie Titus, Terry Condon, Chris Fitzgerald, Ken Mcbryde, Robert Burgess, Shaun Curry, Laurie Milliken, Chris Sweeney, Pavel Braude, Ryan Norton, Jack Looney, Susan Wolfson, Jain Ruvidich‐Higgins

Campus Master Planning Publications

In 2000 the Athletics & Recreation Department at UMass Boston Implemented a five year strategic plan that would more realistically align sports sponsorship with available financial and facility resources. We reduced the number of sports sponsored from 20 to 14 maintaining 7 sports for women and 7 sports for men. The only sports maintained without a facility were Men’s baseball and Cross Country Track. We eliminated football, swimming and indoor & outdoor track and field for men and women.

Since 2005 The Athletics & Recreation Department has been focused on University wide transition and planning efforts. In that period we …

Mcnair Messenger- Fall 2009, Mcnair Staff

McNair Messenger

McNair Scholars Program

Preparing Tomorrow’S World Language Teacher Today: The Case For Seamless Induction, Paul A. Garcia, Todd A. Hernandez, Patricia Davis-Wiley

Spanish Languages and Literatures Research and Publications

This essay is a call to action. It offers a comprehensive overview of the challenges facing world language (WL) teacher educators and their employers, the K-12 schools, during the teacher induction period. We propose a new paradigm for WL teacher education based on national accreditation standards, best-practice pedagogy, insights from the professional literature on methods education, and the enhanced role of the methods instructor/supervisor. In order to become successful in the classroom, the pre-service educator undergoes a seamless period of induction that is student-centered and college/university-supported beyond the classroom arena.

President Nixon’S Decision To Renounce The U.S. Offensive Biological Weapons Program, Jonathan B. Tucker, Erin R. Mahan

WMD Case Studies

The nuclear arms race between the United States and the Soviet Union was a prominent feature of the Cold War. A lesser known but equally dangerous element of the superpower competition involved biological weapons (BW), living microorganisms that cause fatal or incapacitating diseases in humans, animals, or plants. By the late 1960s, the United States and the Soviet Union had both acquired advanced BW capabilities. The U.S. biological weapons complex, operated by the U.S. Army Chemical Corps, consisted of a research and development laboratory at Fort Detrick in Maryland, an open-air testing site at Dugway Proving Ground in Utah, and …

Columns Fall 2009, Southern Adventist University

Alumni Newsletter

Features the article "Still Cool at 40". Take a look at the improvements to McKee Library that are making it an even more popular spot with students as it celebrates its 40th birthday.

Wages Required For Self-Sufficiency In South Dakota, Kristi Corocran, Michael Mccurry

SDSU Extension Circulars

This publication discusses how much money a South Dakota breadwinner has to earn to be considered self-sufficient. The data presented is at the county level, reflecting the difference in cost of living among the state’s counties. The authors replicate the techniques developed by Diana Pearce in The Self-Sufficiency Standard for South Dakota (2000). Pearce described self-sufficiency as “earning adequate wages to provide for basic needs without additional support.” As Pearce’s publication has become dated and it seems unreasonable to wait for another regional study to update our local data, in respectfully updating her report, we stand on Dr. Pearce’s shoulders.

Molt Migration By Giant Canada Geese In Eastern South Dakota, Charles D. Dieter, Bobby J. Anderson

Natural Resource Management Faculty Publications

We captured giant Canada geese (Branta canadensis maxima) in 7 counties in eastern South Dakota during the summer molting period, 2000–2003. We attached very high frequency (VHF) transmitters to 150 adult female geese with brood patches, and leg bands to 3,839 geese. We documented molt migrations using VHF telemetry and indirect band recovery at locations north of South Dakota. Telemetry of radio-collared female geese during the breeding season indicated that 56% of nonbreeders, 81% of unsuccessful breeders, and 19% of successful female breeders embarked on a molt migration. Five of 34 geese that underwent molt migrations moved to …

Political Science Fall 2009, Dan Sabia

Political Science Newsletter Fall 2009

No abstract provided.

Actuarial Review Of The Tenncare And Tenncare Partners Programs, Development Of Fiscal Year 2010 Per Capita Costs, Tennessee. Division Of Tenncare.

TennCare Actuarial Report

No abstract provided.

Effects Of Warming And Altered Precipitation On Plant And Nutrient Dynamics Of A New England Salt Marsh., Heather Charles, Jeffrey S. Dukes

Department of Forestry & Natural Resources Faculty Publications

Salt marsh structure and function, and consequently ability to support a range of species and to provide ecosystem services, may be affected by climate change. To better understand how salt marshes will respond to warming and associated shifts in precipitation, we conducted a manipulative experiment in a tidal salt marsh in Massachusetts, USA. We exposed two plant communities (one dominated by Spartina patens–Distichlis spicata and one dominated by short form Spartina alterniflora) to five climate manipulations: warming via passive open-topped chambers, doubled precipitation, warming and doubled precipitation, extreme drought via rainout shelter, and ambient conditions. Modest daytime …

Egfr May Couple Moderate Alcohol Consumption To Increased Breast Cancer Risk, Christopher P. Mill, Julia Chester, David J. Riese Ii

Department of Psychological Sciences Faculty Publications

Alcohol consumption is an established risk factor for breast cancer. Nonetheless, the mechanism by which alcohol contributes to breast tumor initiation or progression has yet to be definitively established. Studies using cultured human tumor cell lines have identified signaling molecules that may contribute to the effects of alcohol, including reactive oxygen species and other ethanol metabolites, matrix metalloproteases, the ErbB2/Her2/Neu receptor tyrosine kinase, cytoplasmic protein kinases, adenylate cyclase, E-cadherins, estrogen receptor, and a variety of transcription factors. Emerging data suggest that the epidermal growth factor receptor (EGFR) tyrosine kinase may contribute to breast cancer genesis and progression. Here we integrate …

Observations Of Neck-Collared Canada Geese Near John F. Kennedy International Airport, New York, Thomas W. Seamans, Scott E. Clemons, Allen L. Gosser

United States Department of Agriculture Wildlife Services: Staff Publications

Canada geese (Branta canadensis) often cause significant damage when they strike aircraft. They are responsible for a reported minimum of $2.6 million in damage per year to civil aviation in the United States. Knowledge of goose movements in relation to airports would allow wildlife managers to allocate time and funds to manage those populations that pose the greatest threat to aircraft. We placed alpha-numeric neck collars on 300 Canada geese within 8 km of both John F. Kennedy International Airport (JFKIA) and LaGuardia Airport in New York, New York. We conducted weekly observations for 2 years within a …

The Saudi Thrombosis And Familial Thrombophilia Registry. Design, Rational, And Preliminary Results, Jalal N. Saour, Mohammed M. Shoukri, Layla A. Mammo

Saudi Medical Journal

OBJECTIVE: To describe the Registry and report preliminary data for the prevalence of 5 prothrombotic gene mutations in the normal Saudi population. METHODS: Blood from consenting healthy Saudi individuals and patients with venous thrombosis (VT) from different regions of the Kingdom was collected from November 2001 until July 2007. The extracted DNA of each sample was kept at -70 degrees C until tested for 5 known prothrombotic factors using established methods. Only patients with confirmed VT were included. Data generated through direct interview were entered into the Saudi Thrombosis and Familial Thrombophilia (S-TAFT) Register. The consent and demographic data collection …

Pseudomyxoma Peritonei. Presenting As A Localized Perforation Of The Cecum, Fraz Fahim, Saleh M. Al-Salamah

Saudi Medical Journal

No abstract provided.

Anthropological, Theological, And Ethical Aspects Of Human Life And Procreation, Christopher Kaczor

Philosophy Faculty Works

No abstract provided.

Philosophy And Theology: Notes On Procreative Beneficence, Christopher Kaczor

Philosophy Faculty Works

No abstract provided.

Teaching Star Trek As Anthropology, Margaret Williamson Huber

Southern Anthropologist

The original Star Trek television show is a “natural” for teaching anthropology. Like all science fi ction, the show is a refl ection of contemporary concerns--a form of mythology. Beyond this, the original show relied extensively on anthropological theory and ethnography in the construction of its plots. The author’s undergraduate course, described in this paper, aims to make students aware of these and also of the concerns of the nineteen-sixties (Viet Nam, the Cold War, civil rights, Hippies) that motivated many of the episodes. In the process, it illustrates how popular culture texts can be used in the classroom to …