Digital Commons Network^™

Methods And Devices For Cryopreservation Of Biological Cells And Tissues, Dayong Gao, Gary Van Zant, Xiangdong Cui

Mechanical Engineering Faculty Patents

Novel methods, compositions, and devices for achieving optimal cooling of living cells during cryopreservation are disclosed. In one aspect, the method comprises gradually cooling the cell to a first predetermined temperature, followed by rapidly cooling the cell to a second predetermined temperature. In another aspect, a device is described for achieving a desired cooling rate for a cell, comprising a first container for holding a cell, a second container for holding the first container, and optionally a frame for holding the first container in a spaced apart relationship with the second container. The method of the invention comprises placing cells …

St-08 - North Dakota - 2009-10-20, Alfred Peterson

State Representatives

No abstract provided.

Montana Kaimin, October 20, 2009, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Modulation Of The Phospholipase A2 Pathway As A Therapeutic, Daniel Paris, Terrence C. Town, Michael J. Mullan

USF Patents

There is provided a method of modifying vasoactivity by regulating a soluble Aβ pro-inflammatory pathway. Also provided is a method of modifying inflammatory reactions in microglia and neurons by regulating a soluble Aβ pro-inflammatory pathway. A method of treating patients with vascular disease by modifying an intracellular soluble Aβ pro-inflammatory pathway is also provided. A pharmaceutical composition consisting essentially of an effective amount of a soluble Aβ pro-inflammatory pathway regulator in a pharmaceutically effective carrier is also provided.

An Eiav Field Isolate Reveals Much Higher Levels Of Subtype Variability Than Currently Reported For The Equine Lentivirus Family, Jodi K. Craigo, Shannon Barnes, Baoshan Zhang, Sheila J. Cook, Laryssa Howe, Charles J. Issel, Ronald C. Montelaro

Veterinary Science Faculty Publications

BACKGROUND: Equine infectious anemia virus (EIAV), a lentivirus that infects horses, has been utilized as an animal model for the study of HIV. Furthermore, the disease associated with the equine lentivirus poses a significant challenge to veterinary medicine around the world. As with all lentiviruses, EIAV has been shown to have a high propensity for genomic sequence and antigenic variation, especially in its envelope (Env) proteins. Recent studies have demonstrated Env variation to be a major determinant of vaccine efficacy, emphasizing the importance of defining natural variation among field isolates of EIAV. To date, however, published EIAV sequences have been …

The Current Volume 20 : Issue 10, Nova Southeastern University

Student Newspapers

No abstract provided.

The George-Anne, Georgia Southern University

The George-Anne

• A Memorial Park or a Parking Lot?
• News
• Opinions
• Features
• Classifieds
• Sports

Integral Membrane Proteins Brr6 And Apq12 Link Assembly Of The Nuclear Pore Complex To Lipid Homeostasis In The Endoplasmic Reticulum, Christine A. Hodge, Vineet Choudhary, Michael J. Wolyniak, John J. Scarcelli, Roger Schneiter, Charles N. Cole

Dartmouth Scholarship

Cells of Saccharomyces cerevisiae lacking Apq12, a nuclear envelope (NE)-endoplasmic reticulum (ER) integral membrane protein, are defective in assembly of nuclear pore complexes (NPCs), possibly because of defects in regulating membrane fluidity. We identified BRR6, which encodes an essential integral membrane protein of the NE-ER, as a dosage suppressor of apq12 Delta. Cells carrying the temperature-sensitive brr6-1 allele have been shown to have defects in nucleoporin localization, mRNA metabolism and nuclear transport. Electron microscopy revealed that brr6-1 cells have gross NE abnormalities and proliferation of the ER. brr6-1 cells were hypersensitive to compounds that affect membrane biophysical properties and to …

Minimal Membrane Docking Requirements Revealed By Reconstitution Of Rab Gtpase-Dependent Membrane Fusion From Purified Components, Christopher Stroupe, Christopher M. Hickey, Joji Mima, Amy S. Burfeind, William Wickner

Dartmouth Scholarship

Rab GTPases and their effectors mediate docking, the initial contact of intracellular membranes preceding bilayer fusion. However, it has been unclear whether Rab proteins and effectors are sufficient for intermembrane interactions. We have recently reported reconstituted membrane fusion that requires yeast vacuolar SNAREs, lipids, and the homotypic fusion and vacuole protein sorting (HOPS)/class C Vps complex, an effector and guanine nucleotide exchange factor for the yeast vacuolar Rab GTPase Ypt7p. We now report reconstitution of lysis-free membrane fusion that requires purified GTP-bound Ypt7p, HOPS complex, vacuolar SNAREs, ATP hydrolysis, and the SNARE disassembly catalysts Sec17p and Sec18p. We use this …

Grand Valley Forum, Volume 034, Number 08, October 19, 2009, Grand Valley State University

2009-2010, Volume 34

Grand Valley Forum is Grand Valley State's faculty and staff newsletter, published from 1976 to the present.

Tryptophan Depletion By Indoleamine 2,3-Dioxygenase (Ido) Contributes To Medial Immunoprivilege In Graft Arteriosclerosis, Amanda Silverio

Yale Medicine Thesis Digital Library

TRYPTOPHAN DEPLETION BY INDOLAMINE 2,3-DIOXYGENASE (IDO) CONTRIBUTES TO MEDIAL IMMUNOPRIVILEGE IN GRAFT ARTERIOSCLEROSIS. Amanda M. Silverio, Madison C. Cuffy, and George Tellides. Interdepartmental Program in Vascular Biology and Transplantation and the Departments of Surgery and Immunobiology, Yale University, School of Medicine, New Haven, CT. Introduction: Since blood vessels and their endothelial lining are major stimulators and targets of the graft rejection response, the study of the differential immune properties of vascular cells is needed for the proper application of human vessels in the transplant setting. Experimental models of atherosclerosis and graft arteriosclerosis show leukocytes selectively infiltrating the intima and adventitia …

The Statesman, V. 53, I. 12, Stony Brook University

Stony Brook Statesman-Sucolian

v. 53, i. 12

Current, October 19, 2009, University Of Missouri-St. Louis

Current (2000s)

No abstract provided.

Daily Eastern News: October 19, 2009, Eastern Illinois University

October

No abstract provided.

The Collegian (2009-10-19), Julianna Sosa

UTB/TSC Archives - The Collegian [Newspaper]

Vol. 62, No. 9

Central Florida Future, Vol. 41 No. 82, October 19, 2009

Central Florida Future

Crime down 22.2 percent from '08; Kitchen confidential; H&M opening attracts students; Students struggle to find part-time work; War protesters gather near UCF.

October 19, 2009 Reporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Tubular Carcinoma Of The Breast Versus Invasive Ductal Carcinoma Treated With Breast Conservation Therapy, Gene-Fu Liu

Yale Medicine Thesis Digital Library

Purpose: The purpose of our study is to evaluate our institutional experience of treating Tubular Carcinoma of the Breast (TC) and Invasive Ductal Carcinoma (IDC) with Breast Conservation Therapy (BCT), consisting of conservative surgery (CS) and radiation therapy (RT), and to compare clinical-pathologic features and long-term outcomes. Materials and Methods: A review of our institutions tumor registry from 1975-2007 was performed, followed by a central pathology review of available slides, yielding 71 cases of Stage I/II TC and 2238 cases of Stage I/II IDC treated with BCT. Results: Clinical-pathologic features and outcomes were then analyzed by subtype to detect significant …

Systematics And Biogeography Of The Didymopanax Group Of Schefflera (Araliaceae), Pedro Fiaschi

Theses and Dissertations

Schefflera is the largest genus in the angiosperm family Araliaceae, with about 900 species, of which c. 300 belong to five subgeneric groups in the Neotropical region. Previous phylogenetic studies of Schefflera have been limited to a small number of species from this region, and very little is know about phylogenetic relationships in the Brazilian-centered Didymopanax group of this genus. Therefore, to gain a better understanding of the diversity and evolution of the Didymopanax group of Schefflera, I investigated the systematics of these plants in the broader context of the entire Neotropical clade. The main goals were (1) to investigate …

Monitor Newsletter October 19, 2009, Bowling Green State University

Monitor

Official Publication of Bowling Green State University for Faculty and Staff

Isotopic Evaluation Of Carbon Dioxide In Soil Gas In Utah For A More Accurate Input Variable In Groundwater Age Determining Models, Rachelle Hart

Theses and Dissertations

In order to achieve a more accurate input value for groundwater age determining models, δ13CVPDB values for soil gas were evaluated at 50 cm depths in locations throughout Utah in order to define correlations between δ13C and environmental parameters. 16 sites were chosen that exploited large changes in elevation and latitude which provided variations in climate, precipitation, plant community, etc. Gas samples were collected over 1-1½ years, and soil samples were collected at depth during installations. Field and laboratory studies were also used to evaluate CO2 and δ13C change with depth. It was discovered that in mountainous recharge areas, the …

Ensemble Concerts: Men's Glee Club Reunion Concert, October 19, 2009, School Of Music

School of Music Programs

Center for the Performing Arts
Sunday Afternoon
October 19, 2009
3:00 p.m.

Capillary Blood Gas Measurement As A Novel Means Of Assessing Flap Perfusion In Free Tissue Transfer, Aaron Remenschneider

Yale Medicine Thesis Digital Library

CAPILLARY BLOOD GAS MEASUREMENT AS A NOVEL MEANS OF ASSESSING FLAP PERFUSION IN FREE TISSUE TRANSFER. Aaron K. Remenschneider and Douglas A. Ross (Sponsored by Dr. Clarence Sasaki). Section of Otolaryngology, Department of Surgery, Yale University, School of Medicine, New Haven, CT. To demonstrate that in comparison to implantable O2 microelectrodes, Capillary Blood Gas measurements represent a reliable, accessible and easy method of identifying failing free flaps, and furthermore, to assess post-operative free-flap monitoring techniques nation-wide, determining the openness of surgeons to new surveillance modalities. Groin fasciocutaneous flaps were elevated in 10 rats and following arterial or venous occlusion, oxygen …

October 19, 2009, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Medical School Watercooler Newsletter - October 18, 2009, Lindsey Lyle

Watercooler Newsletter

This is the October 18, 2009 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler

Contents Include

• This Week's DSS - "Pharmacogenomics and Individualized Drug Therapy"
• Dr. David Laycock Joins USA Physicians Group

Modeling Multilevel Sleep Transitional Data Via Poisson Log-Linear Multilevel Models, Bruce J. Swihart

COBRA Preprint Series

This paper proposes Poisson log-linear multilevel models to investigate population variability in sleep state transition rates. We specifically propose a Bayesian Poisson regression model that is more flexible, scalable to larger studies, and easily fit than other attempts in the literature. We further use hierarchical random effects to account for pairings of individuals and repeated measures within those individuals, as comparing diseased to non-diseased subjects while minimizing bias is of epidemiologic importance. We estimate essentially non-parametric piecewise constant hazards and smooth them, and allow for time varying covariates and segment of the night comparisons. The Bayesian Poisson regression is justified …

Sphingolipid-Induced Activation Of The Volume-Sensitive Cl− Current Is Mediated By Mitochondrial Reactive Oxygen Species, Frank Raucci

Theses and Dissertations

Swelling-activated Cl− current (ICl,swell) is an outwardly-rectifying current that plays an important role in cardiac electrical activity, cellular volume regulation, apoptosis, and acts as a potential effector of mechanoelectrical feedback. Persistent activation of ICl,swell has been observed in a number of models of cardiovascular disease. Previously we showed that angiotensin II (Ang II), endothelin-1 (ET-1), endothelial growth factor receptor (EGFR), and reactive oxygen species (ROS) produced by NADPH oxidase (NOX) and mitochondria are involved in the activation of ICl,swell by both osmotic swelling and Beta1 integrin stretch. Sphingolipid metabolism is modulated in several cardiopathologies and because sphingolipids are bioactive lipids …

Jeff Corwin, Center For Performing Arts

Center for Performing Arts Memorabilia

Playbill insert for the October 17, 2009 performance of Tales from the Field by Jeff Corwin.

The Murray Ledger And Times, October 17, 2009, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

The Plain Person And The Catholicity Of Philosophy, Bryan R. Cross

Conference on Philosophy and Theology

No abstract provided.