Digital Commons Network^™

Kajian Bioaktiviti Dan Kandungan Kimia Cassia Alata L. Dan Cassia Tora L. / Mastura Binti Abd. Malek, Mastura Abd. Malek

Student Works (2000-2009)

Kajian telah dijalankan ke atas dua spesies tumbuhan ubatan iaitu Cassia alata L. dan Cassia tora L. untuk mengenalpasti kandungan kimia yang hadir dan bioaktivitinya. Penskrinan fitokimia terhadap ekstrak-ekstrak tumbuhan kajian menunjukkan kehadiran sebatian-sebatian seperti antrakuinon, terpenoid dan flavanoid. Aktiviti antimikrob oleh ekstrak tumbuhan kajian dikaji terhadap beberapa strain bakteria, yis dan kulat yang bersifat patogenik kepada manusia. Cassia alata L. dan Cassia tora L. menunjukkan aktiviti antimikrob yang kuat ke atas strain bakteria. Ujian antioksidan yang terdiri daripada tiga jenis asai iaitu asai pelupusan DPPH, asai pengurangan kuasa dan asai pelunturan β-karotena telah dijalankan untuk mengkaji aktiviti antioksidan ekstrak …

Synthesis, Characterization, And Photocatalytic Degradation Of Some Organotin Compounds / Mohammad Reza Reisi, Mohammad Reza Reisi

Student Works (2000-2009)

Organotin compounds (OTCs) are the compounds that have at least one C- Sn bond. Some of the organotin compounds are hazardous to the environment. This is particularly true for tributyltin chloride (TBTCl) which has been used as antifouling agent on painting of the ships. This compound caused hazardous problems for marine environment. In this work, photo-degradation of this compound in water was performed by ultraviolet irradiation, ultraviolet irradiation in the presence of TiO2 and ultraviolet irradiation in the presence of a mixture of TiO2 and polyoxometallate (POM). The rate of photo-degradation reaction of TBTCl was investigated and rate of reactions …

Teori Istihalah Menurut Perspektif Islam Dan Sains : Aplikasi Terhadap Beberapa Penghasilan Produk Makanan / Mohammad Aizat Bin Jamaludin, Mohammad Aizat Jamaludin

Student Works (2000-2009)

Kajian ini memfokuskan aplikasi teori Istihalah menurut perspektif Islam dan sains. Pada dasarnya, teori ini tidak distrukturkan dengan sistematik dalam khazanah perbendaharaan fiqh Islam. Manakala dalam perspektif sains tiada satu perbincangan khusus yang melibatkan Istihalah. Walaupun begitu, ia mempunyai konotasi yang hampir sinonim dengan teori perubahan zat. Kajian ini melibatkan aplikasi teori Istihalah terhadap beberapa penghasilan produk makanan. Untuk mencapai objektif yang ditetapkan, pengkaji telah menggunakan beberapa metode. Di antaranya ialah metode pengumpulan data yang merangkumi kajian perpustakaan dan kajian lapangan. Kajian perpustakaan diaplikasi untuk mendapatkan data-data primer dan sekunder khususnya sebagai landasan dan struktur teori Istihalah. Manakala dalam kajian …

Efl Learning Strategies Used By Female Undergraduate Students / Wafa Ismail Saud, Ismail Saud Wafa

Student Works (2000-2009)

The aim of the present study was to provide an accurate and holistic description of the language learning strategies used by female EFL undergraduate students, as well as to explore the relationship of language learning strategies with the two variables: major field of study and performance level in the English language. It also aimed at specifying the English language learning strategies that were associated with the four language skills. The survey method was used on a sample of 264 female EFL undergraduate students who were enrolled in the first and second year of their undergraduate degree programme. Their majors were …

An Investigation Into Hotel Employees' Perception Of Green Practices, Sun-Hwa Kim

Electronic Theses and Dissertations

This study examined how employees of the hotel industry perceived green practices. Data was collected from 220 employees working in eight green certified hotels in Orlando. Research results revealed that performance levels of green practices implemented by hotels were lower than the importance levels of those same green practices as perceived by hotel employees. The results of the study illustrated that (1) the employees' perception regarding green practices was not different than one of hoteliers in terms of importance and performance, and (2) employees weighted the green practices that were beneficial to them as more important than green practices that …

Delayed Rejection Of Mhc Class Ii-Disparate Skin Allografts In Mice Treated With Farnesyltransferase Inhibitors, Ken Field

Faculty Journal Articles

Farnesyltransferase inhibitors (FTIs), developed as anti-cancer drugs, have the potential to modulate immune responses without causing nonspecific immune suppression. We have investigated the possibility that FTIs, by affecting T cell cytokine secretion, can attenuate alloreactive immune responses. The effects of FTIs on murine alloreactive T cells were determined both in vitro, by measuring cytokine secretion or cell proliferation in mixed lymphocyte cultures, and in vivo, by performing skin allografts from H-2^bm12mice to MHC class II-disparate B6 mice. We found that two different FTIs, ABT-100 and L-744,832, blocked secretion of IFN-γ, IL-2, IL-4, and TNF-α from naïve …

Roses Are Red, Violets Are Bluehow Poetry In Science Can Help Students Learn Something New, Kimberly Casselman

Electronic Theses and Dissertations

This study was an attempt to examine how poetry integrated with science could assist eighth graders in the memorization of key science vocabulary words. Furthermore, it would investigate if student attitude, interest, and motivation would improve with the use of the poetry. Instruction was adjusted to implement poetry into astronomy lessons. Memorization activities such as poems, chanting, and repetition were used to help students remember the vocabulary and the definitions. Pre/post tests were used to interpret if the poetry did assist in the memorization of the astronomy vocabulary. Science interest surveys and science attitude surveys were used to interpret if …

Changes In Longitudinally Assessed Biomechanical Parameters Related To Increased Risk Of Anterior Cruciate Ligament (Acl) Injuries In Adolescent Female And Male Athletes, Kevin Ray Ford

University of Kentucky Doctoral Dissertations

Females suffer anterior cruciate ligament (ACL) injuries at a 2 to 10-fold greater rate compared to male athletes participating in similar sports. Altered movement patterns and inadequate knee stiffness are two interrelated factors that may increase ACL injury risk. Onset of these neuromuscular risk factors may coincide with the rapid adolescent growth that results in the divergence of a multitude of neuromuscular parameters between sexes. The overall purpose of this dissertation was to determine if neuromuscular ACL injury risk factors in female athletes increase following rapid growth and development compared to males. Male and female athletes were tested with three-dimensional …

The Interaction Between Personality Traits And Contextual Disadvantage On Criminal Behavior: A Longitudinal Study Of High Risk-Females, Lauren C. Gudonis

University of Kentucky Doctoral Dissertations

This investigation examined several dimensions of personality functioning in a longitudinal sample of females. These data are part of an existing project evaluating female development across 3 different time points starting in adolescence and transitioning into adulthood. Subjects were categorized into a clinical group (females with a high degree of psychiatric comorbidity) and a normal control group. All participants were initially recruited when they were between 14-18 years of age, and were followed up twice when they were 19-23, and 24-28. In an attempt to explore possible heterogeneity in personality trait development, the research is presented as three separate studies …

Regulation Of Low Density Lipoprotein Receptor Splicing Efficiency, I-Fang Ling

University of Kentucky Doctoral Dissertations

Low density lipoprotein receptor (LDLR) is an apolipoprotein E (apoE) receptor and may play a role in Alzheimer’s disease (AD) development. A single nucleotide polymorphism (SNP), rs688, that has been identified to modulate the splicing efficiency of LDLR exon 12 and is associated with higher cholesterol and AD in some case-control populations. The exon 12 deleted mRNA is predicted to produce a soluble form of LDLR that fails to mediate apoE uptake. To gain additional insights, in this study, I seek to understand the regulation of LDLR splicing efficiency. To identify functional cis-elements within LDLR exon 12, I mutated several …

Direct Products And The Intersection Map Of Certain Classes Of Finite Groups, Julia Chifman

University of Kentucky Doctoral Dissertations

The main goal of this work is to examine classes of finite groups in which normality, permutability and Sylow-permutability are transitive relations. These classes of groups are called T , PT and PST , respectively. The main focus is on direct products of T , PT and PST groups and the behavior of a collection of cyclic normal, permutable and Sylow-permutable subgroups under the intersection map. In general, a direct product of finitely many groups from one of these classes does not belong to the same class, unless the orders of the direct factors are relatively prime. Examples suggest that …

Age May Be Hazardous To Outcome Following Traumatic Brain Injury: The Mitochondrial Connection, Lesley Knight Gilmer

University of Kentucky Doctoral Dissertations

Older individuals sustaining traumatic brain injury (TBI) experience a much higher incidence of morbidity and mortality. This age-related exacerbated response to neurological insult has been demonstrated experimentally in aged animals, which can serve as a model to combat this devastating clinical problem. The reasons for this worse initial response are unknown but may be related to age-related changes in mitochondrial respiration.

Evidence is shown that mitochondrial dysfunction occurs early following traumatic brain injury (TBI), persists long after the initial insult, and is severitydependent. Synaptic and extrasynaptic mitochondrial fractions display distinct respiration capacities, stressing the importance to analyze these fractions separately. …

Droplet Flows In Microchannels Using Lattice Boltzmann Method, Amit Gupta

Electronic Theses and Dissertations

Microelectromechanical systems (MEMS) have widespread applications in medical, electronical and mechanical devices. These devices are characterized by the smallest dimension which is at least one micrometer and utmost one millimeter. Rapid progress in the manufacture and utilization of these microdevices has been achieved in the last decade. Current manufacturing techniques of such devices and channels include surface silicon micromachining; bulk silicon micromachining; lithography; electrodeposition and plastic molding; and electrodischarge machining (EDM). In recent years, electrostatic, magnetic, electromagnetic and thermal actuators, valves, gears and diaphragms of dimensions of hundred microns or less have been fabricated successfully. Sensors have been manufactured that …

Learning Semantic Features For Visual Recognition, Jingen Liu

Electronic Theses and Dissertations

Visual recognition (e.g., object, scene and action recognition) is an active area of research in computer vision due to its increasing number of real-world applications such as video (image) indexing and search, intelligent surveillance, human-machine interaction, robot navigation, etc. Effective modeling of the objects, scenes and actions is critical for visual recognition. Recently, bag of visual words (BoVW) representation, in which the image patches or video cuboids are quantized into visual words (i.e., mid-level features) based on their appearance similarity using clustering, has been widely and successfully explored. The advantages of this representation are: no explicit detection of objects or …

New Computational Approaches For Multiple Rna Alignment And Rna Search, Daniel Deblasio

Electronic Theses and Dissertations

In this thesis we explore the the theory and history behind RNA alignment. Normal sequence alignments as studied by computer scientists can be completed in O(n2) time in the naive case. The process involves taking two input sequences and finding the list of edits that can transform one sequence into the other. This process is applied to biology in many forms, such as the creation of multiple alignments and the search of genomic sequences. When you take into account the RNA sequence structure the problem becomes even harder. Multiple RNA structure alignment is particularly challenging because covarying mutations make sequence …

Vortex Model Of Open Channel Flows With Gravel Beds, Brian James Belcher

University of Kentucky Doctoral Dissertations

Turbulent structures are known to be important physical processes in gravel-bed rivers. A number of limitations exist that prohibit the advancement and prediction of turbulence structures for optimization of civil infrastructure, biological habitats and sediment transport in gravel-bed rivers. This includes measurement limitations that prohibit characterization of size and strength of turbulent structures in the riverine environment for different case studies as well as traditional numerical modeling limitations that prohibit modeling and prediction of turbulent structure for heterogeneous beds under high Reynolds number flows using the Navier-Stokes equations. While these limitations exist, researchers have developed various theories for the structure …

The Role Of The Hip Abductor Muscle Complex In The Function Of The Pathological Hip Joint, Maureen Kelly Dwyer

University of Kentucky Doctoral Dissertations

The number of patients electing to undergo total hip arthroplasty (THA) in the United States has been projected to double by the year 2030, with a growing number of these patients below the age of 65 years. This cohort of patients not only desires to return to pain free daily activity, but wishes to participate in recreation and sporting activities. However, many of these patients report pain, impairments, and functional limitations following THA. The number one deficit observed for patients who fail conventional post-operative rehabilitation is persistent weakness of the hip abductor muscles. In order to safely progress these patients …

Investigations Of S-Glutathionylation Of Brain Proteins In The Progression Of Alzheimer's Disease And Of A Potential Glutatione Mimetic As A Treatment Of Alzheimer's Disease, Shelley Faye Newman

University of Kentucky Doctoral Dissertations

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by neurofibrillary tangles, senile plaques and loss of synapses. Many studies support the notion that oxidative stress plays an important role in AD pathogenesis. Previous studies from our laboratory employed redox proteomics to identify oxidatively modified proteins in the AD inferior parietal lobule (IPL). The proteins were consistent with AD pathology and have been central to further investigations of the disease. The present study was focused on the identification of specific targets of protein S-glutathionylation in AD, early AD (EAD), and mild cognative impairment (MCI) using a redox proteomics approach. In AD …

Lipid-Based Paclitaxel And Doxorubicin Nanoparticles To Overcome P-Gp-Mediated Drug Resistance In Solid Tumors, Xiaowei Dong

University of Kentucky Doctoral Dissertations

Multidrug resistance (MDR) is a major obstacle limiting chemotherapeutic efficacy. The purpose of these studies was to investigate the potential application of injectable paclitaxel (PX) and doxorubicin (Dox)-loaded nanoparticles (NPs) engineered from oil-in-water microemulsion precursors for overcoming P-glycoprotein (P-gp)- mediated drug resistance in solid tumors.

An in-vitro study was performed to test whether the oil (stearyl alcohol and cetyl alcohol) used to make lipid nanoparticles could be metabolized. The results showed that the concentrations of the fatty alcohols within nanoparticles, which were quantitatively determined over time by gas chromatography, decreased to only 10-20% of the initial concentration after 15-24 h …

Studies On The Role Of Acid Sphingomyelinase And Ceramide In The Regulation Of Tace Activity And Tnfα Secretion By Macrophages, Krasimira Rozenova

University of Kentucky Doctoral Dissertations

Acid Sphingomyelinase (ASMase) activity has been proposed to mediate LPS signaling in various cell types. This study shows that in macrophages, ASMase is a negative regulator of LPS-induced TNFα secretion. ASMasedeficient (asm^-/-) mice and isolated peritoneal macrophages produce several fold more TNFα than their wild-type (asm^+/+) counterparts when stimulated with LPS. The mechanism for these differences however is not transcriptional but post-translational.

The TNFα converting enzyme (TACE) catalyzes the maturation of the 26kD precursor (proTNFα) to the active 17kD form (sTNFα). In mouse peritoneal macrophages, the activity of TACE rather than the rate of TNFα mRNA …

Computational Design Of 3-Phosphoinositide Dependent Kinase-1 Inhibitors As Potential Anti-Cancer Agents, Mohamed Diwan Mohideen Abdulhameed

University of Kentucky Doctoral Dissertations

Computational drug design methods have great potential in drug discovery particularly in lead identification and lead optimization. 3-Phosphoinositide dependent kinase-1 (PDK1) is a protein kinase and a well validated anti-cancer target. Inhibitors of PDK1 have the potential to be developed as anti-cancer drugs. In this work, we have applied various novel computational drug design strategies to design and identify new PDK1 inhibitors with potential anti-cancer activity. We have pursued novel structure-based drug design strategies and identified a new binding mode for celecoxib and its derivatives binding with PDK1. This new binding mode provides a valuable basis for rational design of …

Biology And Management Of The Bed Bug, Cimex Lectularius L. (Heteroptera: Cimicidae), Alvaro Romero

University of Kentucky Doctoral Dissertations

The near absence of bed bugs from human dwellings for fifty or more years has left us with limited knowledge of its biology and few answers to eliminate populations. I explored a diverse set of objectives to answer key questions concerning bed bug biology and control. Major objectives were studies of circadian rhythmicity, pyrethroid resistance, sublethal effects of insecticides, synergism of pyrethroids, and evaluation of a pyrrole insecticides, chlorfenapyr. Additional studies included persistence of Borrelia in bed bugs after ingestion, and aggregation factors from feces.

In the absence of host stimuli, insects were much more active in the dark than …

Synthesis And Evaluation Of Prouteolysis Taurgeting Chimeras (Protacs): A Potential Chemical Genetic Approach To Breast Cancer Therapy, Kedra C. Cyrus

University of Kentucky Doctoral Dissertations

The use of small molecules to probe the function of proteins is referred to as chemical genetics. The Proteolysis Targeting Chimera (PROTAC) is a chemical genetic tool that contains the ligand for a target protein of interest and the recognition motif for an E3 ubiquitin ligase attached by a linker. The PROTAC is capable of binding to and recruiting specific target proteins to the intracellular degradation system, the ubiquitin proteasome system (UPS). While the approach has had success it has not been optimized to be used on a broader scale.

Optimization efforts focused on elucidating the ideal linker length between …

The Social Construction Of Client Participation: The Evolution And Transformation Of The Role Of Service Recipients In Child Welfare And Mental Disabilities, Terry Mizrahi, Mayra Humphreys-Lopez, Denise Torres

The Journal of Sociology & Social Welfare

This article presents a comparative analysis of client participation (CP) in child welfare and mental health and mental retardation systems. It identifies three rationales for client participation (philosophical, pragmatic, and political), along with the limitations surrounding each rationale. It uses social construction theory to examine the historical and ideological underpinnings of organized, institutionally-sanctioned client involvement inside and outside government. In order to enhance the capacity of clients to influence service and benefit systems, their role must evolve through the mutual efforts of government-strengthening client participation policies and independent organizing from the bottom up through community development and advocacy programs.

Detection And Determination Of Degradation And Metabolic Products Of Drugs Of Abuse And Explosives, Melissa Gayton Ely

Graduate Theses, Dissertations, and Problem Reports (ETD)

Among the different means of decomposition, thermal, environmental, and metabolic degradation play a significant role in how forensic related compounds are analyzed. In the first stage of this research, cocaine and methamphetamine were pyrolyzed utilizing a pyroprobe to detect reported products of pyrolytic/thermal degradation and smoked markers. This simple and rapid method has laid the groundwork for future smoked drug analyses. In the second stage of research, a new focus was developed on detection of explosives in soil from detonated UXO at the West Virginia Maneuver Area. TNT, RDX, HMX, tetryl, and TNT environmental degradation products were analyzed using a …

At The End Of The Clinical Trial: Does Access To Investigational Technology End As Well?, Richard S. Saver

Western New England Law Review

No abstract provided.

Environmental Law/Administrative Law--United States V. Rapanos: Justice Stevens's Suggestion May Not Be The Yellow Brick Road, But It Is The Best Pathway To Oz, Kristen M. Sopet

Western New England Law Review

No abstract provided.

Opening The Door To "Hard-Look" Review Of Agency Preemption, Karen A. Jordan

Western New England Law Review

No abstract provided.

Bridging The Gap Between Real World Polar Science And The Classroom, William Robertson, Vanessa Lougheed, Craig Tweedie, Aaron Velasco, Claudia Garcia

Departmental Papers (TE)

The International Polar Year - Research and Educational Opportunities in Antarctica for Minorities (IPY-ROAM) program was designed to increase minority participation in polar science by immersing participants in an academic program that included a trip to Antarctica. The IPY-ROAM program was focused on increasing the public understanding of the Polar Regions and stimulating a new interest in polar science. This effort was coordinated by faculty from the University of Texas at El Paso (UTEP) and was implemented to positively contribute to the intense, internationally coordinated IPY scientific campaign. Through a grant from the National Science Foundation (NSF), a team of …

International Human Rights Law, Co-Parent Adoption, And The Recognition Of Gay And Lesbian Families, Elizabeth Burleson

Elisabeth Haub School of Law Faculty Publications

Children would benefit substantially if governments legally recognized same sex marriages and parenting. This article analyzes international human rights law, co-parent adoption, and the legal recognition of gay and lesbian families. It addresses civil marriage and adoption challenges for same sex families and assesses European Court of Human Rights jurisprudence relating to same-sex adoption. This Article considers the international community's efforts to implement the best interest of the child standard concluding that recognition of same sex families is in the best interest of the child and should be facilitated in a timely manner by jurisdictions at all levels.