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Differential Regulation Of Vitamin D Receptor (Vdr) By P53, P63 And P73, Ramakrishna Kommagani

Browse all Theses and Dissertations

The tumor suppressor p53 is the single most altered gene in human cancers. p53 homologues, p63 and p73 play a major role in development and in human cancer. Both p63and p73-null mice exhibit profound developmental abnormalities, suggesting a vital role for p63 and p73 in development. Although the role of p73 in human cancers is well established, the role of p63 still remains to be understood. While p63 plays a major role in development, p73 plays a major role in tumor suppression as well as in development. Although a functional co-operation is evident between each member of p53 family, additional …

An Overview Of Cardiovascular Risk Factor Burden In Sub-Saharan African Countries: A Socio-Cultural Perspective, Rhonda Belue, Titilayo A. Okoror, Juliet Iwelunmor, Kelly D. Taylor, Arnold N. Degboe, Charles Agyemang, Gbenga Ogedegbe

Africana Studies Faculty Scholarship

Background: Sub-Saharan African (SSA) countries are currently experiencing one of the most rapid epidemiological transitions characterized by increasing urbanization and changing lifestyle factors. This has resulted in an increase in the incidence of non-communicable diseases, especially cardiovascular disease (CVD). This double burden of communicable and chronic non-communicable diseases has long-term public health impact as it undermines healthcare systems.

Purpose: The purpose of this paper is to explore the socio-cultural context of CVD risk prevention and treatment in sub-Saharan Africa. We discuss risk factors specific to the SSA context, including poverty, urbanization, developing healthcare systems, traditional healing, lifestyle and socio-cultural factors. …

Master Of Health Science 2009, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Hss Departmental Developments Winter 2009, Department Of Health And Sport Sciences

Health and Sport Sciences Newsletter

• A Shot of Health Annual Health Fair
• Updates from the Majors

A Simple Chemical Free Arsenic Removal Method For Community Water Supply - A Case Study From West Bengal, India, B. Sen Gupta, S. Chatterjee, U. Rott, H. Kauffman, A. Bandopadhyay, W. Degroot, N.K. Nag, A.A. Carbonell-Barrachina, S. Mukhopadhyay

Research Publications (2006 to 2010)

This report describes a simple chemical free method that was successfully used by a team of European and Indian scientists (www.qub.ac.uk/tipot) to remove arsenic (As) from groundwater in a village in West Bengal, India. Six such plants are now in operation and are being used to supply water to the local population (www.insituarsenic.org). The study was conducted in Kasimpore, a village in North 24 Parganas District, approximately 25 km from Kolkata. In all cases, total As in treated water was less than the WHO guideline value of 10 mg/L. The plant produces no sludge and the operation cost is 1.0 …

Biomechanical Responds Of Instep Kick Between Different Positions In Professional Soccer Players, M.A. Khorasani, Noor Azuan Abu Osman, A. Yusof

Research Publications (2006 to 2010)

No abstract provided.

Breakfast Skipping And Its Associated Factors Among Undergraduates In A Public University In Kuala Lumpur, Foong Ming Moy, Johari Surin, Y. Ismail, R. Mahad, F.H. Tie, W.M.A. Wan Ismail

Research Publications (2006 to 2010)

An analytical cross-sectional study was conducted in a public university in Kuala Lumpur among a random sample of 2665 undergraduates. The objective was to study the prevalence of breakfast skipping and its associated factors. Data collection was conducted via a self-administered pre-tested questionnaire. There were 43.5 male respondents, with Malays being the majority (58.3). The prevalence of breakfast skipping was 29.2 (95 CI: 27.3- 30.3) . The factors significantly associated with breakfast skipping (p<0.05) were age, race, accommodation, faculty and skipping dinner. As the respondents age increased, their risk of breakfast skipping was lower (OR: 0.95; 0.89 -0.99). Malays (OR: 1.94; 1.48 - 2.54), Indians (OR: 1.70; 1.08-2.66), and students from the Sabah and Sarawak indigenous communities (OR: 2.13; 1.37 - 3.33) were more likely to skip breakfast compared to their Chinese counterparts. Respondents who stayed in their own houses were also less likely to skip breakfast compared to those staying in hostel with meals catered (OR: 2.32; 1.39 -3.84), hostel with cafeteria (OR: 2.92; 1.74 -4.91) or in rented houses (OR: 2.08; 1.25-3.46). Respondents majoring in Arts & Economics had 1.40 (1.07- 1.82) times risk of breakfast skipping compared to those majoring in Life Sciences. Those who skipped dinner too had twice the odds (1.47 - 2.77) of breakfast skipping. In conclusion the prevalence of breakfast skipping among the undergraduates of this university was moderately high. Health awareness campaigns or introduction of healthy eating guidelines should be initiated for the undergraduates as well as food caterers in campus. The policy and pricing of catered food in campus should also be reviewed.

Effects Of Cultivation Techniques And Processing On Antimicrobial And Antioxidant Activities Of Hericium Erinaceus (Bull.:Fr.) Pers. Extracts, K.H. Wong, V. Sabaratnam, N. Abdullah, U.R. Kuppusamy, M. Naidu

Research Publications (2006 to 2010)

Hericium erinaceus, a temperate mushroom, is currently cultivated in Malaysia. As cultivation and processing conditions may affect the medicinal properties, antimicrobial and antioxidant properties of locally grown H. erinaceus have been investigated. The fruitbodies that were fresh, oven-dried or freeze-dried were extracted with methanol. Their properties were compared to those exhibited by mycelium extract of the same mushroom. Various extracts of H. erinaceus inhibited the growth of pathogenic bacteria but not of the tested fungus. Mycelium extract contained the highest total phenolic content and the highest ferric reducing antioxidant power (FRAP). The fresh fruitbody extract showed the most potent 1,1-diphenyl-2-picrylhydrazyl …

Elevated Levels Of Urinary Hydrogen Peroxide, Advanced Oxidative Protein Product (Aopp) And Malondialdehyde In Humans Infected With Intestinal Parasites, S. Chandramathi, K. Suresh, Z.B. Anita, U.R. Kuppusamy

Research Publications (2006 to 2010)

Oxidative stress has been implicated as an important pathogenic factor in the pathophysiology Of various life-threatening diseases such as cancer, cardiovascular diseases and diabetes. It occurs when the production of free radicals (generated during aerobic metabolism, inflammation, and infections) overcome the antioxidant defences in the body. Although previous Studies have implied that oxidative stress is present in serum of patients with parasitic infection there have been no Studies confirming oxidative stress levels in the Malaysian population infected with intestinal parasites. Three biochemical assays namely hydrogen peroxide (H(2)O(2)), lipid peroxidation (LP) and advanced oxidative protein product (AOPP) assays Were carried out …

F2-Isoprostanes As Novel Biomarkers For Type 2 Diabetes: A Review, Subramanian Kaviarasan, Sekaran Muniandy, Rajes Qvist, Ikram Shah Ismail

Research Publications (2006 to 2010)

Oxidative stress (OS) has been implicated as one of the major underlying mechanisms behind many acute and chronic diseases. However, the measurement of free radicals or their end products is complicated. Isoprostanes, derived from the non-enzymatic peroxidation of arachidonic acid are now considered to be reliable biomarkers of oxidant stress in the human body. Isoprostanes are involved in many of the human diseases such as type 2 diabetes. In type 2 diabetes elevated levels of F-2-Isoprostanes (F-2-IsoPs) have been observed. The measurement of bioactive F-2-IsoPs levels offers a unique noninvasive analytical tool to study the role of free radicals in …

Intestinal Parasitic Infections Amongst Orang Asli (Indigenous) In Malaysia: Has Socioeconomic Development Alleviated The Problem?, Y.A.L. Lim, N. Romano, N. Colin, S.C. Chow, H.V. Smith

Research Publications (2006 to 2010)

Orang Asli are the indigenous minority peoples of peninsular Malaysia. Despite proactive socioeconomic development initiated by the Malaysian Government in upgrading the quality of life of the Orang Asli communities since 1978, they still remained poor with a current poverty rate of 76.9. Poverty exacerbates the health problems faced by these communities which include malnourishment, high incidences of infectious diseases (eg. tuberculosis, leprosy, malaria) and the perpetual problem with intestinal parasitic infections. Studies reported that the mean infection rate of intestinal parasitic infections in Orang Asli communities has reduced from 91.1 in 1978, to 64.1 in the subsequent years. Although …

Multi-Tissue Coexpression Networks Reveal Unexpected Subnetworks Associated With Disease, Radu Dobrin, Jun Zhu, Cliona Molony, Carmen Argman, Mark L. Parish, Sonia Carlson, Mark F. Allan, Daniel Pomp, Eric E. Schadt

Department of Animal Science: Faculty Publications

Background: Obesity is a particularly complex disease that at least partially involves genetic and environmental perturbations to gene-networks connecting the hypothalamus and several metabolic tissues, resulting in an energy imbalance at the systems level.

Results: To provide an inter-tissue view of obesity with respect to molecular states that are associated with physiological states, we developed a framework for constructing tissue-to-tissue coexpression networks between genes in the hypothalamus, liver or adipose tissue. These networks have a scale-free architecture and are strikingly independent of gene-gene coexpression networks that are constructed from more standard analyses of single tissues. This is the first systematic …

Additional Files For “Multi-Tissue Coexpression Networks Reveal Unexpected Subnetworks Associated With Disease”, Radu Dobrin, Jun Zhu, Cliona Molony, Carmen Argman, Mark L. Parrish, Sonia Carlson, Mark F. Allan, Daniel Pomp, Eric E. Schadt

Department of Animal Science: Faculty Publications

Figure S1 shows the connectivity distribution P(k) for GGC networks. Figure S2 shows FDR curves for each tissue in the analysis. Figure S3 shows modules in single tissue GGC networks as detected by the algorithm. Each cluster is marked by the yellow rectangles. Figure S4 shows single tissue module enrichment. Each panel has the following structure: top, P-values from FET for cis-eQTL blue bars over- and red bars under-enriched; middle, percentage overlap between module and genes with cis-eQTL; bottom, percentage overlap between each module and genes on each chromosome. The scale is between green and black where green represents 0% …

Evaluation Of Antral Follicle Count And Ovarian Morphology In Crossbred Beef Cows: Investigation Of Influence Of Stage Of The Estrous Cycle, Age, And Birth Weight, R. A. Cushman, M. F. Allan, Larry A. Kuehn, W. M. Snelling, Andrea S. Cupp, H. C. Freetly

Department of Animal Science: Faculty Publications

Depletion of the ovarian reserve is associated with reproductive senescence in mammalian females, and there is a positive relationship between the size of the ovarian reserve and the number of antral follicles on the surface of the ovary. Therefore, we conducted a series of experiments to investigate the influence of stage of the estrous cycle, age, and birth weight on antral follicle counts (AFC) in beef cows and heifers. Pairs of ovaries were collected from crossbred beef cows at slaughter (n = 72) or at necropsy (n = 333; 0 to 11 yr of age); all visible antral follicles were …

Evaluation Of Antral Follicle Count And Ovarian Morphology In Crossbred Beef Cows: Investigation Of Influence Of Stage Of The Estrous Cycle, Age, And Birth Weight, R. A. Cushman, M. F. Allan, L. A. Kuehn, W. M. Snelling, Andrea S. Cupp, H. C. Freetly

Department of Animal Science: Faculty Publications

Depletion of the ovarian reserve is associated with reproductive senescence in mammalian females, and there is a positive relationship between the size of the ovarian reserve and the number of antral follicles on the surface of the ovary. Therefore, we conducted a series of experiments to investigate the influence of stage of the estrous cycle, age, and birth weight on antral follicle counts (AFC) in beef cows and heifers. Pairs of ovaries were collected from crossbred beef cows at slaughter (n = 72) or at necropsy (n = 333; 0 to 11 yr of age); all visible antral follicles were …

Evaluation Of Revalor-Ih And Revalor-Is As Initial Implants Compared With Traditional Initial Implants For Finishing Heifers And Steers, J. D. Folmer, T. B. Farran, G. E. Erickson, T. J. Klopfenstein, C. D. Reinhardt, B. D. Dicke, J. S. Drouillard, M. N. Streeter, J. T. Vasconcelos

Department of Animal Science: Faculty Publications

Two commercial feedlot experiments were conducted to compare performance and carcass characteristics of feedlot heifers and steers using 2 implant strategies. In Exp. 1, heifers (n = 1,124; initial BW = 279 ± 5 kg) were administered either Revalor-IH [Intervet/ Schering Plough Animal Health, DeSoto, KS; 8 mg of estradiol (E2) and 80 mg of trenbolone acetate (TA)] or Synovex-H (Fort Dodge Animal Health, Overland Park, KS; 20 mg of estradiol benzoate and 200 mg of testosterone propionate) at initial processing, with both treatment groups receiving Revalor-200 (20 mg E2 and 200 mg TA) as the common terminal implant 81 …

Effects Of Ractopamine (Optaflexx) Fed In Combination With Melengestrol Acetate On Feedlot Heifer Performance, W. A. Griffin, G. E. Erickson, B. D. Dicke, T. J. Klopfenstein, R. J. Cooper, D. J. Jordon, R. S. Swingle, W. M. Moseley, G. E. Sides, D. J. Weigel

Department of Animal Science: Faculty Publications

Two commercial feedlot experiments were conducted to determine the effects of feeding melengestrol acetate (MGA) or MGA plus ractopamine (MGA+OPT) on the performance and carcass characteristics of finishing heifers. In Nebraska (Exp. 1), 1,807 heifers (337.3 ± 20.0 kg) and in Texas (Exp. 2), 1,964 heifers (331.5 ± 6.1 kg) were fed 0.4 mg of MGA daily. For heifers fed MGA+OPT, 200 mg of ractopamine was fed daily the last 29 (Exp. 2) or 36 d (Exp. 1). Live and carcass-adjusted performance data were collected. On a carcass-adjusted basis, G:F for the entire feeding period was improved (P < 0.01) by 1.7 and 3.7% in Exp. 1 and 2, respectively, for heifers fed MGA+OPT compared with MGA. For the last 29 to 36 d, G:F was increased (P < 0.02) by 8.1% (Exp. 1) or 27.2% (Exp. 2) on a carcass-adjusted basis for heifers fed MGA+OPT compared with MGA. Fat thickness, USDA YG, marbling score, LM area, and percentage USDA Choice were not different (P > 0.47) between …

The Relationship Between Acid Detergent Insoluble Nitrogen And Nitrogen Digestibility In Lactating Dairy Cattle, K. J. Machacek, P. J. Kononoff

Department of Animal Science: Faculty Publications

Five trials (19 treatments) conducted at the University of Nebraska-Lincoln (UNL) on lactating dairy cattle were analyzed to determine how the concentration of ADIN in the ration affects total tract N digestibility. Additionally, 6 published studies (13 treatments) were included to expand the data set. Results from the UNL trials showed that as the concentration of ADIN in the ration increased, the digestibility of ADIN also increased. However, the relationship was poor (r² = 0.29). To account for random effects among trials, a meta-analysis was conducted. In the UNL trials, as the ration concentration of ADIN increased, total tract …

Influence Of Distillers Dried Grain Supplementation Frequency On Forage Digestibility And Growth Performance Of Beef Cattle, L. A. Stalker, D. C. Adams, T. J. Klopfenstein

Department of Animal Science: Faculty Publications

Three experiments evaluated the influence of supplementation frequency of distillers dried grains plus solubles (DDGS) on forage digestibility (Exp. 1) and growth of yearling heifers (Exp. 2) and steers (Exp. 3). In Exp. 1, 6 steers (371 ± 30 kg) were used in a replicated 3 × 3 Latin square design with three 21-d periods. Treatments were DDGS fed at 16.7% of the diet (DM) either 1) daily, 2) every other day, or 3) every third day. In Exp. 2, 48 heifers (193 ± 20 kg) were fed hay and supplemented with the daily equivalent of 1.3 kg/ heifer of …

Age And Diet Affect Gene Expression Profile In Canine Skeletal Muscle, Ingmar S. Middelbos, Brittany M. Vester, Lisa K. Karr-Lilienthal, Lawrence B. Schook, Kelly S. Swanson

Department of Animal Science: Faculty Publications

We evaluated gene transcription in canine skeletal muscle (biceps femoris) using microarray analysis to identify effects of age and diet on gene expression. Twelve female beagles were used (six 1-year olds and six 12-year olds) and they were fed one of two experimental diets for 12 months. One diet contained primarily plant-based protein sources (PPB), whereas the second diet contained primarily animal-based protein sources (APB). Affymetrix GeneChip Canine Genome Arrays were used to hybridize extracted RNA. Age had the greatest effect on gene transcription (262 differentially expressed genes), whereas the effect of diet was relatively small (22 differentially expressed genes). …

Performance And Digestibility Characteristics Of Finishing Diets Containing Distillers Grains, Composites Of Corn Processing Coproducts, Or Supplemental Corn Oil, K. J. Vander Pol, Matt K. Luebbe, G. I. Crawford, Galen E. Erickson, Terry J. Klopfenstein

Department of Animal Science: Faculty Publications

Three experiments evaluated the lipids in distillers grains plus solubles compared with corn or other sources of lipid in finishing diets. Experiment 1 utilized 60 individually fed yearling heifers (349 ± 34 kg) fed treatments consisting of 0, 20, or 40% (DM basis) wet distillers grains plus solubles (WDGS), or 0, 2.5, or 5.0% (DM basis) corn oil in a finishing diet based on high-moisture corn (HMC) and dry-rolled corn (DRC). Cattle fed 20 and 40% WDGS had greater (P < 0.10) G:F than cattle fed 0% WDGS. Cattle fed the 5.0% corn oil had lower overall performance than cattle fed the other diets. Results from Exp. 1 indicated that adding fat from WDGS improves performance, whereas supplementing 5.0% corn oil depressed G:F, suggesting that the fat within WDGS is different than corn oil. Experiment 2 used 234 yearling steers (352 ± 16 kg) fed 1 of 5 treatments consisting of 20 or 40% (DM basis) dry distillers grains plus solubles (DDGS), 1.3% or 2.6% (DM basis) tallow, or HMC. All diets contained 20% (DM basis) wet corn gluten feed (WCGF) as a method of controlling acidosis. No differences between treatments for any performance parameters were observed in Exp. 2. The DDGS may be similar to tallow and HMC in finishing diets containing 20% WCGF. Experiment 3 used 5 Holstein steers equipped with ruminal and duodenal cannulas in a 5x5 Latin square design. Treatments were a 40% WDGS diet, 2 composites, one consisting of corn bran and corn gluten meal (COMP), and one consisting of corn bran, corn gluten meal, and corn oil (COMP + OIL), and 2 DRC-based diets supplemented with corn oil (CON + OIL) or not (CON). Cattle fed the WDGS diet had numerically lower rumen pH compared with cattle fed other treatments. Cattle fed WDGS had greater (P < 0.10) molar proportions of propionate, lower (P < 0.10) acetate:propionate ratios, greater (P < 0.10) total tract fat digestion, and a greater (P < 0.10) proportion of unsaturated fatty acids reaching the duodenum than cattle fed other treatments. Therefore, the higher energy value of WDGS compared with corn may be due to more propionate production, higher fat digestibility, and more unsaturated fatty acids reaching the duodenum.

University Of New Hampshire Undergraduate Course Catalog, 2009-2010, University Of New Hampshire

Undergraduate Catalog

No abstract provided.

Uri Undergraduate And Graduate Course Catalog 2009-2010, University Of Rhode Island

URI Course Catalogs Archive

This is a digitized, downloadable version of the University of Rhode Island course catalog.

Defining Gerontechnology For R&D Purposes, Johanna E.M.H. Bronswijk, Herman Bouma, James L. Fozard, William D. Kearns, Gerald C. Davison, Pan-Chio Tuan

Rehabilitation and Mental Health Counseling Faculty Publications

Gerontechnology is an interdisciplinary field that links existing and developing technologies to the aspirations and needs of aging and aged adults. It helps support ‘successful aging’, is organized according to the WHO definition of health, and is a response to the combination of the aging of society and rapidly emerging new technologies. Distinguishing it from other technology approaches is its focus on the total human life-span, its recognition of different technology generations, its cross-fertilization of specific technology and gerontology disciplines, its public health goals and the encompassing of all domains of human activity. An enhanced quality of life in older …

Privatizing Ethics In Corporate Reorganizations, A. Mechele Dickerson

Minnesota Law Review, Vols. 1-106:1 (1917-2021)

No abstract provided.

Table Of Contents, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

Instructional Use Of Research-Based Practices For Students With Autism Spectrum Disorder, Eric Jay Nach

Graduate Student Dissertations, Theses, Capstones, and Portfolios

Parents and educators have limited resources to devote to the education and training of students with autism spectrum disorder (ASD). Research has identified numerous scientifically-based practices and promising practices teachers can use when working with students with ASD, while other types of practices that teachers are using have been identified as having limited support or are not recommended practices for educating children with ASD (Simpson, 2005).

The purpose of this quantitative, non-experimental and exploratory (correlational) study using a predictive research design is to determine if the types of training teachers have, years of teacher experience educating students with ASD, student …

The Application Of Social Marketing In Reducing Binge Drinking Among Female College Students: An Investigation Of A Third Level College In Cork, Fergus Murphy

Theses

Ireland has one of the highest levels of alcohol consumption in the EU, consuming 10.6 litres of pure alcohol per person in 2003, increasing to 13.4 litres in 2006. This rise in consumption has led to increases in alcohol-related harm and disease, and has resulted in more than 1,775 deaths according to the Health Research Board (Mongan et al., 2007). In general, increases in overall consumption are accompanied by a greater incidence of health and social problems. In addition to the high volume of alcohol consumed by people in Ireland, drinking occasions appear to be strongly related to heavy episodic …

Faith-Based Assumptions About Performance: Does Church Affiliation Matter For Service Quality And Access?, Anna A. Amirkhanyan, Hyun Joon Kim, Kristina T. Lambright

Public Administration Faculty Scholarship

To date, the common rhetoric and assumptions on the performance of faith-based organizations (FBOs), ironically, appear to be faith based rather than empirically supported: There is a paucity of research evaluating the effectiveness of FBOs that uses sufficiently rigorous methods and multiple measures of organizational performance. This study seeks to inform the debate on the relative effectiveness of FBOs by comparing religiously affiliated and secular nonprofit nursing homes using two distinct but complementary measures of organizational performance: service quality and access for impoverished clients. Using nationally representative panel data on 11,877 church-affiliated and secular nonprofit nursing homes, this study examines …

2009 Annual Report, Children's Advocacy Institute, University Of San Diego School Of Law

CAI Annual Reports

No abstract provided.