Digital Commons Network^™

Dna Structure Modulates The Oligomerization Properties Of The Aav Initiator Protein Rep68, Jorge Mansilla-Soto, Miran Yoon-Robarts, William J. Rice, Shailee Arya, Carlos R. Escalante, R. Michael Linden

Physiology and Biophysics Publications and Presentations

Rep68 is a multifunctional protein of the adeno-associated virus (AAV), a parvovirus that is mostly known for its promise as a gene therapy vector. In addition to its role as initiator in viral DNA replication, Rep68 is essential for site-specific integration of the AAV genome into human chromosome 19. Rep68 is a member of the superfamily 3 (SF3) helicases, along with the well-studied initiator proteins simian virus 40 large T antigen (SV40-LTag) and bovine papillomavirus (BPV) E1. Structurally, SF3 helicases share two domains, a DNA origin interaction domain (OID) and an AAA+ motor domain. The AAA+ motor domain is also …

Biodiversity Of Inland Saltscapes Of The Iberian Peninsula, Katia Hueso Kortekaas, Jesus-F. Carrasco Vaya

Natural Resources and Environmental Issues

The Iberian Peninsula hosts a wide variety of inland saltscapes, from man-made solar evaporation salterns to hyper-saline lakes and salt rivers, most of them unknown to other European countries. The present contribution deals with this diversity of saltscapes, briefly introduces their main features and locations, and presents a general overview of their conservation status. Some of their natural values are not even well understood by the scientists themselves, and therefore they are very rare and fragile and in need of protection. However, many of these natural saltscapes have been and are currently under threat, having been desiccated, used as waste …

Medicine@Yale November/December 2009 Volume 5, Issue 5, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Eco-Bio-Social Factors Of Vector Density-Developing Effective Approaches To Dengue Control In The Philippines, Jesusa Marco

SDRC Publications

No abstract provided.

Science, Technology, And American Diplomacy: Background And Issues For Congress, Deborah D. Stine

Congressional Research Service Reports

Science and engineering activities have always been international. Scientists, engineers, and health professionals frequently communicate and cooperate with one another without regard to national boundaries. This report discusses international science and technology (S&T) diplomacy, instances when American leadership in S&T is used as a diplomatic tool to enhance another country’s development and to improve understanding by other nations of U.S. values and ways of doing business. According to the National Research Council, five developmental challenges where S&T could play a role include child health and child survival, safe water, agricultural research to reduce hunger and poverty, micro-economic reform, and mitigation …

Transcriptional Regulation Of Adipocyte Function, Kivanç Birsoy

Student Theses and Dissertations

The increased white adipose tissue mass associated with obesity is the result of both hyperplasia and hypertrophy of adipocytes. While adipocyte development and transcriptional processes are well studied in vitro, regulation of in vivo genes (such as leptin), the identity of the adipocyte progenitor cells and the development of the adipose organ have not been defined invivo. In this thesis, firstly KLF4 was discovered to be an essential early regulator of adipogenesis. KLF4 together with Krox20 cooperatively transactivates C/EBPβ, suggesting that KLF4 and Krox20 are part of an immediate early transcriptional network. This network is upregulated in a lipodystrophic animal …

The Neglect Of The Umbilical Cord: Ohio's Failure To Adequately Promote Banking Of Umbilical Cord Blood Stem Cells And The Need For New Legislation, Shannon Folger

Journal of Law and Health

Because current legislation, including OH H.B. 237, is insufficient in that it does not have the potential to significantly increase the number of cord blood donations, it will be necessary to enact legislation that is more demanding. Such legislation should be modeled after current "required request" organ donation laws, which mandate that health professionals actively pursue organ donations by expressly asking the family to consent to donation. Modeled after these laws, better legislation will not only require that state health departments generate information about donation opportunities, but also that health professionals then provide each maternity patient with materials about cord …

Germs On A Plane: Legal Protections Afforded To International Air Travelers And Governments In The Event Of A Suspected Or Actual Contagious Passenger And Proposals To Strengthen Them, Alexandra R. Harrington

Journal of Law and Health

This article calls for the creation of an international public health do-not-fly list akin to those used by Interpol and the United States government as a stop-gap measure to ensure that passengers who have been diagnosed with infectious diseases or have been exposed to infectious diseases are unable to travel until it is established that it is medically safe for them to do so. This article has also called for amendments to the IHR and the Vienna Conventions to clarify the rights and obligations of travelers and states in the event of a suspected or established case of infectious disease …

Childhood Obesity: The Law's Response To The Surgeon General's Call To Action To Prevent And Decrease Overweight And Obesity, Leah Loeb

Journal of Health Care Law and Policy

No abstract provided.

Marketing Mothers' Milk: The Commodification Of Breastfeeding And The New Markets For Breast Milk And Infant Formula, Linda C. Fentiman

Elisabeth Haub School of Law Faculty Publications

This paper explores the commodification of women and biological processes, the confusion of scientific evidence with social agendas, and the conflict between marketing and public health. I assert that key actors in the healthcare marketplace - government, businesses, and doctors – have acted to enable weak medical and scientific evidence to be manipulated by ideological and profit-making partisans in a poorly regulated market. I focus on the unique role of the medical profession, which has acted with government and the private sector to shape the markets in human milk and infant formula. In a striking parallel to the pharmaceutical industry, …

Healthy Planet, Healthy People: Integrating Global Health Into The International Response To Climate Change, Lindsay Wiley

Scholarly Articles in Law Reviews & Journals

The potentially groundbreaking negotiations currently underway on the international response to climate change and national implementation of commitments under the United Nations Framework Convention on Climate Change (UNFCCC) include a number of hotly contested issues: (1) what degree of climate change is acceptable as a basis for emissions targets, (2) to what extent and in what ways climate change mitigation should incorporate emissions reductions or increased sinks for developing countries, (3) whether the legal regime governing mitigation can take advantage of the huge mitigation potential of changed practices in the land use and agricultural sectors, (4) how adaptation should be …

Transferrin Lipoplex-Mediated Suicide Gene Therapy Of Oral Squamous Cell Carcinoma In An Immunocompetent Murine Model And Mechanisms Involved In The Antitumoral Response, S. Neves, Henrique Faneca, S. Bertin, Krystyna Konopka, Nejat Düzgüneş, V. Pierrefite-Carle, S. Simões, M. C. Pedroso De Lima

All Dugoni School of Dentistry Faculty Articles

Suicide gene therapy has been used for the treatment of a variety of cancers. We reported previously the in vitro efficacy of the Herpes Simplex Virus Thymidine kinase (HSV-tk)/ganciclovir (GCV) system to mediate cytotoxicity in oral squamous cancer cells, using transferrin (Tf)-lipoplexes, prepared from cationic liposomes composed of 1,2-dioleoyl-3-(trimethylammonium) propane (DOTAP) and cholesterol. In the present study, we evaluated the antitumoral efficacy mediated by this lipoplex formulation in two suicide gene therapy strategies, HSV-tk/GCV and cytosine deaminase (CD)/5-fluorocytosine (5-FC), using a syngeneic, orthotopic murine model for head and neck squamous cell carcinoma. The cellular and molecular events associated with the …

Restricted Ap-Pcr Fingerprinting Of Salmonella Enterica Serovar Typhimurium / Sara Sheibani Esfarjani, Sara Sheibani Esfarjani

Student Works (2000-2009)

No abstract provided.

Smoking Out The Impact Of Tobacco-Related Decisions On Public Health Law, Micah L. Berman

Brooklyn Law Review

No abstract provided.

Global Ky (Winter 2009), University Of Kentucky International Center

Global Kentucky

No abstract provided.

Reforming The Illinois Freedom Of Information Act: An Opportunity To Repair The Leaky Boat, Nathan T. Nieman

DePaul Law Review

No abstract provided.

Escherichia Coli, Salmonella, And Mycobacterium Avium Subsp. Paratuberculosis In Wild European Starlings At A Kansas Cattle Feedlot, Shannon M. Gaukler, George M. Linz, Julie S. Sherwood, Neil W. Dyer, William J. Bleier, Yvonne M. Wannemuehler, Lisa K. Nolan, Catherine M. Logue

United States Department of Agriculture Wildlife Services: Staff Publications

The prevalence of Escherichia coli, Salmonella spp., and Mycobacterium avium subsp. paratuberculosis isolated from the feces of wild European starlings (Sturnus vulgaris) humanely trapped at a feedlot in central Kansas was assessed. All E. coli and Salmonella isolates recovered were tested for antimicrobial susceptibility using National Antimicrobial Resistance Monitoring System panels and the E. coli isolates were classified as to their content of genes associated with pathogenic E. coli of birds and cattle, including cvaC, iroN2, ompTp, hlyF2, eitC, iss, iutA, ireA, papC, stxI, stxII, sta, K99, F41, and eae. Escherichia coli O157:H7 and Mycobacterium avium …

Monitoring Exposure To Avian Influenza Viruses In Wild Mammals, Kaci K. Vandalen, Susan A. Shriner, Heather J. Sullivan, J. Jeffrey Root, Alan B. Franklin

United States Department of Agriculture Wildlife Services: Staff Publications

1. Avian influenza (AI) viruses primarily circulate in wild waterfowl populations and are occasionally transmitted to domestic poultry flocks. However, the possible roles of other wildlife species, such as wild mammals, in AI virus ecology have not been adequately addressed.

2. Due to their habitat and behavior, many wild mammals may be capable of transmitting pathogens among wild and domestic populations. Exposure to AI viruses has been reported in an array of wild and domestic animals. The presence of wild mammals on farms has been identified as a risk factor for at least one poultry AI outbreak in North America. …

Ecological Correlates Of Risk And Incidence Of West Nile Virus In The United States, Brian F. Allan, R. Brian Langerhans, Wade A. Ryberg, William J. Landesman, Nicholas W. Griffin, Rachael S. Katz, Brad J. Oberle, Michele R. Schutzenhofer, Kristina N. Smyth, Annabelle De St. Maurice, Larry Clark, Kevin R. Crooks, Daniel E. Hernandez, Robert G. Mclean, Richard S. Ostfeld, Jonathan M. Chase

United States Department of Agriculture Wildlife Services: Staff Publications

West Nile virus, which was recently introduced to North America, is a mosquito-borne pathogen that infects a wide range of vertebrate hosts, including humans. Several species of birds appear to be the primary reservoir hosts, whereas other bird species, as well as other vertebrate species, can be infected but are less competent reservoirs. One hypothesis regarding the transmission dynamics of West Nile virus suggests that high bird diversity reduces West Nile virus transmission because mosquito blood-meals are distributed across a wide range of bird species, many of which have low reservoir competence. One mechanism by which this hypothesis can operate …

The Problem Of Vaccination Noncompliance: Public Health Goals And The Limitations Of Tort Law, Daniel B. Rubin, Sophie Kasimow

Michigan Law Review First Impressions

Imposing tort liability on parents who fail to vaccinate their children would not serve the public health and public policy interests that drive childhood immunization efforts. The public policy goals of vaccination are to slow the spread of disease and to reduce mortality and morbidity. Our country’s public health laws already play a substantial role in furthering these goals. Although application of tort law may be an appropriate response to some of the problems that result from vaccination noncompliance, there also is a need to cultivate public understanding of the connection between individual actions and collective wellbeing. It is doubtful …

Gambling With The Health Of Others, Stephen P. Teret, Jon S. Vernick

Michigan Law Review First Impressions

The health and wellbeing of the public is, in part, a function of the behavior of individuals. When one individual’s behavior places another at a foreseeable and easily preventable risk of illness or injury, tort liability can play a valuable role in discouraging that conduct. This is true in the context of childhood immunization.

Parents Should Not Be Legally Liable For Refusing To Vaccinate Their Children, Jay Gordon

Michigan Law Review First Impressions

Should a parent who takes advantage of a personal belief exemption to avoid vaccinating a child be held liable if that child infects other people? No, because there are valid medical reasons for choosing this exemption and tracing direct transmission of these illnesses from an unvaccinated child to another person is virtually impossible.

Choices Should Have Consequences: Failure To Vaccinate, Harm To Others, And Civil Liability, Douglas S. Diekema

Michigan Law Review First Impressions

A parent’s decision not to vaccinate a child may place others at risk if the child becomes infected and exposes others to the disease. Should an individual harmed by an infection transmitted from a child whose parents chose to forgo vaccination have a negligence claim against those parents? While I do not hold a legal degree and therefore cannot speak directly to issues of law, as a physician and ethicist it seems to me that the basic elements that comprise negligence claims—harm, duty, breach of duty, and causation—are met in some cases where parents forgo vaccination.

Uab Magazine - Fall 2009, University Of Alabama At Birmingham

UAB Magazine

No abstract provided.

Ms225: 2009 Faculty Meeting Minutes, Thomas R. Cole

Thomas R. Cole, PhD Papers

Original Filename: Faculty Meeting Minutes 010709.doc. Format Details: fmt/40; Microsoft Word Document; 97-2003. See more at Thomas R. Cole, PhD Papers and its finding aid.

Freedom To Live, Freedom To Die: Health Disparities In El Salvador, Shaina Elizabeth Rose

Senior Honors Theses and Projects

No abstract provided.

The Effects Of Goldshield Antimicrobial On Bacillus Anthracis Sterne And Clostridium Difficile, Victor Petreca

Senior Honors Theses and Projects

Clostridium difficile, a non-aerobic spore former, is currently one of the most serious causes of nosocomial infections and antibiotic associated diarrhea (AAD). Due to the resilient nature of spores, its propagation can be difficult to control. Preventing infections through efficient and durable disinfection of hospitals’ facilities would result in diminished contaminations. This project was based on testing the efficacy of a new substance called Goldshield® Antimicrobial (a patented nano-molecular-assembly technology developed at Emory University) against Clostridium difficile. The tests were also done with the aerobic spore forming Bacillus anthracis Sterne.

Goldshield’s active reagents were tested against the …

Possibilities Of A Third Epidemiological Occurrence, Sue A. Bentley

Senior Honors Theses and Projects

The purpose of this paper is to examine the possibilities of a third epidemiological occurrence. An epidemiological occurrence is where large segments of population and culture have been adversely affected either by disease or through manmade causes of disease. According to World Health Organization an epidemic is an outbreak of a disease that attacks many people at the same time and may spread through more than one community. An endemic outbreak is a disease that exists permanently in a region or within a population. A pandemic is an epidemic that spreads throughout the world.

Happiness And Punishment, John Bronsteen, Christopher Buccafusco, Jonathan Masur

Faculty Scholarship

This Article continues our project of applying new findings in the behavioral psychology of human happiness to some of the most deeply analyzed questions in law. When a state decides how to punish criminal offenders, at least one important consideration is the amount of harm any given punishment is likely to inflict. It would be undesirable, for example, to impose greater harm on those who commit less serious crimes or to impose harm that rises to the level of cruelty. Our penal system fits punishments to crimes primarily by adjusting the size of monetary fines and the length of prison …

Emergency Department Capacity Planning For A Pandemic Scenario: Nurse Allocation, Florentino Antonio Rico

USF Tampa Graduate Theses and Dissertations

The problem considered in this research is the efficient allocation of resources in an emergency department during a large flow of patient consequent to a pandemic influenza breakout. Predicting the impact of a Pandemic Influenza is very complex due to the many unknown variables that may play a role to how severe a pandemic can be. Scenario planning is considered in this research to forecast different potential outcomes and help decision makers better understand the role of uncertainties and become prepared to make important decisions. The goal is to first create a forecast model to estimate the patient demand during …