Digital Commons Network^™

How Early Do Antibiotics Have To Be To Impact Mortality In Severe Sepsis? A Prospective, Observational Study From An Emergency Department., Shahla Siddiqui, Nawal Salahuddin, Adeel Raza, Junaid Abdul Razzak

Department of Emergency Medicine

BACKGROUND:

The objective of this study was to assess the promptness of antibiotic administration to patients presenting with sepsis and the effects on survival and length of hospitalization.

METHODS:

Consecutive, adult patients presenting with Systemic Inflammatory Response Syndrome (SIRS) to the emergency department of the Aga Khan University hospital were enrolled in a prospective, observational study over a period of 4 months. Univariate, multivariate regression modeling and one-way ANOVA were used to examine the effects of various variables on survival and for significant differences between timing of antibiotic administration and survival, two-sided p values < 0.05 were considered significant.

RESULTS:

One hundred and eleven patients …

Undergraduate Student Catalog Fall 2009, Nova Southeastern University

Undergraduate Programs Course Catalogs

No abstract provided.

Scared Sick? Predator-Pathogen Facilitation Enhances The Exploitation Of A Shared Resource, Ricardo A. Ramirez, W E. Snyder

Biology Faculty Publications

Resource use generally increases with greater consumer diversity, an effect often attributed to resource partitioning. Pathogens and predators are two classes of consumer that exhibit differences in ecologically important traits (e.g., size, resource acquisition strategy, foraging location) that could lead to complementary effects on shared prey/hosts. To examine this possibility, we manipulated diversity among a community of predators and pathogens that together attack an herbivorous beetle, Leptinotarsa decemlineata, and measured resulting effects on herbivore suppression and resulting plant damage. We found that herbivore mortality increased, and plant damage decreased, when more natural enemy species were present. However, closer examination revealed …

Abaton, 2009, Des Moines University

Abaton

Issue three of Des Moines University's literary review, Abaton published in Fall 2009. This Global Health issue came with a CD addition at the end of the book. The CD is titled "Change one life, change the world: Simon Estes on the power of compassion".

The Effect Of All-Trans Retinoic Acid And Fatty Acids On Mcf-7 Breast Cancer Cell Progression, David A. Brown

Master's Theses

Vitamin A metabolites and retinoids may slow the progression of breast cancer and elicit anti-neoplastic properties similar to those of omega-3 fatty acids. Studies using animal models show a decrease in the incidence, growth and metastisis of mammary tumors in the presence of specific fatty acids. This effect is also seen with use of retinoids, specifically all-trans retinoic acid (AtRA). Thus, fatty acids may also alter retinoid homeostasis in mammary carcinoma cells (MCF-7s). The potential for inter/co dependency among fatty acids and retinoids is considerable, and here it has been hypothesized that a decrease in cancer progression will occur in …

Montana Business Quarterly, Fall 2009, University Of Montana--Missoula. Bureau Of Business And Economic Research

Montana Business Quarterly, 1949-2021

This is an academic publication produced by the Bureau of Business and Economic Research (BBER) at the University of Montana’s College of Business. This is volume 47, number 3.

Wound Healing Ethnomedicinal Plants Popular Among The Malayali Tribes In Vattal Hills, Dharmapuri, Tn, India, S. Ramya, N. Alaguchamy, V. M. Maruthappan, R. Sivaperumal, M. Sivalingam, A. Krishnan, V. Govindaraji, K. Kannan, R. Jayakumararaj

Ethnobotanical Leaflets

Healing of chronic lower extremity wounds is a global problem, especially in developing countries where traditional medicine is often used by the people in remote places. India has a rich tradition of plant based knowledge pertinent to healthcare. A survey of ethnomedicinal plant species used by Malayali’s to heal cut/ wounds in Vattal Hills of Dharmapuri was made. A large number of plants/ extracts/ decoctions/ pastes are used by tribals to heal wounds, cuts and burns. In the present study, an attempt has been made to document ethnobotanical knowledge base and methods employed by Malayali’s for treatment of cut/ wounds. …

Wbwg News, Volume 5, No. 2, Fall 2009, Lorraine Andrusiak, Julie York

WBWG News

Contents: President's Corner -- Introducing the Editors -- WBWG Announcements -- State/Provincial Updates -- WBWG News -- PDF Corner -- Upcoming Events -- Upcoming BCI Workshops -- Oregon Bat Workshop -- 2009 NASBR Highlights

October 2009, Syracuse University Biology Department

BioLog

No abstract provided.

Is Routine Antenatal Screening For Syphilis In Nigeria Still Justified Clinically And Economically?, Mohammed Bukar, Bala M. Audu, Usman I. Takai, Bamidele B. Ajayi, Abubakar A. Kullima

Saudi Medical Journal

OBJECTIVE: To determine the seroprevalence and cost effectiveness of antenatal syphilis screening at the University of Maiduguri Teaching Hospital (UMTH), Maiduguri, Nigeria. METHODS: A retrospective chart analysis of venereal disease research laboratory (VDRL) results among pregnant women at the UMTH, Maiduguri, Nigeria, during a 10-year period (from 1st January 1999 to 31st December 2008) was undertaken. RESULTS: A total of 18,712 women registered for antenatal care during the study period. Of these, 18,101 had serological screening for syphilis. Only 12 of the 18,101 screened were seropositive by VDRL, 9 (75%) were confirmed by Treponema pallidum hemagglutination assay (TPHA), giving a …

Risk Factors And Outcome In Extended Spectrum Beta-Lactamase Producing Escherichia Coli And Klebsiella Pneumoniae Bacteremia, Stijn Blot, Javed I. Memon

Saudi Medical Journal

No abstract provided.

Ccl3l1 And Hiv/Aids Susceptibility, Thomas J. Urban, Amy C. Weintrob, Jacques Fellay, Sara Colombo, Kevin V. Shianna, Curtis Gumbs, Margalida Rotger, Kimberly Pelak, Kristen K. Dang, Roger Detels, Jeremy J. Martinson, Stephen J. O'Brien, Norman L. Letvin, Andrew J. Mcmichael, Barton F. Haynes, Mary Carrington, Amalio Telenti, Nelson L. Michael, David B. Goldstein

Biology Faculty Articles

No abstract provided.

Incentives For Surveillance Of Infections Disease Outbreaks, Anup Malani, Ramanan Laxminarayan

Coase-Sandor Institute for Law & Economics Research Paper Series

This paper examines the incentives for countries to report disease outbreaks such as swine flu, avian flu and SARS to the international community. Even cursory analysis suggests countries have conflicting incentives regarding whether to report an outbreak. Reporting an outbreak may bring medical assistance, but also trigger trade sanctions to contain an outbreak. Modeling the decision as a signaling game where a country has private but imperfect evidence of an outbreak provides additional insights. First, not all sanctions discourage reporting. Sanctions based on fears of an undetected outbreak (false negatives) encourage disclosure by reducing the relative cost of sanctions that …

Tennessee Birth Defects 2002-2006, Tennessee. Department Of Health.

Tennessee Birth Defects

No abstract provided.

How Early Do Antibiotics Have To Be To Impact Mortality In Severe Sepsis? A Prospective, Observational Study From An Emergency Department, Shahla Siddiqui, Nawal Salahuddin, Adeel Raza, Junaid Razzak

Department of Anaesthesia

BACKGROUND: The objective of this study was to assess the promptness of antibiotic administration to patients presenting with sepsis and the effects on survival and length of hospitalization.

METHODS: Consecutive, adult patients presenting with Systemic Inflammatory Response Syndrome (SIRS) to the emergency department of the Aga Khan University hospital were enrolled in a prospective, observational study over a period of 4 months. Univariate, multivariate regression modeling and one-way ANOVA were used to examine the effects of various variables on survival and for significant differences between timing of antibiotic administration and survival, two-sided p values < 0.05 were considered significant.

RESULTS: One hundred and eleven patients …

Ethj Vol-47 No-2

East Texas Historical Journal

No abstract provided.

Trans-Mississippi Miasmas: Malaria & Yellow Fever Shaped The Course Of The Civil War In The Confederacy's Western Theater, Andrew M. Bell

East Texas Historical Journal

No abstract provided.

Correlation Between Acupuncture And Left-Handed Patients After Stroke, Mutasem M. Abuhamed, Xiao Bo, Song Zhi, Wu Zhiguo, Walid Alsharafi, Zi Xiaohong, Tu Q. Yun

Saudi Medical Journal

No abstract provided.

Norm Conflict In International Law: Whither Human Rights?, Marko Milanovic

Duke Journal of Comparative & International Law

No abstract provided.

Comparative Life Cycles And Life Histories Of North American Rhabdias Spp. (Nematoda: Rhabdiasidae): Lungworms From Snakes And Anurans, Gabriel J. Langford, John J. Janovy Jr.

John J. Janovy, Jr. Publications

The present study used experimental infections to compare the life cycles and life histories of 6 Rhabdias spp. infecting snakes and anurans. Free-living development of anuran lungworms was primarily limited to heterogonic reproduction, and females utilized matricidal endotoky exclusively, whereas snake lungworms primarily reproduced homogonically and, when heterogonic reproduction occurred, females used a combination of releasing eggs and matricidal endotoky. Infective snake lungworms survived for longer periods in fresh water compared to anuran worms. Infective anuran lungworms penetrated into the skin of frogs and toads; few infections resulted from per os infections. In contrast, snake lungworms were unable to penetrate …

Serodiagnosis Of Cutaneous Leishmaniasis In The Syrian Arab Republic, Mahmood D. Al-Mendalawi, Samar A. Al-Nahhas

Saudi Medical Journal

No abstract provided.

Eimeria Spp. (Apicomplexa: Eimeriidae) From The Plateau Pika, Ochotona Curzoniae, From Haibei Area, Qinghai Province, China, With The Description Of Two New Species, Yi-Fan Cao, Run-Roung Ye, Jian-Hua Wu, Jiang-Hui Bian, Donald W. Duszynski

Harold W. Manter Laboratory of Parasitology: Faculty Publications

Fifty-two fecal samples from the Plateau pika, Ochotona curzoniae, collected in the Haibei Area, Qinghai Province, China, were examined for the presence of coccidia (Apicomplexa: Eimeriidae). Five distinct morphotypes, all Eimeria species, were distinguished based on the structure of their sporulated oocysts. Three of these included Eimeria banffensis, Eimeria calentinei, and Eimeria cryptobarretti, all of which have been described previously from other Ochotona species. We also studied 2 morphotypes that we feel have sufficient qualitative and quantitative characters to distinguish them from all previously described species; herein, we identify them as putative new species. Eimeria qinghaiensis …

Antibiotic And Disinfectant Resistance Of Methicillin-Resistant Staphylococcus Aureus, Christopher Justin Steed

Senior Honors Theses

Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterium that has developed an increasing resistance to antibiotic drugs. This bacterium is very prevalent in hospitals but is becoming more prevalent in community-based settings. The goals of this research are to test the antibiotic sensitivity of two strains of MRSA, discover the proper disinfectants to use in households and hospital settings, and develop and test antibiotic derivatives to determine the future of antibiotic use against this bacterium. Research indicated that each strain was resistant to β-lactam antibiotics as well as other antibiotics. Each strain tested was unique in its resistance against antibiotics, thus …

When What You Don’T Know Can Hurt You: Third Party Liability For Fraudulent Misrepresentation In Non-Commercial Settings After Doe V. Dilling, 888 N.E.2d 24 (Ill. 2008), Laura Barke

Southern Illinois University Law Journal

Fraudulent misrepresentation actions most commonly arise in the commercial context. In Doe v. Dilling, however, the plaintiff attempted to expand the tort’s usage to an extremely personal context and hold the parents of her fiancée liable for fraudulently misrepresenting her fiancée’s HIV status. Although this Casenote agrees that the Illinois Supreme Court reached the correct result in denying the plaintiff’s claim, it argues that the court failed to provide a clear framework for future cases. Because this case is susceptible to misinterpretation and could potentially bar all claims for fraudulent misrepresentation within non-commercial settings, this Casenote sets forth a test …

Jefferson Alumni Bulletin – Volume 58, Number 3, Fall 2009

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 58, Number 3, Fall 2009 Dean’s Message, page 2 Findings--Researchers Counter Allergy to Plavix with Steroids and Antihistamines, page 4 Why in the World Would You Go into Medicine Today?, page 6 Philadelphia 1918: The Flu Pandemic Hits Home, page 14 New Movie Underscores Healthcare Conflicts, page 20 Faculty Profile: Vincenzo Berghella, MD ’90, page 22 On Campus, page 24 Class Notes, page 28 Looking at Scholarships from Both Sides, page 36 Alumni Giving, page 38 In Memoriam, page 50 By the Numbers, page 53

High Content Screening Identifies Decaprenyl-Phosphoribose 2’ Epimerase As A Target For Intracellular Antimycobacterial Inhibitors, Thierry Christophe, Mary Jackson, Hee Kyoung Jeon, Denis Fenistein, Monica Contreras-Dominguez, Jaeseung Kim, Auguste Genovesio, Jean-Philippe Carralot, Fanny Ewann, Eun Hye Kim, Sae Yeon Lee, Sunhee Kang, Min Jung Seo, Eun Jung Park, Henrieta Skovierová, Ha Pham, Giovanna Riccardi, Ji Youn Nam, Laurent Marsollier, Marie Kempf, Marie-Laure Joly-Guillou, Taegwon Oh, Won Kyung Shin, Zaesung No, Ulf Nehrbass, Roland Brosch, Stewart T. Cole

Faculty and Staff Publications

A critical feature of Mycobacterium tuberculosis, the causative agent of human tuberculosis (TB), is its ability to survive and multiply within macrophages, making these host cells an ideal niche for persisting microbes. Killing the intracellular tubercle bacilli is a key requirement for efficient tuberculosis treatment, yet identifying potent inhibitors has been hampered by labor-intensive techniques and lack of validated targets. Here, we present the development of a phenotypic cell-based assay that uses automated confocal fluorescence microscopy for high throughput screening of chemicals that interfere with the replication of M. tuberculosis within macrophages. Screening a library of 57,000 small molecules led …

Prevalence And Intensity Of Trypanosome Infections In Stable And Declining Populations Of Brush-Tailed Bettongs (Bettongia Penicillata), Melissa Chiasson

Independent Study Project (ISP) Collection

The brush-tailed bettong (Bettongia penicillata), or woylie, is an endemic Australian marsupial that has recently suffered a large population crash in the Upper Warren region of Western Australia. Research has shown that both the declining Upper Warren population of brush-tailed bettongs and a stable population at Karakamia Wildlife Sanctuary are infected with a novel Trypanosoma sp., and the declining Upper Warren population was found to have a higher prevalence of trypanosome infection that that of the stable Karakamia population. In this study, further work was done to see if 1) the prevalence and intensity of trypanosome infection still differed significantly …

Learning Opportunities 2009/2010, Illinois Mathematics And Science Academy

Course Catalogs

The graduation requirements of the Illinois Mathematics and Science Academy are in concert with those maintained by the State of Illinois with additional requirements as established by the IMSA Board of Trustees. Each semester students must take a minimum of 2.5 credits and a maximum of 3.5 credits. One-semester classes generally receive .5 credits and two semester classes (e.g., World Languages) generally receive 1.0 credit. Most students will take between 5 and 7 academic classes per semester. Fine Arts, Wellness, and Independent Study courses do not count towards the 2.5 credit minimum. However, if a student wishes to take 3.5 …

Bactericidal Effects Of Low Temperature Atmospheric Pressure Plasma On Porphyromonas Gingivalis, Arwa Mahasneh

Dental Hygiene Theses & Dissertations

Purpose: The biomedical application of low temperature atmospheric pressure plasma (LTAPP) is a collaborative interest for engineering, medical, dental and biological researchers. This laboratory study tested whether LTAPP can limit growth of Porphyromonas gingivalis, a periodontal pathogen strongly associated with periodontal disease, disease progression, and refractory periodontitis. Methods: After extensive pilot trials, the study consisted of 24 agar plate samples of P. gingivalis- 20 samples were exposed to LTAPP at 5, 7, 9 and 10 minutes and 4 control samples were exposed to helium gas only. Immediately after exposures, the samples were incubated anaerobically for 72 hour at …

October 2009: Novel H1n1 Flue (Swine Flu), Dacus Library

Dacus Docs News

No abstract provided.