Digital Commons Network^™

Mechanism For Sortase Localization And The Role Of Sortase Localization In Efficient Pilus Assembly In Enterococcus Faecalis, Kimberly Kline, Andrew L. Kau, Swaine L. Chen, Adeline Lim, Jerome S. Pinkner, Jason Rosch, Sreedhar R. Nallapareddy, Barbara E. Murray, Birgitta Henriques-Normark, Wandy Beatty, Michael G. Caparon, Scott J. Hultgren

Open Access Publications

No abstract provided.

Serologic Evidence Of Frequent Human Infection With Wu And Ki Polyomaviruses, Nang L. Nguyen, Binh-Minh Le, David Wang

Open Access Publications

No abstract provided.

Role And Regulation Of Escrt-Iii In Multivesiculr Body Biogenesis, Soomin Shim

All Theses and Dissertations (ETDs)

Endosomal sorting complex required for transports: ESCRT) machinery responsible for multivesicular body: MVB) biogenesis is essential for receptor downregulation, viral budding and cytokinesis. ESCRT-III is a large polymer built from related ESCRT-III proteins that is thought to help generate intralumenal vesicles: ILVs) within the MVB. How ESCRT-III functions is poorly understood. Although ESCRT-III assembles on the endosomal membrane, its components are predominantly soluble in the cytoplasm. I found that the transition between these two states is controlled by autoinhibitory domains within ESCRT-III proteins, which I identified by structure/ function analysis in four human ESCRT-III proteins - Charged multivesicular body protein2A: …

Detecting Mutations Related To Antibiotic Resistance In Pseudomonas Aeruginosa, Neda Nemat-Gorgani

Master's Theses

No abstract provided.

Is Paromomycin An Effective And Safe Treatment Against Cutaneous Leishmaniasis? A Meta-Analysis Of 14 Randomized Controlled Trials, Dae Hyun Kim, Hye Jin Chung, Joachim Bleys, Reza F Ghohestani

Faculty, Staff and Student Publications

BACKGROUND: High cost, poor compliance, and systemic toxicity have limited the use of pentavalent antimony compounds (SbV), the treatment of choice for cutaneous leishmaniasis (CL). Paromomycin (PR) has been developed as an alternative to SbV, but existing data are conflicting.

METHODOLOGY/PRINCIPAL FINDINGS: We searched PubMed, Scopus, and Cochrane Central Register of Controlled Trials, without language restriction, through August 2007, to identify randomized controlled trials that compared the efficacy or safety between PR and placebo or SbV. Primary outcome was clinical cure, defined as complete healing, disappearance, or reepithelialization of all lesions. Data were extracted independently by two investigators, and pooled …

Semiparametric Prevalence Estimation From A Two-Phase Survey, Denis H. Y. Leung, J Qin

Research Collection School Of Economics

This paper studies a semi-parametric method for estimating the prevalence of a binary outcome using a two-phase survey. The motivation for a two-phase survey is, due to time, money and ethical considerations, it is impossible to carry out comprehensive evaluation on all subjects in a large random sample of the population. Rather, a relatively inexpensive "screening test" is given to all subjects in the random sample and only individuals more likely to have a positive outcome (cases) will be selected for a further "gold standard" test to verify the outcome. Therefore, individuals with verified outcome form a non-random sample from …

Ecological Models In Support Of Regulatory Risk Assessments Of Pesticides: Developing A Strategy For The Future [Short Communication], Valery E. Forbes, Udo Hommen, Pernille Thorbek, Fred Heimbach, Paul J. Van Den Brink, Jörn Wogram, Hans-Hermann Thulke, Volker Grimm

Valery Forbes Publications

This brief communication reports on the main findings of the LEMTOX workshop, held from September 9 to 12,2007, at the Helmholtz Centre for Environmental Research (UFZ) in Leipzig, Germany. The workshop brought together a diverse group of stakeholders from academia, regulatory authorities, contract research organizations, and industry, representing Europe, the United States, and Asia, to discuss the role of ecological modeling in risk assessments of pesticides, particularly under the European regulatory framework. The following questions were addressed: What are the potential benefits of using ecological models in pesticide registration and risk assessment? What obstacles prevent ecological modeling from being used …

Making Pregnancy Work: Overcoming The Pregnancy Discrimination Act's Capacity-Based Model, Joanna L. Grossman, Gillian Thomas

Faculty Journal Articles and Book Chapters

This article considers the gaps and obstacles in current law faced by the pregnant woman whose job duties may conflict with pregnancy's physical effects. While there is no inherent conflict between pregnancy and work, women in physically strenuous or hazardous occupations, from nursing to law enforcement, routinely confront situations in which they are physically unable to perform aspects of their job or, though physically able, they seek to avoid certain tasks or situations because of the potential risks to maternal or fetal health. The Pregnancy Discrimination Act of 1978 (PDA) broadly protects against "pregnancy discrimination," but it provides absolute rights …

Establishing Public Health Security In A Postwar Iraq: Constitutional Obstacles And Lessons For Other Federalizing States, David P. Fidler, Kumanan Wilson, Christopher W. Mcdougall, Harvey Lazar

Articles by Maurer Faculty

The public health consequences of the conflict in Iraq will likely continue after the violence has subsided. Reestablishing public health security will require large investments in infrastructure and the creation of effective systems of governance. On the question of governance, the allocation of powers in the new constitution of Iraq is critical. Given the ease with which public health threats cross borders, the constitution needs to grant to the federal government the legal authority to manage such threats and simultaneously meet international requirements. Unfortunately, the draft constitution does not accomplish this objective. If politically possible, the constitution should be amended …

Eastphalia Rising?: Asian Influence And The Fate Of Human Security, David P. Fidler, Sung Won Kim, Sumit Ganguly

Articles by Maurer Faculty

No abstract provided.

After The Revolution: Global Health Politics In A Time Of Economic Crisis And Threatening Future Trends, David P. Fidler

Articles by Maurer Faculty

In 2008, global health’s political revolution, which unfolded over the preceding 10-15 years, ended when four global crises damaged global health and altered the political, diplomatic, and governance contexts in which global health activities operate. The climate change, energy, food, and economic crises revealed limitations in global health’s ability to shape large-scale political, economic, and environmental problems that adversely affect health or harm underlying determinants of health. In addition, projected trends in world affairs potentially threaten health and the ability of countries to craft effective collective action responses to global problems damaging health directly and indirectly. In the post-revolution period, …

Annual Report, Fiscal Year 2009, Tennessee. Department Of Correction

Annual Reports

This document is the annual report for the Tennessee Department of Correction during the fiscal year.

Validation Of Inverse Seasonal Peak Mortality In Medieval Plagues, Including The Black Death, In Comparison To Modern Yersinia Pestis-Variant Diseases, Mark R. Welford, Brian H. Bossak

Earth, Environment & Sustainability: Faculty Publications

Background: Recent studies have noted myriad qualitative and quantitative inconsistencies between the medieval Black Death (and subsequent ‘‘plagues’’) and modern empirical Y. pestis plague data, most of which is derived from the Indian and Chinese plague outbreaks of A.D. 1900615 years. Previous works have noted apparent differences in seasonal mortality peaks during Black Death outbreaks versus peaks of bubonic and pneumonic plagues attributed to Y. pestis infection, but have not provided spatiotemporal statistical support. Our objective here was to validate individual observations of this seasonal discrepancy in peak mortality between historical epidemics and modern empirical data.

Methodology/Principal Findings: …

Controlled Evaluation Of Bactec Peds Plus/F And Bactec Lytic/10 Anaerobic/F Media For Isolation Of Salmonella Enterica Serovars Typhi And Paratyphi A From Blood, Megan E. Reller, Anita K. M. Zaidi, Shazia Sultana, Shazia Azeem, Beenish Hanif, Shahida Qureshi, Rumina Hasan, Zulfiqar Ahmed Bhutta, Rehana Akhter, Donald A. Goldmann

Department of Paediatrics and Child Health

We compared anaerobic lytic (AL) and pediatric aerobic resin-containing (Peds Plus/F) blood culture media for the isolation of Salmonella enterica serotype Typhi or Paratyphi A from children. The yields from AL and Peds Plus/F media were the same with equal volumes of blood, but recovery was faster from AL medium than Peds Plus/F medium (10.7 and 16.4 h, respectively) (P < 0.001).

The Public’S Right To Health: When Patient Rights Threaten The Commons, Elizabeth Weeks Leonard

Scholarly Works

This Article offers a contemporary examination of traditional public health objectives to address social problems not amenable to individual resolution. Taking the tradition a step further, it defines a "public health right" that may justify certain government actions that otherwise appear to impair individual rights. For example, lawmakers are considering whether current regulations on prescription drugs should be loosened to allow terminally ill patients to access drugs before they have been tested and approved for the general public. This Article concludes that expanding access to experimental drugs would violate the public health right to scientific knowledge and new drug development. …

Rethinking Risk: The Relevance Of Condoms And Viral Load In Hiv Nondisclosure Prosecutions, Isabel Grant

All Faculty Publications

An HIV-positive individual who fails to disclose his or her status to a sexual partner may face charges ranging from nuisance to murder for such behaviour, with the most common charges being aggravated assault and aggravated sexual assault. The number of prosecutions in Canada against individuals who fail to disclose their HIV-positive status to their sexual partners has risen over the last ten years. At the same time, scientific advancements in treatment options and our understanding of transmission, condom usage, and viral load are constantly influencing the assessment of the risk that nondisclosure poses to the complainant in any given …

Responding To Change In A Northern Aboriginal Community (Fort Resolution, Nwt, Canada): Linking Social And Ecological Perspectives, Sonia Darienne Wesche

Theses and Dissertations (Comprehensive)

Human and environmental systems in the circumpolar north are particularly affected by the Earth’s changing climate, thus acting as a bellwether for other parts of the globe. Rural indigenous communities are most visibly impacted due to their close relationship with the land. These challenges are compounded by socio-economic transformations typical of peripheral communities within a larger, centrally governed system.

This dissertation links a community-based study of environmental change in Fort Resolution, Northwest Territories, Canada to evolving adaptation science. The study was prompted by local concern about changing environmental conditions caused by climatic, hydrological and resource development drivers. Its collaborative research …

Institutional Analysis Of Integrated Treatment For Co-Occurring Mental Health, Substance Use And Gambling Problems In Ontario: A Case Study, Gabriela Novotná

Theses and Dissertations (Comprehensive)

This dissertation explores the institutionalized response of the mental health and addiction sectors in Ontario to the pervasive demand for integrated services for people with concurrent disorders. Building on neo-institutional theory, I argue that despite the fact that different stakeholders on multiple levels—provincial governments, service providers, and clients—have called for the integration of treatment for concurrent disorders, this integrated treatment is implemented as a rationalized myth and adopted only ceremonially.

This is demonstrated through a case study of two treatment programs that provide services to populations with concurrent mental health and substance use problems and gambling problems. Both programs are …

Hmgb1 Mediates Endogenous Tlr2 Activation And Brain Tumor Regression, James Curtin, Naiyou Liu, Marianela Candolfi, Weidong Xiong, Hikmat Assi, Kader Yagiz, Matthew Edwards, Kathrin Michelsen, Kurt Kroeger, Chunyan Liu, Akm Ghulam Muhammad, Mary Clark, Moshe Arditi, Begonya Comin-Anduix, Antoni Ribas, Pedro Lowenstein, Maria Castro

Articles

BACKGROUND: Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor that carries a 5-y survival rate of 5%. Attempts at eliciting a clinically relevant anti-GBM immune response in brain tumor patients have met with limited success, which is due to brain immune privilege, tumor immune evasion, and a paucity of dendritic cells (DCs) within the central nervous system. Herein we uncovered a novel pathway for the activation of an effective anti-GBM immune response mediated by high-mobility-group box 1 (HMGB1), an alarmin protein released from dying tumor cells, which acts as an endogenous ligand for Toll-like receptor 2 (TLR2) signaling …

Climate Adaptation And Federalism: Mapping The Issues, Daniel F. Farber

San Diego Journal of Climate & Energy Law

There is a vigorous debate about the appropriate roles of the state and federal governments in reducing greenhouse gases and mitigating climate change. ...
...
This Article is a first step in mapping this new terrain. Part I provides a short introduction to climate adaptation. The United States will face significant climate impacts in the next few decades, and governmental responses will be required. Part II discusses the role of the federal government in setting adaptation standards, while Part III analyzes the appropriateness of state versus federal funding for adaptation. States are likely to play the leading role in funding …

The Political Ecology Of Intestinal Parasites Among Nicaraguan Immigrants In Monteverde, Costa Rica, Jason D. Lind

USF Tampa Graduate Theses and Dissertations

Over the past 15 years Monteverde, Costa Rica has undergone rapid economic, social, political, and environmental change due to a flourishing ecotourism economy. While the effects of ecotourism development in Monteverde are many, two important consequences have been: 1) the immigration of Nicaraguan nationals to the area seeking low-skilled wage labor; and 2) compromised water resources management due to pollution and rapid population growth. The objective of this research is to investigate and identify the inter-relationships between ecotourism development in Monteverde and its affect on infectious diseases outcomes within the context of immigration and water resources management. Specifically, this dissertation …

Pregnancy, Work, And The Promise Of Equal Citizenship, Joanna L. Grossman

Hofstra Law Faculty Scholarship

Can women capture the benefits of equal citizenship in a legal system that does not mandate necessary accommodations for pregnant workers? This article argues that current pregnancy discrimination law, which bases the right to work on full capacity, systematically deprives women of equal opportunity to make use of their innate capacities and talents in the workplace. This failure, in turn, compromises the quest for equal social citizenship - the right of equal access to paid work - that has been a cornerstone of the modern women’s movement.

This article first examines the nature and extent of conflicts between pregnancy and …

Stopping For Death: Re-Framing Our Perspective On The End Of Life, Ruth C. Stern, J. Herbie Difonzo

Hofstra Law Faculty Scholarship

How we die is increasingly becoming a matter of law and public policy. We grapple with issues of patient autonomy, the proper parameters of doctor-patient discussions on the end of life, the right to hasten death, and the right to control our own medical treatment. But it is physicians and patients, not judges and legislators, who are the principal actors in events at the end of life. Palliative medicine is just beginning to probe the multi-dimensional totality of suffering in dying and seriously ill patients. What we learn will influence our options at the end of life and tell us …

When Every Drop Counts: The Public Health Impact Of Drought, Steven Konkel

Environmental Health Planning and Policy

No abstract provided.

Health And The Nature Of Urban Green Spaces, May Elizabeth Carter

Theses: Doctorates and Masters

Recognition that city-dwelling people can benefit from contact with nature is not new. The urban open air movement of the 19th century advised retention of greenways and development of urban parks and gardens to stop disease spread through lack of fresh air, poor sanitation and overcrowding. Now, in the early 21st century, urban green spaces are under threat from inner city infill projects and clearing of remnant vegetation to accommodate suburban sprawl.

While much literature discusses positive health benefits of contact with nature, few studies explore explicit pathways between urban green space and health, despite mounting concern that disassociation between …

Defining Health Law Or The Edgewood Syndrome, Paula Lobato De Faria, Wendy K. Mariner, George J. Annas

Faculty Scholarship

The authors' main purpose is to present ideas on defining Health Law by highlighting the particularities of the field of Health Law as well as of the teaching of this legal branch, hoping to contribute to the maturity and academic recognition of Health Law, not only as a very rich legal field but also as a powerful social instrument in the fulfillment of fundamental human rights. The authors defend that Health Law has several characteristics that distinguish it from traditional branches of law such as its complexity and multidisciplinary nature. The study of Health Law normally covers issues such as …

Toward An Architecture Of Health Law, Wendy K. Mariner

Faculty Scholarship

This article examines 3 questions: What is an academic field of law? Is health law such a field? If it is, how can or should it be described? The first question may have no answer; scholars and practicing lawyers have fashioned their owns spheres of expertise. Describing health law faces particular challenges, including the breadth of applicable doctrines and the decline of unique medically-oriented adaptations of general principles. The article offers a blueprint based on the health and human rights framework as a functional description of the eclectic and translegal field of health law. This approach can identify the principles …

Antiviral Chemotherapeutic Agents Against Equine Herpesvirus Type 1: The Mechanism Of Antiviral Effects Of Porphyrin Derivatives, Galena V. Rybachuk

LSU Doctoral Dissertations

Equine Herpesvirus-1 (EHV-1) is an important ubiquitous enzootic equine pathogen, causing significant economic losses to the horse industry. Despite extensive vaccination protocols, EHV-1 continues to be a major cause of epidemic abortion, perinatal mortality, respiratory disease and neurologic disease. EHV-1 infections are usually dealt with by using management practices that limit spread of the disease and secondary complications, providing symptomatic relief to infected horses, but no specific treatment is available. New therapeutic or virucidal agents could have great utility in slowing both the progression and spread of the disease in an epidemic situation. A number of porphyrins and their derivatives …

Without Improved Security, Biodefense Laboratories May Double As Arsenals For Terrorists, Jim Shen

Quill & Scope

In the wake of the "Amerithrax” anthrax attacks of September and October 2001, the United States committed a large amount of funding towards biodefense research. With this commitment came a large increase in the number of federally-funded and private laboratories conducting biodefense research that was not well-regulated by the federal government. The result is that many laboratories are currently studying dangerous agents such as anthrax with inadequate security measures and little oversight. Unless reform is enacted to correct this situation, these laboratories will continue to represent a potential threat to public safety.

Determination Of Minimum Safe Cooking Temperatures For Shrimp To Destroy Foodborne Pathogens, Sailaja Chintagari

LSU Master's Theses

Shrimp is one of the most common seafoods and a favorite among consumers. Like any other food there are safety concerns about shrimp. Listeria species, Salmonella species, Clostridium species and Vibrio species are among the pathogens of prime importance. Most of these pathogens can be eliminated by cooking. However, the extent of cooking and temperatures greatly influence the safety of these foods. The current study is focused on the determination of minimum cooking temperatures for shrimp to eliminate Listeria species, Salmonella species and Vibrio species. Shrimp were surface inoculated with the three different species mentioned above to about 5.00 log …