Digital Commons Network^™

Public Health Perspectives On The 2009 Novel H1n1 Influenza Pandemic And Population Health, Julie Gleason-Comstock, Walter Davis, Melinda Dixon, Allen Heimann

Michigan Journal of Public Health

No abstract provided.

The Significance Of Heavy Chain Cdr3 Diversity In The Antibody Response To Polysaccharides, Tamer Mahmoud

All ETDs from UAB

An understanding of the molecular mechanisms involved in the generation of protective antibody responses to polysaccharides associated with pathogenic microorganisms is of importance for improving vaccine design. The heavy chain third complementarity-determining region (HCDR3) of an antibody molecule is at the center of its antigen-binding site and plays a determinative role in antigen recognition. The goal of this dissertation was to investigate the role of HCDR3 diversity and composition on the antibody response to the polysaccharide α 1→3 Dextran (DEX). In the first study, we investigated the role of TdT, a DNA polymerase that plays a major role in generating …

Analysis Of The Malaria Vaccine Potential Of Plasmodium Falciparum Merozoite Surface Protein-3, Stephen James Jordan

All ETDs from UAB

Malaria causes an estimated 1-3 million deaths each year, with the majority of deaths being a result of infection with Plasmodium falciparum. No commercially available vaccine currently exists, but multiple subunit-based vaccines are in development including one based on the promising vaccine candidate P. falciparum Merozoite Surface Protein-3 (PfMSP3). PfMSP3 varies in sequence between P. falciparum isolates, but all variation is restricted to the N-terminal domain. This observation has lead to the development of a PfMSP3-based vaccine comprised solely of the highly conserved, yet poorly immunogenic, C-terminal domain. The rationale for supporting the C-terminal domain relies entirely on its conserved …

The Cultural Worldview Of Allopthic And Naturopathic Physicians, Cullen Clark

All ETDs from UAB

Worldview is the socio-cultural compass with which we navigate the existential mysteries of life. It is our way of seeing – and being in – the world. As such it influences every aspect of culture from art to medicine. This exploratory study uses a sequential design combining quantitative and qualitative methodology to explore the worldview of allopathic and naturopathic physicians. Using survey research, the study identifies five basic components of competing worldviews among allopathic (n = 550) and naturopathic physicians (n = 399). It measures agreement among the two groups with these components and explores their influence upon support for …

One Step Forward, Two Steps Back: How Mandating The Human Papillomavirus Vaccine Will Increase The Use Of Vaccine Exemptions And Negatively Impact Our Nation's Health, Katharine Southard

Journal of Law and Policy

No abstract provided.

Supporting Clients On Methadone Maintenance Treatment, Registered Nurses' Association Of Ontario

General Submissions: Community and Population-based Materials

This guideline will focus on recommendations for any youth, adult or older adult either already on MMT or those who are potential candidates for MMT. Particular attention will be paid to priority populations (for whom there are particular physiological implications of MMT).

Supportive Communication, Sense Of Virtual Community And Health Outcomes In Online Infertility Groups, Jennifer L. Welbourne, Anita L. Blanchard, Marla D. Boughton

Management Faculty Publications

Women are turning to online health groups to deal with the stresses and complications of infertility. Online groups may provide a resource that is potentially absent in their face-to-face communities. This study examines how the sense of virtual community (SOVC) that develops in these groups serves as a buffer between perceived stress and physical health symptoms. A sample of 122 women from two virtual communities completed an online survey. Results show that observing the exchange of emotional support was positively related to SOVC while observing informational support was negatively related to SOVC. Further, SOVC was negatively related to physical health …

Decent Respect To The Opinions Of Mankind Sometimes Requires A Second Look, A, Robert Henry

SMU Law Review

No abstract provided.

An Algorithm For Identifying Novel Targets Of Transcription Factor Families: Application To Hypoxia-Inducible Factor 1 Targets, Yue Jiang, Bojan Cukic, Donald A. Adjeroh, Heath D. Skinner, Jie Lin, Qingxi J. Shen, Bing-Hua Jiang

Electrical & Computer Engineering Faculty Research

Efficient and effective analysis of the growing genomic databases requires the development of adequate computational tools. We introduce a fast method based on the suffix tree data structure for predicting novel targets of hypoxia-inducible factor 1 (HIF-1) from huge genome databases. The suffix tree data structure has two powerful applications here: one is to extract unknown patterns from multiple strings/sequences in linear time; the other is to search multiple strings/sequences using multiple patterns in linear time. Using 15 known HIF-1 target gene sequences as a training set, we extracted 105 common patterns that all occur in the 15 training genes …

Financial Crisis Containment, Anna Gelpern

Georgetown Law Faculty Publications and Other Works

This Article maps financial crisis containment - extraordinary measures to stop the spread of financial distress - as a category of legal and policy choice. I make three claims.

First, containment is distinct from financial regulation, crisis prevention and resolution. Containment is brief; it targets the immediate term. It involves claims of emergency, rule-breaking, time inconsistency and moral hazard. In contrast, regulation, prevention and resolution seek to establish sound incentives for the long term. Second, containment decisions deviate from non-crisis norms in predictable ways, and are consistent across diverse countries and crises. Containment invariably entails three kinds of choices: choices …

Super Wicked Problems And Climate Change: Restraining The Present To Liberate The Future, Richard J. Lazarus

Georgetown Law Faculty Publications and Other Works

Climate change may soon have its “lawmaking moment” in the United States. The inherent problem with such lawmaking moments, however, is just that: they are moments. What Congress and the President do with much fanfare can quickly and quietly slip away in the ensuing years. This is famously so for environmental law. Subsequent legislative amendments, limited budgets, appropriations riders, interpretive agency rulings, massive delays in rulemaking, and simple nonenforcement are more than capable of converting a seemingly uncompromising legal mandate into nothing more than a symbolic aspirational statement. Climate change legislation is especially vulnerable to being unraveled over time for …

Model Complexity Affects Transient Population Dynamics Following A Dispersal Event: A Case Study With Pea Aphids, Brigitte Tenhumberg, Andrew J. Tyre, Richard Rebarber

School of Biological Sciences: Faculty Publications

Stage-structured population models predict transient population dynamics if the population deviates from the stable stage distribution. Ecologists’ interest in transient dynamics is growing because populations regularly deviate from the stable stage distribution, which can lead to transient dynamics that differ significantly from the stable stage dynamics. Because the structure of a population matrix (i.e., the number of life-history stages) can influence the predicted scale of the deviation, we explored the effect of matrix size on predicted transient dynamics and the resulting amplification of population size. First, we experimentally measured the transition rates between the different life-history stages and the adult …

The Lived Experience Of Hiv-Positive Tanzanian Orphans, Carol A. Parker

Walden Dissertations and Doctoral Studies

The purpose of this investigation was to generate a context- specific model of the lived experience of HIV positive Tanzanian orphans. With the advent of anti-retroviral drugs, Sub-Saharan African populations with high burdens of human immunodeficiency virus (HIV) face annually accumulating increases in the number of HIV positive children, and ultimately adults. Perinatally infected, these children often become orphans while still young. Extended interviews were performed with a purposive sample of 12 HIV infected orphaned children between 9 and 12 years of age. Half of the research participants lived in an orphanage and half were children living with guardians in …

Advance (Fall 2009), Georgia Southern Division Of Continuing And Professional Education

Division of Continuing & Professional Education

No abstract provided.

Faculty Masthead, Mjlst Editorial Board

Minnesota Journal of Law, Science & Technology

No abstract provided.

Faculty Masthead, Mjlst Editorial Board

Minnesota Journal of Law, Science & Technology

No abstract provided.

Epitope-Based Vaccination Against Pneumonic Tularemia, Stephen H. Gregory, Stephanie Mott, Jennifer Phung, Jinhee Lee, Leonard Moise, Julie A. Mcmurry, William Martin, Anne S. De Groot

Institute for Immunology and Informatics Faculty Publications

Francisella tularensis, the etiological agent of tularemia, is one of the most infectious bacterial pathogens known. No vaccine is currently approved for public use. Previously, we identified epitopes recognized specifically by T cells obtained from individuals following infection with F. tularensis. Here, we report that a subunit vaccine constructed based upon these epitopes elicited protective immunity in “humanized” HLA class II (DRB1*0401) transgenic mice. Vaccinated mice challenged intratracheally with a lethal dose of F. tularensis (Live Vaccine Strain) exhibited a rapid increase in pro-inflammatory cytokine production and diminished number of organisms in the lungs, and a concurrent increased …

The Urban Environment And Childhood Asthma (Ureca) Birth Cohort Study: Design, Methods, And Study Population, James E. Gern, Cynthia M. Visness, Peter J. Gergen, Robert A. Wood, Gordon R. Bloomberg, George T. O'Connor, Meyer Kattan, Hugh A. Sampson, Frank R. Witter, Megan T. Sandel, Wayne G. Shreffler, Rosalind J. Wright, Samuel J. Arbes Jr, William W. Busse

Open Access Publications

No abstract provided.

Distribution Of Brugia Malayi Larvae And Dna In Vector And Non-Vector Mosquitoes: Implications For Molecular Diagnostics, Sara M. Erickson, Kerstin Fischer, Gary J. Weil, Bruce M. Christensen, Peter U. Fischer

Open Access Publications

No abstract provided.

Multiple-Infection And Recombination In Hiv-1 Within A Longitudinal Cohort Of Women, Alan R. Templeton, Melissa G. Kramer, Joseph Jarvis, Jeanne Kowalski, Stephen Gange, Michael F. Schneider, Qiujia Shao, Guang Wen Zhang, Mei-Fen Yeh, Hua-Ling Tsai, Hong Zhang, Richard B. Markham

Open Access Publications

No abstract provided.

Pathogenicity Of A Disease-Associated Human Il-4 Receptor Allele In Experimental Asthma, Raffi Tachdjian, Clinton Mathias, Shadi Al Khatib, Paul J. Bryce, Hong S. Kim, Frank Blaeser, Brian D. O'Connor, Danuta Rzymkiewicz, Andrew Chen, Michael J. Holtzman, Gurjit K. Hershey, Holger Garn, Hani Harb, Harald Renz, Hans C. Oettgen, Talal A. Chatila

Open Access Publications

No abstract provided.

Potentially Pathogenic Bacteria In Shower Water And Air Of A Stem Cell Transplant Unit, Sarah D. Perkins, Jennie Mayfield, Victoria Fraser, Largus T. Angenent

Open Access Publications

No abstract provided.

Induction Of Ifn-Beta And The Innate Antiviral Response In Myeloid Cells Occurs Through An Ips-1-Dependent Signal That Does Not Require Irf-3 And Irf-7, Stephane Daffis, Mehul S. Suthar, Kristy J. Szretter, Michael Gale Jr., Michael S. Diamond

Open Access Publications

No abstract provided.

Helminth Genomics: The Implications For Human Health, Paul J. Brindley, Makedonka Mitreva, Elodie Ghedin, Sara Lustigman

Open Access Publications

No abstract provided.

Between Community And Hospital: Healthcare-Associated Gram-Negative Bacteremia Among Hospitalized Patients, Jonas Marschall, Victoria J. Fraser, Joshua Doherty, David K. Warren

Open Access Publications

No abstract provided.

Developing A Risk Stratification Model For Surgical Site Infection After Abdominal Hysterectomy, Margaret A. Olsen, James Higham-Kessler, Deborah S. Yokoe, Anne M. Butler, Johanna Vostok, Kurt B. Stevenson, Yosef Khan, Victoria J. Fraser

Open Access Publications

No abstract provided.

Difficulty In Diagnosing Surgical Site Infection After Arthroscopy In Developing Countries, Anucha Apisarnthanarak, Siriporn Wittayachanyapong, Pranee Sitaposa, Kanokporn Thongphubeth, Hilary Babcock, Victoria J. Fraser

Open Access Publications

No abstract provided.

Multicenter Study Of The Impact Of Community-Onset Clostridium Difficile Infection On Surveillance For C. Difficile Infection, Erik R. Dubberke, Anne M. Butler, Bala Hota, Yosef M. Khan, Julie E. Mangino, Jeanmarie Mayer, Kyle J. Popovich, Kurt B. Stevenson, Deborah S. Yokoe, L Clifford Mcdonald, John Jernigan, Victoria J. Fraser

Open Access Publications

No abstract provided.

Impact Of An Antimicrobial Utilization Program On Antimicrobial Use At A Large Teaching Hospital: A Randomized Controlled Trial, Bernard C. Camins, Mark D. King, Jane B. Wells, Heidi L. Googe, Manish Patel, Ekaterina V. Kourbatova, Henry M. Blumberg

Open Access Publications

No abstract provided.

Nematode.Net Update 2008: Improvements Enabling More Efficient Data Mining And Comparative Nematode Genomics, John Martin, Sahar Abubucker, Todd Wylie, Yong Yin, Zhengyuan Wang, Makedonka Mitreva

Open Access Publications

No abstract provided.