Digital Commons Network^™

Security Detention, Terrorism, And The Prevention Imperative, John Mcloughlin, Gregory P. Noone, Diana C. Noone

Case Western Reserve Journal of International Law

No abstract provided.

Evaluation Of Ribavirin Genotoxicity With Sister Chromatid Exchange And Micronuclei Assays In Humans, Abdulgani̇ Tatar, Zülal Özkurt, Ahmet Hacimüftüoğlu, Ahmet Yeşi̇lyurt, Serhat Vançeli̇k

Turkish Journal of Medical Sciences

Aim: The main objective of this study was to assess the genotoxicity of ribavirin in 15 patients who were suffering from Crimean-Congo haemorrhagic fever and treated with the therapy dose of the antiviral agent. Materials and Methods: Genotoxicity was evaluated using the cytokinesis-blocked micronucleus (MN) and sister chromatid exchange (SCE) assays in lymphocyte cultures that were prepared from blood samples collected from the 15 patients. The blood samples were taken on day 9 of a 10-day therapeutic regimen of ribavirin and 1 month after the cessation of therapy. Results: In all patients, the frequency of sister chromatid exchanges and the …

Coxiella Burnetii Seroprevalence In The Rural Part Of Bolu, Turkey*, Oğuz Karabay, Esra Koçoğlu, Gökhan Baysoy, Selami̇ Konyalioğlu

Turkish Journal of Medical Sciences

Aim: This study was performed to determine the seroprevalence of Coxiella burnetii in the rural part of Bolu, a city located in the western part of the Black Sea region of Turkey. Materials and Methods: The study population was chosen by cluster sampling to represent the rural population of the city. Serum samples were collected from the 9 rural districts of Bolu. Blood samples were taken to the laboratory while stored at 4 °C in ice-cooled boxes. The sera were then stored at -20 °C until testing. The presence of IgG antibodies against C. burnetii phase-II antigens in the sera …

Antisalmonella Activity Of Selected Medicinal Plants, Chand Pasha, Shaik Sayeed, Sadath Ali, Ziaullah Khan

Turkish Journal of Biology

Antisalmonella activity of some important plants in the Ayurvedic system of traditional medicine used in India to treat enteric diseases was screened. The aqueous and methanol extracts of 47 medicinal plants were studied for their antibacterial activity against pathogenic Salmonella typhi, Salmonella paratyphi A, and Salmonella typhimurium. The in vitro antibacterial activity was performed by agar well diffusion method and the results are expressed as the average diameter of zone of inhibition of bacterial growth around the well. Of the herbal extracts tested, 33 plant extracts were found to have antibacterial activity against at least one of the salmonella strains …

Antibacterial Activity Of Seed Extracts Of Commercial And Wild Lathyrus Species, Noor Afshan Khan, Sadaf Quereshi, Akhilesh Pandey, Ashutosh Srivastava

Turkish Journal of Biology

Butanolic extract of seeds from 2 different Lathyrus species (Lathyrus ratan [commercial variety] and L. aphaca [wild variety]), were investigated for their in vitro antibacterial activity. The antibacterial activity against plant and human pathogenic bacteria was evaluated on the basis of inhibition zones (IZs) measured by disc diffusion method. The maximum inhibition was shown by L. ratan against the gram-positive bacterium Staphylococcus aureus. L. aphaca seeds also showed inhibition but were inactive against Klebsiella pneumoniae. L. ratan extract was more active than L. aphaca. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values for both the seeds (in …

The Toxicity And Teratogenicity Of Gibberellic Acid (Ga3) Based On The Frog Embryo Teratogenesis Assay-Xenopus (Fetax), Ayper Boğa, Seçi̇l Bi̇nokay, Yaşar Sertdemi̇r

Turkish Journal of Biology

This study investigated the developmental toxicity of a plant growth regulator (a type of pesticide) using the frog embryo teratogenesis assay-Xenopus (FETAX). Xenopus laevis embryos were exposed to 11 different concentrations of gibberellic acid (GA_3), from stage 8 to 11, for 96 h under static renewal test conditions. The median lethal concentration (LC_{50}), malformation (EC_{50}), non-observed adverse effect concentration (NOAEC), and lowest observed adverse effect concentration (LOAEC) were calculated. The corresponding LC_{50} and EC_{50} values determined for GA3 exposure were 1117.5 mg/L and 658 mg/L, respectively. The TI (LC50/EC50) value calculated for GA_3 was 1.69. Different anomalies occurred in the …

Randomness In Tree Ensemble Methods, Joran Elias

Graduate Student Theses, Dissertations, & Professional Papers

Tree ensembles have proven to be a popular and powerful tool for predictive modeling tasks. The theory behind several of these methods (e.g. boosting) has received considerable attention. However, other tree ensemble techniques (e.g. bagging, random forests) have attracted limited theoretical treatment. Specifically, it has remained somewhat unclear as to why the simple act of randomizing the tree growing algorithm should lead to such dramatic improvements in performance. It has been suggested that a specific type of tree ensemble acts by forming a locally adaptive distance metric [Lin and Jeon, 2006]. We generalize this claim to include all tree ensembles …

Out Of The Shadows: Preventive Detention, Suspected Terrorists, And War, David Cole

Georgetown Law Faculty Publications and Other Works

This article examines the appropriate and inappropriate role of "preventive detention" in responding to terrorist threats. It offers a constitutional jurisprudence of preventive detention, maintaining that absent a showing that dangerous behaviour cannot be addressed through criminal prosecution, preventive detention is unconstitutional. But criminal prosecution is not always a realistic option, and in those circumstances, preventive detention, carefully circumscribed and meticulously safeguarded by procedural protections, may be permissible. Familiar examples of accepted preventive detention regimes include civil commitment of dangerous persons who because of a mental disability cannot be held criminally responsible, and detention of enemy soldiers in a traditional …

Animals As Vulnerable Subjects: Beyond Interest-Convergence, Hierarchy, And Property, Ani B. Satz

Animal Law Review

This Article presents a new paradigm, premised on the equal protection principle, for the legal regulation of human interactions with domestic animals: Equal Protection of Animals (EPA). EPA combines the insights of vulnerability theorists with the equal protection principle and capability theory to create a mechanism for recognizing the equal claims of human and nonhuman animals to protections against suffering. Under such an approach, domestic animals—like humans—have claims to food, hydration, shelter, bodily integrity (including avoiding pain), companionship, and the ability to exercise and to engage in natural behaviors of movement.

Existing animal welfare and anti-cruelty laws, despite their stated …

Vindicating Vaccines, Poonam Kaushal

Quill & Scope

Autism, an atypical complication of vaccines, has single-handedly created a public health controversy regarding the overall efficacy of vaccinating children. While experts battled out their positions in newspaper articles and TV talk shows, measles cases have been on the rise, cumulating in 2008 with the most cases since 1996. The public controversy coupled with landmark federal cases have allowed the layperson to think that vaccines are indeed harmful and as such has seemingly discouraged their use in health maintenance. Emphasis has shifted away from the appropriate scientific criterion that determines the relationship, or lack thereof, between vaccines and autism. In …

Localization Of Deformed Wing Virus (Dwv) In The Brains Of Apis Mellifera (European Honey Bees), Karan Samir Shah

Honors Theses

The purpose of the current research project is to design a successful in-situ hybridization to identify regions within the brains of honeybees where DWV replicates. The localization of the virus in the brains of the bees can draw a connection between CCDand DWV.In conclusion, these results demonstrate that in bees infected with DWV the virus replicates actively in very important regions of the brain, including neuropils that are responsible for vision and olfaction. This means that the virus could adversely affect the vision and olfaction of the honeybees making it difficult for bees to behave normally.

Demographic Data For Development: Senegal, Rose Maruru, Wendy Baldwin, Sarah Engebretsen

Poverty, Gender, and Youth

Current global developmental frameworks, including the Millennium Development Goals and Poverty Reduction Strategy Papers, require recent and reliable data to measure the achievement of targets. At the same time, increased decentralization and democratization have expanded the role that data play in informing development policies and evaluating development interventions at the national level. Increasingly, programs and policies are assessed by their ability to reach goals that have evidence-based indicators, placing a greater demand on countries to produce clear, timely, reliable, and relevant data. The Senegal case study that forms the basis of this report aimed to develop a general picture of …

Global Trends In Aids Mortality, John Bongaarts, Francois Pelletier, Patrick Gerland

Poverty, Gender, and Youth

This working paper reviews the evolution of the HIV/AIDS epidemic and provides estimates of past trends and future projections of AIDS mortality indicators, including numbers of AIDS deaths, the proportion of all deaths that are due to AIDS, and life expectancy. A cumulative total of 24 million people have died from AIDS between 1980 and 2007, and by 2030 this total is projected to reach 75 million. Despite the rapid spread of this new disease during the 1980s and 1990s, the epidemic has reached a major turning point in recent years as the rate of new infections peaked and began …

On Treatability: Considerations Of Treatment In Context Of Newborn Screening, Marvin R. Natowicz, Shlomit Zuckerman

Health Matrix: The Journal of Law-Medicine

No abstract provided.

Evolution Of Tolerance To Pcbs And Susceptibility To A Bacterial Pathogen (Vibrio Harveyi) In Atlantic Killifish (Fundulus Heteroclitus) From New Bedford (Ma, Usa) Harbor, Diane Nacci, Marina Huber, Denise Champlin, Saro Jayaraman, Sarah Cohen, Eric Gauger, Allison Fong, Marta Gomez-Chiarri

Fisheries, Animal and Veterinary Sciences Faculty Publications

A population of the non-migratory estuarine fish Fundulus heteroclitus (Atlantic killifish) resident to New Bedford (NB), Massachusetts, USA, an urban harbor highly contaminated with polychlorinated biphenyls (PCBs), demonstrates recently evolved tolerance to some aspects of PCB toxicity. PCB toxicology, ecological theory, and some precedence supported expectations of increased susceptibility to pathogens in NB killifish. However, laboratory bacterial challenges of the marine pathogen Vibrio harveyi to wild fish throughout the reproductive season and to their mature laboratory-raised progeny demonstrated comparable survival by NB and reference killifish, and improved survival by NB males. These results are inconsistent with hypothesized trade-offs of adaptation, …

Examination Of The Capacity Of The Cathelicidins To Control Bacillus Anthracis Pathogenesis, Mark W. Lisanby

All ETDs from UAB

cillus anthracis is a gram-positive, spore forming bacterium that causes infection through three routes: cutaneous, gastrointestinal and pulmonary. Historically, anthrax pathogenesis was thought to be initiated via the uptake of spores by resident macrophages, which then transited to the regional lymph nodes. While en-route, the spores germinated and developed into bacilli within the phagolysosome, escaped into the cytoplasm, killed the cell and eventually the host. Following the recent use of B. anthracis as a biological weapon, researchers began to reevaluate anthrax pathogenesis in order to develop novel treatments. One aspect of anthrax pathogenesis that saw renewed interest was the intracellular …

Immunotherapy Of Cancer Employing Γδ-T Cells: A Study Examining Their Utility And Feasibility, Benjamin Hester Beck

All ETDs from UAB

Unlike antigen-specific alpha beta-T cells, gamma delta-T cells can recognize and lyse cancerous cells rapidly upon encounter in a manner that does not require the recognition of tumor-specific antigens. Given the well-documented capacity of gamma delta-T cells to innately kill malignant cells, efforts are now underway to exploit the antitumor properties of gamma delta-T cells for clinical purposes. Here, we present for the first time preclinical in vivo mouse models of gamma delta-T cell-based immunotherapy directed against breast cancer. These studies were explicitly designed to approximate clinical situations in which adoptively-transferred gamma delta-T cells would be employed therapeutically against breast …

Bacterial Community Profiling Of The Eastern Oyster (Crassostrea Virginica): Comparison Of Culture-Dependent And Culture-Independent Outcomes, Kenneth J. La Valley, Steve Jones, Marta Gomez-Chiarri, Joseph Dealteris, Michael A. Rice

Fisheries, Animal and Veterinary Sciences Faculty Publications

Tissue-associated bacterial community profiles generated using a nested polymerase chain reaction–denaturing gradient gel electrophoresis (DGGE) approach and culture-dependent and culture-independent isolation techniques were compared. Oyster samples were collected from 2 harvest areas along the coast of Maine, in the United States. Profiles from both isolation strategies were evaluated using Sorensen’s index of similarity and cluster analysis of gel banding patterns. Culture independent profiles were further evaluated using the Shannon diversity index. In general, the culture-dependent strategy resulted in a greater number of bands within a profile. Bacterial DGGE profiles were found to be highly similar within an isolation strategy, with …

Epilepsy In Patients 60 Years And Above, Yahya M. Mousali, Tahir H. Obeid, Hussein A. Al-Gahtani, Mansour A. Al-Janadi, Ahmed A. Attar, Hassnah O. Dammas

Neurosciences

OBJECTIVE: To evaluate the clinical characteristics and etiology of epilepsy at age 60 years and above in the Western Region of Saudi Arabia (KSA), as epilepsy is now considered to be the third most frequent neurological problem in the elderly population. METHODS: We retrospectively reviewed the medical records of patients 60 years and above at King Khalid National Guard Hospital, Jeddah, KSA between 1999 and 2007 with new onset of seizures and diagnosed as suffering from epilepsy. We excluded patients 60 and above with provoked seizures. RESULTS: Seventy-five patients of late onset epilepsy were studied. Partial seizure (focal) was found …

Depression And Health Related Quality Of Life In Non-Cirrhotic Chronic Hepatitis B Patients And Hepatitis B Carriers, Abdurrahman Altindag, Dursun Cadirci, Fatma Sirmatel

Neurosciences

OBJECTIVE: To measure health related quality of life and level of depression among patients with noncirrhotic chronic hepatitis B patients and hepatitis B surface antigen (HBsAg) carriers. METHODS: The study was conducted at Psychiatry, Gastroenterology, and Infectious Disease Outpatients Clinics of the Harran University, Sanliurfa, Southeastern Turkey, between April and June 2005.A case control study design was used to determine the effect of hepatitis B infection on depressive symptoms and quality of life. The Beck Depression Inventory (BDI) for depressive symptoms, the Short Form-36 for measuring health related quality of life (HRQOL), and semi-structured interviews for assessing psychosocial variables were …

Isolation, Detection And Genomic Differentiation Of Escherichia Coli From Aquatic Environments In Kelantan, Malaysia / Rathi Devi Athimurthy, Rathi Devi Athimurthy

Student Works (2000-2009)

No abstract provided.

Besafe - Asian Pacific Islander Model Book, Nmaetc Staff

National Minority AIDS Education and Training Center Publications

Softback cultural competency book detailing the BESAFE model for Asian Pacific Islander Americans, 6.75 inches by 9.5 inches.

Lesbians, Gays, And People Living With Hiv: Facing And Fighting Barriers To Assisted Reproduction, Bebe J. Anderson

Cardozo Journal of Equal Rights & Social Justice

Numerous discriminatory barriers limit the ability of gays, lesbians, and people living with HIV to participate in assisted reproduction. Many of these barriers are created by laws and regulations, such as state laws criminalizing sperm donation by people living with HIV, and insurance regulations that are interpreted to limit infertility coverage to persons who have engaged in unprotected heterosexual intercourse that has not resulted in pregnancy. Other barriers are rooted in policies or practices of individual entities or individuals. For example, a gay man in Florida and a lesbian in California denied fertility services due to their sexual orientation have …

The Role Of Litigation In Combating Obesity Among Poor Urban Minority Youth: A Critical Analysis Of Pelman V. Mcdonald's Corp., Ashley B. Antler

Cardozo Journal of Equal Rights & Social Justice

The note argues that litigation, particularly when focused on low-income urban minority youth, could serve as a strategic tool to address childhood obesity by reframing the issue and catalyzing policy and industry change. It critiques the Pelman v. McDonald's Corp. lawsuit for failing to address the socioeconomic and racial disparities underlying obesity rates, thereby missing an opportunity to advance meaningful solutions. The analysis suggests that public health litigation, when strategically framed, can complement broader advocacy efforts and push for environmental changes to combat the obesity epidemic.

Production And Application Of Antibodies Produced Against The Flagella And Hemolysin Of Vibrio Parahaemolyticus, Shreya Datta

LSU Doctoral Dissertations

Vibrio parahaemolyticus is a marine bacterium which is the leading cause of bacterial gastroenteritis due to consumption of raw or undercooked bivalve molluscan shellfish in United States and is considered an important seafood-borne pathogen throughout the world. The conventional methods for enumerating this bacteria from seafood is laborious and time consuming, hence the objective of our study was to develop antibody based method which would be sensitive, user-friendly and less time consuming to detect and enumerate Vibrio parahaemolyticus from oysters. In order to condense time and material two rapid and specific antibody based test methods were developed. In the first …

Ecological Risk Models For Visceral Leishmaniais [Sic] In Bahia, Brazil And Diagnosis Of Trypanosoma Cruzi Infection In Dogs In South Central Louisiana, Prixia Nieto

LSU Doctoral Dissertations

Three predictive models were developed within a geographic information system using earth observing satellite remote sensing (RS), the Genetic Algorithm for Rule-Set Prediction (GARP) and the growing degree day-water budget (GDD-WB) concept to predict the distribution and potential risk of visceral leishmaniasis (VL) in the State of Bahia, Brazil. The objective was to define the environmental suitability of the disease as well as to obtain a deeper understanding of the eco-epidemiology of VL by associating environmental and climatic variables with disease prevalence. The RS, the GARP model and the GDD-WB model, using different analysis approaches and with the same human …

Thoracoscopic Decortication Vs Tube Thoracostomy With Fibrinolysis For Empyema In Children: A Prospective, Randomized Trial., Shawn D. St Peter, Kuojen Tsao, Troy L. Spilde, Scott J. Keckler, Christopher J. Harrison, Mary Anne Jackson, Susan W. Sharp, Walter S. Andrews, Douglas C. Rivard, Frank P. Morello, G W. Holcomb Iii, Daniel J. Ostlie

Manuscripts, Articles, Book Chapters and Other Papers

PURPOSE: Management of empyema has been debated in the literature for decades. Although both primary video-assisted thoracoscopic surgery (VATS) and tube thoracostomy with pleural instillation of fibrinolytics have been shown to result in early resolution when compared to tube thoracostomy alone, there is a lack of comparative data between these modes of management. Therefore, we conducted a prospective, randomized trial comparing VATS to fibrinolytic therapy in children with empyema.

METHODS: After Institutional Review Board approval, children defined as having empyema by either loculation on imaging or more than 10,000 white blood cells/microL were treated with VATS or fibrinolysis. Based on …

A Brief Version Of The Family Background Questionnaire, Timothy P. Melchert, Augustine Kalemeera

College of Education Faculty Research and Publications

Although it is lengthy. the Family Background Questionnaire provides reliable behaviorally specific family history information. Results from reliability and validity analyses suggest that a brief version of this instrument that assesses parental responsiveness, child maltreatment, and parental substance abuse would provide a useful screening instrument for obtaining family history information.

An Empirical Analysis Of The Utilization Patterns Of Within Facility And Secondary Healthcare Services By Kentucky State Prison Inmates, Sandra Jane Winter

University of Kentucky Doctoral Dissertations

The inmate population is increasing, aging and generally in poorer health than the non-incarcerated population. Providing healthcare to inmates is constitutionally mandated, and expensive. Little published research exists to assist corrections health policy makers strategically plan for future inmate healthcare needs. This research provides an extensive description of the healthcare utilization patterns of a sample of 577 male and female inmates incarcerated at state-operated prisons in Kentucky during the period January 1, 2007, to December 31, 2007 and who have at least one of the chronic conditions of diabetes, hypertension or hyperlipidemia. The primary outcome measures were a count of …

A Multi-Function, Disposable, Microfluidic Module For Mutation Detection, Tae Yoon Lee

LSU Doctoral Dissertations

Recognition of point mutations in a codon 12 of the K-ras gene, most frequently observed, is considered to be useful in the early diagnosis of several types of the human cancers. We have developed a multifunction, disposable, microfluidic module which detects low-abundant point mutations in human genomic DNA in modular architecture. Each functional component including a microfluidic PCR reactor, a passive diffusional micromixer reactor, and a microfluidic LDR reactor was separately designed and fabricated. Fluidic interconnects were also developed to make a fluidic passage between the functional components. Polycarbonate substrates were micro-molded, using hot embossing with micro-milled brass mold inserts …