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Methods For Preventing And Treating Cancer Using N-Thiolated Β-Lactam Compounds And Analogs Thereof, Q. Ping Dou, Edward Turos, David M. Smith

USF Patents

The subject invention concerns N-thiolated β-lactam compounds of formula A,

wherein R1 is a hydrocarbon group having 1-8 carbon atoms; R3 is an organothio group; and R4 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, cycloalkenyl, or heterocycloalkenyl, and analogs and pharmaceutically acceptable salts, esters and amides thereof. The subject invention also concerns methods for inducing tumor cell death or inhibiting tumor cell proliferation, and methods for inducing DNA damage, inhibiting DNA replication, activating p38 MAP kinase, or activating caspase cascade activation, or releasing cytochrome C from mitochondria into the cytoplasm in a tumor cell. Methods for treating cancer using …

Geanakoplos On Solving The Present Crisis And Managing The Leverage Cycle, John Geanakoplos

Documents

Working paper is associated with John Geanakoplos Written Testimony On Solving the Present Crisis and Managing the Leverage Cycle

Gbdr Regulates Pseudomonas Aeruginosa Plch And Pchp Transcription In Response To Choline Catabolites, Matthew J. Wargo, Tiffany C. Ho, Maegan J. Gross, Laurie A. Whittaker, Deborah A. Hogan

Dartmouth Scholarship

Pseudomonas aeruginosa hemolytic phospholipase C, PlcH, can degrade phosphatidylcholine (PC) and sphingomyelin in eukaryotic cell membranes and extracellular PC in lung surfactant. Numerous studies implicate PlcH in P. aeruginosa virulence. The phosphorylcholine released by PlcH activity on phospholipids is hydrolyzed by a periplasmic phosphorylcholine phosphatase, PchP. Both plcH gene expression and PchP enzyme activity are positively regulated by phosphorylcholine degradation products, including glycine betaine. Here we report that the induction of plcH and pchP transcription by glycine betaine is mediated by GbdR, an AraC family transcription factor. Mutants that lack gbdR are unable to induce plcH and pchP in media …

Real Time Imaging Of Biomarkers In The Parkinson's Brain Using Mini-Implantable Biosensors. Ii. Pharmaceutical Therapy With Bromocriptine, Patricia A. Broderick, Edwin H. Kolodny

Publications and Research

We used Neuromolecular Imaging (NMI) and trademarked BRODERICK PROBE® mini-implantable biosensors, to selectively and separately detect neuro-transmitters in vivo, on line, within seconds in the dorsal striatal brain of the Parkinson’s Disease (PD) animal model. We directly compared our results derived from PD to the normal striatal brain of the non-Parkinson’s Disease (non-PD) animal. This advanced biotechnology enabled the imaging of dopamine (DA), serotonin (5-HT), homovanillic acid (HVA) a metabolite of DA, L-tryptophan (L-TP) a precursor to 5-HT and peptides, dynorphin A 1-17 (Dyn A) and somatostatin (somatostatin releasing inhibitory factor) (SRIF). Each neurotransmitter and neurochemical was imaged at a …

The Murray Ledger And Times, December 21, 2009, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

What Is "The Energy-Water Nexus"?, Gerald Sehlke

Journal of Contemporary Water Research and Education

No abstract provided.

Energy And Water Programs Within The United States Department Of Agriculture, Ron Abramovich, Michael Strobel

Journal of Contemporary Water Research and Education

No abstract provided.

The Energy-Water Nexus: Why Should We Care?, Alexey Voinov, Hal Cardwell

Journal of Contemporary Water Research and Education

No abstract provided.

Effect Of Channel Catfish Stocking Rate On Yield And Water Quality In An Intensive, Mixed Suspended-Growth Production System, Bartholomew W. Green

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

This study was conducted to determine the effect of stocking rate on yield of channel catfish Ictalurus punctatus and water quality in a mixed suspended-growth (biofloc) production system with zero water exchange. Channel catfish (National Warmwater Aquaculture Center 103 strain; average fish weight -- 13 g) were stocked into nine 35-m² tanks (28 m³/tank) at a rate of 2.9, 5.7, or 8.5 fish/m² for a 238-d grow-out period. One 1.865-kW blower for every three tanks supplied air continuously through a diffuser grid (constructed of 2.5-cm-diameter polyvinyl chloride pipe) on the bottom of each tank. Well water …

Germinal Center Reutilization By Newly Activated B Cells., Tanja A Schwickert, Boris Alabyev, Tim Manser, Michel C Nussenzweig

Department of Microbiology and Immunology Faculty Papers

Germinal centers (GCs) are specialized structures in which B lymphocytes undergo clonal expansion, class switch recombination, somatic hypermutation, and affinity maturation. Although these structures were previously thought to contain a limited number of isolated B cell clones, recent in vivo imaging studies revealed that they are in fact dynamic and appear to be open to their environment. We demonstrate that B cells can colonize heterologous GCs. Invasion of primary GCs after subsequent immunization is most efficient when T cell help is shared by the two immune responses; however, it also occurs when the immune responses are entirely unrelated. We conclude …

Deafdigest: Gold Edition, December 20, 2009, Barry Strassler

DeafDigest Gold 2009

No abstract provided.

Ecotourism As An Alternative To Fishing In Yucatan, Mexico, Abigail E. Bennett

USF St. Petersburg campus Honors Program Theses (Undergraduate)

Small-scale fisheries account for a vast majority of fisheries globally. Their overexploitation threatens coastal environments, including the people living there, throughout the world (Basurto, 2008). Finding productive alternatives to unsustainable levels of fishing is a necessary part of curbing this probl em. Ecotourism has offered such an alternative to coastal communities, and there are already some successful examples of community-managed ecotourism groups in Mexico. Beyond providing a source of income for community members, these programs also facilitate environmental education, thus fostering local community involvement in conservation goals. This study focuses on ecotourism programs that have been started in three towns …

The Rise And Fall Of The Louisiana Muskrat, 1890-1960: An Environmental And Social History, Jared Boscareno

LSU New Orleans Theses and Dissertations

As the nineteenth century drew to a close, people living in coastal Louisiana noticed that local rodents called muskrats were rapidly increasing and quickly becoming pests by digging up crops and into levees. Property owners soon demanded their elimination, but to the ire of many, Louisiana officials chose to develop a market for muskrat fur and protect its supply through management laws. The state sought the cooperation of trappers in order to maintain global demand, but when nutria were released alongside the muskrat, the ecological balance of the marsh was permanently altered. Muskrats shrank back into obscurity, and trappers struggled …

A Bruised Sky Falling, Holly Dotson

LSU New Orleans Theses and Dissertations

The following thesis is a memoir in essays. The narrative is a reflection of memory as a chaotic system. Each essay stands alone as a single memory but also is part of the larger story of the writer's life. The fragmentation of the story lends itself to what Roland Barthes called a readerly text. That is, a reader may enter the text at any point and read the chapters in an order, and by doing this, the reader creates his/her own version of the author's life. The overall narrative arch is one of self-discovery and self-destruction.

Melting Dreams, William Scott Whited

LSU New Orleans Theses and Dissertations

No abstract provided.

Sources Of Nest Failure In Mississippi Sandhill Cranes, Grus Canadensis Pulla: Nest Survival Modeling And Predator Occupancy, Rose Butler

LSU New Orleans Theses and Dissertations

Low recruitment is the largest challenge facing the recovery of the critically endangered Mississippi Sandhill Crane (Grus canadensis pulla). Lack of information on sources of nest failure hinders effective management to increase recruitment. I examined sources of nest failure for 54 nests at the Mississippi Sandhill Crane National Wildlife Refuge, 2008-2009. Nest cameras identified predation as the primary source of failure, followed by flooding, abandonment, and egg inviability. Mean daily survival rate (DSR) was 0.72. The best approximating models included covariates for season date, temperature and nest age. DSR decreased with increasing season date, increasing nest age, and decreasing temperature. …

Lucky Ones, Daniel Goodman

LSU New Orleans Theses and Dissertations

No abstract provided.

Empire Of Dirt, Tawni Auxier

LSU New Orleans Theses and Dissertations

No abstract provided.

Meat Man And Bear Boy Fairy Tales For Today, Eva Langston

LSU New Orleans Theses and Dissertations

No abstract provided.

Electro-Disinfection Of Ballast Water, Elizabeth Kathleen Mccraven

LSU New Orleans Theses and Dissertations

This research validates electro-disinfection as a potential secondary ballast water treatment technology. Electricity applied to bacteria laden water produced bactericidal effects, reactive oxygen species and chlorine generation which annihilated bacteria. Evaluation of electro-disinfection experiments showed titanium electrodes had the maximum kill efficacy while disinfection with aluminum and stainless steel electrodes had lesser kill efficacy. A continuous flow electro-disinfection reactor was evaluated utilizing artificial brackish and fresh ballast water. Brackish water had a 100% bacteria kill efficiency utilizing titanium electrodes at a current density of 10 mA/cm2. Fresh water was augmented with the addition of salt to increase its electrical conductivity …

Synthesis Of Amphibian Alkaloids And Synthesis And Affinity Of Novel Cannabinoid Receptor Ligands, April R. Noble

LSU New Orleans Theses and Dissertations

Amphibian alkaloids are attractive targets for synthesis due to their biological activity. An important class of amphibian alkaloids is the 2,5-disubstituted pyrrolidine-based family of compounds. There are many synthetic approaches for the preparation of the trans-2,5- disubstituted pyrrolidines, but methods for the construction of the cis-2,5-pyrrolidines are limited. Therefore, it was desired to develop an enantioselective approach for the preparation of cis-2,5-disubsituted pyrrolidines. (+)-Tropin-2-one derived from cocaine was used as starting material to exploit the inherent stereochemistry for construction of the cis-pyrrolidine ring. This permitted the unequivocal assignment of the absolute configuration of the target pyrrolidine. The structurally simple pyrrolidine …

Augustine And Other Stories, Amanda Pederson

LSU New Orleans Theses and Dissertations

No abstract provided.

Comparison Of Linkage Disequilibrium And Haplotype Diversity On Macro- And Microchromosomes In Chicken., Hendrik-Jan Megens, Richard Pma Crooijmans, John Wm Bastiaansen, Hindrik Hd Kerstens, Albart Coster, Ruud Jalving, Addie Vereijken, Pradeepa Silva, William M. Muir, Hans H. Cheng, Olivier Hanotte, Martien Am Groenen

Department of Animal Sciences Faculty Publications

Background

The chicken (Gallus gallus), like most avian species, has a very distinct karyotype consisting of many micro- and a few macrochromosomes. While it is known that recombination frequencies are much higher for micro- as compared to macrochromosomes, there is limited information on differences in linkage disequilibrium (LD) and haplotype diversity between these two classes of chromosomes. In this study, LD and haplotype diversity were systematically characterized in 371 birds from eight chicken populations (commercial lines, fancy breeds, and red jungle fowl) across macro- and microchromosomes. To this end we sampled four regions of ~1 cM each on …

"Let Heaven Kiss Earth!": The Function Of Humanism And Animism In Shakespeare's Richard Ii And Henry Iv, Parts I And Ii, Kathrin Kottemann

LSU New Orleans Theses and Dissertations

As Shakespeare composed the three history plays discussed here, English culture faced a shift in its dominant belief system from an animistic perspective that valued nature and superstition to a humanistic perspective based on reason and personal relationships. In Richard II, Shakespeare creates characters that fall on either side of this divide, and he shows humanism triumph over animism when Henry deposes Richard. In 1 Henry IV, Shakespeare shows that this binary is not so easily reconciled, and Hal (the future Henry V) creates a dual nature that subsumes the tenets of both animism and humanism. After the death of …

Evaluation Of The Genetic Management Of The Endangered Mississippi Sandhill Crane (Grus Canadensis Pulla), Jessica Renee Henkel

LSU New Orleans Theses and Dissertations

The genetic status of the critically endangered Mississippi sandhill crane (Grus canadensis pulla) was analyzed using 2009 studbook data from the U.S. Fish and Wildlife Service managed captive breeding and release program. Microsatellite DNA data provided information on shared founder genotypes, allowing for refined analysis of genetic variation in the population, and informed breeding recommendations. The genetic variation observed in the Mississippi sandhill crane was contrasted with variation observed in the Florida sandhill crane (Grus canadensis pratensis). Results show far less variation in the Mississippi population. Results also suggest that while gene flow no longer occurs between the two populations, …

What We Thought We Knew Poems, 2007-2009, Katherine Durham Oldmixon

LSU New Orleans Theses and Dissertations

No abstract provided.

Heavy Metal Removal From Bilge Water By Electrocoagulation Treatment, Milton Andrade

LSU New Orleans Theses and Dissertations

The purpose of this research was to observe the removal efficiency for copper (Cu), nickel (Ni), and zinc (Zn) using Electrocoagulation (EC) technique in a continuous flow reactor with a synthetic bilge water emulsion; and additionally, to discuss the operation cost of the treatment. The optimal configuration for EC treatment used combined electrodes, aluminum and carbon steel; flow rate of 1 L/min; effluent recycling and 7.5 amps; this optimal configuration achieved 99% of zinc removal efficiency, 70% of both, copper and nickel removal efficiency, and low operation costs. The current intensity did not have significance incidence on the removal efficiency. …

Informing A Transformative Multicultural Approach: Seeking A Content Form And A Medium For Illinois Indian Resources For Preservice Social Studies Teachers, Dan W. Hechenberger

Dissertations

The demographic imperative drives a fundamental tenet of multicultural education: We must more thoroughly acknowledge US diversity by incorporating authentic ethnic heritage in social studies. The purpose of this study was to investigate recommendations, from three levels of educators, on content form and medium for preservice social studies teachers in using resources for an ethnic minority relevant to the state of Illinois and US history, the Illinois Indians. I also explored how varied participant perspectives informed those recommendations and gave meaning to multicultural education via such content.

Research questions involved perceptions, attributes, and needs of preservice social studies teachers. Data …

Serum Level Of Heart-Type Fatty Acid-Binding Protein In Patients With Chronic Renal Failure, Hafidh A. Al-Hadi, Brent William, Keith A.

Sultan Qaboos University Medical Journal

Objectives: Heart-type fatty acid binding-protein (H-FABP) has been reported to be a potential novel biochemical marker for the early diagnosis of acute myocardial infarction (AMI). The effect of kidney diseases on the renal handling of H-FABP has not yet been fully evaluated. The aim of this study was to compare the effect of renal failure on the level of H-FABP and cardiac troponin (cTnT) concentrations. Methods: The study population was a small group of 16 patients with renal failure (6 females, 10 males aged 30-70 years) on routine regular haemodialysis or peritoneal dialysis. Results: The mean ±SD of serum urea …

Dopamine D2 Receptor Priming Enhances Dopaminergic Response To Amphetamine In The Nucleus Accumbens: Role Of The D1 And D2 Receptors., Kimberly Norris Huggins

Electronic Theses and Dissertations

In past work, we have shown neonatal quinpirole (dopamine D₂/D₃ agonist) treatment produces a significant increase in dopamine D₂ receptor sensitivity, a phenomenon known as D₂ receptor priming. Dopamine D₂ receptor priming is common in psychosis. Male and female rats were administered quinpirole (1mg/kg) or saline from postnatal days 1-11 and raised to adulthood (P60). As adults, rats were administered d-amphetamine sulfate (1mg/kg) or saline every other day for 14 days. Approximately 10 min before each amphetamine or saline injection, animals were administered the D1 antagonist SCH 23390 (0.1 mg/kg), the D2 antagonist eticlopride …