Digital Commons Network^™

On The Involvement Of The Low-Density Lipoprotein Receptor In The Pathogenesis And Progression Of Alzheimer’S Disease, Jose Francisco Abisambra Socarras

USF Tampa Graduate Theses and Dissertations

Alzheimer's disease (AD) is the most prevalent form of age-associated dementia. Cholesterol dysregulation is linked with AD onset. Besides age, the most important risk factor associated with AD is the inheritance of the epsilon-4 allele of apolipoprotein E, a cholesterol transporter. In addition, while hypercholesterolemia has been shown to be an independent risk factor for AD, the nature of the cholesterol-AD link is still not clear. This gap in our understanding is partly due to a lack of knowledge about cholesterol metabolism in the central nervous system (CNS).

The low-density lipoprotein receptor (LDLR) is the main receptor of apoE and …

First Opinion: Taking Revolution Personally, Karen Chandler

First Opinions, Second Reactions

No abstract provided.

One Giant Leap, Mike Wimmer

First Opinions, Second Reactions

No abstract provided.

Abu Safiyeh V. Minister Of Defense, Uzi Vogelman, Dorit Beinisch, Edmond E. Levy

Translated Opinions

Facts: This is a petition to allow free movement of Palestinian vehicles and pedestrians along Road 443 and on the Beituniya Road. In 2002, Road 443, which served as the main traffic artery for the Palestinian residents of the area between the villages in the area and Ramallah, was closed to all Palestinian traffic. This closure was ordered following the numerous terrorist attacks that were perpetrated along the Road. The arguments related to the question of the authority of the military commander to order the restriction of traffic on the Road in general, and closure of the Road to Palestinians …

Stat3 Antagonists And Their Use As Vaccines Against Cancer, Hua Yu, Drew Pardoll, Richard Jove

USF Patents

The present invention relates to methods for treating and/or preventing cancer. In particular the present invention relates to ex vivo immunotherapeutic methods. The methods comprise decreasing Stat3 (signal transducer and activator of transcription3) expression and/or function in tumor cells and the administration of such cells to a subject in need of treatment and/or prevention. Other methods of the invention comprise activating T-cells by co-culturing the T-cells with the tumor cells with decreased Stat3 expression or function. The invention further encompasses methods comprising decreasing Stat3 expression or function in antigen-presenting cells and co-administering tumor cells and the antigen-presenting cells with decreased …

Institutional Racism, Ice Raids, And Immigration Reform, Bill Ong Hing

University of San Francisco Law Review

Although immigration raids are not a recent phenomenon, this Article focuses on a few egregious ICE raids that occurred after President Bush’s push for immigration reform in 2004. the ICE operations targeted Latinos—usually Mexicans. The exceptions were Chinese restaurants and other businesses that relied on workers of color. That racial effect is the focus of this Article and the basis for advocating that both immigration policies and ICE enforcement need to be rethought.

Biochemical And Haematological Evaluation Of Homoeopathic Drug Tribulus Terrestris In Rats, E. N. Sundaram, K. P. Singh, P. Uma Maheswara Reddy, K. R.J. Nair, C. Nayak

Indian Journal of Research in Homoeopathy

Although in Homoeopathy different potencies of Tribulus terrestris (Ikshugandha) have been commonly prescribed in urinary affections, especially dysuria and in debilitated status of the sexual organs, no scientific experimental data has been documented to establish their safe use. The present study was, therefore, undertaken to generate preliminary data on the biochemical and haematological parameters with homoeopathic drug Tribulus terrestris. The four potencies (3x, 6x, 12x and 30c) of this drug were administered orally in daily doses of 0.1ml, 0.2ml and 0.5ml/rat for 14 days and their effects on biochemica/ and haematological parameters were studied on 21" and 28" day during …

Scarring And None Scarring Facial Acne Vulgaris And The Frequency Of Associated Skin Diseases, Khalifa E. Sharquie, Khalil I. Al-Hamdi, Adil A. Noaimi, Razan A. Al-Battat

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Acne vulgaris(AV)is chronic inflammatory disease of pilosebaceous unit of young people. Patients with acne with or with out scarring might differ in regard to their immunological background from those free from acne. OBJECTIVES: To evaluate the problem of facial AV especially patients with scarring and to determine the frequency of associated skin diseases and to be compared with acne free control. METHODS: A cross sectional randomized controlled epidemiological study was conducted from Oct.2005-Oct. 2006.Three hundred students from Basra University; 132 (44%) males and 168 (56%) females were enrolled, their ages ranged from 18-25 (20.9±1.8) years. They were divided …

Role Of Antioxidant On Nephropathy In Alloxan Induced Diabetes In Rabbits, Israa F. Jaffar Alsamaraee, Huda Arif Jasim

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: The development and progression of diabetic nephropathy is dependent on glucose homeostasis and many other contributing factors. Diabetic nephropathy is a leading cause of end-stage renal failure, accounting for 35 to 40% of all new cases that require dialysis therapy worldwide. Recent clinical studies clearly demonstrated that hyperglycemia and oxidative stress is an important causal factor in mediating the development and progression of diabetic kidney disease. OBJECTIVE: To evaluate the therapeutic effect of levamesole in diabetic nephropathy . METHODS: The study included 10 rabbits Weight (1kg ±20 gm); they were followed up for 7months. Blood was aspirated from …

Effectiveness Of Immediate Mitomycin C Instillation In Patients With Low Risk Non-Muscle Invasive Bladder Cancer, Usama Sulaiman Al-Nasiri, Wisam Ali Kareem

Iraqi Postgraduate Medical Journal

BACKGROUND: We determined if immediate instillation chemotherapy after transurethral resection (TUR) decrease the risk of recurrence andor progression in patient with stage Ta T1 bladder cancer. OBJECTIVES: This study has been designed to analyze the impact of a single immediate mitomycin C instillation after transurethral resection of bladder cancer on recurrence and progression rates in patients with low risk superficial bladder cancer. METHODS: A total of 50 patients with low risk superficial bladder cancer were included in a prospective randomized controlled trial. All patients had a 3 cm. or less single, papillary bladder tumer. The tumor was completely resected before …

Urbanisation In The United Arab Emirates: The Challenges For Ecological Mitigation In A Rapidly Developing Country, Andrew Gardner, Brigitte Howarth

All Works

Th e United Arab Emirates is a small Gulf country with perhaps the fastest rate of infrastructure development anywhere. While there is legislation in place requiring environmental impact assessments (EIA) to be undertaken for all major projects, the speed and scope of development provides special challenges in devising and implementing ecological mitigation against the loss of habitats and biodiversity that this development engenders. Th is paper critically discusses mitigation strategies that have been attempted, and suggests mitigation strategies in the local context. It is hoped that this will assist both the environmental consultants involved in the EIA process and the …

Theoria, Theos, And Therapeia In Aristotle's Ethical Endings, Lawrence Jost

The Society for Ancient Greek Philosophy Newsletter

My basic complaint is that it’s not at all obvious that maximizing the theoretical activity of our most divine element does full justice to the richly textured environment provided by the first 9 1/2 books of the NE, which seemed to call for focused development of the full range of our human potential, combining moral and intellectual virtues along with provision for adequate supplies of external goods. The older language of the seemingly endless debate about whether or not the NE settles for an inclusive or dominant-end conception of eudaimonia has been redescribed - in Michael Pakaluk’s new terminology - …

Ethics Of Human Enhancement: An Executive Summary, Fritz Allhoff, Patrick Lin, Jesse Steinberg

Philosophy

With multi-year funding from the U.S. National Science Foundation (NSF), a team of researchers has just released a comprehensive report detailing ethical issues arising from human enhancement (Allhoff et al. 2009). While we direct the interested reader to that (much longer) report, we also thank the editors of this journal for the invitation to provide an executive summary thereof. This summary highlights key results from each section of that report and does so in a self-standing way; in other words, this summary presupposes no familiarity with the report and offers the opportunity to gain quick familiarity with its most central …

Double Superhelix Model Of High Density Lipoprotein, Zhiping Wu, Valentin Gogonea, Xavier Lee, Mathew A. Wagner

Chemistry Faculty Publications

High density lipoprotein (HDL), the carrier of so-called “good” cholesterol, serves as the major athero-protective lipoprotein and has emerged as a key therapeutic target for cardiovascular disease. We applied small angle neutron scattering (SANS) with contrast variation and selective isotopic deuteration to the study of nascent HDL to obtain the low resolution structure in solution of the overall time-averaged conformation of apolipoprotein AI (apoA-I) versus the lipid (acyl chain) core of the particle. Remarkably, apoA-I is observed to possess an open helical shape that wraps around a central ellipsoidal lipid phase. Using the low resolution SANS shapes of the protein …

Florida Sentinel Bulletin, December 25, 2009, Gwen Hayes

Florida Sentinel Bulletin Collection

The December 25, 2009, issue of the Florida Sentinel Bulletin.

Church Bulletin, December 24, 2009

Church Bulletin

A newsletter published for Deaf Catholics in Ottawa, Canada

Church Bulletin Finding Aid

The Weekly Challenger, December 24, 2009, The Weekly Challenger, Et Al

Weekly Challenger Newspaper Collection

The December 24, 2009, issue of The Weekly Challenger.

A Unique Role For The Host Escrt Proteins In Replication Of Tomato Bushy Stunt Virus, Daniel Barajas, Yi Jiang, Peter D. Nagy

Plant Pathology Faculty Publications

Plus-stranded RNA viruses replicate in infected cells by assembling viral replicase complexes consisting of viral- and host-coded proteins. Previous genome-wide screens with Tomato bushy stunt tombusvirus (TBSV) in a yeast model host revealed the involvement of seven ESCRT (endosomal sorting complexes required for transport) proteins in viral replication. In this paper, we show that the expression of dominant negative Vps23p, Vps24p, Snf7p, and Vps4p ESCRT factors inhibited virus replication in the plant host, suggesting that tombusviruses co-opt selected ESCRT proteins for the assembly of the viral replicase complex. We also show that TBSV p33 replication protein interacts with Vps23p ESCRT-I …

Chylomicrons Promote Intestinal Absorption And Systemic Dissemination Of Dietary Antigen (Ovalbumin) In Mice, Yuehui Wang, Sarbani Ghoshal, Martin Ward, Willem De Villiers, Jerold Woodward, Erik Eckhardt

Internal Medicine Faculty Publications

BACKGROUND: A small fraction of dietary protein survives enzymatic degradation and is absorbed in potentially antigenic form. This can trigger inflammatory responses in patients with celiac disease or food allergies, but typically induces systemic immunological tolerance (oral tolerance). At present it is not clear how dietary antigens are absorbed. Most food staples, including those with common antigens such as peanuts, eggs, and milk, contain long-chain triglycerides (LCT), which stimulate mesenteric lymph flux and postprandial transport of chylomicrons through mesenteric lymph nodes (MLN) and blood. Most dietary antigens, like ovalbumin (OVA), are emulsifiers, predicting affinity for chylomicrons. We hypothesized that chylomicron …

Ecology Of Urban Bees: A Review Of Current Knowledge And Directions For Future Study, J. L. Hernandez, G. W. Frankie, R. W. Thorp

Cities and the Environment (CATE)

Urban bee ecology is an emerging field that holds promise for advancing knowledge of bee community dynamics and promoting bee conservation. Published studies of bee communities in urban and suburban habitats are fewer than those documenting bees in agricultural and wildland settings. As land lost to urbanization is predicted to increase in coming years the necessity of studying urban bee populations is growing. We reviewed 59 publications on urban bee ecology with the following goals, to assess current knowledge, to highlight areas in need of further research, and to suggest applications of study findings to bee conservation. Methodological variation between …

Fgf2 Maintains The Proliferation Of Neural Progenitors By Actively Suppressing The Cki P27kip1 Through Regulation Of Cks1b Transcription, Andrew J. Darr

Open Access Dissertations

Identifying the mechanisms that regulate neural precursor cell (NPC) proliferation and differentiation is important for understanding CNS development among different vertebrates. My work has focused specifically on understanding how mitogenic factors, like basic fibroblast growth factor (FGF2), regulate the NPC cell cycle. Mitogenic factors and serum are thought to drive cell cycle and therefore proliferation mainly by activating G1-type cyclin-dependent kinases (CDKs). The general hypothesis being addressed here is that FGF2 also promotes cell cycle progression of NPCs through the degradation of the cell cycle inhibitor p27Kip1. I show that, in the presence of FGF2 in vitro, embryonic rat cortical …

Gain In Cellular Organization Of Inflammatory Breast Cancer: A 3d In Vitro Model That Mimics The In Vivo Metastasis, Jorge Morales, Mary L. Alpaugh

Publications and Research

Background The initial step of metastasis in carcinomas, often referred to as the epithelial-mesenchymal transition (EMT), occurs via the loss of adherens junctions (e.g. cadherins) by the tumor embolus. This leads to a subsequent loss of cell polarity and cellular differentiation and organization, enabling cells of the embolus to become motile and invasive. However highly malignant inflammatory breast cancer (IBC) over-expresses E-cadherin. The human xenograft model of IBC (MARY-X), like IBC, displays the signature phenotype of an exaggerated degree of lymphovascular invasion (LVI) in situ by tumor emboli. An intact E-cadherin/α, β-catenin axis mediates the tight, compact clump of cells …

Berghuis V. Smith: Brief For Social Scientists, Statisticians, And Law Professors, Jeffrey Fagan, Et Al., As Amici Curiae Supporting Respondent, Samuel R. Gross

Appellate Briefs

Amici curiae are leading social scientists, statisticians, and law professors actively engaged in social scientific research focused on the criminal justice system. Included among amici are authors of authoritative books and articles on statistics and the application of statistics in social science. Amici have written and conducted studies on a broad range of topics concerning the criminal justice and jury systems. Many amici are members and leaders of associations in their fields, including the National Academy of Sciences, the National Science Foundation, and the American Society of Criminology.

Amici curiae submit this brief to evaluate the various proposed methods for …

Biosynthesis Of Menaquinone (Vitamin K2) And Ubiquinone (Coenzyme Q)., R. Meganathan, Ohsuk Kwon

Faculty Articles, Papers, and Other Scholarship

Escherichia coli and Salmonella contain the naphthoquinones menaquinone (MK; vitamin K2) and demethylmenaquinone and the benzoquinone ubiquinone (coenzyme Q; Q). Both quinones are derived from the shikimate pathway, which has been called a "metabolic tree with many branches." There are two different pathways for the biosynthesis of the naphthoquinones. The vast majority of prokaryotes, including E. coli and Salmonella, and the plants use the o-succinylbenzoate pathway, while a minority uses the futalosine pathway. The quinone nucleus of Q is derived directly from chorismate, while that of MK is derived from chorismate via isochorismate. The prenyl side chains of both quinones …

Richard Deweese V. Natl Rr Passenger

2009 Decisions

USDC for the Eastern District of Pennsylvania

Trumpeter Swan Survey Of The Rocky Mountain Population, U.S. Breeding Segment Fall 2009, Dave Olson

United States Fish and Wildlife Service: Publications

Observers counted 473 swans (white birds and cygnets) in the U.S. Breeding Segment of the Rocky Mountain Population of trumpeter swans during fall of 2009, 3.1% higher than the count from last year (459). The number of white birds in the tri-state region (361) decreased for the second year in a row from the recent high count in 2007 (383). The total number of cygnets increased by 3.1% from 2008. The numbers of young produced in Montana and Idaho increased by 66.7% and 76.2%, respectively, from 2008. However, Wyoming had a decrease in cygnet production of 9.1% from that of …

John Geanakoplos Written Testimony On Solving The Present Crisis And Managing The Leverage Cycle, John Geanakoplos

Documents

No abstract provided.

Bringing Freud To Fraud: Understanding The State-Of-Mind Of The C-Level Suite/White Collar Offender Through “A-B-C” Analysis, Sridhar Ramamoorti, Daven Morrison, Joseph W. Koletar

Accounting Faculty Publications

In this paper we use a primarily “behavioral lens” (cf. Ramamoorti, 2008; Ramamoorti & Olsen, 2007) to try to understand the state-of-mind and motivations of the C-level suite/white collar offender before, during, and after the perpetration of management fraud. We offer a useful conceptual approach called “A-B-C Analysis” to understand the incidence of fraud from individual and group perspectives, as well as more macro-oriented, cultural/contextual levels. It is our hypothesis that fraud occurs either because of an individual criminal’s calculated/intentional betrayal of trust, a duo or team of “bad boys” who push ethical envelopes, and/or an organizational/social/national culture of passivity, …

Mammalian Multipotent Stem Cells And Compositions, Methods Of Preparation And Methods Of Administration Thereof, Kiminobu Sugaya, Christopher Brannen, Xiajing Dong, Hojoong Kim, Jose Pulido, Tingyu Qu, Ankur Vaghani

UCF Patents

This invention provides methods for preparing novel mammalian multipotent stem cells (MSCs), compositions thereof, and methods of preparing and administering the cells.

Near-Infrared Fluorescent Nanogumbos For Biomedical Imaging, David K. Bwambok, Bilal El-Zahab, Santhosh K. Challa, Min Li, Lin Chandler, Gary A. Baker, Isiah M. Warner

Faculty Publications

Herein, we report on near-infrared (NIR) fluorescent nanoparticles generated from an emergent class of materials we refer to as a Group of Uniform Materials Based on Organic Salts (GUMBOS). GUMBOS are largely frozen ionic liquids, although the concept is more general and is also easily applied to solid ionic materials with melting points in excess of 100 °C. Nanoparticles based on GUMBOS (nanoGUMBOS) derived from a NIR fluorophore are prepared using a reprecipitation method and evaluated for in vivo fluorescence imaging. Due to their uniformity, single-step preparation, and composite nature, nanoGUMBOS help to resolve issues with dye leakage problems innate …