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2009

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Host Defense Mechanisms Against Mycobacterium Tuberculosis, Laurin Nicole Holloway Jan 2009

Host Defense Mechanisms Against Mycobacterium Tuberculosis, Laurin Nicole Holloway

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Mycobacterium tuberculosis is one of the world's most infectious diseases. Approximately 2 million people die each year from Mycobacterium tuberculosis infection and one-third of the world's population remains infected. For decades research has focused on uncovering the tactics used by Mycobacterium tuberculosis to evade host immune responses and defense mechanisms used to fight tuberculosis infection. The following review focuses on the host defense mechanisms used to combat Mycobacterium tuberculosis with an emphasis placed on the roles that Toll-like receptors (TLRs), T cells (gamma delta, CD4, CD8), and macrophages play in mounting the innate and adaptive immune responses necessary to eradicate …

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Tcdd-Induced Modulation Of The Hs1,2 Enhancer Within The 3'Immunoglobulin Heavy Chain Regulatory Region, Tharu M. Fernando Jan 2009

Tcdd-Induced Modulation Of The Hs1,2 Enhancer Within The 3'Immunoglobulin Heavy Chain Regulatory Region, Tharu M. Fernando

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2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a potent environmental toxin that inhibits immunoglobulin (Ig) gene expression in mice. Transcriptional regulation of the Ig heavy chain (IgH) involves the 3'IgH regulatory region (3'IgH RR). The murine 3'IgH RR consists of four enhancers (hs3A, hs1,2, hs3B, and hs4), which are homologous to the human 3'IgH RR enhancers (hs3, hs1,2, and hs4). In humans, a polymorphism of the hs1,2 enhancer, resulting in a varying number of tandem repeats of a 53 bp sequence, has been correlated with autoimmune diseases like IgA nephropathy and Celiac disease. The repeated sequence contains a kB and DRE binding site. Previous …

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Identification Of Potential Protein Biomarkers Of Low Level Kidney Degradation, Christopher Lee Woolard Jan 2009

Identification Of Potential Protein Biomarkers Of Low Level Kidney Degradation, Christopher Lee Woolard

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The purpose of this research was the identification of potential dose-dependent and time-dependent serum protein biomarkers of low level kidney degradation in a rat model. Potential biomarkers were evaluated based on differential protein expression between control and dosed samples in rat serum. Proteins of interest demonstrated upregulation at a minimum 1.5 fold increase in protein concentration control versus dosed sample. In order to identify common biomarkers of kidney decrement, three nephrotoxins were chosen to target specific locations of the kidney: 1) D-Serine, which causes necrosis of the proximal straight tubules, 2) Puromycin, an antibiotic that degrades the Glomerular Basement Membrane …

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Embryonic And Postnatal Development Of The Neural Circuitry Involved In Motor Control, Valerie Cari Ann Siembab Jan 2009

Embryonic And Postnatal Development Of The Neural Circuitry Involved In Motor Control, Valerie Cari Ann Siembab

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The development of locomotion is believed to result from the maturation of the spinal circuits controlling motor output, however little is known about its mechanisms. To shed some light into this process we studied the development of the synaptic connectivity of two spinal inhibitory interneurons. Adult motoneurons are controlled by inhibitory networks that include recurrent and reciprocal inhibition (Pierrot-Deseilligny & Burke, 2005). Each is modulated by different ventral horn spinal interneurons that display synaptic connectivity adapted to their function: Renshaw cells (RCs) mediate recurrent inhibition, receive excitatory inputs from motor axons and inhibit homonymous and synergistic motoneurons; while Ia inhibitory …

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Hif-1 Alpha: A Master Regulator Of Trophoblast Differentiation And Placental Development, Kashmira Kulkarni Jan 2009

Hif-1 Alpha: A Master Regulator Of Trophoblast Differentiation And Placental Development, Kashmira Kulkarni

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Early embryonic development occurs under low oxygen levels. The placenta is an organ transiently formed during pregnancy and plays a crucial role during development of the embryo. Alterations in the placental structure or function have been associated with the pathologies such as preeclampsia in humans. In mammals, the hypoxia inducible factor (HIF) transcription factors have been identified as the major regulators of cellular responses in low oxygen. In the current study, we investigated the effects of low oxygen on the differentiation of trophoblast stem cells, lineage committed trophoblast giant cells and labyrinthine lineage-committed cells. We examined the effects of an …

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Physiological Effects On The Expression Of Aquaporin 1-Like Hc-1 In Cope's Gray Tree Frog, Hyla Chrysoscelis, Ram Naresh Pandey Jan 2009

Physiological Effects On The Expression Of Aquaporin 1-Like Hc-1 In Cope's Gray Tree Frog, Hyla Chrysoscelis, Ram Naresh Pandey

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Aquaporin 1 is a cell membrane integral protein, which functions for water transport through the hydrophobic cell membrane to the cytoplasm. HC-1 is an aquaporin 1-like protein expressed in Hyla chrysoscelis and amphibian that survives at sub-freezing temperatures in its natural habitat. The goal of the current study was to investigate the expression of HC-1 during changing physiological conditions. The expression level of HC-1 was determined in skin, muscle, liver, kidney, and intestines of warm, cold, frozen, and dehydrated frogs using Western blot and immunohistofluorescence. Although HC-1 was widely distributed, the expression level varied among tissues and physiological conditions. In …

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Inhibition Of Pro-Inflammatory Processes Reduces Sensitization Of The Behavioral Response To Maternal Separation, Kristopher Doojin Paik Jan 2009

Inhibition Of Pro-Inflammatory Processes Reduces Sensitization Of The Behavioral Response To Maternal Separation, Kristopher Doojin Paik

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The current study examined the behavioral sensitization of guinea pig pups in response to consecutive days of maternal separation. In the first experiment, guinea pigs that received centrally administered artificial cerebrospinal fluid or IL-10 exhibited sensitization of passive behaviors from Day 1 to Day 2. IL-10 decreased the levels of passive behaviors on Day 1, as well as the increase on Day 2. The second experiment used unoperated pups, which also showed sensitization of the passive response from Day 1 to Day 2, though the effect appeared reduced relative to control pups of Experiment 1. Collectively, this investigation confirms previous …

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Novel Neuroprotectants For Sarin Plus Cbdp Induced Convulsions, Kaushal V. Joshi Jan 2009

Novel Neuroprotectants For Sarin Plus Cbdp Induced Convulsions, Kaushal V. Joshi

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Sarin, also known as Sarin (German agent B) is classified as a weapon of mass destruction. Sarin (O-isopropyl methyl phosphonofluoridate) is a highly toxic nerve agent originally produced for chemical warfare and has been used in terrorist activities. Sarin is an extremely potent acetylcholinesterase inhibitor with high specificity and affinity for the enzyme. High sarin doses causes death due to anoxia resulting from airway obstruction, weakness of the muscles of respiration, respiratory failure and convulsions. Current treatments are still not effective at protecting against long term effects following exposure. A current approach aims to counteract the increased glutamatergic and cholinergic …

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Central Mechanisms Regulating Pituitary-Adrenal Activity In Infant Guinea Pigs (Cavia Porcellus) During Exposure To Psychological Stressors: Independent And Combined Effects Of Maternal Separation And Novelty, Deborah Suzanne Maken Jan 2009

Central Mechanisms Regulating Pituitary-Adrenal Activity In Infant Guinea Pigs (Cavia Porcellus) During Exposure To Psychological Stressors: Independent And Combined Effects Of Maternal Separation And Novelty, Deborah Suzanne Maken

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Separation from the maternal attachment figure, particularly when it occurs in a novel or threatening environment, reliably increases pituitary-adrenal activity in a number of species, and is thought to increase later susceptibility to psychopathology in humans. However, little is known about the central mechanisms mediating these effects. Therefore, I investigated cortisol and ACTH levels in plasma, corticotropin-releasing factor (CRF) mRNA expression in the hypothalamic paraventricular nucleus (PVN), and c-Fos activity in a circuit [medial amygdala (MeA)- bed nucleus of the stria terminalus (BNST)] thought to drive pituitary-adrenal activity during exposure to psychological stressors, as well as in the PVN. Measurements …

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Genetic Differentiation In Ambystomatid Salamanders Across A Fragmented Landscape, Joseph E. Bartoszek Jan 2009

Genetic Differentiation In Ambystomatid Salamanders Across A Fragmented Landscape, Joseph E. Bartoszek

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It is generally recognized that amphibian populations declining across the globe. Habitat loss is the primary cause of decline. The salamander family Ambystomatidae has experienced significantly more rapid decline than the average for amphibians. Coefficients of Conservatism (CoC) have been developed for amphibians in Ohio. These are based primarily on habitat requirements with high CoCs for amphibians with stringent habitat requirements (e.g. vernal pools associated with large, intact, undisturbed forest), and low CoCs for amphibians with less stringent habitat requirements. Genetic diversity in five species and one hybrid complex of ambystomatid salamander in southwest Ohio were examined and compared to …

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Development And Evaluation Of A Flexible Framework For The Design Of Autonomous Classifier Systems, Priya Ganapathy Jan 2009

Development And Evaluation Of A Flexible Framework For The Design Of Autonomous Classifier Systems, Priya Ganapathy

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We have established a modular virtual framework to design accurate, robust, efficient and cost-conscious autonomous target/object detection systems. Developed primarily for image-based detection problems, such as automatic target detection or computer-aided diagnosis, our approach is equally suitable for non-image-based pattern recognition problems. The framework features six modules: 1) the detection algorithm module accepts two-dimensional, spatially-coded sensor outputs; 2) the evaluation module uses our receiver operator characteristic (ROC)-like assessment tool to evaluate and fine-tune algorithm outputs; 3) the fusion module compares outputs combined under various fusion schemes; 4) the classifier selection module exploits the double-fault diversity measure (F2 DM) to identify …

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Characterization Of Excitatory Amino Acid Neurotransmitters At Motoneuron Synapses Contacting Renshaw Cells, Dannette Shanon Richards Jan 2009

Characterization Of Excitatory Amino Acid Neurotransmitters At Motoneuron Synapses Contacting Renshaw Cells, Dannette Shanon Richards

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Motoneurons are among the best studied neurons in the central nervous system. The motoneuron synapses have been well characterized in the periphery where they release acetylcholine at the neuromuscular junction. However excitatory amino acids also seem to be released from motoneuron terminals in the periphery, and centrally at their synapses contacting Renshaw cells. Although excitatory amino acids are suggested to be released from motoneuron synapses it is not known which excitatory amino acids (either aspartate or glutamate) are released, nor is the mechanism for their release known. To examine the presence and mechanism of release for aspartate and glutamate at …

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Churches As First Amendment Institutions: Of Sovereignty And Spheres, Paul Horwitz Jan 2009

Churches As First Amendment Institutions: Of Sovereignty And Spheres, Paul Horwitz

Articles

This Article offers a novel way of approaching the role of churches and other religious institutions within the First Amendment framework Beyond that it offers a broader organizing structure for the legal treatment of First Amendment institutions entities whose fundamental role in shaping and contributing to public discourse entitles them to substantial autonomy to organize and regulate themselves without state interference Drawing on the work of the neoCalvinist writer Abraham Kuyper it encourages us to think about churches and other First Amendment entities as sovereign spheres nonstate institutions whose authority is ultimately coequal to that of the state In the …

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The Suspension Theory: Hurricane Katrina Looting, Property Rights, And Personhood Comment, Casey E. Faucon Jan 2009

The Suspension Theory: Hurricane Katrina Looting, Property Rights, And Personhood Comment, Casey E. Faucon

Articles

No abstract provided.

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The Influence Of Temperature On Population Growth And Allergen Production In Cultured House Dust Mites - Dermatophagoides Pteronyssinus And Dermatophagoides Farinae, Lakshmi Yella Jan 2009

The Influence Of Temperature On Population Growth And Allergen Production In Cultured House Dust Mites - Dermatophagoides Pteronyssinus And Dermatophagoides Farinae, Lakshmi Yella

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Dermatophagoides pteronyssinus and Dermatophagoides farinae are commercially cultured to produce materials to make extracts for diagnostic tests and immunotherapy. There is some speculation as to how the culture conditions such as time of culture, temperature, relative humidity and food might influence the mite populations and subsequent production of allergens. The purpose of our investigation was to see how temperature influenced the population growth and allergen production of cultured house dust mites. D. pteronyssinus and D. farinae were cultured at 20°C and 25°C. Samples were collected at two week intervals for live mite count, life stage composition and to determine Group …

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Permitting Under The Clean Air Act: How Current Standards Impose Obstacles To Achieving Environmental Justice, Annise Katherine Maguire Jan 2009

Permitting Under The Clean Air Act: How Current Standards Impose Obstacles To Achieving Environmental Justice, Annise Katherine Maguire

Michigan Journal of Race and Law

Most studies about the environmental justice movement focus on the disproportionate share of environmental burdens minority and low-income populations bear, the negative effects of an unequal distribution of undesirable land uses, and how industry contributes to the adverse impacts suffered by the communities. Unfortunately, trying to prove that an injury was caused by actions of a nearby facility is difficult, and this approach has yielded few legal victories for environmental justice communities. While it is important to remain focused on how environmental justice communities are disproportionately impacted by undesirable land uses, the analysis must shift if the law is to …

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Understanding The Link Between Ethanol Production And Food Prices, Nathalia Ferreira Monteiro Jan 2009

Understanding The Link Between Ethanol Production And Food Prices, Nathalia Ferreira Monteiro

Theses

Food prices have increased rapidly in recent years, and so has ethanol consumption. Some studies have claimed that there is a connection between those two. Net exporters of food tend to benefit from higher prices, while regions that are net importers of food, tend to be adversely affected. The large amount of poor countries in the second group justifies an investigation of the causes of increasing food prices. This thesis aims to contribute to the discussion, analyzing, theoretically and empirically, the impact that the diversion of feedstock from food to ethanol production has on food prices. The interaction between food …

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Panelists Biographies , American University Washington College Of Law Office Of Student Affairs Jan 2009

Panelists Biographies , American University Washington College Of Law Office Of Student Affairs

American University Journal of Gender, Social Policy & the Law

No abstract provided.

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Concentration Of Metabolites And Behavior Of Live Weight In Llamas (Lama Glama) Fed With Natural Grass And Barley During Gestation, Postpartum, And New Born Phases In Turco, Department Of Oruro, Eduardo Ticona Benique Jan 2009

Concentration Of Metabolites And Behavior Of Live Weight In Llamas (Lama Glama) Fed With Natural Grass And Barley During Gestation, Postpartum, And New Born Phases In Turco, Department Of Oruro, Eduardo Ticona Benique

Theses and Dissertations

The llama, a potential socioeconomic resource in the Bolivian highlands, faces serious nutritional deficiencies during the gestational and postpartum stages that negatively affect production. This study was conducted at the Tika Huta Experimental Center in the Llachu community of the Oruro prefecture. Our objectives were to determine metabolite concentration in blood plasma as well as live weight performance of pregnant and postpartum female llamas. Adult and juvenile llamas were fed diets of either plain natural grass or natural grass combined with 0.4 kg of barley hay. In addition, we determined metabolite concentrations in blood plasma and live weight performance of …

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Zoometric Measures In Llamas (Lama Glama) Of Rural Families In The T'Olar And Pajonal Natural Grazing Fields Of The Municipality Santiago De Machaca - Department Of La Paz, Eloy Tuco Cano Jan 2009

Zoometric Measures In Llamas (Lama Glama) Of Rural Families In The T'Olar And Pajonal Natural Grazing Fields Of The Municipality Santiago De Machaca - Department Of La Paz, Eloy Tuco Cano

Theses and Dissertations

Llamas have provided, and continue to provide, fiber, meat, skins, fertilizer and transport for the Andean people. In addition, they are part of the traditional and religious culture of the Aymara and the Quechua. Both are currently unaware of the productive qualities of llamas, especially those related to meat production, which is the principle product responsible for generating greater income for farmers. For this reason, 554 llamas were evaluated from a total of 3,693 in 2005. The llamas came from T’olar and Pajonal grasslands in the Santiago de Machaca region of La Paz, Bolivia and represented males and females from …

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Irreconcilable Differences? The Troubled Marriage Of Science And Law, Susan Haack Jan 2009

Irreconcilable Differences? The Troubled Marriage Of Science And Law, Susan Haack

Law and Contemporary Problems

There haven't always been scientific witnesses: in fact, there haven't always been witnesses. In early medieval times, courts relied on tests by oath, ordeal, and sometimes by combat. Here, Haack provides a brief historical background to the use of scientific experts in law and then proceeds to discuss in greater detail the values underlying scientific inquiry, the uncertainty in the quest of knowledge and understanding, and the methods by which consensus is reached, even if that consensus is always tentative. She then contrasts scientific inquiry with the law's quest for "truth" in the courtroom and, particularly, the normative and temporal …

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How Much Evidence Is Enough? Conventions Of Causal Inference, David Kriebel Jan 2009

How Much Evidence Is Enough? Conventions Of Causal Inference, David Kriebel

Law and Contemporary Problems

One of the most important issues for science in the courtroom is the determination of causality. Like science in the courtroom, science in the regulatory arena can also bring a clash of cultures, misunderstanding, and controversy--especially when decisions must be made with some urgency with interested parties watching closely. Here, Kriebel discusses some conventions in the conduct of science and in the ways that scientific information is communicated to nonscientists that can make it difficult for judges, lawyers, regulators, and politicians to do their jobs making decisions about complex environmental and health issues.

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Merton And The Hot Tub: Scientific Conventions And Expert Evidence In Australian Civil Procedure, Gary Edmond Jan 2009

Merton And The Hot Tub: Scientific Conventions And Expert Evidence In Australian Civil Procedure, Gary Edmond

Law and Contemporary Problems

Recently in Australia, common-law judges began to modify the way expert evidence is prepared and presented. Judges from a range of civil jurisdictions have conscientiously sought to reduce expert partisanship and the extent of expert disagreement in an attempt to enhance procedural efficiency and improve access to justice. One of these reforms, concurrent evidence, enables expert witnesses to participate in a joint session with considerable testimonial latitude. This represents a shift away from an adversarial approach and a conscientious attempt to foster scientific values and norms. Here, Edmond describes how changes to Australian civil procedure, motivated by judicial concerns about …

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In The Wake Of Ledbetter V. Goodyear Tire & Rubber Company: Applying The Discovery Rule To Determine The Start Of The Limitations Period For Pay Discrimination Claims, Nancy Zisk Jan 2009

In The Wake Of Ledbetter V. Goodyear Tire & Rubber Company: Applying The Discovery Rule To Determine The Start Of The Limitations Period For Pay Discrimination Claims, Nancy Zisk

Duke Journal of Gender Law & Policy

"14 These laws include Title VII of the Civil Rights Act of 1964,15 Section 1981 of the Civil War Reconstruction statutes,16 the Age Discrimination in Employment Act of 1967 (ADEA),17 the Equal Pay Act (EPA),18 and the Americans with Disabilities Act of 1990 (ADA).19 While the statutes define different types of discrimination, each addresses discrimination in employment and defines a limitations period in which an employee can bring a claim.20 With Title VII defining the "paradigm," the first step in determining whether a claim is timely under any statute is determining when the discriminatory act takes place.21 To do that, …

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Theodicy And Execution For Expiation In 2 Samuel 21:1-14, Carrie S. Rhodes Jan 2009

Theodicy And Execution For Expiation In 2 Samuel 21:1-14, Carrie S. Rhodes

Master's Theses

Problem The execution of Saul’s descendants in 2 Sam 21:1-14 has long been interpreted as resulting from David’s succession motives, and may appear to be posthumous ruler punishment, expiation on Saul’s behalf, or an error in judgment on David’s part in whom to turn to in order to know what to do in this case. In addition, the delay in justice until David’s reign for something that Saul had done is puzzling. Method Analysis of the Hebrew text, comparison between ANE and biblical homicide law, examination of the sociological structure of the ANE family, examination of the characters of Saul …

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A Remote Sensing And Gis-Assisted Spatial Decision Support System For Hazardous Waste Site Monitoring, John R. Jensen, Michael E. Hodgson, Maria Garcia-Quijano, Jungho Im, Jason A. Tullis Jan 2009

A Remote Sensing And Gis-Assisted Spatial Decision Support System For Hazardous Waste Site Monitoring, John R. Jensen, Michael E. Hodgson, Maria Garcia-Quijano, Jungho Im, Jason A. Tullis

Faculty Publications

Humans produce large amounts of waste that must be processed or stored so that it does not contaminate the environment. When hazardous wastes are stored, waste site monitoring is typically conducted in situ which can lead to a serious time lag between the onset of a problem and detection. A Remote Sensing and GIS-assisted Spatial Decision Support System for Hazardous Waste Site Monitoring was developed to improve hazardous waste site management. The system was designed to be recursive, flexible, and integrative. It is recursive because the system is implemented iteratively until the risk assessment subsystem determines that an event is …

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Role Of Cyclophilin D In Secondary Spinal Cord And Brain Injury, Jordan Mills Clark Jan 2009

Role Of Cyclophilin D In Secondary Spinal Cord And Brain Injury, Jordan Mills Clark

University of Kentucky Doctoral Dissertations

In the hours and days following acute CNS injury, a secondary wave of events is initiated that exacerbate spinal tissue damage and neuronal cell death. A potential mechanism driving these secondary events is opening of the mitochondrial permeability transition pore (mPTP) and subsequent release of several cell death proteins. Previous studies have shown that inhibition of cyclophilin D(CypD), the key regulating component in mPTP opening, was protective against insults that induce necrotic cell death. We therefore hypothesized that CypD-null mice would show improved functional and pathological outcomes following spinal cord injury (SCI) and traumatic brain injury (TBI). Moderate and severe …

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Glutamate Regulation In The Hippocampal Trisynaptic Pathway In Aging And Status Epilepticus, Michelle Lee Stephens Jan 2009

Glutamate Regulation In The Hippocampal Trisynaptic Pathway In Aging And Status Epilepticus, Michelle Lee Stephens

University of Kentucky Doctoral Dissertations

A positive correlation exists between increasing age and the incidence of hippocampal-associated dysfunction and disease. Normal L-glutamate neurotransmission is absolutely critical for hippocampal function, while abnormal glutamate neurotransmission has been implicated in many neurodegenerative diseases. Previous studies, overwhelmingly utilizing ex vivo methods, have filled the literature with contradicting reports about hippocampal glutamate regulation during aging. For our studies, enzyme-based ceramic microelectrode arrays (MEA) were used for rapid (2 Hz) measurements of extracellular glutamate in the hippocampal trisynaptic pathway of young (3-6 months), late-middle aged (18 mo.) and aged (24 mo.) urethane-anesthetized Fischer 344 rats. Compared to young animals, glutamate terminals …

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"My Dear Mrs. Baskin": Marjorie Kinnan Rawlings And Hamilton Holt, Maurice O'Sullivan Jan 2009

"My Dear Mrs. Baskin": Marjorie Kinnan Rawlings And Hamilton Holt, Maurice O'Sullivan

The Marjorie Kinnan Rawlings Journal of Florida Literature

No abstract provided.

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The Rawlings/Holt Correspondence Jan 2009

The Rawlings/Holt Correspondence

The Marjorie Kinnan Rawlings Journal of Florida Literature

No abstract provided.

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