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Richard J. Clifford, Ed. Wisdom Literature In Mesopotamia And Israel, Alan Lenzi

College of the Pacific Faculty Articles

The article reviews the book "Wisdom Literature in Mesopotamia and Israel," edited by Richard J. Clifford.

The Cab Model Of Pain-Related Activity Avoidance: Description And Implications For Research And Practice, Todd E. Davenport, Andrea B. Austin, Kimiko A. Yamada, Cathryn A. Peterson

School of Pharmacy Faculty Articles

Background and Purpose: Pain-related activity avoidance is a phenomenon that causes substantial annual patient morbidity. Therefore, it has been the subject of many recent studies related to physical therapist practice. The purposes of this review are: (1) to provide a rationale for considering cognition and affect in physical therapist practice, and (2) to propose the CAB Model for patient education in physical therapist management of pain-related activity avoidance.

Method: Narrative review. Findings: 'CAB' is an acronym that emphasizes _Cognition and Affect in designing patient education programs that facilitate change in avoidant Behavior.

Clinical Relevance: This review synthesizes literature that suggests …

The International Law Commission Adopts Draft Articles On Transboundary Aquifers, Stephen C. Mccaffrey

McGeorge School of Law Scholarly Articles

No abstract provided.

Acceptance Of Evolution Increases With Student Academic Level: A Comparison Between A Secular And A Religious College, Guillermo Paz-Y-Mino C., Avelina Espinosa

Arts & Sciences Faculty Publications

Acceptance of evolution among the general public, high schools, teachers, and scientists has been documented in the USA; little is known about college students’ views on evolution; this population is relevant since it transits from a high-school/parent-protective environment to an independent role in societal decisions. Here we compare perspectives about evolution, creationism, and intelligent design (ID) between a secular (S) and a religious (R) college in the Northeastern USA. Interinstitutional comparisons showed that 64% (mean S + R) biology majors vs. 42/62% (S/R) nonmajors supported the exclusive teaching of evolution in science classes; 24/29% (S/R) biology majors vs. 26/38% (S/R) …

The Numerical Comparison Of Flow Patterns And Propulsive Performances For The Hydromedusae Sarsia Tubulosa And Aequorea Victoria, Mehmet Sahin, Kamran Mohseni, Sean Colin

Arts & Sciences Faculty Publications

The thrust-generating mechanism of a prolate hydromedusa Sarsia tubulosa and an oblate hydromedusa Aequorea victoria was investigated by solving the incompressible Navier–Stokes equations in the swirl-free cylindrical coordinates. The calculations clearly show the vortex dynamics related to the thrust-generating mechanism, which is very important for understanding the underlying propulsion mechanism. The calculations for the prolate jetting hydromedusa S. tubulosa indicate the formation of a single starting vortex ring for each pulse cycle with a relatively high vortex formation number. However, the calculations for the oblate jet-paddling hydromedusa A. victoria indicate shedding of the opposite-signed vortex rings very close to each …

Crawling To Collapse: Ecologically Unsound Ornamental Invertebrate Fisheries, Andrew L. Rhyne, Randi Rotjan, Andrew Bruckner, Michael Tlusty

Arts & Sciences Faculty Publications

Background: Fishery management has historically been an inexact and reactionary discipline, often taking action only after a critical stock suffers overfishing or collapse. The invertebrate ornamental fishery in the State of Florida, with increasing catches over a more diverse array of species, is poised for collapse. Current management is static and the lack of an adaptive strategy will not allow for adequate responses associated with managing this multi-species fishery. The last decade has seen aquarium hobbyists shift their display preference from fish-only tanks to miniature reef ecosystems that include many invertebrate species, creating increased demand without proper oversight. The once …

Contradance And Quadrille Culture In The Caribbean, Peter L. Manuel

Publications and Research

No abstract provided.

Profits Above The Law: China’S Melamine Tainted Milk Incident, Chenglin Liu

Faculty Articles

There are fundamental flaws within China’s food safety regulatory regime that permeate both its supervision system and governing laws. This is especially prevalent within the market structure in the dairy industry. The government continues to fail in regulating the chaotic market forcing competitors to internalize costs, which has resulted in melamine tainted milk.

This tainted milk scandal has resulted in the death of thousands of infants in a number of Asian countries. The scandal was concealed by the Sanlu Group and local government for fear of bad publicity and loss of profits.

The Chinese government should search for a new …

Computational Analysis Of Metabolomic Toxicological Data Derived From Nmr Spectroscopy, Benjamin J. Kelly

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Nuclear magnetic resonance (NMR) spectroscopy is a non-invasive method of acquiring metabolic profiles from biofluids. The most informative metabolomic features, or biomarkers, may provide keys to the early detection of changes within an organism such as those that result from exposure to a toxin. One major difficulty with typical NMR data, whether it come from a toxicological, medical or other source, is that it features a low sample size relative to the number of variables measured. Thus, traditional pattern recognition techniques are not always feasible. The "curse of dimensionality" is an important consideration in selecting appropriate statistical and pattern recognition …

Dose-Dependent Effects Of Oxygen On Metabolism In Rat Cortico-Hippocampal Brain Tissue Slices, Jennifer Lynne Hollyfield

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Studies have shown that 95% oxygen increases neuronal excitability and ROS production. We wanted to investigate the dose-dependent effects of oxygen on brain slice metabolism. We exposed rat brain cortico-hippocampal tissue slices to 0.40, 0.95, and 4.50 ATA O2 for 60 minutes, made dual-phase tissue extracts, and used multi-nuclear NMR experiments to elucidate the slice metabolism. We found that low doses of oxygen may shift metabolism toward anaerobic glycolysis. Elevated lactate suggests this shift, along with elevated ratios of NAD+/NADH which may drive the reactions toward the production of lactate. The results also suggest that high doses of oxygen may …

Cellular Function Of The Ia-Motoneuron Circuit Following Peripheral Nerve Regeneration, Katie Leigh Bullinger

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Successful regeneration of a severed peripheral nerve is insufficient to restore the stretch reflex. This deficit occurs despite successful muscle reinnervation and functional restoration of the circuit components. For example, Ia afferents encode muscle stretch, Ia-motoneuron synapses reform to the extent of restoring low frequency transmission, and activation of motoneurons results in muscle force output. However, when recording intracellularly from reinnervated rat motoneurons during ramp hold and release muscle stretch, no excitatory synaptic potentials are detected in 2/3 motoneurons (Haftel et al., 2005), a clear sign that the synapses connecting Ia afferents with motoneurons are physiologically disrupted. This thesis examines …

Visual Contributions To Spatial Perception During A Remote Navigation Task, Candace Lee Eshelman-Haynes

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The purpose of this study was to explore the implications of perception and action coupling for the design of control and display interfaces in remotely piloted vehicles. Three experiments were conducted: spatial arrangement, path perception, and remote navigation. The results showed that panning independent of forward motion gives observers a greater sense of depth in a scene and aides in efficient navigation while rotation during forward motion results in ambiguities during passive observation. This research has implications for the design of control and visualization interfaces for remote navigation.

Ischemic Stroke In Type Ii Diabetic Mice: Deregulation Of Sdf-1a/Cxcr4 Axis, Avik Das

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Type 2 diabetes mellitus is a major risk factor for ischemic stroke. Also diabetes is associated with poor outcome after stroke. Underlying mechanisms are however not fully understood. Alteration in the expression of the SDF-1a/CXCR4 axis, which is important for ischemic tissue repair, can be a probable cause. In this study, we have determined the expression of SDF-1a/CXCR4 in the brains of type II diabetic mice at basal and in response to ischemic stroke and have investigated a method for overexpression of SDF-1a in the brains of the diabetic mice. Adult male C57BLKS/J mice (db/db) of age 8 weeks were …

The Presynaptic Regulation Of Isolated Neonatal Rat Carotid Body Type I Cells By Histamine, Drew C. Burlon

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It has been previously shown that Carotid Body Type I cells have the ability to synthesize, package and release histamine in response to hypoxia, thereby contributing to the modulation of respiration within the rat. Here, isolated neonatal rat carotid body type I cells were used to identify the presynaptic effects of histamine and the specific receptor subtypes that modulate them. Although all four histamine receptor subtypes are expressed on the type I cells, and preliminary data showed promising results, further data proved that the activation of these receptors with histamine or selective agonists caused no rise in intracellular calcium ([Ca2+]i) …

Risk-Sensitive Foraging Facilitates Species-Level Trophic Cascades Among Terrestrial Mammals: A Meta-Analysis, Bryan David Murray

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The widespread removal of large carnivores from terrestrial ecosystems may be contributing to plant species loss and biotic homogenization through trophic cascades. A few plants not preferred by ungulates are increasing in abundance while the majority of preferred plants are in decline. A meta-analysis of recruitment gaps in browse-sensitive tree species demonstrated that failed recruitment coincided in time with carnivore loss. In all studies recruitment continued in nearby browsing refugia. A second meta-analysis revealed that the mechanism of mammalian herbivore-mediated trophic cascades contains a behavioral component. Foraging mammals exhibited higher giving-up densities (GUDs) when under higher predation risk. GUDs were …

Effect Of Low-Dose Sarin Exposure On The Neurochemistry Of Different Brain Structures In Mice, Dhawal Pravin Oswal

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Sarin (GB) is a toxic organophosphate (OP) nerve agent that was released in the Gulf War and was used in terrorist attacks in Japan. People who survive such attacks exhibit various long-term effects including alterations in neuropsychological performances. It has also been hypothesized that the Gulf War Illness could be a result of low level exposure to OP's. In order to understand the effect of low dose exposure to GB on physiological and behavioral functions, we analyzed the levels of monoamines and their metabolites in different brain areas after exposure of mice to a sublethal dose of GB. Mice (male …

Impact Of Diabetes On Ace/Ace2 Balance And Angiotensin Ii Type 1 Receptor Expression In Db/Db Diabetic Mice, Malav Navinchandra Madhu

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Alterations in the renin-angiotensin system (RAS) are considered to be crucial for the development of diabetic complications like hypertension and nephropathy. Our previous work demonstrated role of AT1 receptors (AT1R) in the development of hypertension in db/db diabetic mice. The aim of this study was to test the hypothesis that there is upregulation of renal AT1R and imbalance in renal ACE/ACE2 homeostasis in db/db mice. In addition, we hypothesize that treatment with an anti-hyperglycemic or an AT1R blocker will correct this imbalance. Five week old control and db/db mice were housed in metabolic cages for 24 hour collection of urine. …

A Potential Strategy To Maintain Hsv-1 In A Latent State: Use Of Immunoregulatory Peptide Mimetics, Nasrin Majidi

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This study reviews the role of interferon-gamma (IFN-gamma) in HSV-1 latency. CD8+ T cells inhibit the reactivation of HSV-1 in trigeminal ganglia (TG) by production of IFN-gamma. Although CD8+ T cells include all the cytotoxic apparatus for cytotoxicity, latently infected neuronal cells are not killed by CD8+ T cells. The CD94-NKG2a molecule on CD8+ T cells, binds to Qa-1b (a MHC class I like molecule) present on neuronal cell to inhibit CD8+ T cells cytotoxicity. Other studies have also determined that the IFN-gamma peptide mimetic 95-132 inhibits HSV-1 replication in the same way as IFN-gamma in infected cells. IFN-gamma mimetic …

Finding The Trophic Trickle: Using Herbaceous Indicator Species To Investigate Plant Recovery From Intense Browsing By White-Tailed Deer (Odocoileus Virginianus) After The Re-Colonization Of A Top Predator (Canis Lupus), Krystle A. Bouchard

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High densities of white-tailed deer (Odocoileus virginianus) have been implicated in changing forest community structure and composition. Top predators, including gray wolf (Canis lupus), were extirpated from much of their range by the mid 1900s, but have since returned to Northern Wisconsin. To determine whether the re-colonization of wolves could initiate a trophic cascade resulting in the recovery of understory plants from deer browsing, I surveyed four herbaceous species in areas without wolves and areas with 4-6 year old wolf packs and 12-13 year old wolf packs. Plant size and reproduction were greater in areas where wolves had been for …

The Role Of Nucleotide Signaling In The Regulation Of Icl,Swell In Human 1321n1 Astrocytoma Cells, Ian C. Wenker

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Swollen cells expel osmolytes to decrease volume in a process referred to as Regulatory Volume Decrease, or RVD. The plasma membrane current ICl,swell is ubiquitously expressed in mammalian cells and contributes significantly to RVD. In a variety of cell types, activation of ICl,swell is enhanced by nucleotide signaling. In this study, we used human astrocytoma cells to examine whether nucleotide signaling is necessary or sufficient for ICl,swell activation. Three clones of the 1321N1 human astrocytoma cell line were used for voltage clamp recordings. One clone was transfected with P2Y1 receptors, another with P2Y2 receptors and a third was devoid of …

Small Conductance Calcium-Activated Potassium (Sk) Channels In Mammalian Spinal Motoneurons, Zhihui Deng

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Three homologous small conductance calcium-activated potassium (SK) channel subunits (SK1, SK2, and SK3) are expressed in distinct and overlapping patterns in mammalian central nervous system. SK channels likely mediate the medium afterhyperpolarization (mAHP), which plays an essential role in regulating neuron repetitive firing frequency. In spinal motoneurons (MNs) the mAHP duration is shorter on average in fast (F-type) MNs than that in slow (S-type) MNs. To better understand the molecular basis for mAHP, we determined the expression and sub-cellular distribution of SK channels in normal, axonally-injured, and developing spinal MNs in vivo using immunohistochemistry and quantitative confocal imaging techniques.

SK2 …

Characterization Of Infectivity And Pathogenesis Of Partially Reconstructed 1918 And Highly Pathogenic Avian Influenza Viruses In The Balb/C Mouse Model, John Allen Pyles

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Influenza viruses are consistently responsible for an average of 20,000 deaths and 114,000 hospitalizations per year. To a great extent, these viruses always stay one step ahead of the available vaccines and people's immunity year after year because they have the ability to either mutate part of their genetic material, or to be transmitted from one species to another. That same genetic variability explains why highly pathogenic influenza viruses emerge that cause great mortality over several countries resulting in pandemics. Highly pathogenic strains of influenza A virus have emerged occasionally in recent history, producing pandemics such as the one in …

Immunolocalization And Changes In Expression Levels Of Glyceroporin Hc-3 In Several Tissues Of Gray Tree Frogs, Hyla Chrysoscelis Under Different Physiological Conditions, Sushmita Yaganti

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Previous studies show that aquaporin HC-3 in gray tree frogs, Hyla chrysoscelis, a homolog of mammalian AQP3 is an aqua glyceroporin also responsible for freeze tolerance. Our study tried to localize and compare the protein expression levels of aquaporin HC-3 in seven different organs of gray tree frogs under five different physiological conditions using immuno histofluorescence and western blot. HC-3 was immunolocalized in the epidermis and dermis of the skin, basolateral portion of the collecting ducts in the kidney, red blood cells in the liver and other tissues, muscle Schwann cells and the basolateral portion of the large intestine epithelial …

Induction Of Socs-1 In Hsv-1-Infected Murine Keratinocytes: A Mechanism Of Inhibition Of Interferon Gamma, Kenneth Gene Frey

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Epidermal cells such as keratinocytes are the major site of Herpes Simplex Virus Type 1 (HSV-1) replication in active primary or recurring herpes infection. In this study, a murine keratinocyte cell line (HEL-30) was shown to be refractory to IFNγ induction of an antiviral state to HSV-1 infection, while IFNγ did induce an antiviral state in a murine fibroblast cell line (L929). Particularly, IFN-gamma and its peptide mimetic protected fibrobasts from viral-induced cytopathic effect while the keratinocytes were destroyed by the infection. Suppressor of cytokine synthesis-1 (SOCS-1) a negative regulator of IFNγ, was hypothesized to be responsible for the refractiveness …

Inflammatory Cytokines In Jet Propulsion Fuel-8 Induced Irritant Contact Dermatitis In Male Fischer Rats, Thomas Joseph Kannanayakal

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Contact dermatitis is one of the most common occupational diseases. Absenteeism of the affected workers and associated health care costs makes this disease an economically important issue. Irritant contact dermatitis (ICD) is a common contact dermatitis observed among workers. As each category of irritants triggers the inflammatory process by different method, studying the mechanism of ICD is difficult. Information on the mechanism of action of an irritant is indispensable for the development of effective prophylactic and therapeutic measures. In this study, we have investigated the early changes in rat skin induced by jet fuel-8 (JP-8). Although previous studies have described …

Conservation Genetics Of A Near Threatened Freshwater Mussel Species (Lampsilis Cardium) And Improved Prospects For Recovery: How Nuclear And Mitochondrial Dna Analyses Inform Natural History And Conservation, Chad D. Ferguson

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Freshwater mussels (Bivalvia: Unionidae) are among the most imperiled organisms in North America. While there is an urgent need for effective conservation planning and management of these organisms, important basic biological information is lacking. This research characterizes levels of genetic diversity and population structure in the Near Threatened (IUCN) freshwater mussel Lampsilis cardium in populations from Twin Creek (southwest Ohio), Little Darby and Big Darby Creeks (central Ohio), and Little Muskingum River (eastern Ohio) and assesses the extent to which regional geological events explain population structuring. Data from the congener Lampsilis ovata from Clinch River (Tennessee) are included for comparison. …

Using Morphometrics, Phylogenetic Systematics And Parsimony Analysis To Gain Insight Into The Evolutionary Affinities Of The Calymenidae Trilobita, Alex J. Chestnut

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The most common trilobite in the Silurian carbonates of Ohio - especially the Springfield Dolomite - is a species that has been assigned to at least five genera over the past 100 years. This trilobite has been variously referred to as Calymene celebra, Apocalymene celebra, Flexicalymene celebra, Gravicalymene celebra, and Sthenarocalymene celebra. Reexamination of the species "Calymene" celebra through parsimony and morphometric analysis was conducted to properly place this calymenid species within the correct genus. What compounds the confusion is that the characters used to seperate the genera within the family Calymenidae, and therefore create the basis for the argument …

Reorganization Of Ia Afferent Synapses On Motoneurons After Peripheral Nerve Injuries, Haley E. Titus

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After peripheral nerve injuries patients lose and do not recover the stretch reflex which leads to altered locomotor function. The focus of this thesis is to investigate the structural integrity of the central connection between Ia afferents and alpha motoneurons that mediate the stretch reflex. The overall hypothesis is that the density and distribution of Ia synapses on motoneurons is altered after peripheral nerve injuries. Analysis of Ia afferent-motoneuron contacts, revealed by vesicular glutamate transporter 1 (VGLUT1) immunoreactivity, on the soma and dendritic arbor of motoneurons after peripheral nerve injuries revealed major reorganizations in the distribution and density of Ia …

Clamping Of Intracellular Ph In Neurons From Neonatal Rat Brainstem During Hypercapnia, Vivian C. Nanagas

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In this work, I have made attempts to clamp intracellular pH in the presence of hypercapnic acidosis (HA) in neurons from the locus coeruleus (LC) and nucleus of the solitary tract (NTS) in neonatal rat (ages P3 to P17) brainstem slices. Two approaches were used to minimize hypercapnia-induced ΔpH_i: 1) an increase in intracellular buffering power with a high HEPES concentration using whole cell patching techniques in individual neurons, and 2) a weak acid diffusion technique that relies on an efflux of weak acid to counterbalance HA influx thereby clamping pH_i in multiple neurons at once. pH …

Host Defense Mechanisms Against Mycobacterium Tuberculosis, Laurin Nicole Holloway

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Mycobacterium tuberculosis is one of the world's most infectious diseases. Approximately 2 million people die each year from Mycobacterium tuberculosis infection and one-third of the world's population remains infected. For decades research has focused on uncovering the tactics used by Mycobacterium tuberculosis to evade host immune responses and defense mechanisms used to fight tuberculosis infection. The following review focuses on the host defense mechanisms used to combat Mycobacterium tuberculosis with an emphasis placed on the roles that Toll-like receptors (TLRs), T cells (gamma delta, CD4, CD8), and macrophages play in mounting the innate and adaptive immune responses necessary to eradicate …