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2008

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Ly2109761, A Novel Transforming Growth Factor Beta Receptor Type I And Type Ii Dual Inhibitor, As A Therapeutic Approach To Suppressing Pancreatic Cancer Metastasis, Davide Melisi, Satoshi Ishiyama, Guido M Sclabas, Jason B Fleming, Qianghua Xia, Giampaolo Tortora, James L Abbruzzese, Paul J Chiao Apr 2008

Ly2109761, A Novel Transforming Growth Factor Beta Receptor Type I And Type Ii Dual Inhibitor, As A Therapeutic Approach To Suppressing Pancreatic Cancer Metastasis, Davide Melisi, Satoshi Ishiyama, Guido M Sclabas, Jason B Fleming, Qianghua Xia, Giampaolo Tortora, James L Abbruzzese, Paul J Chiao

Faculty, Staff and Student Publications

Most pancreatic cancer patients present with inoperable disease or develop metastases after surgery. Conventional therapies are usually ineffective in treating metastatic disease. It is evident that novel therapies remain to be developed. Transforming growth factor beta (TGF-beta) plays a key role in cancer metastasis, signaling through the TGF-beta type I/II receptors (TbetaRI/II). We hypothesized that targeting TbetaRI/II kinase activity with the novel inhibitor LY2109761 would suppress pancreatic cancer metastatic processes. The effect of LY2109761 has been evaluated on soft agar growth, migration, invasion using a fibroblast coculture model, and detachment-induced apoptosis (anoikis) by Annexin V flow cytometric analysis. The efficacy …

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Google And The Search For Federal Government Information, Bonnie Klein Apr 2008

Google And The Search For Federal Government Information, Bonnie Klein

Against the Grain

No abstract provided.

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Full Page Ads, Editor Apr 2008

Full Page Ads, Editor

Against the Grain

No abstract provided.

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The Montclarion, April 01, 2008, The Montclarion Apr 2008

The Montclarion, April 01, 2008, The Montclarion

The Montclarion

Student Newspaper of Montclair State University

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After The Storm: Post-Katrina Reflections From Afs Members In Louisiana And Mississippi, Martin O'Connell Apr 2008

After The Storm: Post-Katrina Reflections From Afs Members In Louisiana And Mississippi, Martin O'Connell

Earth and Environmental Sciences Faculty Publications

No abstract provided.

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Little Red Herrings -- Irs Rx For Libs? Possibly., Mark Y. Herring Apr 2008

Little Red Herrings -- Irs Rx For Libs? Possibly., Mark Y. Herring

Against the Grain

No abstract provided.

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Atg Interviews Skip Pritchard, Katina Strauch Apr 2008

Atg Interviews Skip Pritchard, Katina Strauch

Against the Grain

No abstract provided.

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Using Rare Books To Inspire Learning -- Part 2: Drama - Travel, Gene Waddell Apr 2008

Using Rare Books To Inspire Learning -- Part 2: Drama - Travel, Gene Waddell

Against the Grain

No abstract provided.

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Imperfect Tools: Google Scholar Vs. Traditional Commercial Library Databases, Julie Arendt Apr 2008

Imperfect Tools: Google Scholar Vs. Traditional Commercial Library Databases, Julie Arendt

Against the Grain

No abstract provided.

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Trail Mediates Liver Injury By The Innate Immune System In The Bile Duct-Ligated Mouse., Alisan Kahraman, Fernando J. Barreyro, Steven F. Bronk, Nathan W. Werneburg, Justin L. Mott, Yuko Akazawa, Howard C Masuoka, Charles L Howe, Gregory J. Gores Apr 2008

Trail Mediates Liver Injury By The Innate Immune System In The Bile Duct-Ligated Mouse., Alisan Kahraman, Fernando J. Barreyro, Steven F. Bronk, Nathan W. Werneburg, Justin L. Mott, Yuko Akazawa, Howard C Masuoka, Charles L Howe, Gregory J. Gores

Journal Articles: Biochemistry & Molecular Biology

The contribution of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a death ligand expressed by cells of the innate immune system, to cholestatic liver injury has not been explored. Our aim was to ascertain if TRAIL contributes to liver injury in the bile duct-ligated (BDL) mouse. C57/BL6 wild-type (wt), TRAIL heterozygote (TRAIL(+/-)), and TRAIL knockout (TRAIL(-/-)) mice were used for these studies. Liver injury and fibrosis were examined 7 and 14 days after BDL, respectively. Hepatic TRAIL messenger RNA (mRNA) was 6-fold greater in BDL animals versus sham-operated wt animals (P < 0.01). The increased hepatic TRAIL expression was accompanied by an increase in liver accumulation of natural killer 1.1 (NK 1.1)-positive NK and natural killer T (NKT) cells, the predominant cell types expressing TRAIL. Depletion of NK 1.1-positive cells reduced hepatic TRAIL mRNA expression and serum alanine aminotransferase (ALT) values. Consistent with a role for NK/NKT cells in this model of liver injury, stress ligands necessary for their recognition of target cells were also up-regulated in hepatocytes following BDL. Compared to sham-operated wt mice, BDL mice displayed a 13-fold increase in terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) and an 11-fold increase in caspase 3/7-positive hepatocytes (P < 0.01). The number of TUNEL and caspase 3/7-positive cells was reduced by >80% in BDL TRAIL knockout animals (P < 0.05). Likewise, liver histology, number of bile infarcts, serum ALT values, hepatic fibrosis, and animal survival were also improved in BDL TRAIL(-/-) animals as compared to wt animals. Conclusion: These observations support a pivotal role for TRAIL in cholestatic liver injury mediated by NK 1.1-positive NK/NKT cells.

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Volunteer Researchers: Moving Beyond Cooperators, Terrell P. Salmon, Ben Faber, Gary Bender, Dave Shaw Apr 2008

Volunteer Researchers: Moving Beyond Cooperators, Terrell P. Salmon, Ben Faber, Gary Bender, Dave Shaw

Journal of Extension

Engaging volunteer cooperators to perform field research presents a new approach to conducting applied research. We enlisted Extension Service users to conduct research. This allowed for an increased sample size and expanded study area than was possible using traditional approaches. Cooperators received comprehensive training that briefed them on the subject and research protocols. Data were collected via research workbooks and informal written surveys. We obtained acceptable data for demonstrating the efficacy of rodenticide treatment under operational conditions. Unexpectedly, cooperators favored one control method and indicated they would use it in the future, despite no statistical difference between treatment methods.

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Public Awareness And Knowledge Of Red Tide Blooms, Sherry L. Larkin, Charles M. Adams Apr 2008

Public Awareness And Knowledge Of Red Tide Blooms, Sherry L. Larkin, Charles M. Adams

Journal of Extension

We measured the knowledge of Southwest Florida residents regarding red tides by surveying 1,006 randomly selected individuals. Although 89% were aware of red tides, 72% erroneously believed that finfish and crustaceans were unsafe to eat and that waters were unsafe for swimming during a red tide. Because respondents primarily rely on newspapers and television (70% and 62%, respectively), these media should be pursued in Extension efforts to correct these misunderstandings and reduce revenue losses to local businesses. Costly brochures, workshops, and Internet sites do not warrant additional educational efforts at this time because only 6% of respondents identified those sources.

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The Best Pharmaceuticals For Children Act And The Pediatric Research Equity Act-Helping Or Hurting America's Children?, Lisa Jerles Apr 2008

The Best Pharmaceuticals For Children Act And The Pediatric Research Equity Act-Helping Or Hurting America's Children?, Lisa Jerles

Cardozo Public Law, Policy & Ethics Journal

The note examines the effectiveness of the Best Pharmaceuticals for Children Act (BPCA) and the Pediatric Research Equity Act (PREA), which were enacted to address the lack of pediatric-specific drugs and devices. While these laws have improved the availability of pediatric treatments, they face significant challenges, including short authorization periods, loopholes exploited by pharmaceutical companies, and ethical concerns related to clinical trials. The 2007 reauthorization and the addition of the Pediatric Medical Device Safety and Improvement Act have partially addressed these issues but highlight the need for further reforms to ensure safer and more effective pediatric care.

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In Defense Of Prometheus: Some Ethical, Economic, And Regulatory Issues Of Sports Doping, Richard A. Posner Apr 2008

In Defense Of Prometheus: Some Ethical, Economic, And Regulatory Issues Of Sports Doping, Richard A. Posner

Duke Law Journal

No abstract provided.

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The Problem Of Doping, Doriane Lambelet Coleman, James E. Coleman Jr. Apr 2008

The Problem Of Doping, Doriane Lambelet Coleman, James E. Coleman Jr.

Duke Law Journal

No abstract provided.

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The Working Lawyer As Subject And The Juridical Event, Kirk W. Junker Apr 2008

The Working Lawyer As Subject And The Juridical Event, Kirk W. Junker

Cardozo Law Review

When introducing the respective roles of the philosopher and the mathematician in Being and Event, Alain Badiou notes that when representing mathematics: "placing being in the general position of an object, would immediately corrupt the necessity, for any ontological operation, of de-objectification. Hence, of course, the attitude of those the Americans call working mathematicians: they always find general considerations about their discipline vain and obsolete. They only trust whomever works hand in hand with them grinding away at the latest mathematical problem. . . . Empirically, the mathematician always suspects the philosopher of not knowing enough about mathematics to have …

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Compass, Armstrong State University Apr 2008

Compass, Armstrong State University

Armstrong News & Publications: Compass (Archived)

No abstract provided.

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The Use Of Molecular Scatology To Study River Otter (Lontra Canadensis) Genetics, Barbara Mcelwee Apr 2008

The Use Of Molecular Scatology To Study River Otter (Lontra Canadensis) Genetics, Barbara Mcelwee

Theses

North American river otters (Lontra canadensis) were extirpated throughout all of Western New York due to habitat loss, pollution, and trapping. Between 1995 and 2000, 279 river otters were released throughout Western New York, 31 of which were released in the Genesee river watershed. Since their release there have been no followup studies on the river otters until the RIT River Otter Lab was formed in 2004. Researchers surveyed three local creeks to record data on toilet site locations and collect otter feces in order to perform dietary and genetic analyses. Through the use of molecular scatology I extracted DNA …

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Philosophy And Theology: Notes On Early/Late Term Abortion, Non-Human Rational Animals, And Twinning, Christopher Kaczor Apr 2008

Philosophy And Theology: Notes On Early/Late Term Abortion, Non-Human Rational Animals, And Twinning, Christopher Kaczor

Philosophy Faculty Works

No abstract provided.

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An Application Of The Theory Of Planned Behavior To Sorority Alcohol Consumption, Karen Huchting, Andrew Lac, Joseph W. Labrie Apr 2008

An Application Of The Theory Of Planned Behavior To Sorority Alcohol Consumption, Karen Huchting, Andrew Lac, Joseph W. Labrie

Heads Up!

Greek-affiliated college students have been found to drink more heavily and frequently than other students. With female student drinking on the rise over the past decade, sorority women may be at particular risk for heavy consumption patterns. The current study is the first to apply the Theory of Planned Behavior (TPB) to examine drinking patterns among a sorority-only sample. Two-hundred and forty-seven sorority members completed questionnaires measuring TPB variables of attitudes, norms, perceived behavioral control, and intentions, with drinking behaviors measured one month later. Latent structural equation modeling examined the pathways of the TPB model. Intentions to drink mediated the …

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Jeb Byers, Associate Professor Of Zoology, Travels To Australia, James E. Byers Apr 2008

Jeb Byers, Associate Professor Of Zoology, Travels To Australia, James E. Byers

Faculty Travel Reports

Professor James (Jeb) Byers spent the 2007-08 academic year in Australia conducting research on a highly invasive alga species.

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Spring 2008, The Global Citizens Of The International Affairs Dual Major, Center For International Education Apr 2008

Spring 2008, The Global Citizens Of The International Affairs Dual Major, Center For International Education

UNH International Educator Newsletter

No abstract provided.

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An Appreciation Of Marc Galanter’S Scholarship, John Lande Apr 2008

An Appreciation Of Marc Galanter’S Scholarship, John Lande

Law and Contemporary Problems

Lande highlights three of Marc Galanter's works to illustrate qualities that seem especially worth emulating. He includes extended excerpts of his writing because his concepts and language are so evoctive that paraphrasing often does not do them justice. Galanter's works that Lande focuses, include the classic articles, "Why the "Haves" Come Out Ahead: Speculations on the Limits of Legal Change"; and "Case Congregations and Their Careers". The professor's recent book, Lowering the Bar: Lawyer Jokes and Legal Culture, is also featured. The book is the culmination of much of his work on American law.

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Come Hell Or High Water: Reexamining The Takings Clause In A Climate Changed Future, Michael A. Hiatt Apr 2008

Come Hell Or High Water: Reexamining The Takings Clause In A Climate Changed Future, Michael A. Hiatt

Duke Environmental Law & Policy Forum

No abstract provided.

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James W. Allard, The Logical Foundations Of Bradley's Metaphysics: Judgment, Inference, And Truth, Sam Addison Apr 2008

James W. Allard, The Logical Foundations Of Bradley's Metaphysics: Judgment, Inference, And Truth, Sam Addison

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

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Full Issue 3.1 Apr 2008

Full Issue 3.1

Genocide Studies and Prevention: An International Journal

No abstract provided.

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The Three “Switches” Of Identity Construction In Genocide: The Nazi Final Solution And The Cambodian Killing Fields, Maureen S. Hiebert Apr 2008

The Three “Switches” Of Identity Construction In Genocide: The Nazi Final Solution And The Cambodian Killing Fields, Maureen S. Hiebert

Genocide Studies and Prevention: An International Journal

If we want to understand why political elites choose to commit genocide, we need to inquire into how elite perpetrators reconstruct the collective identity of the victim group such that genocide becomes the only possible policy option. This article argues that elites decide to commit genocide, and not some other less catastrophic policy of repression or violence, when three conceptual ‘‘switches’’ concerning the identity, interests, and future actions of the victim group are ‘‘turned on’’ by the perpetrators. First, members of the victim group lose their (often marginal) status within the political community and are constructed as outsiders, to whom …

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Drug Metabolism In Human Brain: High Levels Of Cytochrome P4503a43 In Brain And Metabolism Of Anti-Anxiety Drug Alprazolam To Its Active Metabolite, Varsha Agarwal, Reddy P. Kommaddi, Khader Valli, Daniel Ryder, Thomas M. Hyde, Joel E. Kleinman, Henry W. Strobel, Vijayalakshmi Ravindranath Apr 2008

Drug Metabolism In Human Brain: High Levels Of Cytochrome P4503a43 In Brain And Metabolism Of Anti-Anxiety Drug Alprazolam To Its Active Metabolite, Varsha Agarwal, Reddy P. Kommaddi, Khader Valli, Daniel Ryder, Thomas M. Hyde, Joel E. Kleinman, Henry W. Strobel, Vijayalakshmi Ravindranath

Faculty, Staff and Student Publications

Cytochrome P450 (P450) is a super-family of drug metabolizing enzymes. P450 enzymes have dual function; they can metabolize drugs to pharmacologically inactive metabolites facilitating their excretion or biotransform them to pharmacologically active metabolites which may have longer half-life than the parent drug. The variable pharmacological response to psychoactive drugs typically seen in population groups is often not accountable by considering dissimilarities in hepatic metabolism. Metabolism in brain specific nuclei may play a role in pharmacological modulation of drugs acting on the CNS and help explain some of the diverse response to these drugs seen in patient population. P450 enzymes are …

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Just Green Iguanas? The Associated Costs And Policy Implications Of Exotic Invasive Wildlife In South Florida, Arthur Sementelli, Henry T. Smith, Walter E. Meshaka Jr., Richard M. Engeman Apr 2008

Just Green Iguanas? The Associated Costs And Policy Implications Of Exotic Invasive Wildlife In South Florida, Arthur Sementelli, Henry T. Smith, Walter E. Meshaka Jr., Richard M. Engeman

United States Department of Agriculture Wildlife Services: Staff Publications

Invasive exotic species have begun to emerge as a policy issue at the federal, state, and local levels. Although invasive species are often understood as a function of the damage they cause to localized ecosystems, this study diverges by discussing the infrastructural damage caused by an invasive exotic species, the green iguana (Iguana iguana). Specifically, the authors discuss the magnitude and scope of damage caused by iguana burrows on canals in southern Florida and offer policy recommendations to move discussions of this potentially disastrous public works issue forward.

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Monte Carlo Analysis Of Parameter Uncertainty In Matrix Models For The Weed Cirsium Vulgare, Brigitte Tenhumberg, Svata M. Louda, James O. Eckberg, Masaru Takahashi Apr 2008

Monte Carlo Analysis Of Parameter Uncertainty In Matrix Models For The Weed Cirsium Vulgare, Brigitte Tenhumberg, Svata M. Louda, James O. Eckberg, Masaru Takahashi

School of Biological Sciences: Faculty Publications

1. Parameter uncertainty challenges the use of matrix models because it violates key assumptions underlying elasticity analyses. We have developed a matrix model to compare Monte Carlo methods with elasticity analyses for estimation of the relative importance of factors in the asymptotic population growth rate, λ, of Cirsium vulgare (spear thistle) in Nebraska, USA.
2. We calculated λ for a base model using 11 parameter estimates available for Nebraska populations plus eight extracted from the literature, causing parameter uncertainty. We then calculated λ for 10 000 alternative models using Monte Carlo parameter estimation; parameters were drawn from the full range …

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