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Cellular And Synaptic Actions Of Acetylcholine In The Lamprey Spinal Cord, Katharina A. Quinlan, James T. Buchanan

Biological Sciences Faculty Research and Publications

This study investigated cellular and synaptic mechanisms of cholinergic neuromodulation in the in vitro lamprey spinal cord. Most spinal neurons tested responded to local application of acetylcholine (ACh) with depolarization and decreased input resistance. The depolarization persisted in the presence of either tetrodotoxin or muscarinic antagonist scopolamine and was abolished with nicotinic antagonist mecamylamine, indicating a direct depolarization through nicotinic ACh receptors. Local application of muscarinic ACh agonists modulated synaptic strength in the spinal cord by decreasing the amplitude of unitary excitatory and inhibitory postsynaptic potentials. The postsynaptic response to direct application of glutamate was unchanged by muscarinic agonists, suggesting …

Bh3-Only Protein Mimetic Obatoclax Sensitizes Cholangiocarcinoma Cells To Apo2l/Trail-Induced Apoptosis., Justin L. Mott, Steve F. Bronk, Ruben A. Mesa, Scott H. Kaufmann, Gregory J. Gores

Journal Articles: Biochemistry & Molecular Biology

Human cholangiocarcinomas evade apoptosis by overexpression of Mcl-1. The drug obatoclax (GX15-070) inhibits antiapoptotic members of the Bcl-2 family including Mcl-1. The purpose of this study is to determine if obatoclax sensitizes human cholangiocarcinoma cells to apoptosis. The human cholangiocarcinoma cell lines, KMCH, KMBC, and TFK, were employed for these studies. Protein expression was assessed by immunoblot and protein-protein interactions detected by coprecipitation of the polypeptide of interest with S-tagged Mcl-1. Activation of Bak and Bax was observed by immunocytochemistry with conformation-specific antisera. Obatoclax induced minimal apoptosis alone; however, it increased apoptosis 3- to 13-fold in all three cancer cell …

Intergenerational Communication: Its Effect On Early Screening Activities In African-American Adult Daughters Of Mothers With Breast Cancer, Rita R. Callahan Phd, Ma, Bsn, Rn

Dissertations

Health communication at numerous levels is vital to sustainability of healthy individuals. The notion of African-American mothers and adult daughters sharing breast health and breast cancer knowledge openly and honestly could be the initial step in addressing the high morbidity and mortality that continues to affect this population. Communication is a variable that has yet to be studied between African-American mothers diagnosed with breast cancer and their adult daughters. This study first examined whether this relationship existed, and secondly if it was strong enough in supporting and encouraging one another towards consistent breast health and breast cancer screening activities. The …

Armstrong Academics August 2008, Armstrong Atlantic State University

Armstrong State University Collections: Armstrong Academics (Archived)

No abstract provided.

Roots Of Ancient Wisdom For Contemporary Education, Patricia Ottow Keen Edd

Dissertations

Scholars have long contended that the main purpose of education is to guide youth towards more authentic, fruitful ways of being in the world; this ancient wisdom continues to challenge educators to serve as effective role models (e.g., Aristotle, 1963; 1985; Maslow, 1993; Palmer, 1998). Yet, until now, teachers' levels of self-actualization have not been investigated with valid and reliable instruments. This quantitative study used two psychometrically sound, closed-ended surveys to investigate the extent to which teachers consider themselves self-actualized and mindful; it measured the direction and strength of the correlation between their self-actualization and mindfulness scores; and, investigated the …

Water And Mining Conflicts In Peru, Anthony J. Bebbington, Mark Williams

Geography

Impacts on water quality and quantity are among the most contentious aspects of mining projects. Companies insist that the use of modern technologies will ensure environmentally friendly mining practices. However, evidence of the negative environmental impacts of past mining activity causes local and downstream populations to worry that new mining activities will adversely affect their water supply. We report on one mine site in Peru where water has become a: particularly conflictive issue. We then provide a detailed proposal for a monitoring plan to recover trust among stakeholders. A welldesigned and executed monitoring plan for water quantity and quality is …

Ecological Effects Of Volcanic Co2 Vents, Jm Hall-Spencer, R Rodolfo-Metalpa

School of Biological and Marine Sciences

No abstract provided.

Development Of Volunteer-Driven Indices Of Biological Integrity For Wetlands In West Virginia, Walter Emil Veselka Iv

Graduate Theses, Dissertations, and Problem Reports (ETD)

Wetland indices of biological integrity (IBIs) are used to satisfy the water resources monitoring requirements of the Clean Water Act (CWA). However, debate still exists on what classification systems and taxa to base these IBIs upon. Our cumulative research, representing indices of biological integrity designed for regional HGM subclasses, designated HGM management classes and Cowardin et al. (1979) classes for West Virginia. The indices were derived from metrics calculated from anuran, avian, macroinvertebrate, and vegetation communities; each representing increasing levels of resources associated with gathering the necessary data. For example, avian and anuran data used to derive floodplain wetland IBI …

Genomic Profiling Reveals An Alternate Mechanism For Hepatic Tumor Promotion By Perfluorooctanoic Acid In Rainbow Trout, Susan C. Tilton, Gayle A. Orner, Abby D. Benninghoff, Hillary M. Carpenter, Jerry D. Hendricks, Cliff B. Pereira, David E. Williams

Animal, Dairy, and Veterinary Science Faculty Publications

Background

Perfluorooctanoic acid (PFOA) is a potent hepatocarcinogen and peroxisome proliferator (PP) in rodents. Humans are not susceptible to peroxisome proliferation and are considered refractory to carcinogenesis by PPs. Previous studies with rainbow trout indicate they are also insensitive to peroxisome proliferation by the PP dehydroepiandrosterone (DHEA), but are still susceptible to enhanced hepatocarcinogenesis after chronic exposure.

Objectives

In this study, we used trout as a unique in vivo tumor model to study the potential for PFOA carcinogenesis in the absence of peroxisome proliferation compared with the structurally diverse PPs clofibrate (CLOF) and DHEA. Mechanisms of carcinogenesis were identified from …

Squash Bug, Diane Alston, James Barnhill

All Current Publications

Squash bug (Anasa tristis) is a “true bug” with piercingsucking mouthparts (Order Hemiptera) in the leaffooted bug family (Coreidae). It is common throughout the U.S. and found from Canada to Central America. Adults (Fig. 1) emit a foul odor when disturbed and may be called “stink bugs”; however, true stink bugs are in a different true bug family.

Differential Changes In Mglu2 And Mglu3 Gene Expression Following Pilocarpine-Induced Status Epilepticus: A Comparative Real-Time Pcr Analysis, Boris Ermolinsky, Luis F. Pacheco Otalora, Massoud F. Arshadmansab, Masoud M. Zarei, Emilio R. Garrido-Sanabria

Health & Biomedical Sciences Faculty Publications

Group II metabotropic glutamate (mGlu II) receptors subtype 2 and 3 (mGlu2 and mGlu3) are subtle regulators of neuronal excitability and synaptic plasticity in the hippocampus. In recent years, researchers have investigated the potential neuroprotective and anticonvulsant effects of compounds acting on mGlu II receptors. However, abnormal expression and function of mGlu2 and mGlu3 have been reported in temporal lobe epilepsy, a phenomena that may limit the therapeutic effectiveness of these potentially new antiepileptic drugs. Here, we investigated seizure-induced changes in mGlu2 and mGlu3 mRNA following pilocarpine-inducted status epilepticus (SE) and subsequent epileptogenesis. Relative changes in gene expression …

Deficit Of Kcnma1 Mrna Expression In The Dentate Gyrus Of Epileptic Rats, Boris Ermolinsky, Massoud F. Arshadmansab, Luis F. Pacheco Otalora, Masoud M. Zarei, Emilio R. Garrido-Sanabria

Health & Biomedical Sciences Faculty Publications

Epileptogenesis in mesial temporal lobe epilepsy is determined by several factors including abnormalities in the expression and function of ion channels. Here, we report a long-lasting deficit in gene expression of Kcnma1 coding for the large-conductance calcium-activated potassium (BK, MaxiK) channel α-subunits after pilocarpine-induced status epilepticus. By using comparative realtime PCR, Taqman gene expression assays, and the delta-delta comparative threshold method we detected a significant reduction in Kcnma1 expression in microdissected dentate gyrus at different intervals after status epilepticus (24 h, 10 days, 1 month, and more than 2 months). BK channels are key regulators of neuronal excitability and transmitter …

Originalism And Regulatory Takings: Why The Fifth Amendment May Not Protect Against Regulatory Takings, But The Fourteenth Amendment May, Michael B. Rappaport

San Diego Law Review

This Article explores the widely disputed issue of whether Takings Clause protects against regulatory takings, offering a novel and intermediate solution. Critics of the regulatory takings doctrine have argued that the original meaning of the Fifth Amendment Takings Clause does not cover regulatory takings. They have quickly moved from this claim to the conclusion that the incorporated Takings Clause under the Fourteenth Amendment also does not cover regulatory takings. In this Article, I accept the claim that the Fifth Amendment Takings Clause does not cover regulatory takings, but then explore the possibility that the incorporated Takings Clause does cover such …

Making The Difference In High Poverty; High Achieving Urban Elementary Schools: Selected Principal's Perspectives, Penny Larsen

Dissertations

This study is a mixed-method design focusing on ten White and ten non-White elementary principals working in urban areas. The qualitative methodology uses interviews and observations to examine how principals conceptualize the student achievement gaps and through what practices do they attempt to remedy the condition. The quantitative data resulted from the Quick Discrimination Index and relied on descriptive statistics. The primary audience for this study includes PK-12 public school administrators, particularly those in urban high-diversity, high-achieving schools.

The investigation (1) examined cultural differences between White and non-White administrators and their student constituency in terms of ethnicity and language use, …

Perceptions Of Quality Of Life Of Latinos With Diabetes Living In The U.S.: Variations By Geographic Region Of Origin, Janice M. Long

Dissertations

The Latino population, the largest ethnic minority in the United States, is a diverse group originating from numerous geographic regions of Latin America. Latinos vary in the risk for type 2 diabetes, a condition that exacts a costly burden on those who suffer with it. With the Latino population diversity, diverse strategies are needed. One strategy is to improve outcomes of life quality by improving knowledge of those who deliver health services to Latinos with type 2 diabetes. Through measurement of quality of life (QOL), the more precious aspects of living, how one feels about living with diabetes, can be …

Combined Cognitive Behavioral Treatment Plus Caregiver Sessions For Childhood Depression, Dikla Eckshtain

Dissertations

Childhood depression is intimately related to the family context and caregiver-child relations, but only a limited number of treatment outcome studies for depressed youth have formally included members of the family in the intervention. To address this discrepancy the present study evaluated the efficacy of adding caregiver sessions to individual cognitive behavioral therapy (CBT) for the treatment of depressed youth. The treatment included 16 individual sessions and 7 caregiver sessions administered in the child's school to promote accessibility. Fifteen children (10 females and 5 males ranging in age from 8-13), who met inclusion criteria based on self-report and interview measures …

The Theory And Practice Of Drug Courts: Wolves In Sheep Clothing?, Kristen E. Devall

Dissertations

This dissertation is a case study of an adult drug court in a medium-size Midwestern city. The primary impetus behind the creation of the drug court model was the partial recognition that the "get tough" approach to crime and the "war on drugs" was ineffective in "solving the United States' drug problem. Drug courts represent an integration of a public-health approach and a public-safety strategy of fighting crime and administering "justice." The bulk of the extant research regarding drug courts addresses one central question: "Do drug courts work?" Researchers and evaluators alike have attempted to answer this question over the …

Emotion Recognition And The Propensity To Engage In Sexually Coercive Behaviors: A Study With College Males, Beth J. Dietzel

Dissertations

Several variables have been investigated over the past years as risk factors for sexual aggression. Among them, substance use/abuse, family environment, attitudes towards women, and lack of empathy. Although researchers have identified several risk factors, predicting aggressive behaviors continues to be a difficult task. One variable that has received less attention in the literature is men's emotion recognition skills. Do men's emotion recognition skills affect their propensity to aggress?

The purpose of this study was to investigate emotion recognition skills/deficits and how such skills predict propensity to engage in sexually coercive behavior. There were two main goals of this study. …

The Daily Egyptian, July 31, 2008, Daily Egyptian Staff

July 2008

No abstract provided.

Body Burden Of Pahs And Cardiovascular Disease In The United States, John D. Clark Iii

Open Access Dissertations

Polycyclic aromatic hydrocarbons (PAHs) are environmental and occupational carcinogens that are produced by the incomplete combustion of organic material, such as from the burning of tobacco, coal, and petroleum products. In addition to causing cancer, exposure to PAHs is hypothesized to contribute to atherosclerosis and to lead to increased incidence rates of cardiovascular disease in populations. Considering the number of deaths attributable to tobacco smoke exposure, ambient air pollution, and occupational hazards, PAHs may be a significant contributor to the prevalence of cardiovascular disease in human populations. However, a clear exposure-response relationship between PAHs and measures of cardiovascular disease has …

2008 Uc/Csu/Ccc Sustainability Conference Program

Sustainability Conference

UC/CSU/CCC Sustainability Conference 2008. Cal Poly, San Luis Obispo. July 31st - August 3rd, 2008.

Exploring The Cognitive Underpinnings Of Word Retrieval Deficits In Dyslexia Using The Tip-Of-The-Tongue Paradigm, Sarah Margaret Hanly

Dissertations

Over the past thirty years a consensus has emerged that the word reading difficulties of dyslexic readers stem from deficits in phonological processing. One experimental paradigm that has provided support for this view is the finding that dyslexic readers demonstrate deficits in word retrieval from long term memory on picture naming tasks. Dyslexic readers are able to retrieve fewer words in their receptive vocabularies and are less accurate than normally developing readers. However, the conclusion that dyslexic readers? difficulties in picture naming are the consequence of deficits in phonological processing is inferential. The current study uses the tip-of-the-tongue (TOT) paradigm …

The Impact Of Gender Socialization On Women?S Learned Technological Helplessness And Its Andragogical Implications, Joy Elise Harris

Dissertations

This research investigated a proposed construct of learned technological helplessness (LTH) in female adult learners, which is believed to be impacted by socialization into traditional gender roles, teacher modeling, and age. A two-pronged approach was used to examine women?s attitudes and beliefs about their abilities to use technology as a learning and personal productivity tool. Participants were females, over age 18, on two campuses of a public Midwest research university. Prior to the primary research, a pilot study (n=204) was undertaken for the purpose of creating a teacher modeling instrument, which measured how teachers model the use of technology. The …

Does Institutional Capacity Matter? A Case Study Of The Zambian Forestry Department., Rosemary Fumpa Makano

Dissertations

Understanding why some organizations are more effective in their service delivery than others is a central discourse in both public administration and political organization. Scholars and practitioners all agree that the defining factor is institutional (state) capacity. Since the mid-1980s, deforestation in Zambia has been on the rise, especially in Protected Forest Areas, suggesting poor management by the Forestry Department, an institution mandated to manage these public lands. Ironically, despite the strategic position that forests hold in sustaining both the daily subsistence needs of over 90% of the Zambian population as well as the as the numerous industries that depend …

07-31-2008 Students Attend Sure-Step At Swosu, Southwestern Oklahoma State University

THE BARK ARCHIVE 2008

Southwestern Oklahoma State University in Weatherford recently hosted 14 students at a SURE-STEP program designed to provide an exciting opportunity for high school seniors seeking degrees in biology and chemistry at SWOSU.

Sbe Notícias, Ano 3, No. 94, July 31, 2008, Marcelo A. Rasteiro, Delci K. Ishida

SBE Notícias

Aumentar a produção não resolve - Livro: Maravilhoso Brasil Subterrâneo - Cecav faz vistoria em caverna na Paraíba - Abrigos-sob-rocha na Paraíba - Caverna Santa Rosa: uma réplica para Educação Ambiental - Apresentação da Akakor em Curitiba - Curso de resgate em cavernas na Argentina - Caverna pode ser a melhor atração do país - Mudança na legislação de área cárstica será debatida em MG - IX Congresso Nacional Mexicano de Espeleologia - Foto do Leitor: Gruta das Rãs (TO-59).

Central Florida Future, Vol. 40 No. 67, July 31, 2008

Central Florida Future

Declare yourself; Florida voter registration; Med school goes green; UCF clinic assists in stroke therapy; Speech Disorders and language barriers; UCF officer joins narcotics task force; Knightro competes in games.

The Weekly Challenger, July 31, 2008, The Weekly Challenger, Et Al

Weekly Challenger Newspaper Collection

The July 31, 2008, issue of The Weekly Challenger.

Online Travel Information Search Behaviors: An Information Foraging Perspective, Evan Jordan

All Theses

Information search has been a topic of research for a multitude of studies across
several fields, including travel and tourism. However, information search on the internet,
especially in travel and tourism, has rarely been examined. As a result, this research was
undertaken to explore travel information search behaviors on the Internet.
This thesis uses information foraging theory (Pirolli & Card, 1999) as a basis to
examine online travel information search behaviors. In addition, other established
measures of online information search (Hodkinson, Kiel, & McColl-Kennedy, 2000)
were used to supplement findings based upon information foraging theory. Groups of
students from two …

Endocrine And Follicular Dynamics During The Perideviation Period In Cattle, Morgan Krause

All Theses

Ovarian hyperstimulation used in conjunction with embryo transfer techniques is an assisted reproductive technology that aids cattle producers in reaching their reproductive, genetic, and financial goals; however, viable embryo recovery results are inconsistent, possibly because the reproductive endocrine profile is poorly understood. The objective of these experiments was to evaluate the endocrinological and ovarian dynamics surrounding follicular deviation in hyperstimulated cows.
In Experiment 1, the perideviation period (PDP; largest follicle diameter from 8 - 10- mm) was examined in Hyperstimulated (50 mg FSH) or Control (saline) dry Holstein cows (n = 4 / group). Daily blood samples began at the …