Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2008

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 3931 - 3960 of 15505

Full-Text Articles in Entire DC Network

Hvac Design: College Of San Mateo Building 36 - Science/Planetarium, Jose D. Nunez Aug 2008

Hvac Design: College Of San Mateo Building 36 - Science/Planetarium, Jose D. Nunez

Sustainability Conference

This session includes presentations from winners of the Higher Education Energy Efficiency Partnership Program Best Practices Competition in the categories of New Construction HVAC Design and Lighting Design/Retrofit. Cal Poly, San Luis Obispo will present on their satellite central plant. Jose Nunez will present on the CSM Science Building Planetarium, UC Berkeley will present on their wireless lighting controls retrofit, Contra Costa CCD will present on their district wide lighting retrofit, and CSU Channel Islands will present on their new standards for and retrofit of campus exterior lighting.


Deficit Of Kcnma1 Mrna Expression In The Dentate Gyrus Of Epileptic Rats, Boris Ermolinsky, Massoud F. Arshadmansab, Luis F. Pacheco Otalora, Masoud M. Zarei, Emilio R. Garrido-Sanabria Aug 2008

Deficit Of Kcnma1 Mrna Expression In The Dentate Gyrus Of Epileptic Rats, Boris Ermolinsky, Massoud F. Arshadmansab, Luis F. Pacheco Otalora, Masoud M. Zarei, Emilio R. Garrido-Sanabria

Health & Biomedical Sciences Faculty Publications

Epileptogenesis in mesial temporal lobe epilepsy is determined by several factors including abnormalities in the expression and function of ion channels. Here, we report a long-lasting deficit in gene expression of Kcnma1 coding for the large-conductance calcium-activated potassium (BK, MaxiK) channel alpha-subunits after pilocarpine-induced status epilepticus. By using comparative real-time PCR, Taqman gene expression assays, and the delta-delta comparative threshold method we detected a significant reduction in Kcnma1 expression in microdissected dentate gyrus at different intervals after status epilepticus (24 h, 10 days, 1 month, and more than 2 months). BK channels are key regulators of neuronal excitability and transmitter …


Fish Distributions And Nutrient Cycling In Streams: Can Fish Create Biogeochemical Hotspots, Peter B. Mcintyre, Alexander S. Flecker, Michael J. Vanni, James M. Hood, Brad W. Taylor, Steven A. Thomas Aug 2008

Fish Distributions And Nutrient Cycling In Streams: Can Fish Create Biogeochemical Hotspots, Peter B. Mcintyre, Alexander S. Flecker, Michael J. Vanni, James M. Hood, Brad W. Taylor, Steven A. Thomas

Dartmouth Scholarship

Rates of biogeochemical processes often vary widely in space and time, and characterizing this variation is critical for understanding ecosystem functioning. In streams, spatial hotspots of nutrient transformations are generally attributed to physical and microbial processes. Here we examine the potential for heterogeneous distributions of fish to generate hotspots of nutrient recycling. We measured nitrogen (N) and phosphorus (P) excretion rates of 47 species of fish in an N-limited Neotropical stream, and we combined these data with population densities in each of 49 stream channel units to estimate unit- and reach-scale nutrient recycling. Species varied widely in rates of N …


Decline In A Dominant Invertebrate Species Contributes To Altered Carbon Cycling In A Low-Diversity Soil Ecosystem, Byron J. Adams, J. E. Barrett, Ross A. Virginia, Diana H. Wall Aug 2008

Decline In A Dominant Invertebrate Species Contributes To Altered Carbon Cycling In A Low-Diversity Soil Ecosystem, Byron J. Adams, J. E. Barrett, Ross A. Virginia, Diana H. Wall

Faculty Publications

Low-diversity ecosystems cover large portions of the Earth's land surface, yet studies of climate change on ecosystem functioning typically focus on temperate ecosystems, where diversity is high and the effects of individual species on ecosystem functioning are difficult to determine. We show that a climate-induced decline of an invertebrate species in a low-diversity ecosystem could contribute to significant changes in carbon © cycling. Recent climate variability in the McMurdo Dry Valleys of Antarctica is associated with changes in hydrology, biological productivity, and community composition of terrestrial and aquatic ecosystems. One of the greatest changes documented in the dry valleys is …


Attributionally More Complex People Show Less Punitiveness And Racism, Kim-Pong Tam, Al Au, Angela K. Y. Leung Aug 2008

Attributionally More Complex People Show Less Punitiveness And Racism, Kim-Pong Tam, Al Au, Angela K. Y. Leung

Research Collection School of Social Sciences

Based on past findings that attributionally more complex people make less fundamental attribution error, it was hypothesized that they would show less punitiveness and racism. In a study of 102 undergraduates, this hypothesis received robust support. The effect of attributional complexity was significant in two different punitiveness measures, a rehabilitation support measure, and two different racism measures. Also, this effect still held when demographic variables, crime victimization history, and need for cognition were statistically controlled. Moreover, attributional complexity mediated the effect of need for cognition and gender on punitiveness and racism. Theoretical implications are discussed.


August 2008 Commencement Program, Bowling Green State University Aug 2008

August 2008 Commencement Program, Bowling Green State University

Commencement Programs

No abstract provided.


2008 August, Office Of Communications & Marketing, Morehead State University. Aug 2008

2008 August, Office Of Communications & Marketing, Morehead State University.

Morehead State Press Release Archive, 1961 to the Present

Press releases for August of 2008.


Optimization And Validation Of An Enzymatic Method To Quantify Glucose In Potato Tubers, Engil Isadora Pujol Pereira, Tatiana Emanuelli, Dilson Antonio Bisognin, Sergio T. De Freitas Aug 2008

Optimization And Validation Of An Enzymatic Method To Quantify Glucose In Potato Tubers, Engil Isadora Pujol Pereira, Tatiana Emanuelli, Dilson Antonio Bisognin, Sergio T. De Freitas

School of Earth, Environmental, & Marine Sciences Faculty Publications

The processing industry requires potato tubers with low levels of reduced sugars, glucose and fructose, which is responsible for the whiteness of the chip color. The objective of this research was to optimize and validate a simple, inexpensive, and precise enzymatic method to quantify glucose in potato tubers. This method will be useful in breeding programs to select clones for processing purposes with low levels of glucose. The validation procedure followed the recommendations described in INMETRO document DOQ-CGCRE-008 in 2003. The method was linear between 1.25 to 40µg of glucose in the sample. The quantification limit was 0.319mg g-1 of …


Oil Recovery Through Deemulsification Research : Separation Of Water From Emulsified Oil, Aaron Russell, Matthew S. Clay, Christopher A. Cox, Jessica E. Nichols, Summer Scott, Sirikarn Surawanvijit Aug 2008

Oil Recovery Through Deemulsification Research : Separation Of Water From Emulsified Oil, Aaron Russell, Matthew S. Clay, Christopher A. Cox, Jessica E. Nichols, Summer Scott, Sirikarn Surawanvijit

Chemical Engineering Undergraduate Honors Theses

In an effort to improve the environment, there is a need to recover and reuse the oil and water components of lubricating emulsions used in copper drawing and rolling processes. The Freeport-McMoRan Copper and Gold Inc. copper rod mill located in El Paso, TX was chosen as the site location for this project. It is one of the largest rolling and drawing operation facilities in the world, and it meets the established criteria set by Project ORDER. A large facility generates an average of 8,400 gallons of spent lubricant per day. The WERC emulsion sample contains 98 v% water and …


Evaluation Of The Xpert Methicillin-Resistant Staphylococcus Aureus (Mrsa) Assay Using The Genexpert Real-Time Pcr Platform For Rapid Detection Of Mrsa From Screening Specimens., Celine M. Herra Aug 2008

Evaluation Of The Xpert Methicillin-Resistant Staphylococcus Aureus (Mrsa) Assay Using The Genexpert Real-Time Pcr Platform For Rapid Detection Of Mrsa From Screening Specimens., Celine M. Herra

Articles

The need for rapid methods to accurately detect methicillin-resistant Staphylococcus aureus (MRSA) is widely acknowledged, and a number of molecular assays are commercially available. This study evaluated the Xpert MRSA assay, which is run on the GeneXpert real-time PCR platform (Cepheid) for use in a clinical laboratory. The following parameters were investigated: (i) the limits of detection (LoDs) for four MRSA strains; (ii) the ability to detect isolates of MRSA from a collection representative of MRSA in Ireland since 1974 (n 114) and the ability to detect control strains with staphylococcal cassette chromosome mec types IVa (IV.1.1.1), IVb (IV.2.1.1), IVc …


Role Of Nono-Histone Interaction In Tnfα-Suppressed Prolyl-4-Hydroxylase Α1, Cheng Zhang, Ming-Xiang Zhang, Ying H Shen, Jared K Burks, Xiao-Nan Li, Scott A Lemaire, Koichi Yoshimura, Hiroki Aoki, Masunori Matsuzaki, Feng-Shuang An, David A Engler, Risë K Matsunami, Joseph S Coselli, Yun Zhang, Xing Li Wang Aug 2008

Role Of Nono-Histone Interaction In Tnfα-Suppressed Prolyl-4-Hydroxylase Α1, Cheng Zhang, Ming-Xiang Zhang, Ying H Shen, Jared K Burks, Xiao-Nan Li, Scott A Lemaire, Koichi Yoshimura, Hiroki Aoki, Masunori Matsuzaki, Feng-Shuang An, David A Engler, Risë K Matsunami, Joseph S Coselli, Yun Zhang, Xing Li Wang

Faculty, Staff and Student Publications

Inflammation is a key process in cardiovascular diseases. The extracellular matrix (ECM) of the vasculature is a major target of inflammatory cytokines, and TNFalpha regulates ECM metabolism by affecting collagen production. In this study, we have examined the pathways mediating TNFalpha-induced suppression of prolyl-4 hydroxylase alpha1 (P4Halpha1), the rate-limiting isoform of P4H responsible for procollagen hydroxylation, maturation, and organization. Using human aortic smooth muscle cells, we found that TNFalpha activated the MKK4-JNK1 pathway, which induced histone (H) 4 lysine 12 acetylation within the TNFalpha response element in the P4Halpha1 promoter. The acetylated-H4 then recruited a transcription factor, NonO, which, in …


Volunteer Development In 4-H: Constructivist Considerations To Improve Youth Science Literacy In Urban Areas, Martin H. Smith Aug 2008

Volunteer Development In 4-H: Constructivist Considerations To Improve Youth Science Literacy In Urban Areas, Martin H. Smith

Journal of Extension

The 4-H Youth Development Program can play an important role in targeting improved science literacy among urban youth in the U. S. However, 4-H volunteers must be trained effectively in order to be competent in their roles as science educators, and existing methods of volunteer training in urban areas are inadequate. Lesson study, a professional development model for educators that uses a constructivist approach to learning, is a viable option. Lesson study occurs within the context of the specific learning setting, takes place incrementally over extended periods of time, and has been shown to be effective.


Neutralization Of Botulinum Neurotoxin By A Human Monoclonal Antibody Specific For The Catalytic Light Chain., Sharad P Adekar, Tsuyoshi Takahashi, R Mark Jones, Fetweh H Al-Saleem, Denise M Ancharski, Michael J Root, B P Kapadnis, Lance L Simpson, Scott K Dessain Aug 2008

Neutralization Of Botulinum Neurotoxin By A Human Monoclonal Antibody Specific For The Catalytic Light Chain., Sharad P Adekar, Tsuyoshi Takahashi, R Mark Jones, Fetweh H Al-Saleem, Denise M Ancharski, Michael J Root, B P Kapadnis, Lance L Simpson, Scott K Dessain

Department of Biochemistry and Molecular Biology Faculty Papers

BACKGROUND: Botulinum neurotoxins (BoNT) are a family of category A select bioterror agents and the most potent biological toxins known. Cloned antibody therapeutics hold considerable promise as BoNT therapeutics, but the therapeutic utility of antibodies that bind the BoNT light chain domain (LC), a metalloprotease that functions in the cytosol of cholinergic neurons, has not been thoroughly explored.

METHODS AND FINDINGS: We used an optimized hybridoma method to clone a fully human antibody specific for the LC of serotype A BoNT (BoNT/A). The 4LCA antibody demonstrated potent in vivo neutralization when administered alone and collaborated with an antibody specific for …


The Scientist, Fall 2008, San Jose State University, College Of Science Aug 2008

The Scientist, Fall 2008, San Jose State University, College Of Science

The Scientist (College of Science)

No abstract provided.


2008 Exhibitors, Deja J. Waymer Aug 2008

2008 Exhibitors, Deja J. Waymer

Small Satellite Conference

Listings and Descriptions of 2008 Small Satellite Conference Exhibitors


Response Properties Of The Auditory Telencephalon In Songbirds Change With Recent Experience And Season, Thomas A. Terleph, Kai Lu, David S. Vicario Aug 2008

Response Properties Of The Auditory Telencephalon In Songbirds Change With Recent Experience And Season, Thomas A. Terleph, Kai Lu, David S. Vicario

Biology Faculty Publications

The caudomedial nidopallium (NCM) is a telencephalic auditory area that is selectively activated by conspecific vocalizations in zebra finches and canaries. We recently demonstrated that temporal and spectral dynamics of auditory tuning in NCM differ between these species [1]. In order to determine whether these differences reflect recent experience, we exposed separate groups of each species and sex to different housing conditions. Adult birds were housed either in an aviary with conspecifics (NORM), with heterospecifics (canary subjects in a zebra finch aviary, and vice versa: (CROSS)), or in isolation (ISO) for 9 days prior to testing. We then recorded extracellular …


Perceptions Of Power In A Predominantly Female Environment: A Case Study Approach, Virginia Russell Curley Aug 2008

Perceptions Of Power In A Predominantly Female Environment: A Case Study Approach, Virginia Russell Curley

Department of Educational Administration: Dissertations, Theses, and Student Research

The lived experience of women and men in terms of how they perceived power within their predominantly-female organization was the focus of this qualitative study. The case study explored the multi-dimensional reality of power as individuals in the same organization experienced it.

The research question that guided the study was: How do men and women in a predominantly-female organization describe their perceptions of power? Other research questions included how power was defined and described by individuals when their gender was dominant or in the minority.

The case study methodology included interviews with 25 faculty, staff and administrators at a Midwestern …


Introduction To The Developmental Contextualism Surrounding Identity Vulnerability And The Emergence Of Depression And Anxiety, Paul T. Constantino Aug 2008

Introduction To The Developmental Contextualism Surrounding Identity Vulnerability And The Emergence Of Depression And Anxiety, Paul T. Constantino

Theses, Dissertations and Culminating Projects

According to Cicchetti and Toth (1998), the integration of inadequate biological, ecological, socioemotional, cognitive, and self-representational forces may foster psychopathological organization. These forces comprise developmental contextualism. Contextualism can be visualized as a bidirectional relationship between the individual and the context (Lemer, 2002). In other words, internal and external forces interact with one another as they are affecting the organism. Ecology, socioemotionality, cognition, and biology interact to form the self-representational sense of self or “other” source. This other source is the subjective experience of the organism and emerges as a force in and of itself and influences superceding interactions between ecology, …


Resource Allocation And Bionomics Of Indigenous And Exotic Cotesia (Hymenoptera: Braconidae) Species Reared On Sesamia Calamistis, Y. Hailemichael, F. Schulthess, J. Smith, W. Overholt, A. Chabi-Olaye Aug 2008

Resource Allocation And Bionomics Of Indigenous And Exotic Cotesia (Hymenoptera: Braconidae) Species Reared On Sesamia Calamistis, Y. Hailemichael, F. Schulthess, J. Smith, W. Overholt, A. Chabi-Olaye

All Peer-Reviewed Publications

The braconid larval parasitoids Cotesia chilonis (Matsumura), C. flavipes Cameron and a strain of Cotesia sesamiae (Cameron) from coastal Kenya, reared at the International Centre of Insect Ecology and Physiology, were introduced at the International Institute of Tropical Agriculture in the Republic of Benin for suitability testing on West African stemborers prior to release. C. chilonis was originally collected in Japan while C. flavipes was imported into Kenya from Pakistan. The host species used was the noctuid Sesamia calamistis (Hampson), the most important noctuid maize pest in the region. All three Cotesia species attacked and successfully developed in 2nd to …


Distribution Of Tetranychus Evansi And Its Predator Phytoseiulus Longipes (Acari: Tetranychidae, Phytoseiidae) In Southern Brazil, Fernando R. Da Silva, Gilberto J. De Moraes, Markus Knapp Aug 2008

Distribution Of Tetranychus Evansi And Its Predator Phytoseiulus Longipes (Acari: Tetranychidae, Phytoseiidae) In Southern Brazil, Fernando R. Da Silva, Gilberto J. De Moraes, Markus Knapp

All Peer-Reviewed Publications

Tetranychus evansi is an important pest of tomato in several countries. The predatory mite Phytoseiulus longipes has been found in association with it in Uruguaiana, State of Rio Grande do Sul, Brazil. The objective of this study was to evaluate the distribution of those two species in Uruguaiana region. Bi-weekly samples of plant parts were taken between January 28 and April 30, 2007 in Uruguaiana and five neighboring counties. Tetranychus evansi was found in all counties, but P. longipes was only found in Uruguaiana, mainly in the urban area. It is conceivable that such restricted distribution of P. longipes is …


An Investigation Of Some Factors Affecting Attitudes Toward Chemistry In University Education, Mustafa Ozden Aug 2008

An Investigation Of Some Factors Affecting Attitudes Toward Chemistry In University Education, Mustafa Ozden

Essays in Education

This is a study that explores university student attitudes toward chemistry who were taking an introductory chemistry course. Participants included freshmen enrolled in either a science teacher training program, an elementary school teacher training program or a mathematics teacher training program. 627 students were chosen from four different Education Faculties of Adıyaman, İnönü, Anadolu and Gazi University in Turkey. 348 subjects were male and 279 subjects were female students. The research instrument used 20 statements measuring students’ attitudes toward chemistry. Gender and study specialization differences in students’ attitudes toward chemistry were examined. It was found male students have more positive …


Effects Of Complex Vessel Geometries On Neutrophil Margination And Adhesion In Post-Capillary Venules, Josa A. Hanzlik Aug 2008

Effects Of Complex Vessel Geometries On Neutrophil Margination And Adhesion In Post-Capillary Venules, Josa A. Hanzlik

Theses

The inflammatory process is a regular occurrence within a healthy body. As part of the inflammatory process, leukocytes flow through blood vessels and are recruited to the region of the injury. Neutrophils play a significant role in this process; however the margination of neutrophils to particular locations in micro vessels is not fully understood. Post capillary venules, in particular, have complex geometries which may contribute to non-uniform adhesion of neutrophils. Margination is a phenomenon that occurs during the relatively early phases of inflammation; as a result of dilation of capillaries and slowing of the bloodstream, leukocytes tend to occupy the …


Analysis Of Tomato Synthetic Seeds For The Development Of An Optimized Encapsulation System, John E. Porter Aug 2008

Analysis Of Tomato Synthetic Seeds For The Development Of An Optimized Encapsulation System, John E. Porter

Graduate Theses, Dissertations, and Problem Reports (ETD)

In vitro propagules of tomato ( Solanum lycopersicum L.) were used to evaluate the effects of alginate encapsulation and subsequent storage for synthetic seed (synseed) production. Nodal segments were encapsulated in hollow alginate beads with and without supplemental nutrients, auxin (0, 2.5 and 5 muM IBA) and fungicide (0, 50 and 100 muM Daconil 2787). Synseeds were stored for 0, 30 and 90 days at 4+/-1°C in darkness and were given a light treatment (none vs. one week at 25+/-2°C with a 16 hour photoperiod) before sowing in a greenhouse hydroponic system. There was no survival across all treatments of …


Predictive Modeling Of Freshwater Mussels (Unionidae) In The Appalachians, Alison R. Mynsberge Aug 2008

Predictive Modeling Of Freshwater Mussels (Unionidae) In The Appalachians, Alison R. Mynsberge

Graduate Theses, Dissertations, and Problem Reports (ETD)

Freshwater mussels are in decline, particularly in the Appalachian region of North America. This region contains the world's greatest diversity of freshwater mussels, but many species are now threatened or endangered. Little is known of the basic ecology and distributions of species of freshwater mussels relative to other freshwater organisms. The goal of this study was to use predictive modeling to predict distributions of freshwater mussels in the Appalachians and identify correlated factors using a watershed framework. Models were developed in the upper Mid-Atlantic and Ohio drainage regions using subwatersheds and separately in the Tennessee region using catchments. Models developed …


Association Of Changes In Norepinephrine And Serotonin Transporter Expression With The Long-Term Behavioral Effects Of Antidepressant Drugs, Zaorui Zhao Aug 2008

Association Of Changes In Norepinephrine And Serotonin Transporter Expression With The Long-Term Behavioral Effects Of Antidepressant Drugs, Zaorui Zhao

Graduate Theses, Dissertations, and Problem Reports (ETD)

The relationship between the ability of repeated antidepressant treatment to cause down-regulation of the norepinephrine and serotonin transporters (NET, SERT) and produce antidepressant-like effects on behavior was determined. Treatment of rats with 15 mg/kg/day desipramine reduced NET expression, measured by 3H-nisoxetine binding and SDS-PAGE/immunoblotting, in cerebral cortex and hippocampus and reduced the time of immobility in the forced-swim test. The antidepressant-like effect on forced-swim behavior was evident two days following discontinuation of desipramine treatment when plasma and brain levels of desipramine and its major metabolite desmethyldesipramine were not detectable. Reduced NET expression resulted in decreased norepinephrine (NE) uptake, measured in …


Cognitive Appraisal Of Perceived Threat Of Diabetes And Adherence To Self -Management Behaviors, Roger D. Carpenter Aug 2008

Cognitive Appraisal Of Perceived Threat Of Diabetes And Adherence To Self -Management Behaviors, Roger D. Carpenter

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background. Within adherence research, health beliefs have been identified as being significant predictors of adherence. Specifically, perceived threat as a health belief has received considerable attention. However, a gap in current knowledge exists in terms of understanding perceived threat of illness as an event that is appraised by the patient.;Aim. The purpose of this exploratory, descriptive study was to examine cognitive appraisal of perceived threat of illness in relation to adherence to self-management behaviors in uninsured/under-insured persons with type 2 diabetes.;Method. A convenience sample consisted of 80 subjects being treated for type 2 diabetes mellitus at a free clinic in …


Maximum Likelihood Methods In Biology Revisited With Tools Of Computational Intelligence, John E. Seiffertt Iv, Andrew Vanbrunt, Donald C. Wunsch Aug 2008

Maximum Likelihood Methods In Biology Revisited With Tools Of Computational Intelligence, John E. Seiffertt Iv, Andrew Vanbrunt, Donald C. Wunsch

Electrical and Computer Engineering Faculty Research & Creative Works

We investigate the problem of identification of genes correlated with the occurrence of diseases in a given population. The classical method of parametric linkage analysis is combined with newer tools and results are achieved on a model problem. This traditional method has advantages over non-parametric methods, but these advantages have been difficult to realize due to their high computational cost. We study a class of Evolutionary Algorithms from the Computational Intelligence literature which are designed to cut such costs considerably for optimization problems. We outline the details of this algorithm, called Particle Swarm Optimization, and present all the equations and …


Pilot In Loop Assessment Of Fault Tolerant Flight Control Schemes In A Motion Flight Simulator, Girish Kumar Sagoo Aug 2008

Pilot In Loop Assessment Of Fault Tolerant Flight Control Schemes In A Motion Flight Simulator, Girish Kumar Sagoo

Graduate Theses, Dissertations, and Problem Reports (ETD)

This research presents the pilot in the loop tests carried out in a Six-Degree of Freedom (6-DOF) motion flight simulator to evaluate failure detection, isolation and identification (FDII) schemes for an advanced F-15 aircraft. The objective behind this study is to leverage the capability of the flight simulator at West Virginia University (WVU) to carry out a performance assessment of neurally augmented control algorithms developed on a Matlab/Simulink RTM platform. The experimental setup features an interface setup of Gen-2 SimulinkRTM schemes with MOTUS Flight Simulator (MFS). The set up is a close substitute to a real flight and thus is …


A Historical Study Of The Kindergarten And First Grade Programs At The Minot State University Laboratory School (1969 - 1990): A School Ahead Of Its Time, Valeria Noel Wax Aug 2008

A Historical Study Of The Kindergarten And First Grade Programs At The Minot State University Laboratory School (1969 - 1990): A School Ahead Of Its Time, Valeria Noel Wax

Theses and Dissertations

This study uses archival sources and oral interviews to construct a history of the kindergarten and first grade programs at the Minot State University Laboratory School (MSU) from 1966 – 1990. The length of the study is based on the time the kindergarten was in existence at the MSU Laboratory School. The school was unique in North Dakota because it was the last laboratory in the state. A variety of educational methodologies and techniques were developed in an effort to improve instruction. The school also developed and refined an individualized instruction program that was used with all children enrolled in …


Vibration Causes Acute Vascular Injury In A Two-Step Process: Vasoconstriction And Vacuole Disruption, Sandya R. Govindaraju, James L. W. Bain, Thomas J. Eddinger, Danny A. Riley Aug 2008

Vibration Causes Acute Vascular Injury In A Two-Step Process: Vasoconstriction And Vacuole Disruption, Sandya R. Govindaraju, James L. W. Bain, Thomas J. Eddinger, Danny A. Riley

Biological Sciences Faculty Research and Publications

Hand–arm vibration syndrome is a vasospastic and neurodegenerative occupational disease. In the current study, the mechanism of vibration- induced vascular smooth muscle cell (SMC) injury was examined in a rat-tail vibration model. Tails of male Sprague Dawley rats were vibrated continuously for 4 hr at 60 Hz, 49 m/s2 with or without general anesthesia. Ventral tail arteries were aldehyde fixed and embedded in epoxy resin to enable morphological analysis. Vibration without anesthesia caused vasoconstriction and vacuoles in the SMC. Anesthetizing rats during vibration prevented vasoconstriction and vacuole formation. Exposing tail arteries in situ to 1 mM norepinephrine (NE) for 15 …