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Full-Text Articles in Entire DC Network
Numerical Analysis Of A Fractional Step Theta-Method For Fluid Flow Problems, John Chrispell
Numerical Analysis Of A Fractional Step Theta-Method For Fluid Flow Problems, John Chrispell
All Dissertations
The accurate numerical approximation of viscoelastic fluid flow poses two difficulties: the large number of unknowns in the approximating algebraic system (corresponding to velocity, pressure, and stress), and the different mathematical types of the modeling equations. Specifically, the viscoelastic modeling equations have a hyperbolic constitutive equation coupled to a parabolic conservation of momentum equation. An appealing approximation approach is to use a fractional step $\theta$-method. The $\theta$-method is an operator splitting technique that may be used to decouple mathematical equations of different types as well as separate the updates of distinct modeling equation variables when modeling mixed systems of partial …
08-19-2008 Swosu Faculty Honored For Years Of Service, Southwestern Oklahoma State University
08-19-2008 Swosu Faculty Honored For Years Of Service, Southwestern Oklahoma State University
THE BARK ARCHIVE 2008
Several Southwestern Oklahoma State University faculty members were honored for their years of service during the SWOSU Faculty and Administration Workshop held August 18 on the Weatherford campus.
The Effects Of Indirubin Derivitives On Gene Expression And Cellular Functions In The Murine Macrophage, Abigail Babcock
The Effects Of Indirubin Derivitives On Gene Expression And Cellular Functions In The Murine Macrophage, Abigail Babcock
All Dissertations
Indirubin is the active ingredient in the ancient herbal remedy, Danggui Longhui Wan, which is used as an anti-leukemic, anti-inflammatory, and detoxification treatment. Indirubin-3'-monoxime (IO) is the most widely studied of the indirubin derivatives. Most have been shown to inhibit cyclin-dependent kinases and glycogen synthase kinases, triggering cell cycle arrest and apoptosis with different levels of activity depending on the particular structure. These kinases inhibited by indirubin(s) play key roles in cellular proliferation and immune functions, therefore synthetic indirubins may have significant applications as therapeutic agents for cancer, inflammation, and neurological diseases.
Indirubin is also a potent aryl hydrocarbon receptor …
Estimating Geocenter Variations From A Combination Of Grace And Ocean Model Output, Sean Swenson, D. Chambers, John Wahr
Estimating Geocenter Variations From A Combination Of Grace And Ocean Model Output, Sean Swenson, D. Chambers, John Wahr
Marine Science Faculty Publications
In this study, we estimate a time series of geocenter anomalies from a combination of data from the Gravity Recovery and Climate Experiment (GRACE) satellite mission and the output from ocean models. A matrix equation is derived relating total geocenter variations to the GRACE coefficients of degrees two and higher and to the oceanic component of the degree one coefficients. We estimate the oceanic component from t wo state-of-the-art ocean models. Results are compared to independent estimates of geocenter derived from other satellite data, such as satellite laser ranging and GPS. Finally, we compute degree one coefficients that are consistent …
Mothers' Experience Of Having A Child Diagnosed With An Autism Spectrum Disorder, Amanda Gane
Mothers' Experience Of Having A Child Diagnosed With An Autism Spectrum Disorder, Amanda Gane
Theses, Dissertations, and Projects
The purpose of this study was to attempt to understand how mothers experience their relationships with their children diagnosed with an autism spectrum disorder (ASD). This qualitative, exploratory study aimed to expand the body of knowledge on mothers who have children with an ASD and their unique experiences. The majority of previous research done in this area has been quantitative and has not considered the individual experiences of this population. Mothers of children diagnosed with an ASD were recruited from Massachusetts and New Hampshire for this study. Ten mothers with children between the ages of five and nineteen were interviewed …
Together Or Separate : Implications For Expressing Progressive Social Justice And Spiritual Practices, Enroue Halfkenny
Together Or Separate : Implications For Expressing Progressive Social Justice And Spiritual Practices, Enroue Halfkenny
Theses, Dissertations, and Projects
What happens when people have both a spiritual practice and are engaged in progressive social justice work? How does expressing or engaging in them separately or together affect themselves and the work that they do? This relational, fixed methods research looks at those who have both a spiritual practice and are engaged in progressive social justice work and at how expressing them together or separately effects their perception of themselves and the work that they do (both spiritually and as an activist). A survey, containing 40 statements using a Likert-type scale, eight questions collecting demographic information and several open ended …
The Role Of Metal Coordnation In The Inhibition Of Iron(Ii)- And Copper(I)-Mediated Dna Damage By Organoselenium And Organosulfur Compounds, Erin Battin
All Dissertations
Copper and iron are two widely-studied transition metals associated with hydroxyl radical (OH) generation: Fe2+/Cu+ + H2O2 = Fe3+/Cu2+ + OH + OH-. Metal-mediated oxidative damage is a major cause of cellular DNA damage and death, and has been implicated in cancer, neurodegenerative, and cardiovascular diseases. Because sulfur and selenium antioxidants ameliorate oxidative damage, the ability of twenty biological sulfur- and selenium-containing compounds to inhibit metal-mediated DNA damage caused by hydroxyl radical has been quantified. In the Cu+/H2O2 system, six sulfur compounds and three selenium compounds inhibited DNA damage with IC50 values ranging from 3.3 to 25.5 μM. Several sulfur …
Engineered Micro-Environments And Vibrational Culture Systems For Vocal Fold Tissue Engineering, Jaishankar Kutty
Engineered Micro-Environments And Vibrational Culture Systems For Vocal Fold Tissue Engineering, Jaishankar Kutty
All Dissertations
Voice is produced by the conversion of aerodynamic energy from exhalation to acoustical energy for voice production by the vocal folds (membranous connective tissue) located in the larynx. The quality of voice depends on the biomechanical properties of the multi-layered vocal fold tissue which derive from its extracellular matrix (ECM) organization and composition. The wound healing response to vocal fold injuries is characterized by scarring and subsequent dysphonia due to alterations in the biomechanical properties of the tissue.
The work presented here is motivated by the importance of voice in maintaining quality of life and the inability of current treatment …
Effects Of Polyphenol Compounds On Iron-And Copper-Mediated Dna Damage: Mechanisms And Predictive Models, Nathan Perron
Effects Of Polyphenol Compounds On Iron-And Copper-Mediated Dna Damage: Mechanisms And Predictive Models, Nathan Perron
All Dissertations
Polyphenol compounds are widely recognized for their antioxidant activity; however, under some conditions these compounds can also exhibit prooxidant activity. This work examined the interactions of polyphenols with iron and copper to improve understanding of both their antioxidant and prooxidant effects. Polyphenols with catechol and gallol groups effectively inhibit iron-mediated oxidative DNA damage by chelating iron, with IC50 values ranging from 1-59 µM. Gallate compounds are more potent than their catecholate analogues in every instance, and their antioxidant potencies correlate to pKa values for the most acidic phenolic hydrogen. This correlation represents the first predictive model of …
Functionalized Carbon Nanotubes For Biological Applications, Lingrong Gu
Functionalized Carbon Nanotubes For Biological Applications, Lingrong Gu
All Dissertations
Carbon nanotubes with their unique pseudo-one-dimensional nanostructures and related electronic, optical, and mechanical properties have been attracting much attention for potential biological applications, such as biosensors, bio-delivery, bioimaging and so on. In this dissertation, recent studies and advances toward bioapplications of carbon nanotubes are critically reviewed, followed by detailed reports on my research projects concerning the use of carbon nanotubes as unique scaffolds for multivalent display of sugars and the relevant results from bio-evaluation of these novel nanomaterials.
Single-walled (SWNTs) and multiple-walled carbon nanotubes (MWNTs) were functionalized with amine-derivatived monosaccharides (galactoses and mannoses) and their dendritic constructs. These sugar-functionalized carbon …
Mothering The Mother : Can A Postpartum Doula Enhance Maternal Self Confidence And Maternal Empathy In A Primiparous Mother?, Binda Colebrook
Mothering The Mother : Can A Postpartum Doula Enhance Maternal Self Confidence And Maternal Empathy In A Primiparous Mother?, Binda Colebrook
Theses, Dissertations, and Projects
This study asks whether postpartum doulas enhance maternal empathy and maternal self-confidence in primiparous (first time) mothers in the postpartum phase and whether this is true across a socioeconomically diverse sample of women. A postpartum doula provides support to new mothers and their families in the first weeks postpartum. While quite a lot of research has been done on labor support doulas, less is known about the impact of the postpartum doula. No studies were found on whether they enhance maternal self-confidence and empathy. Because there are so few studies on postpartum doulas, an exploratory, qualitative method was used. In …
The Use Of Psychoeducation In The Treatment Of Ptsd With Military Personnel And Their Family Members : An Exploratory Study From A Clinician's Perspective, Mary Elizabeth Fisher
The Use Of Psychoeducation In The Treatment Of Ptsd With Military Personnel And Their Family Members : An Exploratory Study From A Clinician's Perspective, Mary Elizabeth Fisher
Theses, Dissertations, and Projects
This qualitative study explores clinician's use of psychoeducation in the treatment of Posttraumatic Stress Disorder (PTSD) with military personnel and their family members. Seven clinicians working with military personnel or in a military setting were asked a series of questions about psychoeducation and its use in the treatment of PTSD. Utilizing interviews, clinicians provided rich and detailed narratives outlining the following questions: (1) Is psychoeducation an appropriate intervention method in the treatment of PTSD? If so, when is it appropriate to use or incorporate psychoeducation in the treatment process with military personnel and/or their family members? and (2) What have …
Impacts Of Root Invigoration And Its Individual Components On The Performance Of Red Maple (Acer Rubrum), Kelby Fite
Impacts Of Root Invigoration And Its Individual Components On The Performance Of Red Maple (Acer Rubrum), Kelby Fite
All Dissertations
The Root Invigoration process involves soil decompaction with an air tool, amendment with organic matter and prescription fertilizer, and mulching. In the current study, we measured soil chemical and physical properties, tree characteristics, and root system responses to this process and its individual components. Treatments included Root Invigoration (AFM), mulch only (M), fertilization only (F), Airspade® tillage only (A), and an untreated control (C). The experiment was conducted from 2005-2007 at four urban sites: Anderson, SC; Boston, MA; Myrtle Beach, SC and Pittsburgh, PA. Soil strength was initially reduced by Airspade®, mulch and AFM; however only AFM-treated soils sustained this …
The Leaf Ionome As A Multivariable System To Detect A Plant's Physiological Status, Ivan R. Baxter, Olga Vitek, Brett Lahner, Balasubramaniam Muthukumar, Monica Borghi, Joe Morrissey, Mary Lou Guerinot, David E. Salt
The Leaf Ionome As A Multivariable System To Detect A Plant's Physiological Status, Ivan R. Baxter, Olga Vitek, Brett Lahner, Balasubramaniam Muthukumar, Monica Borghi, Joe Morrissey, Mary Lou Guerinot, David E. Salt
Dartmouth Scholarship
The contention that quantitative profiles of biomolecules contain information about the physiological state of the organism has motivated a variety of high-throughput molecular profiling experiments. However, unbiased discovery and validation of biomolecular signatures from these experiments remains a challenge. Here we show that the Arabidopsis thaliana (Arabidopsis) leaf ionome, or elemental composition, contains such signatures, and we establish statistical models that connect these multivariable signatures to defined physiological responses, such as iron (Fe) and phosphorus (P) homeostasis. Iron is essential for plant growth and development, but potentially toxic at elevated levels. Because of this, shoot Fe concentrations are …
Strategies For Expanding The Halogen Bonding Periodic Table And Desigining Complementary Halogen/Hydrogen Bonding Synthons, Hadi Arman
All Dissertations
Halogen bonding is the donation of electron density from an electron donor, such as N, O, S, Se atoms, to an electron acceptor such as a dihalogen or organohalogen. This interaction plays an important role in biological systems, such as the thyroid gland and is useful in many other fields such as drug design, crystal engineering, synthetic chemistry, material science and bioinorganic chemistry. However, currently there is a lack of information for this interaction in systems involving organoiodines with sulfur and selenium electron donors.
A variety of sulfur and selenium Lewis base donors were investigated with various organoiodines. The main …
Cues For Cellular Assembly Of Vascular Elastin Networks, Chandrasekhar Kothapalli
Cues For Cellular Assembly Of Vascular Elastin Networks, Chandrasekhar Kothapalli
All Dissertations
Elastin, a structural protein distributed in the extracellular matrix of vascular tissues is critical to the maintenance of vascular mechanics, besides regulation of cell-signaling pathways involved in injury response and morphogenesis. Thus, congenital absence or disease-mediated degradation of vascular elastin and its malformation within native vessels due to innately poor elastin synthesis by adult vascular cells compromise vascular homeostasis. Current elastin regenerative strategies using tissue engineering principles are limited by the progressive destabilization of tropoelastin mRNA expression in adult vascular cells and the unavailability of scaffolds that can provide cellular cues necessary to up-regulate elastin synthesis and regenerate faithful mimics …
Inferring Mechanical Resonances In Micro - And Nanocantilevers Using The Harmonic Detection Of Resonance (Hdr) Method To Develop A Novel Sensing Platform, Gayatri Keskar
All Dissertations
During the past two decades, advances in microelectromechanical systems (MEMS) have spurred efforts worldwide to develop sensing platforms based on smart microcantilevers. A microcantilever beam is one of the simplest MEMS structures which forms the basis for portable, fast and highly sensitive schemes that are capable of measuring small deflections in static or dynamic response due to changes in external parameters such as mass, pressure, charge, etc.
In this dissertation, I mainly focus on MEMS sensors with transducers in the form of microcantilevers. Variations in the microcantilever's response such as resonant frequency, amplitude, phase and quality factor when exposed to …
Synthesis And Pharmacology Of N-Alkyl-3-(Halo-Naphthoyl)Indoles, Valerie Smith
Synthesis And Pharmacology Of N-Alkyl-3-(Halo-Naphthoyl)Indoles, Valerie Smith
All Dissertations
The medicinal values of marijuana have often been overshadowed due to the psychotropic, 'recreational' effects it brings about in a user. For hundreds of years the therapeutic uses of cannabis sativa were appreciated, but the inability to control the dosage of the main constituent, and therefore the psychotropic effects, rendered the drug a liability. The elucidation of the structure of this main psychoactive constituent, ∆9-tetrahydrocannabinol (∆9-THC) by Gaoni and Mechoulam in 1964 opened the door to the discovery of a vast array of knowledge about cannabinoids. From the multiple classes of cannabinoids and the ways these compounds interact with the …
Electrochemical Synthesis And Characterization Of Polymers From Bis(3,4-Ethylenedioxythiophene)-Thiophenes (Bedot-Ts) And Bis(3,4-Ethylenedioxythiophene)-Benzenes (Bedot-Bs) As Optoelectronic Materials, Kalya Eaiprasertsak
All Dissertations
ABSTRACT
A series of bis(3,4-ethylenedioxythiophene)-thiophene derivatives (BEDOT-Ts) and bis(3,4-ethylenedioxythiophene)-benzene derivatives (BEDOT-Bs) monomers were electrochemically polymerized onto glassy carbon or ITO-coated glass electrodes. Cyclic voltammetry (CV), infrared (IR), UV-vis-NIR and photoluminescence (PL) spectroscopy were employed to investigate and characterize properties of resulting polymers. dc-conductivities of these polymers were measured by the four-point probe method.
Cyclic voltammetry studies show that the redox half potentials of PBEDOT-3BT, PBEDOT-3OT, PBEDOT-3TBS and PBEDOT-3MPT are -290, -297, -325 and -284 mV versus Ag/Ag+, respectively. The redox half potentials of PBEDOT-TOL, PBEDOT-BOB and PBEDOT-FB are -130, -147 and -327 mV vs. Ag/Ag+, respectively, and a bit higher …
Chitosan Derivatives For Tissue Engineering, Yongzhi Qiu
Chitosan Derivatives For Tissue Engineering, Yongzhi Qiu
All Dissertations
Chitosan, a naturally occurring polysaccharide, and its derivatives have been widely explored for biomedical applications due to their biocompatibility and biodegradability. In our studies, we developed a series of chitosan derivatives through chemical modifications. These chitosan derivatives not only possess better processibility in scaffolds fabrication, but also show excellent potentials in tissue engineering applications, including blood vessel and bone tissue engineering.
The excellent antithrombogenic property is crucial for vascular engineering applications, especially in engineering small-diameter blood vessels. In our studies, chitosan was chemically modified by phthalization and the phthalized chitosan exhibited great antithrombogenic property. Through a wet- phase-inversion process, tubular …
Recombinant G3 Domain Protein Of The Rat Laminin-5 Α3 Chain Binds To Integrins On Tumorogenic Breast Cancer Cells To Induce Apoptosis, Brittany Turner
Recombinant G3 Domain Protein Of The Rat Laminin-5 Α3 Chain Binds To Integrins On Tumorogenic Breast Cancer Cells To Induce Apoptosis, Brittany Turner
All Dissertations
The extracellular matrix (ECM) is a network of proteins for holding tissues and cells together. Among the constituents of the ECM is the large molecular weight glycoprotein laminin. Laminin is predominately found in the basement membrane of tissues. Laminins are composed of α, β, and γ chains with 5 globular (G) subdomains at the carboxyl (C) terminal end of the α chain. Of the 12 different laminin isoforms, laminin-5 has been targeted for cancer research. Specifically, the G3 domain has been studied as the specific binding domain. Cells are able to migrate through cell surface adhesion receptors known as integrins. …
The Effects Of Circular And Linear Exercise On Articular Cartilage In Sheep, Kristine Vernon
The Effects Of Circular And Linear Exercise On Articular Cartilage In Sheep, Kristine Vernon
All Dissertations
Excessive exercise may induce osteoarthritis (OA), or degeneration, of articular cartilage, which is a leading cause of lameness and decreased use in horses. The purposes of this study were to utilize a sheep model to determine the effects of circular and linear exercise on the macroscopic and microscopic characteristics of articular cartilage in the metacarpal-phalangeal (MCP) joint and to evaluate biochemical changes in serum and synovial fluid compared to non-exercised control lambs.
Twenty lambs were randomly assigned to three groups: circular exercise (C, 8.5m diameter; n = 8), straight-line exercise (S, treadmill; n = 8) and non-exercised control (CON, n …
The Spaceflight Environment And The Skeletal System, Eric Bandstra
The Spaceflight Environment And The Skeletal System, Eric Bandstra
All Dissertations
The spaceflight environment presents many challenges to the human body. Bone loss in astronauts is a well known consequence of reduced loading in the weightless environment of low-earth orbit. Recent studies have also indicated that spaceflight relevant types of radiation (at relatively high doses) have deleterious effects on trabecular bone. Both of these represent potential skeletal challenges during long-duration spaceflight. The objective of these studies is to examine the response of bone to models of the spaceflight environment.
Astronauts will likely absorb doses of protons and heavy ions during lengthy missions outside the Earth's magnetosphere. Following exposure to a range …
Changes In Brain Biochemistry And Feeding Behavior In Hybrid Striped Bass Exposed To Environmental Contaminants, Kristen Gaworecki
Changes In Brain Biochemistry And Feeding Behavior In Hybrid Striped Bass Exposed To Environmental Contaminants, Kristen Gaworecki
All Dissertations
Biochemical endpoints are useful when determining contaminant exposure in aquatic organisms. However, behaviors can also be impaired by environmental contaminants. Links between changes in brain biochemistry and behavior have been made, and understanding these relationships could increase the utility of these endpoints in ecological risk assessments. The overall goal of this research was to determine relationships between an ecologically relevant fish behavior and brain biochemistry. To accomplish this goal, I developed a behavioral bioassay that quantified the time it took exposed hybrid striped bass (Morone saxatilis x M. chrysops) to capture unexposed prey, fathead minnows (Pimephales promelas). Chemically targeted brain …
Activation Of Degp Chaperone-Protease Via Formation Of Large Cage-Like Oligomers Upon Binding To Substrate Proteins, Jiansen Jiang, Xuefeng Zhang, Yong Chen, Yi Wu, Z Hong Zhou, Zengyi Chang, Sen-Fang Sui
Activation Of Degp Chaperone-Protease Via Formation Of Large Cage-Like Oligomers Upon Binding To Substrate Proteins, Jiansen Jiang, Xuefeng Zhang, Yong Chen, Yi Wu, Z Hong Zhou, Zengyi Chang, Sen-Fang Sui
Faculty, Staff and Student Publications
Cells use molecular chaperones and proteases to implement the essential quality control mechanism of proteins. The DegP (HtrA) protein, essential for the survival of Escherichia coli cells at elevated temperatures with homologues found in almost all organisms uniquely has both functions. Here we report a mechanism for DegP to activate both functions via formation of large cage-like 12- and 24-mers after binding to substrate proteins. Cryo-electron microscopic and biochemical studies revealed that both oligomers are consistently assembled by blocks of DegP trimers, via pairwise PDZ1-PDZ2 interactions between neighboring trimers. Such interactions simultaneously eliminate the inhibitory effects of the PDZ2 domain. …
Drift By Drift: Effective Population Size Is Limited By Advection, John P. Wares, James M. Pringle
Drift By Drift: Effective Population Size Is Limited By Advection, John P. Wares, James M. Pringle
Earth Sciences
Background: Genetic estimates of effective population size often generate surprising results, including dramatically low ratios of effective population size to census size. This is particularly true for many marine species, and this effect has been associated with hypotheses of "sweepstakes" reproduction and selective hitchhiking. Results: Here we show that in advective environments such as oceans and rivers, the mean asymmetric transport of passively dispersed reproductive propagules will act to limit the effective population size in species with a drifting developmental stage. As advection increases, effective population size becomes decoupled from census size as the persistence of novel genetic lineages is …
Assimilation Of High-Frequency Radar Currents In A Nested Model Of The West Florida Shelf, Alexander Barth, Aida Alvera-Azcarate, Robert H. Weisberg
Assimilation Of High-Frequency Radar Currents In A Nested Model Of The West Florida Shelf, Alexander Barth, Aida Alvera-Azcarate, Robert H. Weisberg
Marine Science Faculty Publications
High‐frequency radar currents are assimilated in a West Florida Shelf (WFS) model based on the Regional Ocean Model System (ROMS), which is nested in the Atlantic Hybrid Coordinate Ocean Model (HYCOM) for the purpose of including both local and deep‐ocean forcing, particularly the Gulf of Mexico Loop Current. Tides are not included in this model. An ensemble simulation of the WFS model is carried out under different wind‐forcings in order to estimate the error covariance of the model state vector and the covariance between ocean currents and winds. Radial currents measured by high‐frequency radar antennas near Saint Petersburg and Venice, …
The Collegian (2008-08-18), Isis Lopez
The Collegian (2008-08-18), Isis Lopez
UTB/TSC Archives - The Collegian [Newspaper]
Vol. 61, No. 1
Beckmann Rearrangement Of Cyclotriveratrylene (Ctv) Oxime: Tandem Beckmann-Electrophilic Aromatic Addition, Marlon R. Lutz Jr., Matthias Zeller, Daniel P. Becker
Beckmann Rearrangement Of Cyclotriveratrylene (Ctv) Oxime: Tandem Beckmann-Electrophilic Aromatic Addition, Marlon R. Lutz Jr., Matthias Zeller, Daniel P. Becker
Chemistry: Faculty Publications and Other Works
The Beckmann rearrangement has been performed on the oxime of cyclotriveratrylene (CTV) with thionyl chloride affording the ring-expanded 10-membered ring amide exclusively in high yield. Modified conditions afford a helical pentacycle derived from an unusual tandem Beckmann rearrangement and electrophilic aromatic addition followed by demethylation and tautomerization.
Sandspur, Vol 115, No 01, August 18, 2008, Rollins College
Sandspur, Vol 115, No 01, August 18, 2008, Rollins College
The Rollins Sandspur
Rollins College student newspaper, written by the students and published at Rollins College. The Sandspur started as a literary journal.