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2008

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Staff Nurses' Level Of Diabetes And Diabetes Management Knowledge After A Diabetes Lecture-Based And Computer-Based Educational Intervention, Mary Annette Hess Wright Jan 2008

Staff Nurses' Level Of Diabetes And Diabetes Management Knowledge After A Diabetes Lecture-Based And Computer-Based Educational Intervention, Mary Annette Hess Wright

All ETDs from UAB

Nurses’ knowledge of diabetes and diabetes management and the identification of differences in knowledge gains after completion of a lecture-based or a computer-based diabetes educational intervention in 175 participants from a variety of health care settings, shifts, and specialties in a large acute-care facility in the Southeastern United States was studied. This was a randomized experimental design with a pretest (Time 1), an immediate post test (Time 2), and a 3-week-post test (Time 3) utilizing the conceptual framework of M. S. Knowles’ adult-learning theory. Nurses’ knowledge was assessed by a 45-item Diabetes Basic Knowledge Test (DBKT) with a 21-item demographic/diabetes …

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The Effect Of Malaria And Intestinal Helminth Coinfection On Birth Outcomes In Ghana, Nelly J. Yatich Jan 2008

The Effect Of Malaria And Intestinal Helminth Coinfection On Birth Outcomes In Ghana, Nelly J. Yatich

All ETDs from UAB

Several studies have reported the relationship between malaria during pregnancy and adverse pregnancy outcomes including maternal anemia, low birthweight, as well as preterm delivery and small for gestational age infants. Some studies have also demonstrated the linkage between helminth infection and maternal anemia. Few studies have assessed the occurrence of coinfection of these infections in pregnancy and its effects on maternal anemia and birth outcomes. The objective of this dissertation was to assess the effect of malaria and intestinal helminth coinfection on birth outcomes in Ghana. A cross-sectional study of 785 women presenting for delivery in two hospitals in Kumasi, …

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After Controlling For Other Risk Factors, To What Extent Does The Level Of Parity Account For The Differences In The Probability Of Developing Diabetes Mellitus?, Johnita Dobbs Jan 2008

After Controlling For Other Risk Factors, To What Extent Does The Level Of Parity Account For The Differences In The Probability Of Developing Diabetes Mellitus?, Johnita Dobbs

All ETDs from UAB

No abstract provided.

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Self-Efficacy To Resist Smoking As A Mediator Between Nicotine Dependence And Quit Attempt In Adolescent Smokers In Alabama, Isam G. Vaid Jan 2008

Self-Efficacy To Resist Smoking As A Mediator Between Nicotine Dependence And Quit Attempt In Adolescent Smokers In Alabama, Isam G. Vaid

All ETDs from UAB

No abstract provided.

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Contribution Of Magnocellular And Parvocellular Pathways To Visual Attention, Patricia A. Taylor-Cooke Jan 2008

Contribution Of Magnocellular And Parvocellular Pathways To Visual Attention, Patricia A. Taylor-Cooke

All ETDs from UAB

No abstract provided.

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Structural And Functional Studies Of Human Bile Acid Coa:Amino Acid N-Acyltransferase (Hbat), Erin Mary Shonsey Jan 2008

Structural And Functional Studies Of Human Bile Acid Coa:Amino Acid N-Acyltransferase (Hbat), Erin Mary Shonsey

All ETDs from UAB

No abstract provided.

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Adaptive Procedures To Detect Treatment Effects Under Unexpected Treatment-Covariate Interactions, Nitin K. Nair Jan 2008

Adaptive Procedures To Detect Treatment Effects Under Unexpected Treatment-Covariate Interactions, Nitin K. Nair

All ETDs from UAB

No abstract provided.

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Modulation Of Lipoprotein Metbolism And Atherosclerosis By The G Protein-Coupled Receptor, G2a, Brian W. Parks Jan 2008

Modulation Of Lipoprotein Metbolism And Atherosclerosis By The G Protein-Coupled Receptor, G2a, Brian W. Parks

All ETDs from UAB

No abstract provided.

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Intracellular Signaling Mechanisms Underlying Muscarinic Dependent Plasticity In Visual Cortex And The Impact Of Cholinergic Degeneration, Portia Anne Mccoy Jan 2008

Intracellular Signaling Mechanisms Underlying Muscarinic Dependent Plasticity In Visual Cortex And The Impact Of Cholinergic Degeneration, Portia Anne Mccoy

All ETDs from UAB

No abstract provided.

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The Role Of Neighborhood Residency In The Decision To Evacuate, Naya S. Mcmillan Jan 2008

The Role Of Neighborhood Residency In The Decision To Evacuate, Naya S. Mcmillan

All ETDs from UAB

No abstract provided.

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Provision Of Rapid Hiv Testin G And Nevirapine Administration In Zambian Labor Ward S To Im Prove Population Antiretroviral Coverage Of Hiv-Infected Women And Their Hiv-Exposed Infants, Karen M. Megazzini Jan 2008

Provision Of Rapid Hiv Testin G And Nevirapine Administration In Zambian Labor Ward S To Im Prove Population Antiretroviral Coverage Of Hiv-Infected Women And Their Hiv-Exposed Infants, Karen M. Megazzini

All ETDs from UAB

No abstract provided.

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Green Collar Jobs, Yvonne Sims Murray Jan 2008

Green Collar Jobs, Yvonne Sims Murray

All ETDs from UAB

No abstract provided.

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Human Leukocyte Antigen Supertypes In Relation To Human Immunodeficiency Virus Infection Among Populations Of African Ancestry, Aleksandr Lazaryan Jan 2008

Human Leukocyte Antigen Supertypes In Relation To Human Immunodeficiency Virus Infection Among Populations Of African Ancestry, Aleksandr Lazaryan

All ETDs from UAB

No abstract provided.

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Progression Through The Cell Cycle Is Regulated By Dynamic Chloride Dependent Changes In Cell Volumes, Christa Whelan Habela Jan 2008

Progression Through The Cell Cycle Is Regulated By Dynamic Chloride Dependent Changes In Cell Volumes, Christa Whelan Habela

All ETDs from UAB

No abstract provided.

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The Relationship Of Adolescent Cognitive Ability To Adult Physical Health: Socioeconomic Status And Health Behavior As Mediating Variables, Timothy M. Hale Jan 2008

The Relationship Of Adolescent Cognitive Ability To Adult Physical Health: Socioeconomic Status And Health Behavior As Mediating Variables, Timothy M. Hale

All ETDs from UAB

No abstract provided.

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Evaluation Of Commuter Air Quality, Jason Edward Howanitz Jan 2008

Evaluation Of Commuter Air Quality, Jason Edward Howanitz

All ETDs from UAB

No abstract provided.

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A Statistical Approach Identifying And Limiting The Effect Of Influential Observations In Linear Regression, Tamekia L. Jones Jan 2008

A Statistical Approach Identifying And Limiting The Effect Of Influential Observations In Linear Regression, Tamekia L. Jones

All ETDs from UAB

No abstract provided.

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Diet -Induced Changes In Intra -Abdominal Adipose Tissue And Cardiovascular Disease Risk In African American And European American Women, Konstantina Katsoulis Jan 2008

Diet -Induced Changes In Intra -Abdominal Adipose Tissue And Cardiovascular Disease Risk In African American And European American Women, Konstantina Katsoulis

All ETDs from UAB

No abstract provided.

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A Dual-Action, Armed Replicating Adenovirus For The Treatment Of Bone Metastases Of Breast Cancer, James Joseph Cody Jan 2008

A Dual-Action, Armed Replicating Adenovirus For The Treatment Of Bone Metastases Of Breast Cancer, James Joseph Cody

All ETDs from UAB

Most patients with advanced breast cancer develop osteolytic bone metastases, which have numerous complications. Because current therapies are not curative, new treatments are needed. Conditionally replicating adenoviruses (CRAds) are anti-cancer agents designed to infect and lyse tumor cells. For increased efficacy, CRAds have been armed with therapeutic transgenes. Osteoprotegerin (OPG), an inhibitor of osteoclastic bone resorption, represents a promising candidate with which to arm a CRAd intended to treat osteolytic bone metastases. We hypothesize that a CRAd armed with OPG will inhibit breast cancer bone metastasis and reduce tumor burden in the bone by directly lysing tumor cells and by …

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Mesenchymal Stem Cell Interaction With Nanostructured Biomaterials For Orthopaedic Applications, William Charles Clem Jan 2008

Mesenchymal Stem Cell Interaction With Nanostructured Biomaterials For Orthopaedic Applications, William Charles Clem

All ETDs from UAB

Orthopaedic implants fail when bone loss around the anchoring region of the prosthesis causes the components to loosen. A revision surgery is needed to replace worn components, and bone grafting is often required to fill the void caused by osteolysis. A solution for the problem of osteolysis may be the improvement of wear resistance at the articulating surfaces by substituting materials with greater hardness. This dissertation describes two strategies for increasing the surface hardness of titanium alloy (Ti-6Al-4V) implants, without increasing surface roughness or compromising osseointegration. The first strategy utilizes microwave plasma to induce titanium nitride formation by nitrogen diffusion. …

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Thrombospondin Type-1 Repeats And Their Potential Role In Inhibiting Glioblastoma Angiogenesis, Joshua C. Anderson Jan 2008

Thrombospondin Type-1 Repeats And Their Potential Role In Inhibiting Glioblastoma Angiogenesis, Joshua C. Anderson

All ETDs from UAB

Thrombospondin-1 (TSP-1) is a 420 kilodalton homotrimeric protein; it is one of the first identified anti-angiogenic proteins found to be expressed in some normal tissues. Peptides derived from the type-1 repeat (TSR) domains of full length TSP-1 have been shown to have anti-angiogenic activity, and thus anti-tumor activity in some non-glioma tumor models. I hypothesized that peptides derived from the TSRs of TSP-1, such as ABT-510, could inhibit angiogenesis and thus malignant glioma tumor growth in vivo. I found that ABT-510 inhibited angiogenesis of the human brain microvascular endothelial cell (MvEC) in an in vitro tubulomorphogenesis assay. To determine the …

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Human Papillomavirus: Segregation And Replication, Luan D. Dao Jan 2008

Human Papillomavirus: Segregation And Replication, Luan D. Dao

All ETDs from UAB

Human papillomavirus are small DNA tumor viruses. The viral genome is a small circular double stranded DNA that replicates autonomously as an extrachromosomal plasmid. Occasionally infections by the high risk HPV viruses can lead to DNA integration and progression to cancer. How the HPV DNA is maintained and becomes established in the dividing host cells is not well understood. Additionally, as a double-stranded DNA virus it is likely that double-stranded DNA breaks in the viral genome, either from replication or random damage, will trigger a DNA repair response from the host cell. Such responses have been alternatively reported to be …

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Occupational Stressors, Job Satisfaction, And Back Pain In Firefighters, Mantana Damrongsak Jan 2008

Occupational Stressors, Job Satisfaction, And Back Pain In Firefighters, Mantana Damrongsak

All ETDs from UAB

Occupational back pain is a significant health and safety problem in many industrialized countries for persons who are required to perform work-related forceful movement and lifting. Firefighters, an occupational group at high risk for back injury, perform many job tasks under hazardous work conditions. One-third of firefighters retire due to job-related health and safety problems and 49.4% of this group retire as a result of back pain, the leading cause of early retirements in firefighters. Most studies have examined factors influencing back problems among other workers, especially nurses and hospital workers, but few studies have investigated factors that influence back …

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Metabolism Of Neutrophil-Deprived Chlorinated Isoflavones, Tracy Lyn D'Alessandro Jan 2008

Metabolism Of Neutrophil-Deprived Chlorinated Isoflavones, Tracy Lyn D'Alessandro

All ETDs from UAB

Despite medical advances in both drug therapy and surgical techniques, Americans mostly die from heart disease. Many belong to the low- and middle-class families who do not have sufficient access to medical care due to its high costs. An alternative is the development of healthier lifestyles such as diet which may play a positive role in chronic disease management. Epidemiological and migratory studies suggest that soy plays a pivotal role in the decreased incidence of heart disease in East Asian countries, such as China, Japan, and Korea. The role of soy in cardiovascular disease progression has been the subject of …

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Perception Of Motion-In-Depth: Induced Motion Effects On Monocular And Binocular Cues, John Eric Gampher Jan 2008

Perception Of Motion-In-Depth: Induced Motion Effects On Monocular And Binocular Cues, John Eric Gampher

All ETDs from UAB

Three cues are available to the visual system to determine motion: image displacement across the retina (retinal slip), eye movements, and configuration changes within a scene (Becklen and Wallach, 1985). Any one may lead to the false perception of motion. Induced motion is the illusory movement of one object (or objects) as a result of other movement in the visual field. A wide variety of displays have been used to study induced motion, leading to apparently different classes of induced motion. Current theories of induced motion can be categorized based on local motion, global motion, eye movement suppression, and cognitive …

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Impact Of An Electronic Medical Record On Adherence To Current Diabetes Guidelines In A Family Medicine Center, Thomas Macandrew English Jan 2008

Impact Of An Electronic Medical Record On Adherence To Current Diabetes Guidelines In A Family Medicine Center, Thomas Macandrew English

All ETDs from UAB

OBJECTIVE: Extensive research shows that diabetic care often falls below recommended guidelines. Many believe that Electronic Medical Records (EMR) have the ability to improve quality of care. The primary goal of this study is to evaluate the changes in diabetic care and outcomes pre and post EMR implementation. RESEARCH DESIGN AND METHODS: The study took place at the UAB Huntsville Family Medicine Center. A retrospective chart review was conducted in order to determine the impact of an EMR on diabetes care. This is a natural experiment that uses a pre post model in order to determine impact. Generalized Estimating Equations …

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Functionalizing Hydroxyapatite Biomaterials With Biomimetic Peptides Of Integrin Ligands, Kristin Marie Hennessy Jan 2008

Functionalizing Hydroxyapatite Biomaterials With Biomimetic Peptides Of Integrin Ligands, Kristin Marie Hennessy

All ETDs from UAB

Hydroxyapatite (HA) coatings of hard tissue implants have been shown to increase osseointegration, but the mechanisms by which HA improves implant integration are not well understood. Numerous studies have shown that modifying HA with adhesive peptides, including RGD, and the collagen I mimetics, DGEA and P15, stimulates the adhesion of mesenchymal stem cells (MSCs), a cell type that differentiates along the osteoblast lineage. However, HA is a highly adsorptive biomaterial, and therefore it is unlikely that cells at the implant site would ever encounter a peptidemodified HA surface in the absence of an adsorbed protein layer. In fact, our laboratory …

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Using Rna Interference To Study The Function Of The Tethering Protein P115 In Er-Golgi Traffic, Robert Grabski Jan 2008

Using Rna Interference To Study The Function Of The Tethering Protein P115 In Er-Golgi Traffic, Robert Grabski

All ETDs from UAB

Metazoan cells are characterized with elaborate network of intracellular membranous compartments. These membranes allow the cell to spatially separate antagonistic processes and environments, and maintain sequential order of reactions necessary for maturation and secretion of biosynthetic cargo. The core transport machinery consists of coat proteins, tethering factors, SNAREs and small Ras-like GTPases. We have explored the function of the tethering factor p115 in organellogenesis and in secretory traffic. The p115-depleted system was utilized to explore structurefunction relationships within p115. Here, we analyzed the architecture of the Golgi after RNAi induced depletion of p115. We show that in p115 depleted cells …

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The Role Of Melanopsin Containing Retinal Ganglion Cells In The Pupillary Responses Of Human And Non-Human Primates, David H. Mcdougal Jan 2008

The Role Of Melanopsin Containing Retinal Ganglion Cells In The Pupillary Responses Of Human And Non-Human Primates, David H. Mcdougal

All ETDs from UAB

Historically, the characteristics of the light-evoked neural signals driving the human pupillary light reflex (PLR) have been poorly understood. It was assumed that these light signals originated exclusively from rod and cone photoreceptors, although the measured spectral sensitivity and response dynamics of the PLR were difficult to reconcile with the known properties of rods and cones. Recently, a novel photoreceptive cell class has been discovered in the mammalian retina. These unique retinal ganglion cells not only receive rod and cone inputs, but also express the photopigment melanopsin, and exhibit intrinsic photoresponses independent of rod and cone inputs. These intrinsically photosensitive …

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Mechanism Of The Cross Talk Between Growth Hormone Receptor And Epidermal Growth Factor Receptor, Xin Li Jan 2008

Mechanism Of The Cross Talk Between Growth Hormone Receptor And Epidermal Growth Factor Receptor, Xin Li

All ETDs from UAB

EGF receptor (EGFR) is a receptor tyrosine kinase, mediating cell growth from ectodermal and mesodermal origin. The overexpression and aberrant function of EGFR are involved in a wide range of human carcinomas. Growth hormone receptor (GHR) coexists with EGFR in various cell types and implicated in malignant tumor behavior. Previously in our lab, we found that via ERK activation GH can threonine phosphorylate EGFR and reduce EGF-induced EGFR downregulation. GH also synergizes with EGF in activating ERK. In this project, using reconstitution, we studied the mutation of the ERK phosphorylation consensus residue on EGFR, 669T. CHO-GHR cells, which lack EGFR …

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