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2008

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Mixing And Formulation Of Low Dose Drugs : Underlying Problems And Solutions, Vipin Kukkar, Vikas Anand, Mahesh Kataria, Manoj Gera, Pratim Kumar Choudhury Jan 2008

Mixing And Formulation Of Low Dose Drugs : Underlying Problems And Solutions, Vipin Kukkar, Vikas Anand, Mahesh Kataria, Manoj Gera, Pratim Kumar Choudhury

The Thai Journal of Pharmaceutical Sciences

Mixing and formulation of low dose drugs can be very challenging due to problems related to segregation, content uniformity and physical stability. A careful control on these factors is necessary while manufacturing low dose drug products. Selection of e...

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Mb 800 Research Methods In Missiology, Russell W. West Jan 2008

Mb 800 Research Methods In Missiology, Russell W. West

Syllabi

Course Description This course introduces students to various approaches to research design, research methods and dissertation writing for doctoral students in missiology and intercultural studies. Methods are the link between questions and answers. The problem is finding the appropriate methods that discover data that shed light on the problem at hand. A well-designed research project should provide a door for the researcher to enter the stream of literature being produced about a particular topic. The goal of this course is to introduce students to a variety of research strategies and tools so that the student will be able to contribute …

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Co 730 Advanced Issues In Cross-Cultural Counseling, Javier Sierra Jan 2008

Co 730 Advanced Issues In Cross-Cultural Counseling, Javier Sierra

Syllabi

Pedersen, P. B., Draguns, J. G., Lonner, W. J., & Trimble, J. E. (2007). Counseling Across Cultures, (6th ed.). Thousand Oaks, CA: Sage Sue, D. W., and Sue, D. (2007). Counseling the Culturally Diverse: Theory and practice, (5th ed.). New York: John Wiley & Sons

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Co 730 Advanced Issues In Cross-Cultural Counseling, Javier Sierra Jan 2008

Co 730 Advanced Issues In Cross-Cultural Counseling, Javier Sierra

Syllabi

Pedersen, P. B., Draguns, J. G., Lonner, W. J., & Trimble, J. E. (2007). Counseling Across Cultures, (6th ed.). Thousand Oaks, CA: Sage Sue, D. W., and Sue, D. (2007). Counseling the Culturally Diverse: Theory and practice, (5th ed.). New York: John Wiley & Sons

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Is 502 Vocation Of Ministry, Burrell D. Dinkins Jan 2008

Is 502 Vocation Of Ministry, Burrell D. Dinkins

Syllabi

Course Description This course addresses the question, How is a vocation to Christian ministry discerned, shaped, and sustained? The purpose of the course is to explore the biblical and theological foundations of Christian vocation by examining the connection between a call to ministry and the formation of persons for ministry.

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Ms 674 Mw 708 Introduction To World Religions, Terry C. Muck Jan 2008

Ms 674 Mw 708 Introduction To World Religions, Terry C. Muck

Syllabi

COURSE DESCRIPTION In this course, students study the origin, history, and basic tenets of each of the major religious traditions of the world--Buddhism, Confucianism, Daoism, Hinduism, Islam, Judaism, Sikhism, and Zoroastrianism. Students learn basic religious study skills, and engage in research projects in one or more of these religions.

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Do 690 John Wesley’S Theology Today, Kenneth J. Collins Jan 2008

Do 690 John Wesley’S Theology Today, Kenneth J. Collins

Syllabi

Course Description and Objectives: The course will explore the theology of John Wesley in terms of his doctrine of salvation. Principal attention will be given to the following elements: 1) the nature of justification, 2) the significance of Wesley’s Aldersgate experience, 3) the new birth, 4) assurance 5) the faith of a servant, and 6) Christian perfection. In terms of methodology, the course will proceed in a Socratic and dialogical manner as it entertains an array of possible meanings of selected texts. This process, intense in many ways, should enhance the ability of students not only to understand the thought …

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Co 603 Orientation To Christian Approaches To Diagnosis And Treatment Planning, Virginia Todd Holeman Jan 2008

Co 603 Orientation To Christian Approaches To Diagnosis And Treatment Planning, Virginia Todd Holeman

Syllabi

Entwistle, D. (2004). Integrative approaches to psychology and Christianity: An introduction to worldview issues, philosophical foundations, and models of integration. Wipf & Stock Pub. ISBN: 159-244-7996

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Effects Of Hexosamine Biosynthesis On An In Vitro Model Of Cardiacischemia, Voraratt Champattanachai Jan 2008

Effects Of Hexosamine Biosynthesis On An In Vitro Model Of Cardiacischemia, Voraratt Champattanachai

All ETDs from UAB

Increased levels of protein O-linked-N-acetylglucosamine (O-GlcNAc) have been correlated with increased cell survival following stress. Therefore the goal of this study was to determine whether enhanced flux through the hexosamine biosynthesis pathway (HBP), which leads to elevated levels of O-GlcNAc, improved the tolerance of isolated neonatal rat ventricular myocytes (NRVMs) to ischemia/reperfusion (I/R) injury. NRVMs were exposed to hypoxic medium for 4 hours, followed by oxygenated complete medium for 16 hours. Acute treatment with 5 mM glucosamine showed an increase in viability and decreased both necrosis and apoptosis following I/R. Glucosamine increased O-GlcNAc levels maximally at 2 hours and went …

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The Relationship Of Medical Homeness To The Quality Of Life Of Mothers Of Children With And Without Special Health Care Needs, Cynthia G. Cortes Jan 2008

The Relationship Of Medical Homeness To The Quality Of Life Of Mothers Of Children With And Without Special Health Care Needs, Cynthia G. Cortes

All ETDs from UAB

A cross-sectional study was conducted to investigate the relationship of child, family, and medical home status to quality of life for mothers of children with and without special health care needs. Mothers of children with (n=100) and without (n=80) special health care needs, completed a questionnaire at a children’s hospital in the southeastern United States focusing on the child, family, and medical home and maternal quality of life. Standardized instruments were used to measure quality of life (SF-36) and social support (Social Support Questionnaire). Non-standardized instruments used in other research were incorporated into the maternal questionnaire. Logistic and linear regression …

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Structural And Functional Properties Of Human Αa-Crystallin, Jose Mauro Chaves Jan 2008

Structural And Functional Properties Of Human Αa-Crystallin, Jose Mauro Chaves

All ETDs from UAB

The three specific aims of the project were: (1) compare effects of deamidation alone (i.e., αA-N101D, αA-N123D, αA-N101/123D), truncation alone (αA-NT mutant [deletion of residue no. 1-63], or αA-CT mutant [deletion of residue no. 140-173]), or both truncation plus deamidation on structural and functional properties of human lens αA-crystallin; (2) identify components of complexes in the water soluble-high molecular weight (WS-HMW) proteins of normal aging and cataractous human lenses; and (3) determine interactions among WT-αA, αA-NT and αA-CT crystallin species with filensin and phakinin (beaded filament proteins) in vitro. The comparative structural and functional differences between αA-deamidated and/or truncated mutants …

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Microbial Biofilm Attachment To Caenorhabditis Elegans, Kevin Drace Jan 2008

Microbial Biofilm Attachment To Caenorhabditis Elegans, Kevin Drace

All ETDs from UAB

The closely related bacterial species Xenorhabdus nematophila, Yersinia pestis and Y. pseudotuberculosis make biofilms capable of adhering to the head of the model nematode Caenorhabditis elegans. Y. pestis uses biofilms to block the digestive tract of its vector, the flea, in order to enhance its efficiency of transmission. I investigated the role of biofilms in X. nematophila and found that, like its Yersinia sp. counterparts, production of biofilm requires a four-gene operon: hmsHFRS. X. nematophila is an insect pathogen and an obligate symbiont of the nematode Steinernema carpocapsae. However, an X. nematophila hmsH mutant that failed to make biofilms on …

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Phenomenological Study: What Are Pre-Kindergarten Teachers' Lived Experiences With Children Identified With Conduct Disorder, Oppositional Defiance Disorder, And Attention-Deficit Hyperactivity Disorder In The Southeastern United States?, Danna Benefield Jones Jan 2008

Phenomenological Study: What Are Pre-Kindergarten Teachers' Lived Experiences With Children Identified With Conduct Disorder, Oppositional Defiance Disorder, And Attention-Deficit Hyperactivity Disorder In The Southeastern United States?, Danna Benefield Jones

All ETDs from UAB

To date, a vast amount of research has been conducted on disruptive behavior dis-orders such as conduct disorder (CD), oppositional defiance disorder (ODD), and atten-tion deficit hyperactivity disorder (ADHD. However, a paucity of research exists in spe-cific areas such as how teachers’ handle students diagnosed with these disorders. The cur-rent situation in pre-kindergarten may undermine the ability of these students to succeed in the school system. This is seen in the fact that a large number of these students are removed from pre-kindergarten programs across the United States (Webster-Stratton, Reid, & Hammond, 2004). Understanding pre-kindergarten teachers’ lived experiences in handling …

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Role Of The Gm/Gn Glycoprotein Complex In The Final Assembly And Egress Of The Human Cytomegalovirus (Hcmv), Magdalena Anna Krzyzaniak Jan 2008

Role Of The Gm/Gn Glycoprotein Complex In The Final Assembly And Egress Of The Human Cytomegalovirus (Hcmv), Magdalena Anna Krzyzaniak

All ETDs from UAB

HCMV consists of a dsDNA genome enclosed by, an icosahedral capsid surrounded by a layer of tegument proteins; the virion structure is enclosed in a lipid envelope rich in virus expressed glycoproteins. The HCMV envelope contains an incompletely defined number of glycoproteins. The glycoprotein M (gM) and glycoprotein N (gN) form a gM/gN protein complex which is the most abundant protein component of the HCMV envelope. Recent studies have indicated that deletion of the viral gene encoding either gM or gN is lethal for HCMV. The gM C-terminal cytoplasmic tail (gM-CT) revealed an acidic cluster and a tyrosine-based trafficking motifs. …

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Punctal Occlusion Impact On Tear Film Immuno-Regulatory Proteins Measured By Cytometric Bead-Based Assay, Martin W. Lafrance Jan 2008

Punctal Occlusion Impact On Tear Film Immuno-Regulatory Proteins Measured By Cytometric Bead-Based Assay, Martin W. Lafrance

All ETDs from UAB

PURPOSE: This study compares vendor reagents used for cytometric bead-based assay (CBA) of cytokines in human tears and validates a protocol for use in evaluating punctal occlusion, a treatment for keratoconjunctivitis sicca. It has been proposed that punctal occlusion may alter tear cytokine concentrations based on the facts that: (1) tear clearance, a measure of the balance between tear production and elimination, declines following occlusion and (2) reduced tear clearance and increased levels of pro-inflammatory tear cytokines are correlated in dry eye patients. This study compares tear clearance values and the level of 24 tear cytokines measured by CBA following …

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Transcriptional Regulation Of Cd40 And Class Ii Mhc Molecules In Macrophages And Microglia By Statins, Sun Jung Lee Jan 2008

Transcriptional Regulation Of Cd40 And Class Ii Mhc Molecules In Macrophages And Microglia By Statins, Sun Jung Lee

All ETDs from UAB

Microglia/macrophages are the main intrinsic immune effector cells and the first cell types that respond to a variety of CNS injures. They have important functions including secretion of cytokines/chemokines and antigen presentation, thereby regulating immune responses. Interferon-γ (IFN-γ) is a cytokine involved in many aspects of the immune response, and activates microglia/macrophages to express cell surface antigens such as class II MHC, and co-stimulatory molecules such as CD40. CD40 and class II MHC molecules play a critical role in immune reactivity such as antigen presentation and subsequent T cell activation. However, aberrant CD40 and class II MHC expression have been …

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The Induction Of First Year And Transferring Elementary School Teachers: A Multiple Case Study, Patricia L. Lequier Jan 2008

The Induction Of First Year And Transferring Elementary School Teachers: A Multiple Case Study, Patricia L. Lequier

All ETDs from UAB

This qualitative, multiple case study explored the experiences of elementary teachers and principals participating in school induction processes. The staggering rates at which new teachers are leaving the profession, coupled with high rates of teacher attrition, teacher retirements, and increases in student enrollment formed the impetus for this study. These factors have collectively contributed to the nation’s crucial demand for close to two million teachers. In an effort to increase the retention rate of new teachers, schools across the nation have implemented teacher induction processes. Teacher induction processes focus on providing support for teachers in their transition from their roles …

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Interim Monitoring Efficacy, Safety And Futility In Phase Iii Clinical Trials, Qing Li Jan 2008

Interim Monitoring Efficacy, Safety And Futility In Phase Iii Clinical Trials, Qing Li

All ETDs from UAB

Phase III trials often have both efficacy and safety outcomes. Sometimes the safety outcomes are closely associated with the efficacy outcomes. We sought to find a statistical method to treat both efficacy and safety outcomes as bivariate primary outcomes and set up stopping rules at interim stages based on the following criteria: (1) greater safety; (2) greater efficacy; (3) futility. We first examined the internal pilot design to adjust sample size for clinical trials with a bivariate response (efficacy and safety). Three nuisance parameters (two variances and correlation) need to be considered when doing sample size recalculation for the internal …

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The Au-Rich Element Mrna Decay-Promoting Activity Of Brf1 Is Regulated By Mitogen-Activated Protein Kinase Activated Protein Kinase 2, Sushmit Maitra Jan 2008

The Au-Rich Element Mrna Decay-Promoting Activity Of Brf1 Is Regulated By Mitogen-Activated Protein Kinase Activated Protein Kinase 2, Sushmit Maitra

All ETDs from UAB

Regulated mRNA decay is a highly important process for the tight control of gene expression. Inherently unstable mRNAs contain AU-rich elements (AREs) in the 3’ untranslated regions that direct rapid mRNA decay by interaction with decay-promoting ARE-binding proteins (ARE-BPs). The decay of ARE-containing mRNAs is regulated by signaling pathways, which are believed to directly target ARE-BPs. Here, we show that BRF1 involved in ARE-mediated mRNA decay (AMD) is phosphorylated by MAPK-activated protein kinase 2, MK2. In vitro kinase assays using different BRF1 fragments suggest that MK2 phosphorylates BRF1 at four distinct sites, S54, S92, S203, and an unidentified site at …

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The Physical And Mental Health Of Spouse Caregivers In Dementia: Finding Meaning As A Mediator Of Burden, Susan M. Mclennon Jan 2008

The Physical And Mental Health Of Spouse Caregivers In Dementia: Finding Meaning As A Mediator Of Burden, Susan M. Mclennon

All ETDs from UAB

The purpose of this study was to examine the effect of caregiver burden on the physical and mental health of caregivers of spouses with dementia and to determine if finding meaning through caregiving mediated the relationship between burden and health. This was a cross-sectional, correlational study in a convenience sample of 84 community-residing spouse caregivers of adults with dementia recruited from North- Central Florida. Measures included the Zarit Burden Interview, the Finding Meaning through Caregiving Scale, and the Medical Outcomes Short Form-36, version 2. Data analyses consisted of descriptive, correlational, and standard multiple regression statistical methods. The sample consisted of …

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Modulation Of Transforming Growth Factor (Tgf)-Ss1 And Its Implications In Breast Cancer Metastasis, Lakisha Dionne Moore Jan 2008

Modulation Of Transforming Growth Factor (Tgf)-Ss1 And Its Implications In Breast Cancer Metastasis, Lakisha Dionne Moore

All ETDs from UAB

Overexpresssion of transforming growth factor (TGF)-β has been implicated in promoting immune suppression, tumor angiogenesis, tumor cell migration, and invasion in many cancers including carcinoma of the breast. Thus, targeted downregulation of TGF-β1 expression in breast cancer in situ and determination of its implications potentially could provide new treatment approaches for disease management. siRNA constructs targeting TGF-β1 were validated and used to develop clonal derivatives of the MDA-MB-435 metastatic breast cancer cell line. Inhibition of TGF-β1 expression in MDA-MB-435 cells showed decrease in migration and invasion in vitro with an increase in proliferation. In vivo analysis indicated a 90% decrease …

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The Role Of Centaurin Alpha-1 In The Regulation Of Neuron Al Differentiation, Carlene Drucilla Moore Jan 2008

The Role Of Centaurin Alpha-1 In The Regulation Of Neuron Al Differentiation, Carlene Drucilla Moore

All ETDs from UAB

In the nervous system, PI 3-kinase has been implicated in neuronal differentiation. My studies have focused on a candidate neuronal PI 3-kinase target centaurin alpha-1, which binds PtdIns(3,4,5)P3, and is an Arf6 GAP. Centaurin alpha-1 is localized in dendrites, dendritic spines and synapses, and is required for neuronal differentiation and spine morphogenesis. In dissociated neuronal cultures, expression of centaurin alpha-1 enhances dendritic branching, and increases dendritic filopodia, lamellipodia and spine-like protrusions. Expression of centaurin alpha-1 GAP inactive mutant or knocking down centaurin alpha-1 levels using siRNA leads to inhibition of dendritic outgrowth and branching. Manipulations of centaurin alpha-1 also disrupt …

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Relationships Among Anger, Patterns Of Anger Expression And Blood Pressure, Glucose, And Cortisol In Overweight School-Aged Children, Kimberly Nichols Jan 2008

Relationships Among Anger, Patterns Of Anger Expression And Blood Pressure, Glucose, And Cortisol In Overweight School-Aged Children, Kimberly Nichols

All ETDs from UAB

Overweight and obesity in school-aged children have become a major health issue. With overweight and obesity, children have increased risk of developing elevated blood pressure readings, glucose levels, and cortisol. Trait anger and patterns of anger expression have been shown to contribute to the elevations of blood pressure, glucose and cortisol in normoweight children and overweight adolescents. However, little research has been done with overweight school-aged children. The purpose of this study was to examine the relationships among trait anger and each of the patterns of anger expression (anger-suppression, anger-out, and anger-reflection/control) and blood pressure, glucose, and cortisol in overweight …

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Investigation Of Lipoteichoic Acid Structure And Function To Establish Its Role In Gram-Positive Bacterial Infections, Ho Seong Seo Jan 2008

Investigation Of Lipoteichoic Acid Structure And Function To Establish Its Role In Gram-Positive Bacterial Infections, Ho Seong Seo

All ETDs from UAB

Lipoteichoic acid (LTA) is an essential bacterial membrane polysaccharide (cell wall component) that is linked to a glycerol backbone with two acyl chains. Since an antibody to LTA has been shown to protect from Gr+ bacterial infections or colonization, and the mutant Gr+ bacteria which produce less amount of LTA have less pathogenic than WT, LTA may be an important role in Gr+ bacterial infection and inflammation. The currently accepted structure of pneumococcal LTA has the pentameric repeating unit bound to the lipid anchor {Glc(β1��3)AATGal(β1��3)Glc(α1��3)-acyl2Gro}. Unlike the lipid anchor of other Gr+ bacterial LTA, this pneumococcal LTA lipid anchor has …

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An Exploration Of Factors Related To Hypertension Control In African American And Caucasian Municipal Employees, Sunun Sinsuesatkul Jan 2008

An Exploration Of Factors Related To Hypertension Control In African American And Caucasian Municipal Employees, Sunun Sinsuesatkul

All ETDs from UAB

Hypertension is a major contributor to morbidity, mortality, and medical costs in the United States. African Americans (AAs) have the highest prevalence of hypertension in the world, exhibiting at least twice the rate for Caucasians in almost every age and sex group. AAs are also at higher risk for complications from hypertension than Caucasians. While several factors have been proposed as accounting for those differences, there is no consensus on which factors may be responsible; the reasons for disparities in hypertension control in AAs are complex, and need further investigation. This study explored relationships between multiple factors to identify how …

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A Professional Journey: A Grounded Theory Study On The Experiences Of Reading Coaches As They Transition From Being A Teacher Of Children To A Leader Of Adults, Victoria Spear Jan 2008

A Professional Journey: A Grounded Theory Study On The Experiences Of Reading Coaches As They Transition From Being A Teacher Of Children To A Leader Of Adults, Victoria Spear

All ETDs from UAB

This qualitative grounded theory study described the experiences of Alabama Reading Initiative reading coaches as they transitioned from being teachers of children to being leaders of adults. This study addressed the gap in literature regarding the actual lived experiences of these professionals who were catalysts for change in the highly institutionalized culture of the public school setting. The study highlighted the triumphs and challenges inherent in the complex nature of institutional, professional, and personal change. The research participants were 23 practicing reading coaches in North Alabama and North Central Alabama. Forms of data collected included open-ended interviews, observations, and field …

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Changes In Short-Term Facilitation Are Opposite At Schaffer Collateral And Temporoammonic Ca1 Synapses In The Developing Rat Hippocampus, Haley E. Speed Jan 2008

Changes In Short-Term Facilitation Are Opposite At Schaffer Collateral And Temporoammonic Ca1 Synapses In The Developing Rat Hippocampus, Haley E. Speed

All ETDs from UAB

Hippocampal CA1 pyramidal neurons integrate and filter spatial, temporal, and sensory information from the entorhinal cortex (EC) for memory storage. Synaptic transmission mediates the processing of incoming information, and recent studies have demonstrated that long-term changes in synaptic strength at CA1 synapses are important for learning and memory. Short-term changes in synaptic strength, occurring on a timescale of milliseconds to minutes, do not require lasting modifications and are rapidly reversible. Termed short-term plasticity, it is known to be important for dynamic gain control of synaptic transmission and neural computation. During late postnatal development, there are extensive developmental changes in rat …

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Analysis Of The Hedgehog Pathway In Pancreatic Adenocarcinoma, Adam Steg Jan 2008

Analysis Of The Hedgehog Pathway In Pancreatic Adenocarcinoma, Adam Steg

All ETDs from UAB

Pancreatic adenocarcinoma (PAC) is the fourth leading cause of cancer mortality in the United States. Despite the use of highly aggressive treatment regimens (surgery, chemotherapy and radiation), almost all patients succumb to metastatic disease within 6-10 months of diagnosis. The hedgehog (HH) signaling pathway was originally discov-ered to play a critical role in mammalian embryological development. Interestingly, re-cent studies have suggested that aberrant expression of this pathway is involved in the initiation and continued growth of PAC. Small molecules that antagonize the transmem-brane protein Smoothened (Smo), a critical signaling component of the HH pathway, have proven effective in decreasing PAC …

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Randomized Controlled Trial Of Low Cost Interventions To Reduce Childhood Immunization Dropouts In Pakistan, Hussain Raza Usman Jan 2008

Randomized Controlled Trial Of Low Cost Interventions To Reduce Childhood Immunization Dropouts In Pakistan, Hussain Raza Usman

All ETDs from UAB

Childhood immunization coverage in Pakistan remains sub-optimal despite universal and free of cost availability of vaccines. Structural impediments to progress may include the immunization card that is hard to read and interpret. A randomized controlled trial was conducted to assess the effect of redesigned immunization card and center-based education to mothers on immunization completion at rural immunization centers in Karachi, Pakistan. Other objectives were to identify the predictors of immunization completion and to identify factors associated with delay at first dose of diphtheria-tetanuspertussis (DTP1). Mother-child units were enrolled from six immunization centers at DTP1 and randomized to four study groups: …

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Effects Of Music Therapy On Preterm Infants In The Neonatal Intensive Care Unit, Ashley Hodges Wood Jan 2008

Effects Of Music Therapy On Preterm Infants In The Neonatal Intensive Care Unit, Ashley Hodges Wood

All ETDs from UAB

The study purpose was to examine the effects of a 15-min live-music therapy intervention on heart rate, oxygen saturation, level of motor activity, behavioral distress, and behavioral state levels in premature infants in the neonatal intensive care unit. The convenience sample included 20 infants born at 26 to 29 weeks’ gestational age who were hospitalized in a large teaching hospital in the southern United States. In a 1-group repeated-measures crossover design, infants were randomly assigned order of music versus no-music conditions. Data were collected on 4 occasions over a 2- to 4-week period beginning when the infants were 1 to …

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