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Response Properties Of The Auditory Telencephalon In Songbirds Change With Recent Experience And Season, Thomas A. Terleph, Kai Lu, David S. Vicario

Biology Faculty Publications

The caudomedial nidopallium (NCM) is a telencephalic auditory area that is selectively activated by conspecific vocalizations in zebra finches and canaries. We recently demonstrated that temporal and spectral dynamics of auditory tuning in NCM differ between these species [1]. In order to determine whether these differences reflect recent experience, we exposed separate groups of each species and sex to different housing conditions. Adult birds were housed either in an aviary with conspecifics (NORM), with heterospecifics (canary subjects in a zebra finch aviary, and vice versa: (CROSS)), or in isolation (ISO) for 9 days prior to testing. We then recorded extracellular …

The Influence Of Past Negotiations On Negotiation Counterpart Preferences, Jochen Reb

Research Collection Lee Kong Chian School Of Business

Choosing the right counterpart can have a significant impact on negotiation success. Unfortunately, little research has studied such negotiation counterpart decisions. Three studies examined the influence of past negotiations on preferences to negotiate again with a counterpart. Study 1 found that the more favorable a past negotiated agreement the stronger the preference to negotiate with the counterpart in the future. Moreover, this relation was mediated through liking of the counterpart. Study 2 manipulated the difficulty of achieving a favorable agreement in the negotiation and found a significant effect of this situational factor such that subsequent counterpart preferences were less favorable …

William Blake's Artificial Mythology And Quotations From World Mythos, Teresa L. Cunningham

Graduate Theses, Dissertations, and Problem Reports (ETD)

The central theme of this thesis is the visual analysis of William Blake's art in connection to the available mythological and religious texts by which Blake constructed his own artificial mythology. This analysis will include explorations into Anglo-Saxon, Germanic, Jewish and Hindu myth as well as Christian and mystic texts. The various works or "books" by Blake will be the visual basis, specifically The Marriage of Heaven and Hell (1790), his later "prophetic" work Jerusalem, the Emanation of the Giant Albion (1820) and his last completed work The Illustrations of the Book of Job (1825). This thesis will affirm that …

Environmental Forensics For Characterization Of Unexploded Ordnance In Soils At The Dolly Sods Wilderness Area, Amy Richmond Aylor

Graduate Theses, Dissertations, and Problem Reports (ETD)

The West Virginia Maneuver Area includes locations within the Dolly Sods Wilderness Area, the Canaan Valley National Wildlife Recreation Area, and private land holdings in Grant, Randolph, and Tucker counties of West Virginia. Between 1943 and 1944, the military trained troops in a 50,000 acre area which is now the Dolly Sods Wilderness area. This training was conducted by the U.S. Department of the Army and involved artillery and mortar training for troops destined for World War II combat in the mountains of Italy. This project focused on characterization and investigation of the environmental contamination resulting from military ordnance existing …

Predictive Modeling Of Freshwater Mussels (Unionidae) In The Appalachians, Alison R. Mynsberge

Graduate Theses, Dissertations, and Problem Reports (ETD)

Freshwater mussels are in decline, particularly in the Appalachian region of North America. This region contains the world's greatest diversity of freshwater mussels, but many species are now threatened or endangered. Little is known of the basic ecology and distributions of species of freshwater mussels relative to other freshwater organisms. The goal of this study was to use predictive modeling to predict distributions of freshwater mussels in the Appalachians and identify correlated factors using a watershed framework. Models were developed in the upper Mid-Atlantic and Ohio drainage regions using subwatersheds and separately in the Tennessee region using catchments. Models developed …

Association Of Changes In Norepinephrine And Serotonin Transporter Expression With The Long-Term Behavioral Effects Of Antidepressant Drugs, Zaorui Zhao

Graduate Theses, Dissertations, and Problem Reports (ETD)

The relationship between the ability of repeated antidepressant treatment to cause down-regulation of the norepinephrine and serotonin transporters (NET, SERT) and produce antidepressant-like effects on behavior was determined. Treatment of rats with 15 mg/kg/day desipramine reduced NET expression, measured by 3H-nisoxetine binding and SDS-PAGE/immunoblotting, in cerebral cortex and hippocampus and reduced the time of immobility in the forced-swim test. The antidepressant-like effect on forced-swim behavior was evident two days following discontinuation of desipramine treatment when plasma and brain levels of desipramine and its major metabolite desmethyldesipramine were not detectable. Reduced NET expression resulted in decreased norepinephrine (NE) uptake, measured in …

Mechanical Characterization Of Fabrics For Inflatable Structures, Juan Cruz Molina Pombo

Graduate Theses, Dissertations, and Problem Reports (ETD)

Several mechanical properties of fabrics for inflatable structures have been characterized. In this work, the characterization was done for fabrics in a tunnel plug. As a plug the structure should seal the tunnel and maintain itself static, for that reason the characterization of the frictional system tunnel wall/structure fabric is done. Also, by the study of the maximum stresses under this configuration, the tensile strength of the structural fabrics is studied. In order to characterize the fabric properties, friction and strength, a test for each of them was done.;The tensile strength test was performed for two fabrics, according to the …

Postpartum Depression In Anishinaabe American Indians, Natalie M. Nicholson

Theses and Dissertations

The purpose of this study is to better understand the personal experience of postpartum depression among Anishinaabe American Indian women and further examine how various resources such as family, friends, Traditional healing, local and healthcare options were utilized. In addition advice was sought from a Traditional leader as to how these women can care for themselves in the postnatal period and how providers can properly manage their care.

A descriptive qualitative analysis approach was used. Interviews were conducted in 1-1.5 hours in the home of the Anishinaabe American Indian women who are from Red Lake Band of Chippewa Indian Reservation. …

The Impact Of The Ferst Foundation For Childhood Literacy On The Home Literacy Environment, Gina Bennett Thomason

Doctoral Dissertations and Projects

This study examined if, among families whose children were enrolled in the Ferst Foundation for Childhood Literacy, there was a relationship between the home literacy environment, measured by a scale survey, and the length of time enrolled in the program. Participants were a stratified random sampling from the population of parents in the State of Georgia whose children were enrolled in the Ferst Foundation for Childhood Literacy program. Using a pilot-tested original survey instrument, 2,100 survey packets were mailed to participants. Valid returned surveys totaled 1,082. Valid surveys were analyzed to determine if a relationship existed between the home literacy …

Deficit Of Kcnma1 Mrna Expression In The Dentate Gyrus Of Epileptic Rats, Boris Ermolinsky, Massoud F. Arshadmansab, Luis F. Pacheco Otalora, Masoud M. Zarei, Emilio R. Garrido-Sanabria

Health & Biomedical Sciences Faculty Publications

Epileptogenesis in mesial temporal lobe epilepsy is determined by several factors including abnormalities in the expression and function of ion channels. Here, we report a long-lasting deficit in gene expression of Kcnma1 coding for the large-conductance calcium-activated potassium (BK, MaxiK) channel α-subunits after pilocarpine-induced status epilepticus. By using comparative realtime PCR, Taqman gene expression assays, and the delta-delta comparative threshold method we detected a significant reduction in Kcnma1 expression in microdissected dentate gyrus at different intervals after status epilepticus (24 h, 10 days, 1 month, and more than 2 months). BK channels are key regulators of neuronal excitability and transmitter …

Differential Changes In Mglu2 And Mglu3 Gene Expression Following Pilocarpine-Induced Status Epilepticus: A Comparative Real-Time Pcr Analysis, Boris Ermolinsky, Luis F. Pacheco Otalora, Massoud F. Arshadmansab, Masoud M. Zarei, Emilio R. Garrido-Sanabria

Health & Biomedical Sciences Faculty Publications

Group II metabotropic glutamate (mGlu II) receptors subtype 2 and 3 (mGlu2 and mGlu3) are subtle regulators of neuronal excitability and synaptic plasticity in the hippocampus. In recent years, researchers have investigated the potential neuroprotective and anticonvulsant effects of compounds acting on mGlu II receptors. However, abnormal expression and function of mGlu2 and mGlu3 have been reported in temporal lobe epilepsy, a phenomena that may limit the therapeutic effectiveness of these potentially new antiepileptic drugs. Here, we investigated seizure-induced changes in mGlu2 and mGlu3 mRNA following pilocarpine-inducted status epilepticus (SE) and subsequent epileptogenesis. Relative changes in gene expression …

Deficit Of Kcnma1 Mrna Expression In The Dentate Gyrus Of Epileptic Rats, Boris Ermolinsky, Massoud F. Arshadmansab, Luis F. Pacheco Otalora, Masoud M. Zarei, Emilio R. Garrido-Sanabria

Health & Biomedical Sciences Faculty Publications

Epileptogenesis in mesial temporal lobe epilepsy is determined by several factors including abnormalities in the expression and function of ion channels. Here, we report a long-lasting deficit in gene expression of Kcnma1 coding for the large-conductance calcium-activated potassium (BK, MaxiK) channel alpha-subunits after pilocarpine-induced status epilepticus. By using comparative real-time PCR, Taqman gene expression assays, and the delta-delta comparative threshold method we detected a significant reduction in Kcnma1 expression in microdissected dentate gyrus at different intervals after status epilepticus (24 h, 10 days, 1 month, and more than 2 months). BK channels are key regulators of neuronal excitability and transmitter …

Watertight Trimmed Nurbs, Thomas W. Sederberg, Xin Li, Hongwei Lin, Heather Ipson

Faculty Publications

This paper addresses the long-standing problem of the unavoidable gaps that arise when expressing the intersection of two NURBS surfaces using conventional trimmed-NURBS representation. The solution converts each trimmed NURBS into an untrimmed T-Spline, and then merges the untrimmed T-Splines into a single, watertight model. The solution enables watertight fillets of NURBS models, as well as arbitrary feature curves that do not have to follow isoparameter curves. The resulting T-Spline representation can be exported without error as a collection of NURBS surfaces.

Development Of Volunteer-Driven Indices Of Biological Integrity For Wetlands In West Virginia, Walter Emil Veselka Iv

Graduate Theses, Dissertations, and Problem Reports (ETD)

Wetland indices of biological integrity (IBIs) are used to satisfy the water resources monitoring requirements of the Clean Water Act (CWA). However, debate still exists on what classification systems and taxa to base these IBIs upon. Our cumulative research, representing indices of biological integrity designed for regional HGM subclasses, designated HGM management classes and Cowardin et al. (1979) classes for West Virginia. The indices were derived from metrics calculated from anuran, avian, macroinvertebrate, and vegetation communities; each representing increasing levels of resources associated with gathering the necessary data. For example, avian and anuran data used to derive floodplain wetland IBI …

Genomic Profiling Reveals An Alternate Mechanism For Hepatic Tumor Promotion By Perfluorooctanoic Acid In Rainbow Trout, Susan C. Tilton, Gayle A. Orner, Abby D. Benninghoff, Hillary M. Carpenter, Jerry D. Hendricks, Cliff B. Pereira, David E. Williams

Animal, Dairy, and Veterinary Science Faculty Publications

Background

Perfluorooctanoic acid (PFOA) is a potent hepatocarcinogen and peroxisome proliferator (PP) in rodents. Humans are not susceptible to peroxisome proliferation and are considered refractory to carcinogenesis by PPs. Previous studies with rainbow trout indicate they are also insensitive to peroxisome proliferation by the PP dehydroepiandrosterone (DHEA), but are still susceptible to enhanced hepatocarcinogenesis after chronic exposure.

Objectives

In this study, we used trout as a unique in vivo tumor model to study the potential for PFOA carcinogenesis in the absence of peroxisome proliferation compared with the structurally diverse PPs clofibrate (CLOF) and DHEA. Mechanisms of carcinogenesis were identified from …

Originalism And Regulatory Takings: Why The Fifth Amendment May Not Protect Against Regulatory Takings, But The Fourteenth Amendment May, Michael B. Rappaport

San Diego Law Review

This Article explores the widely disputed issue of whether Takings Clause protects against regulatory takings, offering a novel and intermediate solution. Critics of the regulatory takings doctrine have argued that the original meaning of the Fifth Amendment Takings Clause does not cover regulatory takings. They have quickly moved from this claim to the conclusion that the incorporated Takings Clause under the Fourteenth Amendment also does not cover regulatory takings. In this Article, I accept the claim that the Fifth Amendment Takings Clause does not cover regulatory takings, but then explore the possibility that the incorporated Takings Clause does cover such …

2008 August, Office Of Communications & Marketing, Morehead State University.

Morehead State Press Release Archive, 1961 to the Present

Press releases for August of 2008.

Evaluation Of The Xpert Methicillin-Resistant Staphylococcus Aureus (Mrsa) Assay Using The Genexpert Real-Time Pcr Platform For Rapid Detection Of Mrsa From Screening Specimens., Celine M. Herra

Articles

The need for rapid methods to accurately detect methicillin-resistant Staphylococcus aureus (MRSA) is widely acknowledged, and a number of molecular assays are commercially available. This study evaluated the Xpert MRSA assay, which is run on the GeneXpert real-time PCR platform (Cepheid) for use in a clinical laboratory. The following parameters were investigated: (i) the limits of detection (LoDs) for four MRSA strains; (ii) the ability to detect isolates of MRSA from a collection representative of MRSA in Ireland since 1974 (n 114) and the ability to detect control strains with staphylococcal cassette chromosome mec types IVa (IV.1.1.1), IVb (IV.2.1.1), IVc …

The Use Of Personality Assessments In Designing Environmental Enrichment For Garnett's Bushbabies (Otolemur Garnettii), Lauren Elizabeth Highfill

Dissertations

Recently the study of animal personality has become an important and credible topic of research and a number of studies have revealed personality traits in a variety of species. The consideration of individual animal personality traits is important for animal management and welfare. For example, ensuring inter-individual compatibility in group housing animals may serve to ensure the safety of the whole group. To date, no formal research has been conducted on whether the assessment of individual personality traits could be used as a tool for individualizing environmental enrichment interventions. The goal of environmental enrichment is to increase the rate of …

Knowledge-Based Analysis Of Genomic Expression Data By Using Different Machine Learning Algorithms For The Purpose Of Diagnostic, Prognostic Or Therapeutic Application, Venkata Jagan Mohan Thodima

Dissertations

With more and more biological information generated, the most pressing task of bioinformatics has become to analyze and interpret various types of data, including nucleotide and amino acid sequences, protein structures, gene expression profiling and so on. In this dissertation, we apply the data mining techniques of feature generation, feature selection, and feature integration with learning algorithms to tackle the problems of disease phenotype classification, clinical outcome and patient survival prediction from gene expression profiles.

We analyzed the effect of batch noise in microarray data on the performance of classification. Batchmatch, a batch adjusting algorithm based on double scaling method …

Principles Of Feeding Small Flocks Of Chickens At Home, David D. Frame

All Current Publications

Owning a small flock of chickens is increasing in popularity, particularly in areas prohibiting the raising of larger domestic animals. Chickens not only furnish a ready source of home-grown meat and eggs, but also provide great pleasure as exhibition stock and even as pets.

Basic Tips For 1st Year Junior Livestock Market Projects, Donna Carter

All Current Publications

This fact sheet gives basic tips for 1st year junior market livestock projects.

Fitting The Western Or English Saddle To The Horse, Patricia Evans, Kerry A. Rood

All Current Publications

This publication gives tips on how to properly fit a saddle to the horse.

Selecting A Saddle To Fit The Rider, Patricia Evans, Clinton Depew

All Current Publications

This publication gives tips on selecting a saddle that will be comfortable for both the horse and rider.

Dermestid Beetles, Erin W. Hodgson, Katherine Coats, Alan H. Roe

All Current Publications

Dermestid beetles are in the family Dermestidae and order Coleoptera. These beetles are sometimes called larder beetles or carpet beetles. Adults range from 1 to 12 mm in length and have variable body coloration. In general, they are hairy, dark-colored, elongated, and have clubbed antennae. The larvae are light brown and can be up to 13 mm long. Many larvae have spines, called setae, on the back of the abdomen that are helpful with identification. Dermestid larvae and adults have chewing mouthparts.

Originalism: Lessons From Things That Go Without Saying, Robert W. Bennett

San Diego Law Review

After setting the originalism "stage" and discussion of some of its tribulations, the article turns to the problem of constitutional silences. These come in many shadings, and the article concentrates on three that illustrate different sorts of problems: 1) the failure of the Guarantee Clause to provide a more precise definition of a "republican form of government"; 2) the deafening silence about any role for political parties in the nation's politics and governance; and 3) the absence of guidance about "discretion" to be exercised by presidential elections, which surfaces these days as the problem of the "faithless elector," one who …

Maximum Likelihood Methods In Biology Revisited With Tools Of Computational Intelligence, John E. Seiffertt Iv, Andrew Vanbrunt, Donald C. Wunsch

Electrical and Computer Engineering Faculty Research & Creative Works

We investigate the problem of identification of genes correlated with the occurrence of diseases in a given population. The classical method of parametric linkage analysis is combined with newer tools and results are achieved on a model problem. This traditional method has advantages over non-parametric methods, but these advantages have been difficult to realize due to their high computational cost. We study a class of Evolutionary Algorithms from the Computational Intelligence literature which are designed to cut such costs considerably for optimization problems. We outline the details of this algorithm, called Particle Swarm Optimization, and present all the equations and …

Pegylated Interferon 2a And 2b In Combination With Ribavirin For The Treatment Of Chronic Hepatitis C In Hiv Infected Patients., Ravinder Dhillon, Simona Rossi, Steven K Herrine

Department of Medicine Faculty Papers

Coinfection with hepatitis C virus (HCV) and HIV is an increasingly recognized clinical dilemma, particularly since the advent of highly active antiretroviral therapy. Several studies of this population have demonstrated both more rapid progression of liver disease and poorer overall prognosis compared to HCV monoinfected patients. Consensus guidelines, based primarily on the results of 4 major randomized trials, recommend treatment with peginterferon and ribavirin for 48 weeks in coinfected patients. However, this current standard of care is associated with lower response rates to therapy than those seen in monoinfected patients. Important predictors of response include HCV genotype, pretreatment HCV RNA …

Time-Measuring Device: Making Your Own History Of Remembrance Box With Childhood’S Physical Growth, Sang Hee Huh

Theses

Memories, for most of us, are precious indeed. Reminiscing helps us recall long gone events and a wide range of emotions. However, our recollection is imperfect and we know our memory is limited. Our memories may change or we may forget. We are unwilling to entrust precious memories solely to the unassisted mind. Children, in particular, undergo considerable physical, mental, and emotional changes. It is not easy for them to realize or later recall their growth process without assistance. At present, children can review their growth with different types of records: written data on a medical history, photos in family …

Blunted Cystine–Glutamate Antiporter Function In The Nucleus Accumbens Promotes Cocaine-Induced Drug Seeking, Kristen S. Kau, Aric Madayag, John R. Mantsch, Mark D. Grier, Omer Abdulhameed, David A. Baker

Biomedical Sciences Faculty Research and Publications

Repeated cocaine alters glutamate neurotransmission, in part, by reducing cystine–glutamate exchange via system x_c−, which maintains glutamate levels and receptor stimulation in the extrasynaptic compartment. In the present study, we undertook two approaches to determine the significance of plasticity involving system x_c−. First, we examined whether the cysteine prodrug N-acetylcysteine attenuates cocaine-primed reinstatement by targeting system x_c−. Rats were trained to self-administer cocaine (1 mg/kg/200 μl, i.v.) under extended access conditions (6 h/day). After extinction training, cocaine (10 mg/kg, i.p.) primed reinstatement was assessed in rats pretreated with N-acetylcysteine (0–60 mg/kg, i.p.) in the …