Digital Commons Network^™

The Public Interest, Professionalism, And Pro Bono Publico, Lorne Sossin

Osgoode Hall Law Journal

There is a clear public interest benefit for lawyers to ensure access to the rule of law, especially on the part of the vulnerable. This article seeks to show that the seemingly simple relationship between the legal profession and the public interest is in fact more complicated than it looks. Pro bono may be viewed from two perspectives-that of the lawyer and that of the client. From the perspective of the lawyer, the important question is whether there is ethical motivation to engage in pro bono. If, however, the perspective of the client is paramount, then meeting the client's needs …

Discriminative-Stimulus And Time-Course Effects Of Kava-Kava (Piper Methysticum) In Rats, Natalie R. Bruner

Graduate Theses, Dissertations, and Problem Reports (ETD)

Kava-kava is a widely available and used herbal medicine that is not regulated in many countries, including the United States. There are many questions concerning kava-kava's stimulus properties, potential for therapeutic use, and potential for abuse. Although there is evidence that kava may possess some anxiolytic properties, the supplement's mechanism of action and the extent to which it may serve as an alternative to pharmaceutical anxiolytics are unknown. To date, there is no research examining whether kava shares discriminative-stimulus properties with a standard pharmaceutical anxiolytic such as chlordiazepoxide (CDP). The current study compared different doses of kava in two groups …

Involvement Of Adenosine A1 Receptors In Systemic Inflammation And Altered Vascular Reactivity In Allergic Mice, Dovenia S. Ponnoth

Graduate Theses, Dissertations, and Problem Reports (ETD)

Epidemiological studies have established that people who have lung diseases such as asthma and COPD are likely to develop adverse cardiovascular events. While the reason for this has not been elucidated, it is believed that inflammation could be the key component linking the two conditions. Adenosine, an endogenous purine nucleoside, has been strongly implicated in asthma pathophysiology and also has potent effects on the cardiovascular system. This work was undertaken to gain a better understanding of the relationship between asthma and its cardiovascular effects, and more specifically the possible role adenosine plays under these conditions.;We hypothesize that asthmatic lung inflammation …

Composition, Conservation, Evolution, And Function Of The Cold Shock Domain Proteins In Plants, Kari Beth Thompson

Graduate Theses, Dissertations, and Problem Reports (ETD)

Cold shock domain proteins, or CSPs, are among the most ancient and conserved nucleic acid binding proteins. They have been well characterized in prokaryotic systems but little is known about their function in plants. The overall objective of this study was to understand the evolution and function of the cold shock domain in plant model systems. To pinpoint conserved areas within CSD an alignment was made of the cold shock domain protein sequences based on nucleotide sequence information found within EST databases. A description of domains found in the plant CSPs was prepared and a descriptive nomenclature system was developed. …

Superfeminization As An Effect Of Bisphenol A In Marisa Cornuarietis & Response From Forbes Et Al. To Oehlmann Et Al., Jörg Oehlmann, Ulrike Schulte-Oehlmann, Jean Bachmann, Matthias Oetken, Ilka Lutz, Werner Kloas, Valery E. Forbes, John Aufderheide, Ryan Warbritton, Nelly Van Der Hoeven, Norbert Caspers

Valery Forbes Publications

[Oehlmann et al.]: Recently, we had the opportunity to read two articles in volume 66 of Ecotoxicology and Environmental Safety. Forbes et al. (2007a, , 2007b) declare “to explore the reproducibility of prior work” showing that bisphenol A (BPA) induces superfeminization in the freshwater snail Marisa cornuarietis (Oehlmann et al., 2000, 2006; Schulte- Oehlmann et al., 2001). Based on the outcome of a toxicity test with the same species, the authors conclude that their results “do not support previous claims of enhanced reproduction in M. cornuarietis in response to exposure to BPA.” We take issue with the declaration of …

Mixture Toxicity Of Three Toxicants With Similar And Dissimilar Modes Of Action To Daphnia Magna, Kristian Syberg, Anders Elleby, Henrik Pedersen, Nina Cedergreen, Valery E. Forbes

Valery Forbes Publications

Mixture toxicity of similar- and dissimilar-acting toxicants can be predicted by the models concentration addition (CA) and independent action (IA) using single substance toxicity data. Knowledge of the toxicants mode of action is thus required in order to use the models. In order to test the predictive capability of the models, we conducted Daphnia magna 48 h immobilization experiments with three toxicants with known modes of action (dimethoate, pirimicarb and linear alkyl benzene sulfonate) singly, and in binary and ternary mixtures. Our results indicate that CA and IA predict binary mixtures of similar- and dissimilar-acting toxicants equally well. CA and …

Life History And Population Dynamics Of The Opportunistic Polychaete Capitella Sp. I In Relation To Sediment Organic Matter, Tina Ramskov, Valery E. Forbes

Valery Forbes Publications

Capitella sp. I is a deposit-feeding polychaete that occurs in estuarine and marine environments and that shows boom-bust population dynamics in response to organic pollution. A lifecycle experiment was carried out to quantify the relative importance of individual life-history traits for driving the dynamics of Capitella sp. I populations in response to changes in sediment organic matter concentrations. Individual-level effects were estimated as changes in survival, reproductive characteristics, and growth. Effects at the population-level were assessed by integrating the measured life-history traits in a simple 2-stage demographic model that was used to estimate the population growth rate (λ). Low organic …

The Aesthetics Of Trademarks, Peter H. Karlen

Contemporary Aesthetics (Journal Archive)

Trademarks are not just property, they are aesthetic creations that pervade everyday experience. One estimate is that the average person encounters more than 1,000 trademarks per day, many of which influence purchases and product use.

As pervasive aesthetic creations having literary, pictorial, graphic, sculptural, and musical content, trademarks deserve aesthetic analysis. The article discusses the origins, strength, appeal, and effectiveness of trademarks within the context of aesthetic considerations such as meaning, intention, authorship, and mode of creation. Also reviewed are morphemic and phonemic analysis of trademarks, semantic positioning, the dichotomy between creation and discovery of trademarks, and the differences between …

Can We Get Inside The Aesthetic Sensibility Of The Archaic Past?, Frederic Will

Contemporary Aesthetics (Journal Archive)

This essay is about getting inside the sensibility of the archaic past.[1] Can we get into the creative mind of the painter of The Sorcerer? Can we reconstruct the sensibility of prehistoric humans? Can we recover the humor of the prehistoric artist? Can we do it? After all, sense equipment is the same in men and women of all ages, and though each age inflects its sense usages uniquely, there should remain an underlying continuity among sensibilities. Shouldn't we be able to return into earlier forms of those usages? Can we tell whether we have been successful in accomplishing …

Online Social Presence: A Study Of Score Validity Of The Computer-Mediated Communication Questionnaire, Cherng-Jyh Yen, Chih-Hsiung Tu

Educational Leadership & Workforce Development Faculty Publications

The purpose of this study was to conduct a confirmatory factor analysis of the Computer-Mediated Communication Questionnaire scores, using structural equation modeling, to assess the consistency between the empirical data and the hypothesized factor structure of the CMCQ in the proposed models, which is stipulated by the theoretical framework and previous research. Online social presence is a vital affective learning factor that influences online interaction. In this study, online social presence was defined as the degree of feeling, perception, reaction, and trustworthiness of being connected by computer-mediated communication to another intellectual entity through electronic media. Currently, valid instruments to determine …

Wetlands Restoration Group Final Research Project, Ofelia Alvarado, John Bolthouse, Christina Rivas, Karen Seo, Mark Thompson

Program Design and Evaluation

Research project for the Wetland Restoration and Education project that was developed for the YMCA Camp Surf.

Meaning Of Place: Exploring Long-Term Residents Attachment To The Physical Environment In Northern New Hampshire, Laura A. Alexander

Antioch University Dissertations & Theses

This study explores the meaning of place and the role of the physical setting, relative to sociocultural elements, for long-term, year-round residents of northern New Hampshire for two dimensions of place: attachment and identity. Resident-employed photography was used to prompt research participants to think about how they are attached to place and how it shapes their identity, and their photos served as a way to enter quickly and deeply into a conversation about place meaning. Data was analyzed according to the tradition of grounded theory and five themes of meaning emerged as follows: The physical setting is stable, restorative, where …

Connecting With Nature Through Land Use Decision Making, Cathy Setterlin

Antioch University Dissertations & Theses

This narrative inquiry, which draws on my experience as a land use decision maker, environmental educator, and scholar, examines the complexities of our human-nature relationship as we use and protect the life of the land in local communities. I began this research by interviewing seventeen land use decision makers representing a range of land use perspectives in New Milford, Connecticut, focusing on their views of land as a living community, their connections to land, and their sense of duty and responsibility.

Their responses led me to further inquiry and drew me into a process that transformed my views of both …

Youth Competitors Gain Benefits From Horse Show Judges' Training Program, Pat Evans, S. Mckendrick, J. Wesley, J. Smith

Animal, Dairy, and Veterinary Science Faculty Publications

This article details how youth benefit from a horse show judges’ training program. While judging is subjective, with training, judges can be more consistent in their placings, with the better horses and/or riders being placed at the top of the class. With qualified judges, youth can be more confident that they will be evaluated in a fair and consistent manner during each show all season long.

Foal Hoof Care Fact Sheet, Scott Mckendrick, Kerry Rood, Patricia Evans

All Current Publications

No abstract provided.

Asia Pacific Perspectives Vol. 8 No. 1, June 2008, University Of San Francisco, University Of San Francisco

Asia Pacific Perspectives

Contents:

Jack London Reporting from Tokyo and Manchuria: The Forgotten Role of an Influential Observer of Early Modern Asia by Daniel A. Métraux

ack London is regarded as one of America’s most popular writers for his novels and short stories. Less known today is the fact that he was also a first-rate observer of East Asian politics, societies, and peoples. Working as a journalist for several newspapers and magazines, he filed numerous articles and essays covering the Russo-Japanese war and even foresaw the rise of Japan and China as world powers. This paper provides an overview of his journalistic and …

Foal Hoof Care Fact Sheet, When And How Often To Trim?, Patricia Evans, Scott Mckendrick, Kerry A. Rood

All Current Publications

This publication provides detailed information on proper hoof trimming of foals including the first trim and correcting minor deviations. Includes photos and illustrations.

Meeting The Energy Needs Of The Horse, Patricia Evans, Yvette Connely

All Current Publications

This publication describes energy and how it affects the horse from a nutritional aspect.

2008 Usd Fact Book, University Of San Diego

USD Fact Books (1985- )

No abstract provided.

Alcalá 2007-2008, University Of San Diego

University of San Diego Yearbooks (1968-2010)

No abstract provided.

Ecosystem-Based Management In The Colorado River Delta, Karen Hae-Myung Hyun

Open Access Dissertations

The Colorado River Delta (CRD) is only 8% of its original size and is mainly sustained on agricultural run-off from the Mexicali Valley. Clearly current management of this ecosystem has not been effective and a new paradigm is needed. Ecosystem-based management (EBM), the process of controlling human activities to protect, conserve, and enhance the quality of ecosystems to meet current and future needs, provides a way forward. This study uses nine common EBM principles to analyze legislation, research, management plans, and community actions of six major CRD institutions, establishing a governance baseline. This study also utilizes scenario analysis to depict …

Evaluation Of A Novel Autonomous Detector For Microbial Water Quality Monitoring, Heather L. Saffert

Open Access Dissertations

Rapid testing methods are needed for monitoring waters for fecal contamination to identify associated health hazards. Today, standard methods quantify the amount of indicator bacteria, E. coli and enterococci, using culture-based techniques that require incubation periods from 18 to 48 hours. For recreational waters, this time lag delays the closure of waters when a potential health hazard exists and prolongs closures after contamination has dissipated. A remotely deployable, autonomous sampler capable of rapid automated data analysis and reporting of fecal contamination would provide a more effective warning system for both managers and the public. An in situ instrument may also …

Tandem Conjugate Addition -- Cyclization Reactions Of L-Methyl Prolinate With α,β-Unsaturated Ketones Catalyzed By L-Proline, Sergio Sandoval

Open Access Dissertations

L-methyl prolinate and various α,β-unsaturated ketones were reacted by a tandem sequence of conjugate addition and subsequent autocatalytic intramolecular cyclization to yield 1,3-dicarbonyl-pyrrolizidine ring systems in modest yield. This methodology represents a tandem and green preparative reaction sequence where L-proline is self-generated as an organocatalyst subsequent to the first step and prior to the second step of the process. This sequence of reactions is a one-pot, tandem, and green preparative reaction for the synthesis of various pyrrolizidine derivatives which can be performed in a general and simple way under solventless and room temperature conditions. This methodology is modest yielding and …

Alzheimer's Disease (Ad) Like Pathology Following Developmental Lead Exposure In Primates And The Role Of Aging In Ad-Related Genes Regulation In Rodents And Primates, Jinfang Wu

Open Access Dissertations

Alzheimer's disease is a progressive, irreversible neurodegenerative disease results in memory loss and dementia. The search for the etiology of sporadic AD focuses on environmental links and the role of aging. In manuscript 1, we validated our previous rodent model in primates by the following findings. (1) Developmental Pb exposure caused elevated AD-related APP, BACE1 and Sp1 mRNA expression as well as APP protein and amyloidogenic Aβ40 and Aβ42. (2) The molecular changes were accompanied by AD-like pathological changes in exposed monkey brains. (3) Pb exposure increased 8-oxo-2'-deoxyguanine in the monkey brain. (4) DNA methyltransferase activity was suppressed in exposed …

Study On The Nonenzymatic Glycation Of Nucleosides/Nucleotides And Proteins With Sugars: An In Vitro Investigation Of Advanced Glycation Endproducts (Ages) Formation, Yuyuan Li

Open Access Dissertations

Advanced glycation endproducts (AGEs) are a complex and heterogeneous group 1 of compounds formed by the nonenzymatic reactions of the carbonyl groups of reducing sugars with the free amino groups of biomolecules. Nonenzymatic reactions can occur in vitro and in vivo and affect the structure, function and conformation of many biomolecules, and AGEs has been suggested to associate with the pathogenesis of various disease such as diabetes and Alzheimer disease. The increased number of reports on the nonenzymatic glycation of proteins and nucleic acids has generated great interest in the methods for characterization of AGEs. The lack of universally applicable …

Microstructure Studies In Synthetic And Bio-Colloids, Imaging And Applications, Ashish Kumar Jha

Open Access Dissertations

The mean size of CTAB/HDBS mixed surfactant vesicles confined into the three-dimensional voids generated by the random close packing (RCP) of polystyrene beads, shows a systematic decrease as the characteristic confinement length scale is reduced. The RCP of polystyrene beads of radius Rb = 1.5μm, 0.25μm and 0.1μm, creates voids of characteristic dimensions R ∼ 0.22 Rb = 3300Ã…, 550Ã… and 220Ã… respectively. These void length scales are comparable to or less than the radii of vesicles formed in the system under conditions of no confinement. A simple thermodynamic model was developed accounting for the balance between increased enthalpy when …

Fabrication, Characterization And Application Of The Novel Bionanomaterials, Lan Yao

Open Access Dissertations

This dissertation focuses on developing methods to synthesize novel bionanomaterials, studying their properties and exploring their potential applications. Fabricating semiconducting nanowires is a significant challenge in making nanoscale electronic devices. We propose to use self-assembling biomolecules as templates for the fabrication of nanowires. Here we demonstrate that quantum dots (QDs) could be conjugated to actin filaments, forming long semiconductor filaments. We constructed an optical system and developed the interactive software for fluorescence anisotropy imaging of single QDs and QD-nanowires. The fluorescence anisotropy studies revealed that QD transition dipoles are likely circular (elliptical) dipoles. The fluorescence anisotropy of a single QD …

A Concurrent Validation Of The Violence Sensitivity Scale, Jonathan Corey

Open Access Dissertations

A correlational concurrent validity study of the Violence Sensitivity Scale (VSS) was conducted in which respondents (N=169) also completed the Nonviolence Test (NVT), the Attitudes Toward Violence Scale (ATVS) and the Marlowe-Crowne Social Desirability Scale (MCSD). The VSS was significantly positively correlated with the NVT and MCSD, and significantly negatively correlated with a transformed ATVS distribution. Principal Factors Analysis limited to four, factors assigned 23 of 38 VSS behaviors to the same factors as in a previous study. Multiple regression tests found the NVT and MCSD to be significant predictors of VSS and VSS subscale scores. Demographic variables were examined …

Chemistry Of Antibiotics From Atlantic Actinomycete And Bacillus Bacteria, Aaron Martin Socha

Open Access Dissertations

The emergence of drug-resistant pathogens requires the use of innovative therapeutic agents. Hospital-acquired (nosocomial) infections represent major health and economic burdens for patients and health care professionals. In the United States over 1 million nosocomial infections are caused by drug-resistant bacteria anually, with associated expenditures ranging from $4 to $30 billion. Methicillin-resistant Staphylococcus aureus (MRSA) commonly shows reduced susceptibility to β-lactam, peptide, macrolide, aminoglycoside, tetracycline, and lincosamide classes of antibiotics. The emergence of vancomycin-resistant enterococci (VRE) is even more alarming since glycopeptide antibiotics were once considered the drugs of last resort. Moreover, community-acquired MRSA infections are spreading out of the …

Applications Of Linear And Cyclic Peptides As Enzyme Inhibitors And Molecular Transporters, Guofeng Ye

Open Access Dissertations

The diversity of amino acids in peptides allows the design of different linear or cyclized compounds. Peptides can be designed to act as inhibitors, probes, or molecular transporters of other molecules. The objective of this dissertation research was to exploit the diversity of peptide structures and focused on developing linear and cyclic peptides as c-Src inhibitors and using the information derived from c-Src crystal structure to design novel peptide-based molecular transporters. A series of peptide analogues of Ac-CIYKYY were designed and synthesized to improve the inhibitory potency against active Src Linear peptide Ac-CIYKF(4-NO 2)Y (IC50 = 0.53 μM) and a …