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2007

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A Protein Interaction Map Of The Mitotic Spindle, Jonathan Wong, Yuko Nakajima, Stefan Westermann, Ching Shang, Jung-Seog Kang, Crystal Goodner, Pantea Houshmand, Stanley Fields, Clarence S.M. Chan, David Drubin, Georjana Barnes, Tony R. Hazbun Jul 2007

A Protein Interaction Map Of The Mitotic Spindle, Jonathan Wong, Yuko Nakajima, Stefan Westermann, Ching Shang, Jung-Seog Kang, Crystal Goodner, Pantea Houshmand, Stanley Fields, Clarence S.M. Chan, David Drubin, Georjana Barnes, Tony R. Hazbun

Borch Department of Medicinal Chemistry and Molecular Pharmacology Faculty Publications

The mitotic spindle consists of a complex network of proteins that segregates chromosomes in eukaryotes. To strengthen our understanding of the molecular composition, organization, and regulation of the mitotic spindle, we performed a system-wide two-hybrid screen on 94 proteins implicated in spindle function in Saccharomyces cerevisiae. We report 604 predominantly novel interactions that were detected in multiple screens, involving 303 distinct prey proteins. We uncovered a pattern of extensive interactions between spindle proteins reflecting the intricate organization of the spindle. Furthermore, we observed novel connections between kinetochore complexes and chromatin-modifying proteins and used phosphorylation site mutants of NDC80/TID3 to gain …

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Development Of Chemomechanical Functionalization And Nanografting On Silicon Surfaces, Michael Vernon Lee Jul 2007

Development Of Chemomechanical Functionalization And Nanografting On Silicon Surfaces, Michael Vernon Lee

Theses and Dissertations

Progress in chemomechanical functionalization was made by investigating the binding of molecules and surface coverage on the silicon surface, demonstrating functionalization of silicon with gases by chemomechanical means, analyzing atomic force microscopy probe tip wear in atomic force microscopy (AFM) chemomechanical nanografting, combining chemomechanical functionalization and nanografting to pattern silicon with an atomic force microscope, and extending chemomechanical nanografting to silicon dioxide. Molecular mechanics of alkenes and alkynes bound to Si(001)-2x1 as a model of chemomechanically functionalized surfaces indicated that complete coverage is energetically favorable and becomes more favorable for longer chain species. Scribing a silicon surface in the presence …

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An Evaluation Of Movement Patterns And Effects Of Habitat Patch Size On The Demography Of The Florida Mouse (Podomys Floridanus), Irmgard Lukanik Jul 2007

An Evaluation Of Movement Patterns And Effects Of Habitat Patch Size On The Demography Of The Florida Mouse (Podomys Floridanus), Irmgard Lukanik

USF Tampa Graduate Theses and Dissertations

Habitat degradation by humans has been the main reason for the decline in numbers of P. floridanus, the only mammal indigenous to the state of Florida, in the past century. The mouse inhabits what remains of scrub and sandhill associations, which are characterized by patches of sandy soils within a more mesic landscape. It has long been accepted that small populations are more prone to decline and extinction than are larger ones as a result of environmental fluctuations. I hypothesized that the demography of a population of P. floridanus would be affected by a restriction in numbers through habitat …

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Research Evaluation As A Policy Design Tool: Mapping Approaches Across A Set Of Case Studies , Valeria Papponetti, Massimiano Bucchi Jul 2007

Research Evaluation As A Policy Design Tool: Mapping Approaches Across A Set Of Case Studies , Valeria Papponetti, Massimiano Bucchi

Fondazione Eni Enrico Mattei Working Papers

This paper provides an overview of research evaluation practices across countries. The main aim is to investigate whether research assessment is implemented and to see to what extent its results are used to revise policy strategies, identify new research priorities, allocate financial resources or enhance public understanding of R&D. The paper addresses a set of cases studies, four within Europe (UK, Finland, Italy, and Spain) and two outside (US and Japan). Each case study provides an outline of the strategies devised to improve the domestic science system; offers a map of the main actors of science policy and introduces the …

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Dissecting Biological “Dark Matter” With Single-Cell Genetic Analysis Of Rare And Uncultivated Tm7 Microbes From The Human Mouth, Yann Marcy, Cleber C. Ouverney, Elisabeth M. Bik, Tina Lösekann, Natalia Ivanova, Hector Garcia Martin, Ernest Szeto, Darren Platt, Philip Hugenholtz, David A. Relman, Stephen R. Quake Jul 2007

Dissecting Biological “Dark Matter” With Single-Cell Genetic Analysis Of Rare And Uncultivated Tm7 Microbes From The Human Mouth, Yann Marcy, Cleber C. Ouverney, Elisabeth M. Bik, Tina Lösekann, Natalia Ivanova, Hector Garcia Martin, Ernest Szeto, Darren Platt, Philip Hugenholtz, David A. Relman, Stephen R. Quake

Faculty Publications, Biological Sciences

We have developed a microfluidic device that allows the isolation and genome amplification of individual microbial cells, thereby enabling organism-level genomic analysis of complex microbial ecosystems without the need for culture. This device was used to perform a directed survey of the human subgingival crevice and to isolate bacteria having rod-like morphology. Several isolated microbes had a 16S rRNA sequence that placed them in candidate phylum TM7, which has no cultivated or sequenced members. Genome amplification from individual TM7 cells allowed us to sequence and assemble >1,000 genes, providing insight into the physiology of members of this phylum. This approach …

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The Murray Ledger And Times, July 17, 2007, The Murray Ledger And Times Jul 2007

The Murray Ledger And Times, July 17, 2007, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

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Topoisomerase Ii-Drug Interaction Domains: Identification Of Substituents On Etoposide That Interact With The Enzyme, Amy M. Wilstermann, Ryan P. Bender, Murrell Godfrey, Sungjo Choi, Clemens Anklin, David B. Berkowitz, Neil Osheroff, David E. Graves Jul 2007

Topoisomerase Ii-Drug Interaction Domains: Identification Of Substituents On Etoposide That Interact With The Enzyme, Amy M. Wilstermann, Ryan P. Bender, Murrell Godfrey, Sungjo Choi, Clemens Anklin, David B. Berkowitz, Neil Osheroff, David E. Graves

David Berkowitz Publications

Etoposide is one of the most successful chemotherapeutic agents used for the treatment of human cancers. The drug kills cells by inhibiting the ability of topoisomerase II to ligate nucleic acids that it cleaves during the double-stranded DNA passage reaction. Etoposide is composed of a polycyclic ring system (rings A–D), a glycosidic moiety at the C4 position, and a pendant ring (E–ring) at the C1 position. Although drug-enzyme contacts, as opposed to drug-DNA interactions, mediate the entry of etoposide into the topoisomerase II-drug-DNA complex, the substituents on etoposide that interact with the enzyme have not been identified. Therefore, saturation transfer …

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Moral Intuitions And Organizational Culture, Milton C. Regan Jr. Jul 2007

Moral Intuitions And Organizational Culture, Milton C. Regan Jr.

Saint Louis University Law Journal

No abstract provided.

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Palmitoylation And Oxidation Of The Cysteine Rich Region Of Snap-25 And Their Effects On Protein Interactions, Derek Luberli Martinez Jul 2007

Palmitoylation And Oxidation Of The Cysteine Rich Region Of Snap-25 And Their Effects On Protein Interactions, Derek Luberli Martinez

Theses and Dissertations

Neurons depend upon neurotransmitter release through regulated exocytosis to accomplish the immense processing performed within the central nervous system. The SNARE hypothesis points to a family of proteins that are thought to enable the membrane fusion that leads to exocytosis. The secondary structure of SNAP-25 is unique among SNARE proteins in that it has two alpha helical SNARE motifs and a cysteine rich (C85, C88, C90, C92) membrane interacting region but notransmembrane domain. The cysteines may be modified by palmitoylation or oxidation but the role of these modifications in vivo is not well understood. Our goal is to elucidate possible …

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Cloning And Characterization Of The Salt Overly Sensitive 1 (Sos1) Gene In Chenopodium Quinoa Willd., Taylor Brian Turner Jul 2007

Cloning And Characterization Of The Salt Overly Sensitive 1 (Sos1) Gene In Chenopodium Quinoa Willd., Taylor Brian Turner

Theses and Dissertations

Salt tolerance is a commercially important trait that affects plant species around the globe. Cellular response to saline environments is a well studied but complex system that is far from being completely understood. The SALT OVERLY SENSITIVE 1 (SOS1) gene is a critical component of salt tolerance in many species, encoding a plasma membrane Na+/H+ antiporter that plays an important role in germination and growth in saline environments. Here we report a preliminary investigation of salt tolerance in quinoa (Chenopodium quinoa Willd.). Quinoa is a halophytic grain crop of the Chenopodiaceae family with impressive nutritional content and an increasing world-wide …

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Geomorphology Of Submarine Spring West Of Fort Myers, Florida, Shihadah M. Saleem Jul 2007

Geomorphology Of Submarine Spring West Of Fort Myers, Florida, Shihadah M. Saleem

USF Tampa Graduate Theses and Dissertations

In March of 2000, March of 2001, and April of 2002, multibeam bathymetry and backscatter data were collected, which revealed several low-temperature hydrothermal submarine springs in the Mudhole Submarine Springs (MHSS) area that were investigated by SCUBA divers. High-resolution multibeam sonar provides a precise way of defining the geomorphology of the seafloor. The bathymetry data were used to understand (1) vent geomorphology and how it varied from vent to vent; (2) spatial patterns of active vents compared to extinct vents and known land springs identified by Kohout (1977) and Breland (1980); and (3) potential correlations between geochemical and geomorphological characteristics …

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Synthesis Of Resveratrol And Its Analogs, Phase-Transfer Catalyzed Asymmetric Glycolate Aldol Reaction, And Total Synthesis Of 8,9-Methylamido-Geldanamycin, Jing Liu Jul 2007

Synthesis Of Resveratrol And Its Analogs, Phase-Transfer Catalyzed Asymmetric Glycolate Aldol Reaction, And Total Synthesis Of 8,9-Methylamido-Geldanamycin, Jing Liu

Theses and Dissertations

The phytoalexin resveratrol and its acetyl analogs have been made using a decarbonylative Heck reaction. The acid chloride derived from 3,5-dihydroxybenzoic acid was coupled with suitable protected 4-hydroxystyrene in the presence of palladium acetate and N,N-bis-(2,6-diisopropylphenyl)-4,5-dihydro imidazolium chloride to give the substituted stilbene in good yield as the key step. Human HL-60 cell assays showed the 4'-acetyl resveratrol variant improved activity (ED50 17 μM) relative to resveratrol (24 μM). Cinchona phase-transfer catalysts (PTC) were developed for glycolate aldol reactions to give differentially protected 1,2-diol products. Silyl enol ether of diphenylmethoxy-2,5-dimethoxyacetophenone reacted to generate benzhydryl-protected products. O-Allyl trifluorobenzyl cinchonium hydrodifluoride (20 …

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Cooperative Project To Control Invasive Plants In The New Hampshire Seacoast Region, Rockingham County Conservation District Jul 2007

Cooperative Project To Control Invasive Plants In The New Hampshire Seacoast Region, Rockingham County Conservation District

PREP Reports & Publications

The purpose of the Cooperative Project to Control Invasive Plants in the New Hampshire Seacoast Region is to coordinate with a variety of natural resource agencies and organizations and initiate an innovative collaborative effort to combat invasive species in the seacoast. Those partners include the University of New Hampshire, New Hampshire Estuaries Project, the New Hampshire Coastal Program, the U.S. Fish and Wildlife Service, the Rockingham County Conservation District, New Hampshire Audubon, the Town of Rye, the Natural Resources Conservation Service, and the Corporate Wetlands Restoration Partnership. These groups all have a common interest in protecting existing habitat and restoring …

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The Distribution Of Sexually-Transmitted Human Papillomaviruses In Hiv Positive And Negative Patients In Zambia, Africa, Christopher Ngandwe, John Lowe, Paula J. Richards, Lara Hause, Charles Wood, Peter C. Angeletti Jul 2007

The Distribution Of Sexually-Transmitted Human Papillomaviruses In Hiv Positive And Negative Patients In Zambia, Africa, Christopher Ngandwe, John Lowe, Paula J. Richards, Lara Hause, Charles Wood, Peter C. Angeletti

Nebraska Center for Virology: Faculty Publications

Background: Human Papillomaviruses (HPV) are double-stranded DNA viruses, considered to be the primary etiological agents in cervical intraepithelial neoplasias and cancers. Approximately 15–20 of the 40 mucosal HPVs confer a high-risk of progression of lesions to invasive cancer. In this study, we investigated the prevalence of sexually transmitted HPVs in Human Immunodeficiency Virus (HIV) positive and negative patients in Zambia, Africa. The rate of high-risk HPV genotypes worldwide varies within each country. Thus, we sought to investigate the rates of HPV infection in sub-Saharan Africa and the potential role of HIV in affecting the HPV genotype distribution.

Methods: This retrospective …

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Grand Valley Forum, Volume 032, Number 02, July 16, 2007, Grand Valley State University Jul 2007

Grand Valley Forum, Volume 032, Number 02, July 16, 2007, Grand Valley State University

2007-2008, Volume 32

Grand Valley Forum is Grand Valley State's faculty and staff newsletter, published from 1976 to the present.

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Statistical Considerations In Designing For Biomarker Detection, Trenton C. Pulsipher Jul 2007

Statistical Considerations In Designing For Biomarker Detection, Trenton C. Pulsipher

Theses and Dissertations

The purpose of this project is to develop a statistical method for use in rapid detection of biological agents using portable gas chromatography mass spectrometry (GC/MS) devices. Of particular interest is 2,6-pyridinedicarboxylic acid (dipicolinic acid, or DPA), a molecule that is present at high concentrations in spores of Clostridium and Bacillus, the latter of which includes the threat organism Bacillus anthracis, or anthrax. Dipicolinic acid may be useful as a first-step discriminator of the biological warfare agent B. anthracis. The results of experiments with B. anthracis Sterne strain and Bacillus thuringiensis spores lead to a conceptual model for the chemical …

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Learning Russian Case Endings Through Model Sentences, Sara Lyn Jensen Jul 2007

Learning Russian Case Endings Through Model Sentences, Sara Lyn Jensen

Theses and Dissertations

The current study examines aspects of the Russian language that are particularly challenging for English-speaking students. It focuses on the complexity of Russian's grammatical morphology, specifically Russian case endings. In this study, methods and theories from the field of Second Language Acquisition (SLA) are reviewed to support a study aide designed by the author to help students with the acquisition of Russian case endings. The proposed study aide consists of 24 sentences composed of high-frequency Russian words. The 24 sentences contain all regular (approximately 75) Russian case endings. The purpose of the model sentences is to teach case forms using …

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The Origins, Evolution, And Phylogeny Of The Praying Mantises (Dictyoptera: Mantodea), Gavin John Svenson Jul 2007

The Origins, Evolution, And Phylogeny Of The Praying Mantises (Dictyoptera: Mantodea), Gavin John Svenson

Theses and Dissertations

The relatively small insect order Mantodea (praying mantises) is comprised of approximately 2,366 described species distributed in 436 genera. Members of the group occupy diverse habitats and are distributed across the globe, though their greatest numbers and diversity are concentrated primarily in the tropics. Though continental endemism is common, many groups have a broad global distribution. An immense diversity of morphology is exhibited across the order with adult mantises ranging in size from 2cm to ~25cm, and appearing like a dead leaf, a piece of quartz rock, or a blade of grass. The diversification and specialization of mantises in ecologically …

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Protein Coevolution And Coadaptation In The Vertebrate Bc1 Complex, Kimberly Kay Baer Jul 2007

Protein Coevolution And Coadaptation In The Vertebrate Bc1 Complex, Kimberly Kay Baer

Theses and Dissertations

The cytochrome bc1 complex of the mitochondrial electron transport chain accomplishes the enzymatic reaction known as the modified Q-cycle. In the Q-cycle the bc1 complex transports protons from the matrix to the intermembrane space of the mitochondria, creating the proton gradient used to make ATP. The energy to move these protons is obtained by shuttling electrons from the coenzyme ubiquinol (QH2) to coenzyme ubiquinone (Q) and the mobile cytochrome c. This well studied complex is ideal for examining molecular adaptation because it consists of ten different subunits, it functions as a dimer, and it includes at least five different active …

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Sampling A Littoral Fish Assemblage: Comparison Of Small-Mesh Fyke Netting And Boat Electrofishing, Carl R. Ruetz Iii, Donald G. Uzarski, Damon M. Krueger, Edward S. Rutherford Jul 2007

Sampling A Littoral Fish Assemblage: Comparison Of Small-Mesh Fyke Netting And Boat Electrofishing, Carl R. Ruetz Iii, Donald G. Uzarski, Damon M. Krueger, Edward S. Rutherford

Peer-reviewed scientific publications

We compared small-mesh (4-mm) fyke netting and boat electrofishing for sampling a littoral fish assemblage in Muskegon Lake, Michigan. We hypothesized that fyke netting selects for small-bodied fishes and electrofishing selects for large-bodied fishes. Three sites were sampled during May (2004 and 2005), July (2005 only), and September (2004 and 2005). We found that the species composition of captured fish differed considerably between fyke netting and electrofishing based on nonmetric multidimensional scaling (NMDS). Species strongly associated with fyke netting (based on NMDS and relative abundance) included the brook silverside Labidesthes sicculus, banded killifish Fundulus diaphanus, round goby Neogobius melanostomus, mimic …

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Udall Legacy Bus Tour Heads To Missoula, Flathead, University Of Montana--Missoula. Office Of University Relations Jul 2007

Udall Legacy Bus Tour Heads To Missoula, Flathead, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

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American Academy Of Allergy, Asthma & Immunology Work Group Report: Allergy Diagnosis In Clinical Practice, Dana V. Wallace, Sami L. Bahna, Stan Goldstein, Robert G. Hamilton, John R. Cohn Jul 2007

American Academy Of Allergy, Asthma & Immunology Work Group Report: Allergy Diagnosis In Clinical Practice, Dana V. Wallace, Sami L. Bahna, Stan Goldstein, Robert G. Hamilton, John R. Cohn

Department of Medicine Faculty Papers

No abstract provided.

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Animal Health Matters, David H. Zeman Jul 2007

Animal Health Matters, David H. Zeman

Animal Health MATTERS Newsletter

[Page] 1- Head/Director's Message Diagnostic News [Page] 1- Classical Swine Fever Surveillance (Hog Cholera) at the SDSU ADRDL [Page] 2- Biopsy Service Changes at the ADRDL – Effective July 1, 2007 [Page] 2- Listing of Pharmacies Offering Compounding Services for Veterinarians – April 2007 [Page] 2- Holiday Hours Research News [Page] 3- CIDRV Research Looks at New HIV Drug [Page] 4- Research Spotlight: Dr. Ying Fang Extension News [Page] 5- National Animal Health Monitoring System (NAHMS) to Study Beef Industry in 2007-08 [Page] 6- Pieces and Parts Student News [Page] 7- SDSU Pre-Veterinary Students Accepted to Veterinary School [Page] 7- …

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The Veterinary Profession’S Duty Of Care In Response To Disasters And Food Animal Emergencies, Kenneth E. Nusbaum, Bernard E. Rollin, James S. Wohl Jul 2007

The Veterinary Profession’S Duty Of Care In Response To Disasters And Food Animal Emergencies, Kenneth E. Nusbaum, Bernard E. Rollin, James S. Wohl

Professional Veterinary Ethics Collection

No abstract provided.

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Digitalcommons@University Of Rhode Island Statistics 2006-2007 Jul 2007

Digitalcommons@University Of Rhode Island Statistics 2006-2007

Technical Services Reports and Statistics

Statistics on the total number of full text downloads from the DigitalCommons@University of Rhode Island institutional repository for 2006-2007. Data are provided monthly on the number of full text downloads by collection and document, and on the number of referrals by domain and country. Dissertations are included in the statistics. Digital Commons statistics are COUNTER-compliant, with downloads from robots and automated processes filtered out.

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Completions 2006-07, Southwestern Oklahoma State University Jul 2007

Completions 2006-07, Southwestern Oklahoma State University

IPEDS

IPEDS report on Completions 2006-07

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Enrollment 2006-07, Southwestern Oklahoma State University Jul 2007

Enrollment 2006-07, Southwestern Oklahoma State University

IPEDS

IPEDS report on Enrollment 2006-07

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An Ancestral Variant Of Secretogranin Ii Confers Regulation By Phox2 Transcription Factors And Association With Hypertension, Gen Wen, Jennifer Wessel, Weidong Zhou, Georg B. Ehret, Fangwen Rao, Mats Stridsberg, Sushil K. Mahata, Peter M. Gent, Madhusudan Das, Richard S. Cooper, Aravinda Chakravarti, Huilin Zhou, Nicholas J. Schork, Daniel T. O'Connor, Bruce A. Hamilton Jul 2007

An Ancestral Variant Of Secretogranin Ii Confers Regulation By Phox2 Transcription Factors And Association With Hypertension, Gen Wen, Jennifer Wessel, Weidong Zhou, Georg B. Ehret, Fangwen Rao, Mats Stridsberg, Sushil K. Mahata, Peter M. Gent, Madhusudan Das, Richard S. Cooper, Aravinda Chakravarti, Huilin Zhou, Nicholas J. Schork, Daniel T. O'Connor, Bruce A. Hamilton

Faculty Publications

Granins regulate secretory vesicle formation in neuroendocrine cells and granin-derived peptides are co-released with neurotransmitters as modulatory signals at sympathetic sites. We report evidence for association between a regulatory polymorphism in Secretogranin II (SCG2) and hypertension in African-American subjects. The minor allele is ancestral in the human lineage and is associated with disease risk in two case-control studies and with elevated blood pressure in a separate familial study. Mechanistically, the ancestral allele acts as a transcriptional enhancer in cells that express endogenous Scg2, whereas the derived allele does not. ARIX (PHOX2A) and PHOX2B are identified as potential transactivating factors by …

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Development Of A Simplified And Standardized Protocol With Potential For High-Throughput For Sperm Cryopreservation In Zebrafish Danio Rerio, Huiping Yang, Carrie Carmichael, Zoltan M. Varga, Terrence R. Tiersch Jul 2007

Development Of A Simplified And Standardized Protocol With Potential For High-Throughput For Sperm Cryopreservation In Zebrafish Danio Rerio, Huiping Yang, Carrie Carmichael, Zoltan M. Varga, Terrence R. Tiersch

Faculty Publications

Sperm cryopreservation offers potential for long-term storage of genetic resources. However, the current protocols for zebrafish Danio rerio are cumbersome and poorly reproducible. Our objective was to facilitate adoption of cryopreservation by streamlining methods from sperm collection through thawing and use. First, sperm activation was evaluated, and motility was completely inhibited when osmolality of the extender was ≥295-300 mOsmol/kg. To evaluate cryoprotectant toxicity, sperm were incubated with dimethyl sulfoxide (DMSO), N,N-dimethyl acetamide (DMA), methanol, or glycerol at 5, 10, and 15% concentrations. Based on motility, DMSO, DMA, and methanol (≤10%) were less toxic; therefore, sperm were cryopreserved using these cryoprotectants …

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Serials Solutions Subject Search Report 2006-2007 Jul 2007

Serials Solutions Subject Search Report 2006-2007

Technical Services Reports and Statistics

Statistics on the total number of Serials Solutions subject searches at the University of Rhode Island Libraries by month for 2006-2007. Shows how many times the A-Z full text electronic journal list (at http://zu4tq4pb5v.search.serialssolutions.com/) was browsed by specific subjects.

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