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Articles 12211 - 12240 of 14125
Full-Text Articles in Entire DC Network
The Disciples Of Light: A Way Of Seeing And The Educational Transfer Of Ideas Linking Spirituality And Art Among Southern Painters In The Hensche-Hawthorne Tradition, Barbara Naron Faulkner
The Disciples Of Light: A Way Of Seeing And The Educational Transfer Of Ideas Linking Spirituality And Art Among Southern Painters In The Hensche-Hawthorne Tradition, Barbara Naron Faulkner
LSU Doctoral Dissertations
This study examines the role of artistic education in shaping artistic beliefs and personal philosophy. Its central focus is the origins of a common belief among artists that artmaking or aesthetic response to art can be a form of spiritual activity or experience leading to spiritual insight. The primary data for this study is a series of in-depth oral history interviews with seven painters who studied with Henry Hensche at The Cape School of Art in Provincetown, MA, a school of American plein air painting that is linked with Impressionism. Charles W. Hawthorne, a painter who was a protégé of …
P-Glycoprotein And Membrane Permeability As Determinants Of Xenobiotic Bioavailability And Bioaccumulation, Xiaobing Tan
P-Glycoprotein And Membrane Permeability As Determinants Of Xenobiotic Bioavailability And Bioaccumulation, Xiaobing Tan
LSU Doctoral Dissertations
The ABC transporter P-glycoprotein (Pgp) and membrane permeability are determinant factors for absorption and disposition of xenobiotics. These studies investigated the effects of potential modulators of Pgp and/or membrane function on the disposition, bioavailability and bioaccumulation of environmentally relevant pharmaceuticals, tetracycline and ivermectin, and the carcinogen benzo[a]pyrene in catfish. The pesticide dieldrin and surfactant linear alkylbenzene sulfonate (LAS) were selected as mixture components thought to have potential interactions with these determinants of disposition. Initial in situ experiments demonstrated dieldrin and tetracycline both significantly inhibited biliary excretion of Pgp prototypic substrate Rhodamine-123 in isolated perfused livers. Further, dieldrin (20µM) reduced movement …
An Applied Evaluation Of Resurgence: Functional Communication Training (Fct) And Treatment Relapse, Valerie Marie Volkert
An Applied Evaluation Of Resurgence: Functional Communication Training (Fct) And Treatment Relapse, Valerie Marie Volkert
LSU Doctoral Dissertations
Extinction is a very important component of functional communication training (FCT). Thus, the potential undesirable effects of extinction must be considered before this type of treatment is implemented. Resurgence, the recurrence of previously reinforced behavior when another behavior is placed on extinction, is a possible undesirable effect of extinction. Resurgence may account for some instances of treatment relapse in situations where problem behavior recovers following implementation of extinction-based treatments such as FCT. Despite the potential relevance of resurgence to understanding why problem behavior may re-emerge, few applied studies have examined resurgence effects. The current study attempted to determine whether resurgence …
Developing/Testing A New Approach For Assessing Rapid Visual Identification Of Hematological Cells Using Principles Of Visual Cognition: A Health Science Education Study, Deborah Elizabeth Fox
Developing/Testing A New Approach For Assessing Rapid Visual Identification Of Hematological Cells Using Principles Of Visual Cognition: A Health Science Education Study, Deborah Elizabeth Fox
LSU Doctoral Dissertations
The purpose of this study was the development and testing of a novel method for assessment of white blood cell (WBC) identification skills used in the field of Clinical Laboratory Sciences (CLS). A dual format exam was administered to both novices (students) and experts (laboratory professionals). Format 1 was similar to current assessment formats, simply presenting a series of single WBC images for identification. Format 2 applied principles of visual cognition, grouping WBCs for identification by patient and presenting multiple example images from the patient before requesting identification of individual cells. This novel exam format was intended to: (a) provide …
An Examination Of The Presence Of Social Work Intervention With Home Health Care Recipients Of Related Home Health Care Outcomes, Corie Gail Hebert
An Examination Of The Presence Of Social Work Intervention With Home Health Care Recipients Of Related Home Health Care Outcomes, Corie Gail Hebert
LSU Doctoral Dissertations
The study was prompted by the need for a social work response to the dramatic changes that have occurred in the home health care arena as a result of managed care policies. Social work has been part of home health care since its inception, but the current cost constrained market threatens the viability of social work in providing servies to elderly, ill, homebound individuals. Medicare home health care benefits have traditionally enabled many elderly individuals to live independently in thier communities. However, passage of the Balanced Budget Act of 1997, which mandated the use of a Prospective Payment System for …
Culture-Independent Identification Of Gut Bacteria In Fourth-Instar Red Imported Fire Ant, Solenopsis Invicta Buren, Larvae, Albert Hon-Yu Lee
Culture-Independent Identification Of Gut Bacteria In Fourth-Instar Red Imported Fire Ant, Solenopsis Invicta Buren, Larvae, Albert Hon-Yu Lee
LSU Doctoral Dissertations
Red imported fire ants (RIFA), Solenopsis invicta Buren, are medical, urban, and agricultural pests from South America. Fourth-instar larvae are used by the colony to digest solid food and then regurgitate it for consumption by workers and queens. Larvae are an ideal source of investigations of obligate endosymbiotic bacteria possibly involved in nutrient distributions. I attempted to first identify what bacteria species are in the guts of larvae followed by antibiotic and microscopy work to further study their roles in the ants. The composition of the bacterial community in fire ant larvae was described with culture-independent methods utilizing 16S rDNA …
Receptor-Mediated Calcium Entry In Retinal Amacrine Cells, Scott Michael Crousillac
Receptor-Mediated Calcium Entry In Retinal Amacrine Cells, Scott Michael Crousillac
LSU Doctoral Dissertations
In the vertebrate retina, multiple cell types express g protein-coupled receptors linked to phospholipase C. The signaling pathway engendered by activation of this enzyme can involve Ca2+-permeable transient receptor potential (TRP) channels. To begin to understand the role of these channels in the retina, we undertake an immunocytochemical localization of two TRPC channel subunits, TRPC1 and TRPC4. TRPC1 expression was observed in amacrine cells and their process in the chicken retina. TRPC4 expression was much more widespread with some degree of labeling found in all layers of the retina, and was shown to be expressed in Müller glial …
Population Ecology Of Pseudacteon Tricuspis Borgmeier (Diptera: Phoridae), An Introduced Parasitoid Of The Red Imported Fire Ant Solenopsis Invicta Buren (Hymenoptera: Formicidae) In Louisiana, Donald Charles Henne
Population Ecology Of Pseudacteon Tricuspis Borgmeier (Diptera: Phoridae), An Introduced Parasitoid Of The Red Imported Fire Ant Solenopsis Invicta Buren (Hymenoptera: Formicidae) In Louisiana, Donald Charles Henne
LSU Doctoral Dissertations
Aspects of the population ecology of a parasitoid (Pseudacteon tricuspis) of the red imported fire ant (Solenopsis invicta) in Louisiana were studied. The spatio-temporal abundance patterns, dispersal, population spread, aggregation, direct mutual interference and functional response characteristics of this parasitoid were studied to address deficiencies in our knowledge about phorid flies, particularly Pseudacteon parasitoids. This endoparasitoid was discovered to manipulate host ant behavior in ways that benefit its own survival. Laboratory experiments to gain insights into behavioral and functional responses revealed that fly aggregations were density-dependent and interference was not significant when 1-3 females were simultaneously confined with hosts, although …
Comparing Kin And Non-Kin Foster Parents' Emotional Investment In Their Young Children, Rhonda Norwood
Comparing Kin And Non-Kin Foster Parents' Emotional Investment In Their Young Children, Rhonda Norwood
LSU Doctoral Dissertations
In 2003, there were reports of child maltreatment affecting over 5.5 million children in the United States. As a result of this epidemic, over 500,000 children are in foster care with an estimated additional 300,000 in voluntary kin placements. Because of a shortage of foster families and resources, Child Protective Services (CPS) agencies routinely seek and give priority to family members to serve as foster families to maltreated children. There is a large body of research that demonstrates that children in kinship care are often at greater risk than those children placed in non-kin foster homes, particularly in terms of …
Lanthanide Complexes As Fluorescent Indicators For Neutral Sugars And Cancer Biomarkers, Onur Alpturk
Lanthanide Complexes As Fluorescent Indicators For Neutral Sugars And Cancer Biomarkers, Onur Alpturk
LSU Doctoral Dissertations
Simple water soluble lanthanum and europium complexes are effective at detecting neutral sugars as well as glyco- and phospholipids. In solutions at physiologically relevant pH the fluorescent lanthanum complex binds neutral sugars with apparent binding constants comparable to those of arylboronic acids. Interference from commonly occurring anions is minimal. The europium complex detects sialic acid-containing gangliosides at pH 7.0 over an asialoganglioside. This selectivity is attributed, in large part, to the cooperative complexation of the oligosaccharide and sialic acid residues to the metal center, based on analogous prior studies. In MeOH, lysophosphatidic acid (LPA), a biomarker for several pathological conditions …
Xanthene/Benzoxanthene Dyes: Novel Synthetic Metholologies, Applications In Molecular Recognition, Cellular Imaging And The Design Of A Tunable White (Rgb) Light Emitter, Youjun Yang
LSU Doctoral Dissertations
My graduate work has focused on the development of new fluorophore materials towards addressing several interdisciplinary research problems. Selective detection of sialic acid via a boron-amide interaction. Concentration changes of sialic acid can be monitored ratiometrically in the visible region using a boronic acid based chemosensor. The technique shows great promise for the detection of sialic acid, a critical cell surface residue involved in cancer, graft rejection and virulence in certain bacteria. There is no interference from commonly occurring oligosaccharides, aminosugars and most carboxylic acid-containing compounds. Improved synthetic methodology and studies of novel molecular probe architectures. I have developed a …
The Importance Of The Louisiana Cooperative Extension Service As Perceived By Local Governing Bodies In Louisiana, Peter Charles Cannizzaro
The Importance Of The Louisiana Cooperative Extension Service As Perceived By Local Governing Bodies In Louisiana, Peter Charles Cannizzaro
LSU Doctoral Dissertations
The primary purpose of this study was to determine the importance of the Louisiana Cooperative Extension Service (CES) as perceived by members of local governing bodies in Louisiana. The fundamental objective of the CES is the development of people by means of educational programs. Local governing body members (defined as Police Jury/Council Members) throughout the state of Louisiana were surveyed to determine their perceptions of the importance of the Cooperative Extension Service regarding awareness, attendance of programs/events, use of information and if the needs of local residents were being met by the LCES programs and services. Results of the study …
Particle And Dredge-Scale Kinetic Studies Of Hydrophobic Organic Chemical Desorption From Sediment, Justin Edward Birdwell
Particle And Dredge-Scale Kinetic Studies Of Hydrophobic Organic Chemical Desorption From Sediment, Justin Edward Birdwell
LSU Doctoral Dissertations
The discharge of hydrophobic organic chemicals (HOCs) and other hazardous substances from anthropogenic sources to surface waters and the atmosphere has led to the widespread contamination of bottom sediments throughout the world. HOCs collect in sediments due to their affinity for organic matter and other sorbents present on and within their solid matrices. There is interest in the movement of HOCs from historically contaminated, resuspended sediments to surface waters due to the connection between chemical desorption and bioavailability. Quantitatively accurate predictions of contaminant concentrations in environmental media are needed for reliable risk assessment and to develop strategies for protection of …
Wetting Kinetics Of A Thin Film Evaporating In Air, S. Saritha, Partho Neogi
Wetting Kinetics Of A Thin Film Evaporating In Air, S. Saritha, Partho Neogi
Chemical and Biochemical Engineering Faculty Research & Creative Works
The conservation equation and the equations of motion are solved for a case where a thin liquid film moves out of a slot onto a horizontal surface. The liquid is allowed to evaporate into air. The evaporation process is taken to be isothermal. Lubrication theory approximation is used where only the tangential velocity and its dependence only in the normal direction are considered. The dynamics of thin films includes the use of disjoining pressure for a pure liquid and where there is a dissolved polymer. The results show that evaporation is quicker than film thinning such that a spreading regime …
Cuban Femininity And National Unity In Louisa May Alcott's Moods And Elizabeth Stoddard's "Eros And Anteros", Nina Bannett
Cuban Femininity And National Unity In Louisa May Alcott's Moods And Elizabeth Stoddard's "Eros And Anteros", Nina Bannett
Publications and Research
This book chapter compares the depictions of Cuban women in Louisa May Alcott's first adult novel Moods (1864) and Elizabeth Stoddard's short story "Eros and Anteros" (1862). Both writers configure a love triangle between an Anglo man and two women, one Anglo and one Cuban. In both texts, the Cuban woman is rejected as an unsuitable choice for an Anglo man. Alcott’s and Stoddard’s decision to re-value the Anglo woman as the more appropriate choice can be read as a rejection of the popular nineteenth-century political doctrine of manifest destiny and, at least with Alcott, of the United States’s dependence …
Quantization In Astrophysics, Brownian Motion, And Supersymmetry, Florentin Smarandache, Victor Christianto
Quantization In Astrophysics, Brownian Motion, And Supersymmetry, Florentin Smarandache, Victor Christianto
Branch Mathematics and Statistics Faculty and Staff Publications
The present book discusses, among other things, various quantization phenomena found in Astrophysics and some related issues including Brownian Motion. With recent discoveries of exoplanets in our galaxy and beyond, this Astrophysics quantization issue has attracted numerous discussions in the past few years. Most chapters in this book come from published papers in various peer-reviewed journals, and they cover different methods to describe quantization, including Weyl geometry, Supersymmetry, generalized Schrödinger, and Cartan torsion method. In some chapters Navier-Stokes equations are also discussed, because it is likely that this theory will remain relevant in Astrophysics and Cosmology While much of the …
A Unifying Field In Logics: Neutrosophic Logic. Neutrosophy, Neutrosophic Set, Neutrosophic Probability And Statistics - 6th Ed., Florentin Smarandache
A Unifying Field In Logics: Neutrosophic Logic. Neutrosophy, Neutrosophic Set, Neutrosophic Probability And Statistics - 6th Ed., Florentin Smarandache
Branch Mathematics and Statistics Faculty and Staff Publications
It was a surprise for me when in 1995 I received a manuscript from the mathematician, experimental writer and innovative painter Florentin Smarandache, especially because the treated subject was of philosophy - revealing paradoxes - and logics. He had generalized the fuzzy logic, and introduced two new concepts: a) “neutrosophy” – study of neutralities as an extension of dialectics; b) and its derivative “neutrosophic”, such as “neutrosophic logic”, “neutrosophic set”, “neutrosophic probability”, and “neutrosophic statistics” and thus opening new ways of research in four fields: philosophy, logics, set theory, and probability/statistics. It was known to me his setting up in …
Hadron Models And Related New Energy Issues, Florentin Smarandache
Hadron Models And Related New Energy Issues, Florentin Smarandache
Branch Mathematics and Statistics Faculty and Staff Publications
The present book covers a wide-range of issues from alternative hadron models to their likely implications in New Energy research, including alternative interpretation of lowenergy reaction (coldfusion) phenomena. The authors explored some new approaches to describe novel phenomena in particle physics. M Pitkanen introduces his nuclear string hypothesis derived from his Topological Geometrodynamics theory, while E. Goldfain discusses a number of nonlinear dynamics methods, including bifurcation, pattern formation (complex GinzburgLandau equation) to describe elementary particle masses. Fu Yuhua discusses a plausible method for prediction of phenomena related to New Energy development. F. Smarandache discusses his unmatter hypothesis, and A. Yefremov …
Neutrosophy In Arabic Philosophy, Florentin Smarandache, Salah Osman
Neutrosophy In Arabic Philosophy, Florentin Smarandache, Salah Osman
Branch Mathematics and Statistics Faculty and Staff Publications
Is there an absolute reality? Yes, “God” is the only absolute reality. The three main religions: Judaism, Christianity and Islam have all claimed that God is a supreme reality, and that all other creatures are finite beings. Since they relatively continue and also relatively change, so they can not be absolute. The world is full of paradoxes, there is no absolute persistence, and also there is no change at a stretch. There is no absolute truth and there is no continuous falsehood. What exist are many faces or aspects between the two terms. Those faces are reduced to a neutral …
Developing A Rapid Method For Assessing The Physical Stability Of Streams In Minnesota's Agassiz Beach Ridges, Abigail V. Franklund
Developing A Rapid Method For Assessing The Physical Stability Of Streams In Minnesota's Agassiz Beach Ridges, Abigail V. Franklund
Theses and Dissertations
This thesis assessed the physical characteristics and stability of selected western Minnesota streams that cross the eastern beach ridges of glacial Lake Agassiz. Stream and river channels in this area host unusually diverse aquatic habitat and biodiversity, but incompatible land use along channels and in watersheds impair their quality and function. Previous rapid assessment protocols have been developed for stream attributes and stability, but these methods have been developed elsewhere in the United States and are not necessarily appropriate for western Minnesota’s unique geology and landscape.
A rapid reconnaissance method was developed to assess stream conditions using an integrated numerical …
Bioelectric Effects Of Intense Nanosecond Pulses, Karl H. Schoenbach, Barbara Y. Hargrave, Ravindra P. Joshi, Juergen F. Kolb, Richard Nuccitelli, Christopher J. Osgood, Andrei G. Pakhomov, Michael W. Stacey, James R. Swanson, Jody A. White, Shu Xiao, Jue Zhang, Stephen J. Beebe, Peter F. Blackmore, E. Stephen Buescher
Bioelectric Effects Of Intense Nanosecond Pulses, Karl H. Schoenbach, Barbara Y. Hargrave, Ravindra P. Joshi, Juergen F. Kolb, Richard Nuccitelli, Christopher J. Osgood, Andrei G. Pakhomov, Michael W. Stacey, James R. Swanson, Jody A. White, Shu Xiao, Jue Zhang, Stephen J. Beebe, Peter F. Blackmore, E. Stephen Buescher
Bioelectrics Publications
Electrical models for biological cells predict that reducing the duration of applied electrical pulses to values below the charging time of the outer cell membrane (which is on the order of 100 ns for mammalian cells) causes a strong increase in the probability of electric field interactions with intracellular structures due to displacement currents. For electric field amplitudes exceeding MV/m, such pulses are also expected to allow access to the cell interior through conduction currents flowing through the permeabilized plasma membrane. In both cases, limiting the duration of the electrical pulses to nanoseconds ensures only nonthermal interactions of the electric …
Mutations In Transmembrane Domains 1, 4 And 9 Of The Plasmodium Falciparum Chloroquine Resistance Transporter Alter Susceptibility To Chloroquine, Quinine And Quinidine, Roland A. Cooper, Kristan D. Lane, Bingbing Deng, Jianbing Mu, Jigar J. Patel, Thomas E. Wellems, Xinzhuan Su, Michael T. Ferdig
Mutations In Transmembrane Domains 1, 4 And 9 Of The Plasmodium Falciparum Chloroquine Resistance Transporter Alter Susceptibility To Chloroquine, Quinine And Quinidine, Roland A. Cooper, Kristan D. Lane, Bingbing Deng, Jianbing Mu, Jigar J. Patel, Thomas E. Wellems, Xinzhuan Su, Michael T. Ferdig
Biological Sciences Faculty Publications
Mutations in the Plasmodium falciparum chloroquine (CQ) resistance transporter (PfCRT) can result in verapamil-reversible CQ resistance and altered susceptibility to other antimalarials. PfCRT contains 10 membrane-spanning domains and is found in the digestive vacuole (DV) membrane of intraerythrocytic parasites. The mechanism by which PfCRT mediates CQ resistance is unclear although it is associated with decreased accumulation of drug within the DV. On the permissive background of the P. falciparum 106/1(K76) parasite line, we used single-step drug selection to generate isogenic clones containing unique pfcrt point mutations that resulted in amino acid changes in PfCRT transmembrane domains 1 (C72R, K76N, K76I …
Sequence And The Developmental And Tissue-Specific Regulation Of The First Complete Vitellogenin Message From Ticks, Deborah M. Thompson, Sayed M.S. Khalil, Laura A. Jeffers, Daniel E. Sonenshine, Robert D. Mitchell, Christopher J. Osgood, R. Michael Roe
Sequence And The Developmental And Tissue-Specific Regulation Of The First Complete Vitellogenin Message From Ticks, Deborah M. Thompson, Sayed M.S. Khalil, Laura A. Jeffers, Daniel E. Sonenshine, Robert D. Mitchell, Christopher J. Osgood, R. Michael Roe
Biological Sciences Faculty Publications
The first full-length mRNA for vitellogenin (Vg) from ticks was sequenced. This also represents the first complete sequence of Vg from the Chelicerata and of a heme binding Vg. The Vg cDNA from the American dog tick, Dermacentor variabilis was 5744nt in length (GenBank Accession number AY885250), which coded for a protein of 1843aa with a calculated molecular weight of 208kD. This protein had an 18 aa signal sequence, a single RXXR cleavage signal that would generate two subunits (49.5 and 157K in molecular weight) and lipoprotein N-terminal and carboxy von Willebrand factor type D domains. Tryptic digest MS analysis …
Review Of The Crevalle Jacks, Caranx Hippos Complex (Teleostei: Carangidae), With A Description Of A New Species From West Africa, William F. Smith-Vaniz, Kent E. Carpenter
Review Of The Crevalle Jacks, Caranx Hippos Complex (Teleostei: Carangidae), With A Description Of A New Species From West Africa, William F. Smith-Vaniz, Kent E. Carpenter
Biological Sciences Faculty Publications
The Caranx hippos species complex comprises three extant species: crevalle jack (Caranx hippos) (Linnaeus, 1766) from both the western and eastern Atlantic oceans; Pacific crevalle jack (Caranx caninus) Günther,1868 from the eastern Pacific Ocean; and longfin crevalle jack (Caranx fischeri) new species, from the eastern Atlantic, including the Mediterranean Sea and Ascension Island. Adults of all three species are superficially similar with a black blotch on the lower half of the pectoral fin, a black spot on the upper margin of opercle, one or two pairs of enlarged symphyseal canines on the lower jaw, …
Phytoplankton Productivity In The Tidal Regions Of Four Chesapeake Bay (Usa) Tributaries, Kneeland K. Nesius, Harold G. Marshall, Todd A. Egerton
Phytoplankton Productivity In The Tidal Regions Of Four Chesapeake Bay (Usa) Tributaries, Kneeland K. Nesius, Harold G. Marshall, Todd A. Egerton
Biological Sciences Faculty Publications
Monthly and annual phytoplankton productivity rates of four Virginia tidal rivers were determined based on a 12-year monitoring study that included sampling stations from tidal freshwater, oligohaline, and mesohaline regions in these rivers. The mean monthly rates and range at these locations were 5.52 (Dec.) to 175.12 (Aug.) mg C m-3 h-1 for tidal freshwater, 12.21 (Jan.) to 149.90 (May) mg C m-3 h-1 in oligohaline regions, and 16.20 (Jan.) to 151.33 (May) mg C m-3 h-1 for the mesohaline. The estimated mean annual 12 year productivity for the different Virginia river sites in …
Tissue And Life Stage Distribution Of A Defensin-Like Gene In The Lone Star Tick Amblyomma Americanum, S. Michelle Todd, Daniel E. Sonenshine, Wayne L. Hynes
Tissue And Life Stage Distribution Of A Defensin-Like Gene In The Lone Star Tick Amblyomma Americanum, S. Michelle Todd, Daniel E. Sonenshine, Wayne L. Hynes
Biological Sciences Faculty Publications
The transcript sequence of the Amblyomma americanum Linnaeus (Acari: Ixodidae) defensin, termed amercin (amn), was ascertained and a 219-bp amn coding region identified. The gene encodes a 72-amino acid prepropeptide with a putative 37-amino acid mature peptide. This gene shows little similarity to either of the defensins from Amblyomma hebraeum Koch, the only other Amblyomma species for which a defensin has been described. Sequence comparisons with other tick defensins reveal amn to be shorter (6 bp or 2 amino acids) than the Ixodes scapularis Linnaeus (Acari: Ixodidae) and Dermacentor variabilis (Say) (Acari: Ixodidae) defensin sequences. The amercin prepropeptide …
Sensory Genes And Mate Choice: Evidence That Duplications, Mutations, And Adaptive Evolution Alter Variation In Mating Cue Genes And Their Receptors, Lisa Horth
Biological Sciences Faculty Publications
Fascinating new data, revealed through gene sequencing, comparative genomics, and genetic engineering, precisely establish which genes are involved in mate choice and mating activity—behaviors that are surprisingly understudied from a genetic perspective. Discussed here are some of the recently identified visual and chemosensory genes that are involved in mate choice and mating behavior. These genes’ products are involved in the production, transmission, and receipt of crucial sensory mate-choice cues that affect fitness. This review exposes newfound evidence that alternative splicing, gene-expression pattern changes, and molecular genetic variation in sensory genes are crucial for both intra- and interspecific mate choice and …
Design, Synthesis, And Evaluation Of 10-N-Substituted Acridones As Novel Chemosensitizers In Plasmodium Falciparum, Jane X. Kelly, Martin J. Smilkstein, Roland A. Cooper, Kristin D. Lane, Robert A. Johnson, Aaron Janowsky, Rozalia A. Dodean, David J. Hinrichs, Rolf Winter, Michael Riscoe
Design, Synthesis, And Evaluation Of 10-N-Substituted Acridones As Novel Chemosensitizers In Plasmodium Falciparum, Jane X. Kelly, Martin J. Smilkstein, Roland A. Cooper, Kristin D. Lane, Robert A. Johnson, Aaron Janowsky, Rozalia A. Dodean, David J. Hinrichs, Rolf Winter, Michael Riscoe
Biological Sciences Faculty Publications
A series of novel 10-N-substituted acridones, bearing alkyl side chains with tertiary amine groups at the terminal position, were designed, synthesized, and evaluated for the ability to enhance the potency of quinoline drugs against multidrug-resistant (MDR) Plasmodium falciparum malaria parasites. A number of acridone derivatives, with side chains bridged three or more carbon atoms apart between the ring nitrogen and terminal nitrogen, demonstrated chloroquine (CQ)-chemosensitizing activity against the MDR strain of P. falciparum (Dd2). Isobolograrn analysis revealed that selected candidates demonstrated significant synergy with CQ in the CQ-resistant (CQR) parasite Dd2 but only additive (or indifferent) interaction in the CQ-sensitive …
Dietary Sequestration Of Defensive Steroids In Nuchal Glands Of The Asian Snake Rhabdophis Tigrinus, Deborah A. Hutchinson, Akira Mori, Alan H. Savitsky, Gordon M. Burghardt, Xiaogang Wu, Jerrold Meinwald, Frank C, Schroeder
Dietary Sequestration Of Defensive Steroids In Nuchal Glands Of The Asian Snake Rhabdophis Tigrinus, Deborah A. Hutchinson, Akira Mori, Alan H. Savitsky, Gordon M. Burghardt, Xiaogang Wu, Jerrold Meinwald, Frank C, Schroeder
Biological Sciences Faculty Publications
The Asian snake Rhabdophis tigrinus possesses specialized defensive glands on its neck that contain steroidal toxins known as bufadienolides. We hypothesized that R. tigrinus does not synthesize these defensive steroids but instead sequesters the toxins from toads it consumes as prey. To test this hypothesis, we conducted chemical analyses on the glandular fluid from snakes collected in toad-free and toad-present localities. We also performed feeding experiments in which hatchling R. tigrinus were reared on controlled diets that either included or lacked toads. We demonstrate that the cardiotonic steroids in the nuchal glands of R. tigrinus are obtained from dietary toads. …
In Vivo Imaging Of Transport And Biocompatibility Of Single Silver Nanoparticles In Early Development Of Zebrafish Embryos, Kerry J. Lee, Prakash D. Nallathamby, Lauren M. Browning, Christopher J. Osgood, Xiao-Hong Nancy Xu
In Vivo Imaging Of Transport And Biocompatibility Of Single Silver Nanoparticles In Early Development Of Zebrafish Embryos, Kerry J. Lee, Prakash D. Nallathamby, Lauren M. Browning, Christopher J. Osgood, Xiao-Hong Nancy Xu
Chemistry & Biochemistry Faculty Publications
Real-time study of the transport and biocompatibility of nanomaterials in early embryonic development at single-nanoparticle resolution can offer new knowledge about the delivery and effects of nanomaterials in vivo, and provide new insights into molecular transport mechanisms in developing embryos. In this study, we directly characterized the transport of single silver nanoparticles into an in vivo model system (zebrafish embryos) and investigated their effects on early embryonic development at single-nanoparticle resolution in real time. We designed highly purified and stable (not aggregated and no photodecomposition) nanoparticles and developed single-nanoparticle optics and in vivo assays to enable the study. We …