Digital Commons Network^™

Paternal Effects Without Paternity? Testing Non-Genetic Male Influence On Offspring Size And Brood Size In A Gynogenetic Vertebrate, The Amazon Molly (Poecilia Formosa), Ulrike Scherer, Sean Ehlman, David Bierbach, Jens Krause, Max Wolf

Faculty Publications

Paternal effects, i.e., effects of fathers on the phenotype of their offspring that are not mediated by the transmission of alleles, are increasingly recognized as a potentially significant source of phenotypic variation across taxa – even in the absence of paternal care. Gynogenetic systems, which rely on sperm to trigger embryogenesis without incorporating male genetic material, provide a powerful way to experimentally isolate paternal effects from effects caused by the integration of male genetic material. Up to now, however, paternal effects remain largely unexplored in these systems. Here, we tested for non-genetic paternal effects in the gynogenetic Amazon molly ( …

Dampak Penerapan Integrated Care For Older People Dan Ina-Frail Dalam Menurunkan Sindroma Kerapuhan Pada Lansia, Mochamad Ramadhan Arista Pesat Eka Putra, Vetty Yulianty Permanasari

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

Indonesia is facing a significant increase in its elderly population, requiring effective and sustainable integrated geriatric services, one of which is through the implementation of Integrated Care for Older People (ICOPE) to assess intrinsic capacity decline combined with the Ina-FRAIL questionnaire to measure frailty in the elderly. This study aims to assess the condition of frailty in older adults through the ICOPE approach in integrated geriatric services at Humana Prima Hospital in Bandung using a quantitative design with an experimental approach. The assessment was conducted using the ICOPE and Ina-FRAIL instruments to monitor intrinsic capacity and the level of frailty …

The Role Of Gynecologic Oncologists In Improving Survival Outcomes Of Epithelial Ovarian Cancer: A Retrospective Cohort Study, Widyorini Lh Hanafy, Bambang Dwipoyono, Asri C. Adisasmita, Yosephine E. Regina, Airine S. Lians, Oktaviani P. Rahayu, Jane G. Auwelia

Kesmas

Epithelial ovarian cancer (EOC) is a leading cause of gynecological cancer mortality and is often diagnosed at an advanced stage, resulting in poor survival outcomes. Access to specialized gynecological oncology services has been associated with improved prognosis; however, data on its impact in Indonesia remain limited. This study aimed to evaluate the association between gynecologic oncologist (GO) services and disease-free survival (DFS) in patients with EOC. This retrospective cohort study included 76 patients with EOC who were treated at a national cancer hospital in Jakarta between 2015 and 2018. Patient data were obtained from medical records and followed for three …

Rewiring The Senses: Neural And Perceptual Adaptation Through Cultural Immersion In Chile, Alexa Castillo

University Honors Theses

This thesis explores how cultural immersion reshapes perception over time. Rather than focusing only on language acquisition, the project examines how sustained exposure to a new cultural and linguistic environment alters sensory processing, cognitive effort, and emotional experience. The study draws on cultural neuroscience and neuroplasticity research to frame immersion as a process of adaptive recalibration.

Over four weeks in Valparaíso, Chile, I documented daily changes in auditory processing, visual attention, emotional response, and social interpretation. Journal entries were analyzed using qualitative thematic coding and organized into five categories: language overload, cognitive effort, automaticity, anxiety/frustration, and belonging/comfort. Weekly intensity ratings …

Nanoscale Opportunities In Extracellular Matrix Mimicry, L. Andrew Lyon, Abbygail Caine, Elif Narbay, E. Daniel Cárdenas-Vásquez

Engineering Faculty Articles and Research

We present an overview of the composition, function, energetics, and dynamics of extracellular matrix and its relation to nanoscale structures and phenomena. These concepts are then related to the development of synthetic and biosynthetic materials that aim to mimic the extracellular matrix for regenerative medicine and tissue engineering technologies. Notable successes and advancements towards the goal of biomimicry are outlined, while remaining challenges and knowledge gaps towards that goal are highlighted. Finally, we frame the remaining challenges in the field in terms of nanoscience-related research opportunities that if solved, might prove to be transformative steps forward in the discipline.

Bone Marrow Endosteum Houses Hedgehog-Susceptible Dlx5-Expressing Osteoblast Precursor Cells, Keita Kondo, Yuki Matsushita, Shion Orikasa, Yuta Nakai, Aiko Kuroda, Shinsuke Ohba, Wanida Ono, Noriaki Ono

Faculty, Staff and Student Publications

The bone marrow endosteum provides a robust source of bone-making osteoblasts by housing various types of osteoblast precursor cells, including endosteal stem cells expressing fibroblast growth factor receptor 3 (Fgfr3) and their downstream progenitor cell populations. In fetal bone development, Dlx5 marks early perichondrial cells that populate the diaphyseal bone and marrow stroma in the postnatal stages. However, the location of Dlx5-expressing cells in the postnatal bone marrow and how they contribute to osteogenesis remain undefined. Here, we show that Dlx5

Phase I Trial Of Binimetinib Plus Hydroxychloroquine In Patients With Previously Treated Metastatic Pancreatic Cancer, S Daniel Haldar, Fen Saj, So Jung Hong, Rishi Surana, Lianchun Xiao, J Jack Lee, Brandon Smaglo, Dan Zhao, Huili Zhu, Ryan Huey, Jason Willis, M Pia Morelli, Michael Overman, Florencia Mcallister, Robert Wolff, Anirban Maitra, David Fogelman, Channing Der, Shubham Pant

Faculty, Staff and Student Publications

Background: Dual mitogen-activated protein kinase (MAPK) pathway and autophagy inhibition shows synergistic antitumor activity in preclinical models of RAS-mutant cancers. We hypothesized that autophagy blockade with hydroxychloroquine (HCQ) could overcome resistance to MEK inhibition with binimetinib (BINI) and provide clinical benefit in previously treated, KRAS-mutated, metastatic pancreatic ductal adenocarcinoma (PDAC).

Methods: This investigator-led, single-arm, open-label, phase I dose escalation/expansion trial evaluated the safety and tolerability of BINI + HCQ in patients with previously treated, metastatic PDAC (NCT04132505). Key eligibility criteria: ECOG 0-1, adequate organ function, ≥ 1 prior line of therapy for metastatic disease, and presence of KRAS …

Concurrent Regimes For The Concept Of “Common Heritage” In Seabed Mining, James Kraska, Digvijay Rewatkar

International Law Studies

This article examines the re-emergence of unilateral deep seabed mining by the United States and its implications for the concept of the common heritage of mankind. Triggered by Executive Order 14285 and the resurrection of the Deep Seabed Hard Mineral Resources Act, the U.S. approach challenges the multilateral framework established under Part XI of the United Nations Convention on the Law of the Sea (UNCLOS) and the 1994 Implementing Agreement. While the prevailing view holds that unilateral seabed mining is prohibited by customary international law and that only the International Seabed Authority (ISA) may lawfully operationalize the common heritage principle, …

Endosteal Stem Cells At The Bone-Blood Interface: A Double-Edged Sword For Rapid Bone Formation: Bone Marrow Endosteal Stem Cells Provide A Robust Source Of Bone-Making Osteoblasts Both In Normal And Abnormal Bone Formation, Keita Kondo, Yuki Matsushita, Shion Orikasa, Yuta Nakai, Aiko Kuroda, Shinsuke Ohba, Wanida Ono, Noriaki Ono

Faculty, Staff and Student Publications

Endosteal stem cells are a subclass of bone marrow skeletal stem cell populations that are particularly important for rapid bone formation occurring in growth and regeneration. These stem cells are strategically located near the bone surface in a specialized microenvironment of the endosteal niche. These stem cells are abundant in young stages but eventually depleted and replaced by other stem cell types residing in a non-endosteal perisinusoidal niche. Single-cell molecular profiling and in vivo cell lineage analyses play key roles in discovering endosteal stem cells. Importantly, endosteal stem cells can transform into bone tumor-making cells when deleterious mutations occur in …

Preliminary Objections To Extraterritorial Criminal Prosecutions, Alyssa Resar, Eli Scher-Zagier

NULR Online

No abstract provided.

Sovereign Lands, Brent D. Chicken, Tanner M. Boyzuick

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Alaska, Steven A. Rhodes, Zachary H. Barrett, Kizito Aidam

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

A Revision Of The Psammophilic Genus Liobuthus Birula, 1898 (Scorpiones: Buthidae), With A Description Of Four New Species From Central Asia, Victor Fet, František Kovařík, Graeme Lowe, Matthew R. Graham

Euscorpius

The rare Central Asian psammophilic scorpion genus, Liobuthus Birula, 1898 (Scorpiones: Buthidae), is revised. Five species are delineated according to results from three species delimitation approaches using mitochondrial DNA. Results are supported by diagnostic morphology, including an assessment of the distinctive neobothriotaxy. The type species, L. kessleri Birula, 1898, is confirmed for Iran (northeast), Turkmenistan and Uzbekistan (south). Four new species are described: L. atamuradovi sp. n. (Turkmenistan),  L. danovi sp. n. (Kazakhstan, northern Turkmenistan, Uzbekistan), L. shukurovi sp. n. (southwestern Tajikistan), and L. vachoni sp. n. (southern Kazakhstan), The unique additive neobothriotaxy (on both pedipalp femur and patella) …

Interchange, 1995, V15 N6-7, June-July, Advocate Health - Midwest

Historical Documents - Combined

The lnterChange newsletter was published monthly for the nursing division of St. Luke's Medical Center. It's purpose was to provide health care and shared governance information and inform nurses of new program benefits and upcoming special events.

Interchange, 1990, V10 N5, Septembert-October, Advocate Health - Midwest

Historical Documents - Combined

The lnterChange newsletter was published monthly for the nursing division of St. Luke's Medical Center. It's purpose was to provide health care and shared governance information and inform nurses of new program benefits and upcoming special events.

Interchange, 1988, V8 N5, June, Advocate Health - Midwest

Historical Documents - Combined

The lnterChange newsletter was published monthly for the nursing division of St. Luke's Medical Center. It's purpose was to provide health care and shared governance information and inform nurses of new program benefits and upcoming special events.

Inter-Change, 1984, V4 N10, October, Advocate Health - Midwest

Historical Documents - Combined

The lnter-Change newsletter was published monthly for the nursing division of St. Luke's Medical Center. It's purpose was to provide health care and shared governance information and inform nurses of new program benefits and upcoming special events.

Machine Learning–Driven Prediction Of Dementia From Mri And Clinical Features: A Comparative Analysis Of Ensemble And Baseline Models, Sarah Raad Hameed, Zainab Muhannad Nahid, Rawan Ahmed Abdulmahdi

AUIQ Technical Engineering Science

Early detection of dementia remains a pressing challenge in clinical neuroscience, as delayed diagnosis limits therapeutic impact and healthcare planning. Leveraging the Open Access Series of Imaging Studies (OASIS) cross-sectional dataset of 436 participants, this study developed a robust machine learning pipeline integrating sociodemographic, clinical, and neuroimaging-derived features. Preprocessing included removal of highly sparse variables (Delay), median imputation of partially missing but clinically essential measures (SES, MMSE, CDR, Educ), Winsorization of extreme values, and skewness correction. The target Clinical Dementia Rating (CDR) was binarized (0 = no dementia, ≥ 0.5 = dementia) to align with clinically actionable screening. Categorical features …

An Ai-Enhanced Ant Colony Optimization Based Routing Protocol, Niranjan M M, Srihari P Bhavanasi

Defensive Publications Series

Proposed herein are techniques to address limitations in classical Ant Colony Optimization (ACO) routing protocols that rely on static, hand-crafted probabilistic rules and lack contextual awareness. Traditional ACO-based routing reacts slowly to rapid topology changes or fluctuating link quality, and pheromone evaporation alone cannot ensure fast convergence in highly dynamic or congested environments. To overcome these limitations, techniques herein replace conventional control packets with intelligent software-based AI agents that employ learning-based decision models. These AI agents evaluate link quality, predict route reliability, and optimize exploration behavior in real time by integrating machine-learning-based decision-making with adaptive ACO behavior. The techniques enable …

Improving The Uv Resistance And Service Life Of Polystyrene-Based Building Materials Via Low-Concentration Metal Complex Modifiers, Dina S. Ahmed, Marwa Fadhil, Raghda Alsayed, Mohammed Kadhom, Muna Bufaroosha, Amani Husain, Thura Alyasiri, Hanan Ibraheem, Alaa A. Rashad, Bassam M. Abood, Riyadh Noaman, Ahmed Ahmed, Ruqaya Raad, Ala'a Shaker, Abeer Erfan, Hassan Hashim, Saba Hamza, Rahimi M. Yusop, Emad Yousif

AUIQ Technical Engineering Science

PS is highly susceptible to UV-induced photodegradation, which results in deterioration of its mechanical and aesthetic properties. In the present study, four novel and highly aromatic levofloxacin metal complexes, synthesized from Zn, Sn, Cu, and Ni, were investigated as low-concentration (0.5% w/w) photostabilizer additives for PS. Composite films were prepared by solution casting and subjected to accelerated UV irradiation up to 300 hours. Photostabilizing performance was systematically followed by monitoring changes in the carbonyl index via FT-IR spectroscopy, mass loss measurements, and surface morphology analyses using SEM and AFM. Results showed that all levofloxacin metal complexes had a pronounced inhibition …

The Current - Volume 36 Issue 7, Nova Southeastern University

Student Newspapers

No abstract provided.

Computational Repurposing And Experimental Validation Of Ybx1 Inhibitors In Hepatocellular Carcinoma, Omar Karkoutly, Veerababu Nagati, Subhash Chauhan, Manish Tripathi

School of Medicine Publications

Background/Objectives: Hepatocellular carcinoma (HCC) is the most common type of liver cancer worldwide. While early-stage HCC can often be treated with surgical resection, ablation, or liver transplantation, advanced disease typically relies on systemic chemotherapy. Sorafenib is the standard first-line therapy for advanced and unresectable HCC; however, both intrinsic and acquired resistance remain major clinical challenges. The Y-box binding protein-1 (YBX1), a transcription factor implicated in drug resistance across multiple cancers, is highly expressed in HCC and represents a potential therapeutic target. This study aimed to identify novel YBX1 inhibitors using a drug repurposing strategy to overcome sorafenib resistance. Methods: A …

Spectator 2026-02-26, Editors Of The Spectator

The Spectator

No abstract provided.

Functional Characteristics Of Ice Creams Enriched With Aronia Melanocarpa And Sambucus Nigra L. Extracts, Murat Emre Terzi̇oğlu, Emi̇ne Maci̇t

Turkish Journal of Agriculture and Forestry

In this study, the effects of Aronia melanocarpa and Sambucus nigra L. extracts added at different concentrations (0.5%, 1%,and 1.5%) on the physicochemical, sensory, microbiological, antioxidant capacity (DPPH• and ABTS•+ radical scavenging activity, TPC,TFC, and TAC) antidiabetic (α-amylase and α-glucosidase inhibition), and anti-Alzheimer properties (AChE inhibitory activity) of icecream were investigated. According to the statistical analysis results, extract addition did not have an effect on the total dry matter, fatand ash ratios of the ice cream samples (p > 0.05), but it had an effect on the protein ratio, viscosity, and first drip time at the level ofp < 0.05. The addition of extract positively affected the DPPH• radical scavenging activity IC50 and ABTS•+ radical scavenging activityIC50 values of the ice cream samples, and also increased the TPC, TFC, and TAC values. Indeed, a decrease in the IC50 values of DPPH•and ABTS•+ radical scavenging activities indicates an increase in antioxidant activity. The highest TPC, TFC, and TAC values weredetected in the A-1.5 sample (sample containing 1.5% A. melanocarpa extract) as 749.33 mg GA/kg, 434.70 mg QE/kg, and 290.97 mg/kg, respectively. Similarly, the highest α-amylase inhibitory activity (23.08%), the highest α-glucosidase inhibitory activity (10.41%) andthe highest AChE inhibitory activity (14.70%) were observed in the A-1.5 sample. Extract addition had no effect on microbiologicalproperties and sensory properties except texture. The results of this study showed that A. melanocarpa, S. nigra L. extracts can be usedas a natural additive with antioxidant, antidiabetic and anti-Alzheimer activities in ice cream production.

Cover And Contents

Turkish Journal of Agriculture and Forestry

No abstract provided.

Changes In Metabolomics And Tissue Architectural Alterations Jointly Ameliorate Salt Mediated Injuries In Nigella Sativa L., Noreen Akhter, Ayesha Ali, Muhammad Aqeel, Muhammad Muslim Shahnaz, Saima Iqbal, Ayesha Riaz, Mohammed O. Alshahrani, Ali Noman, Noreen Khalid, Khairah M. Alwutayd Alomran, Fahad Mohamed Al-Zuibar

Turkish Journal of Agriculture and Forestry

This study evaluated plant resistance to salinity across varying salt concentrations: 0, 50, 100, 150, and 200 mM NaCl. Thestudy revealed how these salt levels affected the morphological, physiological, biochemical, and developmental characteristics of theplants. At the 50 mM NaCl treatment level, plant height dropped by 8% in comparison to the control. The shoot fresh and dry weightsof every plant subjected to different levels of salt stress decreased noticeably. At 200 mM NaCl, the plants fresh weight of root decreasedby the greatest percentage (42.8%). The total number of chlorophyll a and chlorophyll b in Nigella sativa L. was significantly lower …

Chrysin Alleviates Salt Stress By Enhancing Antioxidant Enzymes, Nutrient Balance, And Phytohormone Contents In Forage Pea, Sedat Severoğlu

Turkish Journal of Agriculture and Forestry

This study aimed to evaluate the potential protective effects of chrysin (Chr), a flavonoid compound, on growth, biochemical,hormonal, and nutrient levels in forage pea (Pisum sativum ssp. arvense L.) seedlings under NaCl-induced salt stress. The experimentwas conducted under controlled greenhouse conditions in a completely randomized design with three different concentrations of Chr(Chr0: 0 mM, Chr1: 0.1 mM, and Chr2: 0.5 mM Chr) and three levels of salt stress (S0: 0 mM, S1: 100 mM, and S2: 200 mM NaCl),resulting in nine treatment combinations (T0: Chr0S0, T1: Chr0S1, T2: Chr0S2, T3: Chr1S0, T4: Chr1S1, T5: Chr1S2, T6: Chr2S0, T7: Chr2S1, andT8: …

Effects Of Gamma Irradiation On Antioxidant Enzyme Activities In Black Carrot Callus Under Drought Stress, Damla Turan Büyükdi̇nç, Di̇lruba Tabay Sümbül, Sheikh Mansoor

Turkish Journal of Agriculture and Forestry

Daucus carota L. (carrot) is a commercially significant root vegetable widely cultivated in temperate regions for its edible taproot and valued for its high nutritional content. This study aimed to investigate the effects of drought stress on callus tissues of the Hatay black carrot (Daucus carota L. ssp. sativus var. atrorubens Alef.) genotype and to determine the impact of different gamma radiation doses on antioxidant enzyme activities. Black carrot callus tissues were exposed to gamma irradiation at doses of 0, 7, 8, and 9 Gy to evaluate their responses to drought stress. Antioxidant enzyme activities, including superoxide dismutase (SOD), …

Accumulation Of Polyphenolic Compounds In Amelanchier × Lamarckii Fruit In Conditions Of Southwestern Slovakia, Luba Durisova, Tunde Jurikova, Monika Ondrasova, Pavol Elias Jr., Deni̇z Hazar, Jiri Mlcek

Turkish Journal of Agriculture and Forestry

In Slovakia, snowy mespilus (Amelanchier × lamarckii F. G. Schroed.) is recognized both as an ornamental plant and alesser-known fruit species, prized for its high levels of bioactive compounds, particularly polyphenols. The aim of this study was todetect the polyphenolic profile of snowy mespilus and to assess polyphenol accumulation in cells. The total polyphenol content wasdetermined by the Folin–Ciocalteu method, antioxidant activity by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assayand the 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) method, and individual polyphenolic compounds by the highperformanceliquid chromatography (HPLC) method. The results of analyses revealed that among the phenolic acids, chlorogenicacid was the most prevalent [44.24 …

Bioactive Profile And Mineral Composition Of Fruit Extracts From Four Wild Hawthorn (Crataegus Spp.) Species, Özlem Çakir, Kübra Çinar Topçu, Abdurrahman Sefali, İshak Bayyi̇ği̇t, Gülçe İlhan, Jyoti̇ Singh

Turkish Journal of Agriculture and Forestry

This study compared the antioxidant capacity, total phenolic content (TPC), phenolic composition, lipid oxidation level, andmineral profiles of extracts obtained from four wild hawthorn species (Crataegus tanacetifolia, C. orientalis subsp. orientalis, C. orientalissubsp. szovitsii, and C. monogyna) collected from northeastern Türkiye. Significant interspecific variations were observed in DPPH,FRAP, and CUPRAC assays. While C. monogyna had the highest reducing capacity and TPC, C. orientalis subsp. szovitsii had the highestDPPH activity. Ultra-high performance liquid chromatography coupled to tandem mass spectrometry analysis showed that catechin,epicatechin, chlorogenic acid, and quinic acid were the major phenolics, and were particularly abundant in C. monogyna. Despitehaving a …