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2007

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Articles 11401 - 11430 of 14126

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Childhood Among The Etruscans: Mortuary Programs At Tarquinia As Indicators Of The Transition To Adult Status, Marshall Joseph Becker Jan 2007

Childhood Among The Etruscans: Mortuary Programs At Tarquinia As Indicators Of The Transition To Adult Status, Marshall Joseph Becker

Anthropology & Sociology Faculty Publications

No abstract provided.

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The Development Of Intergroup Bias In Children To Ambivalent Sexism In Adults: A Study Of The Role Of Self-Esteem, Noel E. Thomas Wrend Jan 2007

The Development Of Intergroup Bias In Children To Ambivalent Sexism In Adults: A Study Of The Role Of Self-Esteem, Noel E. Thomas Wrend

HIM 1990-2015

Gender differences play an important role in the diversity that exists in our world today. Evan as infants, our young minds are able to grasp that there are large differences in the roles and expectations for males and females and that these differences contribute to the variety of experiences that we encounter in our interactions with the two genders. As we grown from children into adults, it is clear that the biased opinions we form regarding the opposite sex in childhood are too simplistic in their ideologies, and during the time that we mature into young adults, our opinions mature …

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Engendering Agency: Literacies, Social Action, And Wangari Maathai S Green Belt Movement, Cassandra Marie Allen Jan 2007

Engendering Agency: Literacies, Social Action, And Wangari Maathai S Green Belt Movement, Cassandra Marie Allen

Electronic Theses and Dissertations

This thesis analyzes the life and work of Nobel Peace Laureate Wangari Maathai, one of the foremost African woman rhetors of our time. Wangari Maathai--founder of Kenya's Green Belt Movement (GBM), Member of Parliament, and activist for democracy, sustainable development, and human rights--has cultivated a multidimensional literacy that has allowed her to truly understand and address the problems that post-colonial Kenyans face. Her strong solution-oriented approach has allowed her to develop and refine operation of the GBM, which began simply planting trees, to produce a worldwide organization that works for sustainable development, human rights, and environmental conservation/restoration (among many others) …

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Medium Access Control Protocols And Routing Algorithms For Wireless Sensor Networks, Anirban Bag Jan 2007

Medium Access Control Protocols And Routing Algorithms For Wireless Sensor Networks, Anirban Bag

Electronic Theses and Dissertations

In recent years, the development of a large variety of mobile computing devices has led to wide scale deployment and use of wireless ad hoc and sensor networks. Wireless Sensor Networks consist of battery powered, tiny and cheap "motes", having sensing and wireless communication capabilities. Although wireless motes have limited battery power, communication and computation capabilities, the range of their application is vast. In the first part of the dissertation, we have addressed the specific application of Biomedical Sensor Networks. To solve the problem of data routing in these networks, we have proposed the Adaptive Least Temperature Routing (ALTR) algorithm …

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Friend/Foe Identification Accuracy And Shooting Performance: Effects Of Prior Task Loading And Time Pressure, Kelly Ann Burke Jan 2007

Friend/Foe Identification Accuracy And Shooting Performance: Effects Of Prior Task Loading And Time Pressure, Kelly Ann Burke

Electronic Theses and Dissertations

The current dismounted soldier and the soldier of the future will be "loaded" with more information processing tasks while they perform shooting tasks. It is conceivable that some increased level of cognitive tasking may be performed simultaneously with required shooting tasks. The effect of cognitive load on shooting performance has been previously examined (Scribner and Harper, 2001). This study concentrated on the effect of various cognitive workload demands on a friend-foe discrimination shooting task in a single- and dual-task scenario. In light of this, it is imperative that the soldier not be overburdened mentally, which may result in decreased survivability …

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The Effects Of Eicu Technology On Clinical Outcomes Of Icu Patients: Analysis Of The Relationship Of Patient, Hospital, And Unit Characteristics To Proximal And Distal Outcomes, Michelle G. Chandler Jan 2007

The Effects Of Eicu Technology On Clinical Outcomes Of Icu Patients: Analysis Of The Relationship Of Patient, Hospital, And Unit Characteristics To Proximal And Distal Outcomes, Michelle G. Chandler

Electronic Theses and Dissertations

Each year approximately five million people are treated in the nation's intensive care units making intensive care one of the most expensive components of the U.S. healthcare system. Of these patients, 400,000-500,000 will die annually giving the ICU the distinction of having the highest rate of mortality and complications in the hospital setting. Studies have demonstrated that one in ten patients who die each day in ICUs might survive if intensivists were present to manage clinical care and direct treatment plans (Randolph & Pronovost, 2002; Dimick, Pronovost, Heitmiller & Lipsett, 2001; Pronovost et al., 2002). The utilization of supplemental remote …

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Far-Infrared/Millimeter Wave Source And Component Development For Imaging And Spectroscopy, Todd Du Bosq Jan 2007

Far-Infrared/Millimeter Wave Source And Component Development For Imaging And Spectroscopy, Todd Du Bosq

Electronic Theses and Dissertations

The far-infrared and millimeter wave (FIR/mmW) (wavelength 75 micrometer to 10 mm) portion of the electromagnetic spectrum is fairly underdeveloped technologically, owing to the large amount of atmospheric attenuation in that range. At present, the FIR/mmW region is lacking in compact, high-brightness radiation sources and practical imaging systems. This dissertation focuses on development of two complementary technologies in this area - an active mmW imaging system and high-reflectivity Bragg mirrors for the FIR p-Ge laser. The imaging system uses a vector network analyzer in the frequency range of 90-140 GHz as the radiation source and receiver. Raster scanning is used …

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Environmental Security In The Global Capitalist System: A World-Systems Approach And Study Of Panama, Mark Allen Freeman Jan 2007

Environmental Security In The Global Capitalist System: A World-Systems Approach And Study Of Panama, Mark Allen Freeman

Electronic Theses and Dissertations

The current global capitalist system is at odds with environmental protection and the protection of indigenous people that are directly linked to the land on which they live. In environmental security literature, many have argued that, theoretically and functionally, it is possible to link national security with environmental security. However possible this may be on paper, in practice, the global capitalist system prevents this from becoming a reality. Using a world-systems approach, this thesis will show that core countries seeking to expand capital by tapping into new markets, locating new sources of raw materials and even forming strategic military partnerships …

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Sex-Biased Parasitism And The Reproductive Costs Of Parasites In A Social African Ground Squirrel, Melissa Ann Hillegass Jan 2007

Sex-Biased Parasitism And The Reproductive Costs Of Parasites In A Social African Ground Squirrel, Melissa Ann Hillegass

Electronic Theses and Dissertations

Vertebrate males frequently carry higher numbers of parasites than females. This bias in parasite loads could be a consequence of sexual selection. Grouping species are also assumed to be afflicted with larger numbers of parasites than solitary animals and associated costs of this parasitism could vary with group size or structure. I examined sex-biased parasitism and the influence of group size on parasite loads in Cape ground squirrels (Xerus inauris), a highly social species that occurs in the arid regions of southern Africa. Males carried three times as many ectoparasites as females, but females harbored nearly three times more endoparasites …

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Does Habitat Affect Clonal Demography? An Experiment With Polygonella Myriophylla In Roadside And Florida Scrub, Kristina Dianne Horn Jan 2007

Does Habitat Affect Clonal Demography? An Experiment With Polygonella Myriophylla In Roadside And Florida Scrub, Kristina Dianne Horn

Electronic Theses and Dissertations

Polygonella myriophylla (Polygonaceae) is a clonal shrub listed as endangered and narrowly endemic to pyrogenic scrub ecosystems in central Florida. It is almost restricted to gaps within the matrix of shrubs in the scrub but also occurs along adjacent road-side habitats. I hypothesize that persistent disturbed microhabitats and more dynamic sand accretion in roadsides will increase rooting probabilities compared to more stable scrub habitats, affecting survival, growth and reproduction. In April 2004- March 2006, I compared plant (genet) and basal branch (ramet) performance between experimentally manipulated plants in native scrub and roadside habitats at two locations within the Lake Wales …

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Voigt Spectral Profiles In Two-Photon Resonance Fluorescence, Moorad Alexanian, Subir K. Bose Jan 2007

Voigt Spectral Profiles In Two-Photon Resonance Fluorescence, Moorad Alexanian, Subir K. Bose

Faculty Bibliography 2000s

A recent work on two-photon fluorescence is extended by considering the pump field to be a coherent state, which represents a laser field operating well above threshold. The dynamical conditions are investigated under which the two-photon spectrum gives rise, in addition to a Lorentzian line shape at the pump frequency, to two Voigt spectral sideband profiles. Additional conditions are found under which the Voigt profile behaves like either a Gaussian or a Lorentzian line shape.

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A Bayesian Approach To Estimation And Testing In Time-Course Microarray Experiments, Claudia Angelini, Daniela De Canditiis, Margherita Mutarelli, Marianna Pensky Jan 2007

A Bayesian Approach To Estimation And Testing In Time-Course Microarray Experiments, Claudia Angelini, Daniela De Canditiis, Margherita Mutarelli, Marianna Pensky

Faculty Bibliography 2000s

The objective of the present paper is to develop a truly functional Bayesian method specifically designed for time series microarray data. The method allows one to identify differentially expressed genes in a time-course microarray experiment, to rank them and to estimate their expression profiles. Each gene expression profile is modeled as an expansion over some orthonormal basis, where the coefficients and the number of basis functions are estimated from the data. The proposed procedure deals successfully with various technical difficulties that arise in typical microarray experiments such as a small number of observations, non-uniform sampling intervals and missing or replicated …

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Field Production And Functional Evaluation Of Chloroplast-Derived Interferon-Alpha 2b, Philip A. Arlen, Regina Falconer, Sri Cherukumili, Amy Cole, Alexander M. Cole, Karen K. Oishi, Henry Daniell Jan 2007

Field Production And Functional Evaluation Of Chloroplast-Derived Interferon-Alpha 2b, Philip A. Arlen, Regina Falconer, Sri Cherukumili, Amy Cole, Alexander M. Cole, Karen K. Oishi, Henry Daniell

Faculty Bibliography 2000s

Type I interferons (IFNs) inhibit viral replication and cell growth and enhance the immune response, and therefore have many clinical applications. IFN-alpha 2b ranks third in world market use for a biopharmaceutical, behind only insulin and erythropoietin. The average annual cost of IFN-alpha 2b for the treatment of hepatitis C infection is $26 000, and is therefore unavailable to the majority of patients in developing countries. Therefore, we expressed IFN-alpha 2b in tobacco chloroplasts, and transgenic lines were grown in the field after obtaining United States Department of Agriculture Animal and Plant Health Inspection Service (USDA-APHIS) approval. Stable, site-specific integration …

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Intravenous Immunoglobulin (Ivig) Protects The Brain Against Experimental Stroke By Preventing Complement-Mediated Neuronal Cell Death, Thiruma V. Arumugam, Sung-Chun Tang, Justin D. Lathia, Aiwu Cheng, Mohamed R. Mughal, Srinivasulu Chigurupati, Tim Magnus, Sic L. Chan, Dong-Gyu Jo, Xin Ouyang, David P. Fairlie, Daniel N. Granger, Alexander Vortmeyer, Milan Basta, Mark P. Mattson Jan 2007

Intravenous Immunoglobulin (Ivig) Protects The Brain Against Experimental Stroke By Preventing Complement-Mediated Neuronal Cell Death, Thiruma V. Arumugam, Sung-Chun Tang, Justin D. Lathia, Aiwu Cheng, Mohamed R. Mughal, Srinivasulu Chigurupati, Tim Magnus, Sic L. Chan, Dong-Gyu Jo, Xin Ouyang, David P. Fairlie, Daniel N. Granger, Alexander Vortmeyer, Milan Basta, Mark P. Mattson

Faculty Bibliography 2000s

Stroke is among the three leading causes of death worldwide and the most frequent cause of permanent disability. Brain ischemia induces an inflammatory response involving activated complement fragments. Here we show that i.v. Ig (IVIG) treatment, which scavenges complement fragments, protects brain cells against the deleterious effects of experimental ischemia and reperfusion (I/R) and prevents I/R-induced mortality in mice. Animals administered IVIG either 30 min before ischemia or after 3 h of reperfusion exhibited a 50-60% reduction of brain infarct size and a 2- to 3-fold improvement of the functional outcome. Even a single low dose of IVIG given after …

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Stable Expression Of Gal/Galnac Lectin Of Entamoeba Histolytica In Transgenic Chloroplasts And Immunogenicity In Mice Towards Vaccine Development For Amoebiasis, Seethamahalakshmi Chebolu, Henry Daniell Jan 2007

Stable Expression Of Gal/Galnac Lectin Of Entamoeba Histolytica In Transgenic Chloroplasts And Immunogenicity In Mice Towards Vaccine Development For Amoebiasis, Seethamahalakshmi Chebolu, Henry Daniell

Faculty Bibliography 2000s

Chloroplast genetic engineering offers several advantages, including high levels of transgene expression, transgene containment via maternal inheritance and multigene engineering in a single transformation event. Entamoeba histolytica infects 50 million people, causing about 100 000 deaths annually, but there is no approved vaccine against this pathogen. LecA, a potential target for blocking amoebiasis, was expressed for the first time in transgenic plants. Stable transgene integration into chloroplast genomes and homoplasmy were confirmed by polymerase chain reaction and Southern blot analyses. LecA expression was evaluated by Western blots and quantified by enzyme-linked immunosorbent assay (up to 6.3% of total soluble protein …

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Prostasin Induces Protease-Dependent And Independent Molecular Changes In The Human Prostate Carcinoma Cell Line Pc-3, Mengqian Chen, Ya-Yuan Fu, Chen-Yong Lin, Li-Mei Chen, Karl X. Chai Jan 2007

Prostasin Induces Protease-Dependent And Independent Molecular Changes In The Human Prostate Carcinoma Cell Line Pc-3, Mengqian Chen, Ya-Yuan Fu, Chen-Yong Lin, Li-Mei Chen, Karl X. Chai

Faculty Bibliography 2000s

Expression of prostasin in the PC-3 human prostate carcinoma cells inhibited in vitro invasion, but the molecular mechanisms are unknown. Wild-type human prostasin or a serine active-site mutant prostasin was expressed in the PC-3 cells. Molecular changes were measured at the mRNA and the protein levels. Cell signaling changes were evaluated by measuring phosphorylation of the extracellular signal-regulated kinases (Erk 1/2) following epidermal growth factor (EGF) treatment of the cells. Protein expression of the EGF receptor (EGFR) was differentially downregulated by the wild-type and the active-site mutant prostasin. The mRNA expression of EGFR and the transcription repressor SLUG was reduced …

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Domac: An Accurate, Hybrid Protein Domain Prediction Server, Jianlin Cheng Jan 2007

Domac: An Accurate, Hybrid Protein Domain Prediction Server, Jianlin Cheng

Faculty Bibliography 2000s

Protein domain prediction is important for protein structure prediction, structure determination, function annotation, mutagenesis analysis and protein engineering. Here we describe an accurate protein domain prediction server (DOMAC) combining both template-based and ab initio methods. The preliminary version of the server was ranked among the top domain prediction servers in the seventh edition of Critical Assessment of Techniques for Protein Structure Prediction (CASP7), 2006. DOMAC server and datasets are available at: http://www.bioinfotool.org/domac.html.

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Improved Residue Contact Prediction Using Support Vector Machines And A Large Feature Set, Jianlin Cheng, Pierre Baldi Jan 2007

Improved Residue Contact Prediction Using Support Vector Machines And A Large Feature Set, Jianlin Cheng, Pierre Baldi

Faculty Bibliography 2000s

Background: Predicting protein residue-residue contacts is an important 2D prediction task. It is useful for ab initio structure prediction and understanding protein folding. In spite of steady progress over the past decade, contact prediction remains still largely unsolved. Results: Here we develop a new contact map predictor (SVMcon) that uses support vector machines to predict medium- and long-range contacts. SVMcon integrates profiles, secondary structure, relative solvent accessibility, contact potentials, and other useful features. On the same test data set, SVMcon's accuracy is 4% higher than the latest version of the CMAPpro contact map predictor. SVMcon recently participated in the seventh …

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Design And Construction Of An Electric Fish Finder, William G. R. Crampton, Jonathan K. Wells, Charles Smuth, Steven A. Walz Jan 2007

Design And Construction Of An Electric Fish Finder, William G. R. Crampton, Jonathan K. Wells, Charles Smuth, Steven A. Walz

Faculty Bibliography 2000s

We provide notes on the design and construction of an Electric Fish Finder - a portable differential amplifier for detecting the electrostatic fields of gymnotiform knifefishes. The device can be adapted to locate electric fishes in any kind of aquatic environment. It is rugged, water resistant, and powered by alkaline batteries. This contribution is part of a series of technical papers designed to encourage students of neotropical ichthyology to explore the ecology, systematics, and electric signaling of gymnotiform fishes.

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Dna Damage, Homology-Directed Repair, And Dna Methylation, Concetta Cuozzo, Antonio Porcellini, Tiziana Angrisano, Annalisa Morano, Bongyong Lee, Alba Di Pardo, Samantha Messina, Rodolfo Luliano, Alfredo Fusco, Maria R. Santillo, Mark T. Muller, Lorenzo Chiariotti, Max E. Gottesman, Enrico V. Avvedimento Jan 2007

Dna Damage, Homology-Directed Repair, And Dna Methylation, Concetta Cuozzo, Antonio Porcellini, Tiziana Angrisano, Annalisa Morano, Bongyong Lee, Alba Di Pardo, Samantha Messina, Rodolfo Luliano, Alfredo Fusco, Maria R. Santillo, Mark T. Muller, Lorenzo Chiariotti, Max E. Gottesman, Enrico V. Avvedimento

Faculty Bibliography 2000s

To explore the link between DNA damage and gene silencing, we induced a DNA double-strand break in the genome of Hela or mouse embryonic stem (ES) cells using I-SceI restriction endonuclease. The I-SceI site lies within one copy of two inactivated tandem repeated green fluorescent protein (GFP) genes (DR-GFP). A total of 2%-4% of the cells generated a functional GFP by homology-directed repair (HR) and gene conversion. However, similar to 50% of these recombinants expressed GFP poorly. Silencing was rapid and associated with HR and DNA methylation of the recombinant gene, since it was prevented in Hela cells by 5-aza-2 …

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Accd6, A Member Of The Fas Ii Locus, Is A Functional Carboxyltransferase Subunit Of The Acyl-Coenzyme A Carboxylase In Mycobacterium Tuberculosis, Jaiyanth Daniel, Tae-Jin Oh, Chang-Muk Lee, Pappachan E. Kolattukudy Jan 2007

Accd6, A Member Of The Fas Ii Locus, Is A Functional Carboxyltransferase Subunit Of The Acyl-Coenzyme A Carboxylase In Mycobacterium Tuberculosis, Jaiyanth Daniel, Tae-Jin Oh, Chang-Muk Lee, Pappachan E. Kolattukudy

Faculty Bibliography 2000s

The Mycobacterium tuberculosis acyl-coenzyme A (CoA) carboxylases provide the building blocks for de novo fatty acid biosynthesis by fatty acid synthase I (FAS 1) and for the elongation of FAS I end products by the FAS 11 complex to produce meromycolic acids. The M. tuberculosis genome contains three biotin carboxylase subunits (AccA1 to -3) and six carboxyltransferase subunits (AccD1 to -6), with accD6 located in a genetic locus that contains members of the FAS 11 complex. We found by quantitative real-time PCR analysis that the transcripts of accA3, accD4, accD5, and accD6 are expressed at high levels during the exponential …

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Transgene Containment By Maternal Inheritance: Effective Or Elusive?, Henry Daniell Jan 2007

Transgene Containment By Maternal Inheritance: Effective Or Elusive?, Henry Daniell

Faculty Bibliography 2000s

No abstract provided.

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Group-Index Birefringence And Loss Measurements In Silicon-On-Insulator Photonic Wire Waveguides, David Duchesne, Pavel Cheben, Roberto Morandotti, Boris Lamontagne, Dan-Xia Xu, Siegfried Janz, Demetrios Christodoulides Jan 2007

Group-Index Birefringence And Loss Measurements In Silicon-On-Insulator Photonic Wire Waveguides, David Duchesne, Pavel Cheben, Roberto Morandotti, Boris Lamontagne, Dan-Xia Xu, Siegfried Janz, Demetrios Christodoulides

Faculty Bibliography 2000s

Group-index birefringence in silicon-on-insulator photonic wire waveguides is determined through a polarization beating technique and a Fabry-Perot resonance method. A large group-index birefringence, up to 0.67, is obtained as a result of the structural asymmetry and high field confinement of our waveguides. The group index and linear propagation loss are also determined. In particular, the group index is found to be as large as 4.45 due to the significant change in the effective mode index of the waveguide as a function of the wavelength. The effects of structure size on the measured losses and group indices are analyzed. Our experimental …

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Analysis Of 81 Genes From 64 Plastid Genomes Resolves Relationships In Angiosperms And Identifies Genome-Scale Evolutionary Patterns, Robert K. Jansen, Zhengqiu Cai, Linda A. Raubeson, Henry Daniell, Claude W. Depamphilis, James Leebens-Mack, Kai F. Müller, Mary Guisinger-Bellian, Rosemarie C. Haberle, Anne K. Hansen, Timothy W. Chumley, Seung-Bum Lee, Rhiannon Peery, Joel R. Mcneal, Jennifer V. Kuehl, Jeffrey L. Boore Jan 2007

Analysis Of 81 Genes From 64 Plastid Genomes Resolves Relationships In Angiosperms And Identifies Genome-Scale Evolutionary Patterns, Robert K. Jansen, Zhengqiu Cai, Linda A. Raubeson, Henry Daniell, Claude W. Depamphilis, James Leebens-Mack, Kai F. Müller, Mary Guisinger-Bellian, Rosemarie C. Haberle, Anne K. Hansen, Timothy W. Chumley, Seung-Bum Lee, Rhiannon Peery, Joel R. Mcneal, Jennifer V. Kuehl, Jeffrey L. Boore

Faculty Bibliography 2000s

Angiosperms are the largest and most successful clade of land plants with > 250,000 species distributed in nearly every terrestrial habitat. Many phylogenetic studies have been based on DNA sequences of one to several genes, but, despite decades of intensive efforts, relationships among early diverging lineages and several of the major clades remain either incompletely resolved or weakly supported. We performed phylogenetic analyses of 81 plastid genes in 64 sequenced genomes, including 13 new genomes, to estimate relationships among the major angiosperm clades, and the resulting trees are used to examine the evolution of gene and intron content. Phylogenetic trees from …

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Comparative Mitochondrial Genomics Of Snakes: Extraordinary Substitution Rate Dynamics And Functionality Of The Duplicate Control Region, Zhi J. Jiang, Todd A. Castoe, Christopher C. Austin, Matthew D. Herron, Frank T. Burbrink, Jimmy A. Mcguire, Christopher L. Parkinson, David D. Pollock Jan 2007

Comparative Mitochondrial Genomics Of Snakes: Extraordinary Substitution Rate Dynamics And Functionality Of The Duplicate Control Region, Zhi J. Jiang, Todd A. Castoe, Christopher C. Austin, Matthew D. Herron, Frank T. Burbrink, Jimmy A. Mcguire, Christopher L. Parkinson, David D. Pollock

Faculty Bibliography 2000s

Background: The mitochondrial genomes of snakes are characterized by an overall evolutionary rate that appears to be one of the most accelerated among vertebrates. They also possess other unusual features, including short tRNAs and other genes, and a duplicated control region that has been stably maintained since it originated more than 70 million years ago. Here, we provide a detailed analysis of evolutionary dynamics in snake mitochondrial genomes to better understand the basis of these extreme characteristics, and to explore the relationship between mitochondrial genome molecular evolution, genome architecture, and molecular function. We sequenced complete mitochondrial genomes from Slowinski's corn …

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Advances In Homeland Security Series, Naim Kapucu Jan 2007

Advances In Homeland Security Series, Naim Kapucu

Faculty Bibliography 2000s

This is a book review article for the Advances in Homeland Security Series by Purdue University. The series consist of two volumes. Volume one is entitled The Science of Homeland Security. Volume two is entitled Guiding Future Homeland Security Policy. Amass F. S., Bhunia, A. K, Chaturvedi, A. L., Dolk, D. R., Peeta, S., and Atallah, M. J. Advances in Homeland Security Series: The Science of Homeland Security (Volume 1), West Lafayette, IN: Perdue University Press, 2006 227 pp, introduction, notes, bibliography, index (hardcover). Amass F. S., Chaturvedi, A. L., and Peeta, S. Advances in Homeland Security Series: Guiding Future …

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Role Of Crkii In Fc Gamma Receptor-Mediated Phagocytosis, Warren L. Lee, Gabriela Cosio, Keith Ireton, Sergio Grinstein Jan 2007

Role Of Crkii In Fc Gamma Receptor-Mediated Phagocytosis, Warren L. Lee, Gabriela Cosio, Keith Ireton, Sergio Grinstein

Faculty Bibliography 2000s

Phagocytosis of IgG-opsonized pathogens by Fc gamma receptors requires extensive remodeling of the actin cytoskeleton, a process regulated by the small GTPase Rac. Vav was thought to be the guanine nucleotide exchange factor responsible for the activation of Rac, but recent evidence indicates that Fc gamma receptor-mediated phagocytosis is unaffected in macrophages lacking all three isoforms of Vav. We therefore tested whether another GEF, DOCK180, participates in Fc gamma receptor-initiated phagocytosis. DOCK180 associates with the adaptor protein Crk, which mediates recruitment of the GEF to sites of tyrosine phosphorylation. CrkII and DOCK180 were found to accumulate at the phagocytic cup. …

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Specific Grb2-Mediated Interactions Regulate Clathrin-Dependent Endocytosis Of The Cmet-Tyrosine Kinase, Ning Li, Marta Lorinczi, Keith Ireton, Lisa A. Elferink Jan 2007

Specific Grb2-Mediated Interactions Regulate Clathrin-Dependent Endocytosis Of The Cmet-Tyrosine Kinase, Ning Li, Marta Lorinczi, Keith Ireton, Lisa A. Elferink

Faculty Bibliography 2000s

Lysosomal degradation of the receptor-tyrosine kinase cMet requires receptor ubiquitination by the E3 ubiquitin ligase Cbl followed by clathrin-dependent internalization. A role for Cbl as an adaptor for cMet internalization has been previously reported. However, the requirement for Cbl ubiquitin ligase activity in this process and its mode of recruitment to cMet has yet to be determined. Cbl can directly bind cMet at phosphotyrosine 1003 or indirectly via Grb2 to phosphotyrosine 1356 in the multisubstrate binding domain of cMet. The direct binding of Cbl with cMet is critical for receptor degradation and not receptor internalization. Here we show a strict …

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Role Of Enpp1 On Adipocyte Maturation, Jian Liang, Mingui Fu, Ester Ciociola, Manisha Chandalia, Nicola Abate Jan 2007

Role Of Enpp1 On Adipocyte Maturation, Jian Liang, Mingui Fu, Ester Ciociola, Manisha Chandalia, Nicola Abate

Faculty Bibliography 2000s

Background. It is recognized that the ability of adipose tissue to expand in response to energy excess, i.e. adipocyte maturation, is important in determining systemic abnormalities in glucose and lipid metabolism. Ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1, also known as PC-1) has been recently reported to be involved in the pathogenesis of insulin resistance and related diseases. However, its role on adipose tissue physiology as a mechanism of systemic insulin resistance is not understood. This study was performed to evaluate whether ENPP1 is regulated during adipogenesis and whether over-expression in adipocytes can affect adipocyte maturation, a potential novel mechanism of ENPP1-related …

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Characterization Study Of Bonded And Unbonded Polydimethylsiloxane Aimed For Bio-Micro-Electromechanical Systems-Related Applications, Miao Liu, Quanfang Chen Jan 2007

Characterization Study Of Bonded And Unbonded Polydimethylsiloxane Aimed For Bio-Micro-Electromechanical Systems-Related Applications, Miao Liu, Quanfang Chen

Faculty Bibliography 2000s

Authors have demonstrated that by controlling the mixing ratio of polydimethylsiloxane's (PDMS's) two components-base polymer (part A) and a curing agent (part B)-different mechanical properties of PDMS can be achieved. Test results show that the Young's modulus decreases as the increasing of mixing ratios (A: B). However, there is a transitional mixing ratio (part A:part B=10) after which the Young's modulus is almost independent of the mixing ratio. The PDMS's thickness plays an important role in determining the mechanical properties. The results show that the thinner the PDMS, the stiffer it behaves. The bonding strength between two cured PDMS parts …

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