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Contract And Grant Awards Fiscal Year 2007, Office Of The Vice President For Research

Office of the Vice President for Research

I invite you to read this report Contract & Grant Awards, fiscal year 2007, which lists contract and grant (C&G) awards received by the University of New Mexico (UNM) during the period from July 1, 2006 > June 30, 2007 (FY07). These awards represent new funds that were acquired during FY07 by the main campus, branch campuses and education cen> ters, and the Health Sciences Center (HSC). The HSC includes the School of Medicine, College of Nursing, and College of Pharmacy. The awards received for FY07 total $280.1M, of which $156.8M is attributed to the main campus and $123.3M to HSC. …

Pharmacy & Therapeutics Update: Drug Information For Health Care Professionals, Medical University Of South Carolina, Paul W. Bush, Kelli L. Garrison, Jason Cooper

Pharmacy & Therapeutics Update: Drug Information for Health Care Professionals

No abstract provided.

The Effect Of Diarrhea On Appetite In Children Ages One To Five, Amy L. Beck

UCHC Graduate School Masters Theses 2003 - 2010

No abstract provided.

Botanicas In Connecticut: Implications For Allopathic Practitioners, Lisa Rose-Rodriguez

UCHC Graduate School Masters Theses 2003 - 2010

No abstract provided.

Exclusive Breastfeeding Practices In Rural Haitian Women, Susan B. Roman

UCHC Graduate School Masters Theses 2003 - 2010

No abstract provided.

An Evaluation Of Personal Protective Equipment Used With Local Public Health Employees, Aimee E. Eberly

UCHC Graduate School Masters Theses 2003 - 2010

No abstract provided.

Is Chronic Wasting Disease (Cwd) In Deer And Elk Affecting Public Health?, Steven C. Nattrass

UCHC Graduate School Masters Theses 2003 - 2010

No abstract provided.

Pharmacy & Therapeutics Update: Drug Information For Health Care Professionals, June 2007, Medical University Of South Carolina, Paul W. Bush, Kelli L. Garrison, Jason Cooper

Pharmacy & Therapeutics Update: Drug Information for Health Care Professionals

No abstract provided.

Library Without Boundaries, Vol.20 (4) April - June 2007, Houston Academy Of Medicine-Texas Medical Center Library

Library Lines (1998-2009)

No abstract provided.

¡Escriba! ¡Write! Volume 5, June 2007, Hostos Community College Library

¡Escriba!

No abstract provided.

Scwds Briefs: Volume 22, Number 4 (January 2007), Gary L. Doster , Editor, Scwds Briefs, Michael J. Yabsley

Southeastern Cooperative Wildlife Disease Study: Publications

Table of Contents:

SCWDS Celebrates 50 Years

More Bovine TB in Minnesota

Developments in CWD Surveillance and Research

Federal CWD Rule Update

Tularemia in Backyard Wildlife

Osteochondromas in Two Deer

Invasive Exotic Animals in the Southeast

New Field Manual Sales

Skin Lesions On Blue Whales Off Southern Chile: Possible Conservation Implications?, Robert L. Brownell Jr., Carole A. Carlson, Barbara Galletti Vernazzani, Elsa Cabrera

United States Department of Commerce: Staff Publications

We report on three types of skin lesions in a population of blue whales, Balaenoptera musculus, off the northwestern coast of Isla Grande de Chiloe, Chile. These lesions were: (1) cookie-cutter shark, Isistius brasilensis, bites, (2) vesicular or blister lesions, and (3) a tattoo-like skin disease. The presence of these lesions was determined by the examining photos collected in 2006 and 2007 for a blue whale photo-identification project. We examined 289 photographs of 68 individuals for lesions. The cookie-cutter shark lesions are common on these blue whales and similar to those reported from other species of cetaceans. Skin …

A Versatile Computational Pipeline For Bacterial Genome Annotation Improvement And Comparative Analysis, With Brucella As A Use Case, Gongxin Yu, Eric E. Snyder, Stephen M. Boyle, Oswald R. Crasta, Michael Czar, Shrinivasrao P. Mane, Anjan Purkayastha, Bruno Sobral, João C. Setubal

Biology Faculty Publications and Presentations

We present a bacterial genome computational analysis pipeline, called GenVar. The pipeline, based on the program GeneWise, is designed to analyze an annotated genome and automatically identify missed gene calls and sequence variants such as genes with disrupted reading frames (split genes) and those with insertions and deletions (indels). For a given genome to be analyzed, GenVar relies on a database containing closely related genomes (such as other species or strains) as well as a few additional reference genomes. GenVar also helps identify gene disruptions probably caused by sequencing errors. We exemplify GenVar’s capabilities by presenting results from the analysis …

A Condom Versus The Philippine Aids Prevention And Control Act Of 1998: Which Has Holes Leaving Filipinos Unprotected?, David M. Iseminger

Washington International Law Journal

In 1998, the Philippine legislature passed pioneering HIV/AIDS legislation in Southeast Asia called the AIDS Prevention and Control Act (“APCA” or “Act”). This comprehensive legislation sought, in part, to ensure access to health care information and to stop the spread of diseases like HIV/AIDS. Regulations were promulgated by the Philippine National AIDS Council in 1999 to implement the Act. APCA effectively addresses several important HIV/AIDS issues, including prohibiting discrimination and mandatory HIV testing, while ensuring access to basic health care. However, both the regulations and the Act fail to ensure that all scientifically accurate information regarding HIV/AIDS prevention reaches Filipinos. …

Global Stability Results Of An Sis Age-Structured Epidemic Model With Vertical Transmission, M. El-Doma

Applications and Applied Mathematics: An International Journal (AAM)

An SIS age-structured epidemic model for a vertically as well as horizontally transmitted disease is investigated when the fertility, mortality and cure rates depend on age and the force of infection of proportionate mixing assumption type. We determine the steady states and prove the global stability for the endemic equilibriums.

The Big Idea: Prizes To Stimulate R&D For New Medicines, James Love, Tim Hubbard

Chicago-Kent Law Review

No abstract provided.

Erratum: Avian Influenza (H5n1) And The Evolutionary And Social Ecology Of Infectious Disease Emergence (Ecohealth (September 2006) 3:3 (187-194) Doi: 10.1007/S10393-006-0044-6), Durrell D. Kapan, Shannon N. Bennett, Brett R. Ellis, Jefferson Fox, Nancy D. Lewis, James H. Spencer, Sumeet Saksena, Bruce A. Wilcox

Faculty Publications

No abstract provided.

The Flagellum Of Pseudomonas Aeruginosa Is Required For Resistance To Clearance By Surfactant Protein A, Shiping Zhang, Francis X. Mccormack, Roger C. Levesque, George A. O'Toole, Gee W. Lau

Dartmouth Scholarship

Surfactant protein A (SP-A) is an important lung innate immune protein that kills microbial pathogens by opsonization and membrane permeabilization. We investigated the basis of SP-A-mediated pulmonary clearance of Pseudomonas aeruginosa using genetically-engineered SP-A mice and a library of signature-tagged P. aeruginosa mutants. A mutant with an insertion into flgE, the gene that encodes flagellar hook protein, was preferentially cleared by the SP-A(+/+) mice, but survived in the SP-A(-/-) mice. Opsonization by SP-A did not play a role in flgE clearance. However, exposure to SP-A directly permeabilized and killed the flgE mutant, but not the wild-type parental strain. P. aeruginosa …

Research Note: The Irish International Exhibition Of 1907 - Ireland's World Fair, Patricia J. Fanning

Bridgewater Review

No abstract provided.

“教學門診”中被指導醫師學習需求之評估, 姵君 林, 芸 陳, 樹勳 朱

Journal of Medical Education

本研究的目的在瞭解參與教學門診之被指導者之學習需求，以本院參與教學門診之住院醫師及實習醫學生為研究對象。研究方法採用結構式問卷，共回收有效問卷47份，回收率為95.9%。研究結果發現，被指導者最期望指導醫師於教學門診教導用藥原則(93.6%)、病史詢問(91.5%)、身體檢查(85.1%)及溝通技巧(85.1%)；期望的教學門診評量方式以口試(55.4%)與實際演練(53.2%)居多；認為擔任教學門診的老師應具備的教學特質需求，以表達能力佳(95.7%)、能於教學門診前告知病患此為教學門診(89.4%)、能回應我的問題(89.4%)以及能給予學習上的回饋(89.4%)比例較高。最影響被指導者參與教學門診之因素，則以臨床業務纏身(80.9%)所佔比例最高。被指導者普遍認為一個月參與教學門診2次最適切，教學方式可採用學生先看診的方式進行，並給予合理的執行病史詢問、理學檢查及病歷寫作之時間各10分鐘為宜。研究的結果，讓我們了解被指導者對教學門診學習需求，做為未來執行教學門診的參考，以提升被指導者於教學門診之學習成效，確保教學門診之教學品質。

Distinguishing Importation From Diversification Of Quinolone-Resistant Neisseria Gonorrhoeae By Molecular Evolutionary Analysis, Keith A. Crandall, Marcos Perez-Losada, Margaret C. Bash, Michael Dan, Jonathan Zenilman, Raphael P. Viscidi

Faculty Publications

Distinguishing the recent introduction of quinolone resistant gonococci into a population from diversification of resistant strains already in the population is important for planning effective infection control strategies. We applied molecular evolutionary analyses to DNA sequences from 9 housekeeping genes and gyrA, parC and porB of 24 quinolone resistant N. gonorrhoeae (QRNG) and 24 quinolone sensitive isolates collected in Israel during 2000-2001. Results- Phylogenetic and eBURST analyses and estimates of divergence time indicated QRNG were introduced on 3 separate occasions and underwent limited diversification by mutation, deletion and horizontal gene transfer. Reconstruction of N. gonorrhoeae demography showed a slowly declining …

Evolutionary Avenues For, And Constraints On, The Transmission Of Frog Lung Flukes (Haematoloechus Spp.) In Dragonfly Second Intermediate Hosts, Matthew G. Bolek, John J. Janovy Jr.

John J. Janovy, Jr. Publications

Metacercariae survival patterns and their distribution in second intermediate odonate hosts were examined for four species of frog lung flukes. Surveys of aquatic larvae and recently emerged teneral dragonflies and damselflies indicated that prevalence and mean abundance of Haematoloechus spp. metacercariae were significantly lower in teneral dragonflies than larval dragonflies, while there was no significant difference in prevalence or mean abundance of Haematoloechus spp. metacercariae among larval and teneral damselflies. Experimental infections of dragonflies indicated that metacercariae of Haematoloechus coloradensis and Haematoloechus complexus were located in the head, thorax, and branchial basket of dragonflies, whereas metacercariae of Haematoloechus longiplexus and …

An Unequal Consumption? Sex And Gender Differences In Tuberculosis, Sarah K. W. Avink

Masters Theses

In the developing world today, tuberculosis (TB) accounts for 26% of avoidable deaths (Holmes et al 1998). Poverty is considered to be a main risk factor for TB, and since some estimates show that women make up 70% of the world's poor (Thorson and Diwan 1998:11), one might conclude that the incidence of TB worldwide would be much higher for women than men. However, reports reviewed in this thesis show the reverse to be true, with an adult annual male notification ratio for TB at 1.5 to 2.1 times higher than that of females. Both biological reasons and social factors …

A Qualitative Study Of Inpatient Rehabilitation Client Perceptions Of The Semi-Fixed Environment, Liane Hewitt

Loma Linda University Electronic Theses, Dissertations & Projects

Background and Purpose. Literature supports the importance of the environment on promoting or compromising health. However, little is known about how the semi-fixed environment affects client perceptions and recovery from a debilitating condition. The purpose of this study was to investigate beliefs about control within the semi-fixed environment and client perceptions of the rehabilitation process.

Design and Method. This study utilized a basic qualitative research design with 10 rehabilitation clients whose average inpatient length of stay was 14 days. Data were collected in two phases. Phase I included two inpatient visits involving semi-structured interviews on the rehabilitation process and …

Importance Of The Ebp (Endocarditis- And Biofilm-Associated Pilus) Locus In The Pathogenesis Of Enterococcus Faecalis Ascending Urinary Tract Infection, Kavindra V Singh, Sreedhar R Nallapareddy, Barbara E Murray

Faculty, Staff and Student Publications

BACKGROUND: We recently demonstrated that the ubiquitous Enterococcus faecalis ebp (endocarditis- and biofilm-associated pilus) operon is important for biofilm formation and experimental endocarditis. Here, we assess its role in murine urinary tract infection (UTI) by use of wild-type E. faecalis OG1RF and its nonpiliated, ebpA allelic replacement mutant (TX5475).

METHODS: OG1RF and TX5475 were administered transurethrally either at an ~1 : 1 ratio (competition assay) or individually (monoinfection). Kidney pairs and urinary bladders were cultured 48 h after infection. These strains were also tested in a peritonitis model.

RESULTS: No differences were observed in the peritonitis model. In mixed UTIs, …

Acquisition Of A Natural Resistance Gene Renders A Clinical Strain Of Methicillin-Resistant Staphylococcus Aureus Resistant To The Synthetic Antibiotic Linezolid, Seok-Ming Toh, Liqun Xiong, Cesar A Arias, Maria V Villegas, Karen Lolans, John Quinn, Alexander S Mankin

Faculty, Staff and Student Publications

Linezolid, which targets the ribosome, is a new synthetic antibiotic that is used for treatment of infections caused by Gram-positive pathogens. Clinical resistance to linezolid, so far, has been developing only slowly and has involved exclusively target site mutations. We have discovered that linezolid resistance in a methicillin-resistant Staphylococcus aureus hospital strain from Colombia is determined by the presence of the cfr gene whose product, Cfr methyltransferase, modifies adenosine at position 2503 in 23S rRNA in the large ribosomal subunit. The molecular model of the linezolid-ribosome complex reveals localization of A2503 within the drug binding site. The natural function of …

Time-Kill And Synergism Studies Of Ceftobiprole Against Enterococcus Faecalis, Including Beta-Lactamase-Producing And Vancomycin-Resistant Isolates, Cesar A Arias, Kavindra V Singh, Diana Panesso, Barbara E Murray

Faculty, Staff and Student Publications

Ceftobiprole (BAL9141) is an investigational cephalosporin with broad in vitro activity against gram-positive cocci, including enterococci. Ceftobiprole MICs were determined for 93 isolates of Enterococcus faecalis (including 16 beta-lactamase [Bla] producers and 17 vancomycin-resistant isolates) by an agar dilution method following the Clinical and Laboratory Standards Institute recommendations. Ceftobiprole MICs were also determined with a high inoculum concentration (10(7) CFU/ml) for a subset of five Bla producers belonging to different previously characterized clones by a broth dilution method. Time-kill and synergism studies (with either streptomycin or gentamicin) were performed with two beta-lactamase-producing isolates (TX0630 and TX5070) and two vancomycin-resistant isolates …

Quality Of Life For Patients And Caregivers: Palliative Care Funding Opportunities, Edward Joseph Schaub

Master's Theses

Development of the field of palliative care, which was nourished through extensive private foundation funding over more than a decade, has to some extent been stalled because of sharply reduced private funding, a lack of understanding by the general population, and the inaction of major institutions.

This study investigated the current state of palliative care funding efforts in the San Francisco Bay Area (the "Bay Area") and across the U.S. The individuals that participated in the research component of this study included palliative care experts and palliative care funders. Through two separate surveys and two interview groups their perceptions and …

Inhibition Of Enterococcus Faecium Adherence To Collagen By Antibodies Against High-Affinity Binding Subdomains Of Acm, Sreedhar R Nallapareddy, Jouko Sillanpää, Vannakambadi K Ganesh, Magnus Höök, Barbara E Murray

Faculty, Staff and Student Publications

Strains of Enterococcus faecium express a cell wall-anchored protein, Acm, which mediates adherence to collagen. Here, we (i) identify the minimal and high-affinity binding subsegments of Acm and (ii) show that anti-Acm immunoglobulin Gs (IgGs) purified against these subsegments reduced E. faecium TX2535 strain collagen adherence up to 73 and 50%, respectively, significantly more than the total IgGs against the full-length Acm A domain (28%) (P < 0.0001). Blocking Acm adherence with functional subsegment-specific antibodies raises the possibility of their use as therapeutic or prophylactic agents.

Trivalent Vaccine Against Botulinum Toxin Serotypes A, B, And E That Can Be Administered By The Mucosal Route, Easwaran Ravichandran, Fetweh H. Al-Saleem, Denise M. Ancharski, Mohammad D. Elias, Ajay K. Singh, Mohammad Shamim, Yujing Gong, Lance L. Simpson

Department of Medicine Faculty Papers

Most reports dealing with vaccines against botulinum toxin have focused on the injection route of administration. This is unfortunate, because a mucosal vaccine is likely to be more efficacious for patients and pose fewer risks to health care workers and to the environment. Therefore, efforts were made to generate a mucosal vaccine that provides protection against the botulinum serotypes that typically cause human illness (serotypes A, B, and E). This work demonstrated that carboxy-terminal peptides derived from each of the three serotypes were able to bind to and penetrate human epithelial barriers in vitro, and there was no cross inhibition …