Digital Commons Network^™

Regulatory Polymorphisms In The Cyclophilin A Gene, Ppia, Accelerate Progression To Aids, Ping An, Li Hua Wang, Holli Hutcheson-Dilks, George Nelson, Sharyne Donfield, James J. Goedert, Charles Rinaldo, Susan Buchbinder, Gregory D. Kirk, Stephen J. O'Brien, Cheryl Winkler

Biology Faculty Articles

Human cyclophilin A, or CypA, encoded by the gene peptidyl prolyl isomerase A (PPIA), is incorporated into the HIV type 1 (HIV-1) virion and promotes HIV-1 infectivity by facilitating virus uncoating. We examined the effect of single nucleotide polymorphisms (SNPs) and haplotypes within the PPIA gene on HIV-1 infection and disease progression in five HIV-1 longitudinal history cohorts. Kaplan-Meier survival statistics and Cox proportional hazards model were used to assess time to AIDS outcomes. Among eight SNPs tested, two promoter SNPs (SNP3 and SNP4) in perfect linkage disequilibrium were associated with more rapid CD4⁺ T-cell loss (relative hazard = …

Prevalence And Diversity Of Avian Hematozoan Parasites In Asia: A Regional Study, Farah Ishtiaq, Eben Gering, Jon H. Rappole, Asad R. Rahmani, Yadvendradev V. Jhala, Carla J. Dove, Christopher M. Milensky, Storrs L. Olson, Mike A. Peirce, Robert C. Fleischer

Biology Faculty Articles

Tissue samples from 699 birds from three regions of Asia (Myanmar, India, and South Korea) were screened for evidence of infection by avian parasites in the genera Plasmodium and Haemoproteus. Samples were collected from November 1994 to October 2004. We identified 241 infected birds (34.0%). Base-on-sequence data for the cytochrome b gene from 221 positive samples, 34 distinct lineages of Plasmodium, and 41 of Haemoproteus were detected. Parasite diversity was highest in Myanmar followed by India and South Korea. Parasite prevalence differed among regions but not among host families. There were four lineages of Plasmodium and one of …

Climate. Stern Review: The Economics Of Climate Change, Nicholas Stern

New England Journal of Public Policy

This chapter examines the increasingly serious impacts on people as the world warms. Climate change is a serious and urgent issue. The Earth has already warmed by 0.7°C since around 1900 and is committed to further warming over coming decades simply due to past emissions. On current trends, average global temperatures could rise by 2–3°C within the next fifty years or so, with several degrees more in the pipeline by the end of the century if emissions continue to grow. This chapter examines how the physical changes in climate . . . affect the essential components of lives and livelihoods …

Timing Rules And Legal Institutions, Eric A. Posner, Jacob Gersen

Coase-Sandor Institute for Law & Economics Research Paper Series

Constitutional and legislative restrictions on the timing of legislation and regulation are ubiquitous but these "timing rules" have received little attention in the legal literature. Yet the timing of a law can be just as important as its content. The timing of a law determines whether its benefits are created sooner or later, and how the costs and benefits are spread across time, and hence to the advantage and disadvantage of different private groups, citizens, and elected officials. We argue that timing rules are, and should be, used to reduce agency problems within the legislature and between the legislature and …

The Role Of Geographic Information Systems Inwildlife Epidemiology: Models Of Chronic Wasting Disease In Colorado Mule Deer, Matthew L. Farnsworth, Jennifer A. Hoeting, N. Thompson Hobbs, Mary M. Conner, Kenneth P. Burnham, Lisa L. Wolfe, Elizabeth S. Williams, David M. Theobald, Michael W. Miller

Wildland Resources Faculty Publications

The authors present findings from two landscape epidemiology studies of chronic wasting disease (CWD) in northern Colorado mule deer (Odocoileus hemionus). First, the effects of human land use on disease prevalence were explored by formulating a set of models estimating CWD prevalence in relation to differences in human land use, sex and geographic location. Prevalence was higher in developed areas and among male deer suggesting that anthropogenic influences (changes in land use), differences in exposure risk between sexes and landscape-scaled heterogeneity are associated with CWD prevalence. The second study focused on identifying scales of mule deer movement and mixing that …

Consanguinity And Genetic Disorders. Profile From Jordan, Hanan A. Hamamy, Amira T. Masri, Azmy M. Al-Hadidy, Kamel M. Ajlouni

Saudi Medical Journal

OBJECTIVE: With 20-30% of all marriages occurring between first cousins, increasing attention in Jordan is now given to role of consanguinity in the occurrence of genetic diseases. The objective of this study is to define the specific categories of genetic disorders associated with consanguineous marriages. METHODS: Etiological categories and consanguinity rates were studied among 623 families with genetic syndromes, congenital anomalies or mental retardation, or both, seen at the National Center for Diabetes, Endocrinology and Genetics for the period August 2002 to August 2006. Comparisons were made for first cousin marriage rates in the study group and that for the …

A New Species Of Dipetalonema (Filarioidea: Onchocercidae) From Ateles Chamek From The Beni Of Bolivia, Juliana Notarnicola, F. Agustin Jimenez-Ruiz, Scott Lyell Gardner

Harold W. Manter Laboratory of Parasitology: Faculty Publications

We describe a new species of Dipetalonema occurring in the body cavity of Ateles chamek (Humboldt, 1812) from north-central Bolivia. Morphologic characters serving to separate Dipetalonema yatesi n. sp. from known forms include a vagina vera with a simple tube and thin walls and a left spicule, which possesses a handle shorter than the lamina (ratio 2.7); the latter displays an anterior membranous alae similar in length to the terminal flagellum, a distal extremity of the left spicule within a simple hook and a membrane, phasmids at the basis of the lappets, and heterogeneous muscles occupying the whole cavity. Dipetalonema …

Neighborhood Context And Ethnicity Differences In Body Mass Index: A Multilevel Analysis Using The Nhanes Iii (1988-1994), D. Phuong Do, Tamara Dubowitz, Chloe E. Bird, Nicole Lurie, José J. Escarce, Brian K. Finch

Faculty Publications

A growing body of literature has documented a link between neighborhood context and health outcomes. However, little is known about the relationship between neighborhood context and body mass index (BMI) or whether the association between neighborhood context and BMI differs by ethnicity. This paper investigates several neighborhood characteristics as potential explanatory factors for the variation of BMI across the United States; further, this paper explores to what extent segregation and the concentration of disadvantage across neighborhoods help explain ethnic disparities in BMI. Using data geo-coded at the census tract-level and linked with individual-level data from the Third National Health and …

Epstein-Barr Virus Infection Of Langerhans Cell Precursors As A Mechanism Of Oral Epithelial Entry, Persistence, And Reactivation, Dennis M. Walling, Autumn J. Ray, Joan E. Nichols, Catherine M. Flaitz, C. Mark Nichols

Faculty, Staff and Student Publications

Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus associated with many malignant and nonmalignant human diseases. Life-long latent EBV persistence occurs in blood-borne B lymphocytes, while EBV intermittently productively replicates in mucosal epithelia. Although several models have previously been proposed, the mechanism of EBV transition between these two reservoirs of infection has not been determined. In this study, we present the first evidence demonstrating that EBV latently infects a unique subset of blood-borne mononuclear cells that are direct precursors to Langerhans cells and that EBV both latently and productively infects oral epithelium-resident cells that are likely Langerhans cells. These data …

Modeling Habitat And Environmental Factors Affecting Mosquito Abundance In Chesapeake, Virginia, Alan Scott Bellows

Biological Sciences Theses & Dissertations

The models I present in this dissertation were designed to enable mosquito control agencies in the mid-Atlantic region that oversee large jurisdictions to rapidly track the spatial and temporal distributions of mosquito species, especially those species known to be vectors of eastern equine encephalitis and West Nile virus. I was able to keep these models streamlined, user-friendly, and not cost-prohibitive using empirically based digital data to analyze mosquito-abundance patterns in real landscapes.

This research is presented in three major chapters: (II) a series of semi-static habitat suitability indices (HSI) grounded on well-documented associations between mosquito abundance and environmental variables, (III) …

Extending And Measuring The Quality Of Fresh-Cut Fruit And Vegetables: A Review, Catherine Barry-Ryan, Ana Belen Martin-Diana, Daniel Rico, J. Barat

Articles

The market sales of ready-to-use fresh vegetables have grown rapidly in recent decades as a result of changes in consumer attitudes, especially consumption of fresh-cut lettuce and carrot due to their use in prepared salads. Chlorine solutions have been widely used to sanitise fruit and vegetables in the fresh-cut industry. However, the association of chlorine with the possible formation of carcinogenic chlorinated compounds in water has called into question the use of chlorine in food processing. There is a real need to find alternatives for preservation of fresh-cut fruit and vegetables in order to improve the efficacy of washing treatments. …

The Introduction And Emergence Of Wildlife Diseases In North America, Robert G. Mclean

United States Department of Agriculture Wildlife Services: Staff Publications

Contents:

Specific Invasive and Emerging Wildlife Diseases: West Nile Virus, Hantavirus, Lyme Disease, Monkeypox, Raccoon Rabies
Foreign Wildlife Diseases That Could Invade the United States: Highly Pathogenic Avian Influenza, Rift Valley Fever, Nipah Virus, Japanese Encephalitis
Prevention, Detection, and Control of Invading and Emerging Diseases
References

Lipid Profile Among Diabetics In Al-Ramadi City, Iraq, Khalid A. Al-Rawi

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Hyperlipidemia is a strong predictor risk of cardiovascular events. There are insufficient data on the lipid profile in diabetics in Iraq. This study was carried out to determine the lipid profile among diabetics in Al-Anbar governorate. MATERIALS: A total of 136 diabetics (116 were with type 2 diabetes and 20 were with type 1 diabetes) attending Al- Ramadi general hospital, Al-Anbar, were included in the study. Total cholesterol, triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) were estimated. RESULTS: Elevated total cholesterol, HDL, LDL, VLDL and TG were detected among …

Some Maternal Factors Affecting Anthropometric Measurments Of Newborns, Qusay A. Al-Rahim

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Fetal growth may at any time during gestational period be affected by several factors that may cause diseases to fetuses or neonates, and interfere with neonatal morbidity and mortality. Among these factors are racial, genetic, socioeconomic factors and maternal malnutrition and illnesses like diabetes, preeclampsia and anemia. OBJECTIVES: Our aim is to study the effect of maternal height, age, and illnesses on the anthropometric measurements of full term singleton newborns. METHODS: Two hundred full term singleton newborns were studied cross-sectionally in the maternity wards of 2 hospitals in the medical city /Baghdad .They were assessed by measuring the …

Volume 44, Number 79: June 27, 2007, University Of North Dakota

University Letter Archive

No abstract provided.

Coyotes As Sentinels For Monitoring Bovine Tuberculosis Prevalence In White-Tailed Deer, Todd C. Atwood, Kurt C. Vercauteren, Thomas J. Deliberto, Holly J. Smith, Justin S. Stevenson

United States Department of Agriculture Wildlife Services: Staff Publications

Mycobacterium bovis, the causative agent of bovine tuberculosis (bTB), is endemic in free-ranging white-tailed deer (Odocoileus virginianus) in 5 counties (Alcona, Alpena, Montmorency, Oscoda, and Presque Isle) in the northeastern Lower Peninsula of Michigan, USA. The presence of a wildlife reservoir of tuberculosis in Michigan and the incidence of bTB in cattle (Bos taurus) resulted in Michigan losing its bTB accredited-free status. Subsequent wildlife surveillance programs identified relatively high disease prevalence in coyotes (Canis latrans), generating interest in their potential to serve as a sentinel species to detect bTB prevalence in white-tailed deer. …

Analisis Utilisasi Resep Antibiotik Pasien Rawat Jalan Tingkat Pertama (Rjtp) Di Puskesmas Tebet Jakarta Selatan, Tahun 2005, Nurlaili Isnaini

Kesmas

Kecenderungan peningkatan penggunaan antibiotika di Pelayanan Kesehatan Dasar merupakan penggunaaan obat yang tidak rasional dan akan menghambat penurunan angka morbiditas dan mortalitas penyakit. Pemberian antibiotika yang berlebihan akan meningkatkan resistensi bakteri dan meningkatkan pembiayaan obat. Tujuan penelitian ini adalah mengetahui gambaran utilisasi obat antibiotika Hasil penelitian menemukan bahwa persentase resep obat pasien RJTP yang berisi antibiotika 37,74 %. Proporsi terbesar pemanfaatan obat antibiotika pada pasien RJTP di Puskesmas Tebet tahun 2005 ditemukan pada kelompok usia dewasa (12-65 tahun) yaitu sebesar 56,5 %, pasien yang bayar sendiri yaitu sebesar 89,8 %, penyakit infeksi lain selain ISPA yaitu sebesar 61,6 % dan …

Fence-Line Contact Between Wild And Farmed Cervids In Colorado: Potential For Disease Transmission, Kurt C. Vercauteren, Michael J. Lavelle, Nathan W. Seward, Justin W. Fischer, Gregory E. Phillips

United States Department of Agriculture Wildlife Services: Staff Publications

Direct and indirect contact between wild and farmed cervids along perimeter fences may play a role in transmission of diseases like chronic wasting disease (CWD), but no studies have quantified such interactions. At 9 high-fenced commercial elk (Cervus elaphus) farms in Colorado, USA, during October 2003 to January 2005, we used animal-activated video to estimate rates of fence-line use by wild cervids, rates of direct contact between farmed and wild cervids, and probability of direct contact when wild cervids were present. We recorded 8-foldmore wild elk per unit time than mule deer (Odocoileus hemionus) at fence …

Fence-Line Contact Between Wild And Farmed White-Tailed Deer In Michigan: Potential For Disease Transmission, Kurt C. Vercauteren, Michael J. Lavelle, Nathan W. Seward, Justin W. Fischer, Gregory E. Phillips

United States Department of Agriculture Wildlife Services: Staff Publications

Interactions between wild and farmed white-tailed deer (Odocoileus virginianus) along perimeter fences may play a role in the transmission of diseases like bovine tuberculosis and chronic wasting disease. However, no study has evaluated direct contact between wild and farmed deer through fences. We used animal-activated cameras to estimate rates of interaction between wild and farmed deer at 6 high-fenced commercial white-tailed deer farms in Michigan, USA, during October 2003 to January 2005. We recorded only 2 direct, naso-oral contacts between wild and farmed deer during >77,000 hours of camera monitoring. We documented little direct contact between wild and …

From Awareness To Action: The Rhetorical Limits Of Visualizing The Irreparable Nature Of Global Climate Change, Richard D. Besel

Communication Studies

In this paper I examine a recent artistic attempt to publicly visualize a future at risk, Alexis Rockman’s mural painting Manifest Destiny. By turning to J. Robert Cox’s work on the “Locus of the Irreparable,” I contend that Manifest Destiny compels viewers to see the irreparable nature of global climate change in terms of the unique, precarious, and timely. Arguing that Rockman’s creation is a visual example of the rhetoric of the irreparable, I put Cox’s work into conversation with recent efforts to understand the nature of visual rhetoric. However, despite the attention-grabbing nature of Rockman’s work, the production of …

Eastern Washington University Commencement Program, 2007, Eastern Washington University

Commencement Programs

Program for Eastern Washington University's spring commencement in 2007

New Directions V. Reading

2007 Decisions

USDC for the Eastern District of Pennsylvania

Washington University Record, June 14, 2007

Washington University Record

No abstract provided.

Brady Alsaker To Study Development And Culture In India, University Relations

Campus News Archive

Brady Alsaker will participate in the Minnesota Studies in International Development program in India beginning this fall. Alsaker received a NSEP scholarship.

June 11th 2007, Csusb

Coyote Chronicle (1984-)

No abstract provided.

June 11, 2007 Reporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Developement Of Serum-Free Media In Cho-Dg44 Cells Using A Central Composite Statistical Design, Ananth Parampalli, Kent M. Eskridge, Leonard Smith, Michael M. Meagher, M. C. Mowry, Anuradha Subramanian

Anuradha Subramanian Publications

A serum free medium was developed for the production of recombinant antibody against Botulinum A (BoNTA) using dihydrofolate reductase deficient Chinese Hamster Ovary Cells (CHO-DG44) in suspension culture. An initial control basal medium was prepared, which was similar in composition to HAM’s F12: IMDM (1:1) supplemented with insulin, transeferrin, selenium and a lipid mixture. The vitamin concentration of the basal medium was twice that of HAM’s F12: IMDM (1:1). CHO-DG44 cells expressing S25 antibody grew from 2 x 10⁵ cells to maximum cell density of 1.04 x 10⁶ cells/ml after 5 days in this control medium. A central …

Azithromycin In The Extremely Low Birth Weight Infant For The Prevention Of Bronchopulmonary Dysplasia: A Pilot Study, Hubert O. Ballard, Michael I. Anstead, Lori A. Shook

Pediatrics Faculty Publications

BACKGROUND: Azithromycin reduces the severity of illness in patients with inflammatory lung disease such as cystic fibrosis and diffuse panbronchiolitis. Bronchopulmonary dysplasia (BPD) is a pulmonary disorder which causes significant morbidity and mortality in premature infants. BPD is pathologically characterized by inflammation, fibrosis and impaired alveolar development. The purpose of this study was to obtain pilot data on the effectiveness and safety of prophylactic azithromycin in reducing the incidence and severity of BPD in an extremely low birth weight (< or = 1000 grams) population.

METHODS: Infants < or = 1000 g birth weight admitted to the University of Kentucky Neonatal Intensive Care Unit (level III, regional referral center) from 9/1/02-6/30/03 were eligible for this pilot study. The pilot study was double-blinded, randomized, and placebo-controlled. Infants were randomized to treatment or placebo within 12 hours of beginning mechanical ventilation (IMV) and within 72 hours of birth. The treatment group received azithromycin 10 mg/kg/day for 7 days followed by 5 mg/kg/day for the duration of the study. Azithromycin or placebo was continued until the infant no longer required IMV or supplemental oxygen, to a maximum of 6 weeks. Primary endpoints were incidence of BPD as defined by oxygen requirement at 36 weeks gestation, post-natal steroid use, days of IMV, and mortality. Data was analyzed by intention to treat using Chi-square and ANOVA.

RESULTS: A total of 43 extremely premature infants were enrolled in this pilot study. Mean gestational age and …

Ada News - 06/04/2007, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Commencement, Philadelphia (2007), Philadelphia College Of Osteopathic Medicine

Commencements

Philadelphia Campus D.O. Commencement program, 116th Class. Degrees include Doctorate in Osteopathic Medicine.