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Articles 2611 - 2640 of 23216
Full-Text Articles in Entire DC Network
Optimization Of Non-Natural Nucleotides For Selective Incorporation Opposite Damaged Dna, Diana Vineyard, Xuemei Zhang, Alison Donnelley, Irene Lee, Anthony J. Berdis
Optimization Of Non-Natural Nucleotides For Selective Incorporation Opposite Damaged Dna, Diana Vineyard, Xuemei Zhang, Alison Donnelley, Irene Lee, Anthony J. Berdis
Chemistry Faculty Publications
The promutagenic process known as translesion DNA synthesis reflects the ability of a DNA polymerase to misinsert a nucleotide opposite a damaged DNA template. To study the underlying mechanism of nucleotide selection during this process, we quantified the incorporation of various non-natural nucleotide analogs opposite an abasic site, a non-templating DNA lesion. Our kinetic studies using the bacteriophage T4 DNA polymerase reveal that the π-electron surface area of the incoming nucleotide substantially contributes to the efficiency of incorporation opposite an abasic site. A remaining question is whether the selective insertion of these non-hydrogen-bonding analogs can be achieved through optimization of …
The Colby Echo (2007-10-12), Colby College
The Colby Echo (2007-10-12), Colby College
The Colby Echo
Published by the students of Colby College since 1877, The Colby Echo is the weekly, editorially independent student-run newspaper of Colby College in Waterville, Maine. Published monthly, 1877-1886; semi-monthly, 1886-1897; and weekly, during the academic year, 1898-present.
Enhancement Of Efficacy Of Prrsv Vaccines By Altering The Glycosylation Pattern Of Viral Glycoproteins, Asit K. Pattnaik
Enhancement Of Efficacy Of Prrsv Vaccines By Altering The Glycosylation Pattern Of Viral Glycoproteins, Asit K. Pattnaik
School of Veterinary and Biomedical Sciences: Faculty Publications
PRRSV, the causative agent of PRRS is of major economic significance to the pork industry in the USA and around the world. Current commercial vaccine does not provide adequate protection against PRRSV outbreaks. Therefore, there is an urgent need for development of more efficacious vaccine to combat PRRS. Our previous studies have suggested that (i) induction of neutralizing antibody response is an important correlate of evaluating the efficacy of a vaccine; (ii) neutralizing antibodies can be enhanced by hypoglycosylation of the major surface glycoprotein (GP5). While it is known that GP5 plays a prominent role in neutralizing antibody induction, it …
The Eastern Echo, October 12, 2007, Eastern Michigan University
The Eastern Echo, October 12, 2007, Eastern Michigan University
EMU Student Newspaper: The Normal News & The Eastern Echo
No abstract provided.
Volume Cxxv, Number 3, October 12, 2007, Lawrence University
Volume Cxxv, Number 3, October 12, 2007, Lawrence University
The Lawrentian
No abstract provided.
Integrated Piezoresistive Sensing For Feedback Control Of Compliant Mems, Robert K. Messenger
Integrated Piezoresistive Sensing For Feedback Control Of Compliant Mems, Robert K. Messenger
Theses and Dissertations
Feedback control of MEMS devices has the potential to significantly improve device performance and reliability. One of the main obstacles to its broader use is the small number of on-chip sensing options available to MEMS designers. A method of using integrated piezoresistive sensing is proposed and demonstrated as another option. Integrated piezoresistive sensing utilizes the inherent piezoresistive property of polycrystalline silicon from which many MEMS devices are fabricated. As compliant MEMS structures flex to perform their functions, their resistance changes. That resistance change can be used to transduce the structures' deflection into an electrical signal. This dissertation addresses three topics …
Time Dependent Discrete Ordinates Neutron Transport Using Distribution Iteration In Xyz Geometry, James R. Dishaw
Time Dependent Discrete Ordinates Neutron Transport Using Distribution Iteration In Xyz Geometry, James R. Dishaw
Theses and Dissertations
The DI algorithm is an alternative to source iteration that, in our testing, does not require an accelerator. I developed a formal verification plan and executed it to verify the results produced by my code that implemented DI with the above features. A new, matrix albedo, boundary condition treatment was developed and implemented so that infinite-medium benchmarks could be included in the verification test suite. The DI algorithm was modified for parallel efficiency and the prior instability of the refinement sweep was corrected. The testing revealed that DI performed as well or faster than source iteration with DSA and that …
The Murray Ledger And Times, October 12, 2007, The Murray Ledger And Times
The Murray Ledger And Times, October 12, 2007, The Murray Ledger And Times
The Murray Ledger & Times
No abstract provided.
Characterization Of Mazfsa, An Endoribonuclease From Staphylococcus Aureus, Zhibiao Fu, Niles P. Donegan, Guido Memmi, Ambrose L. Cheung
Characterization Of Mazfsa, An Endoribonuclease From Staphylococcus Aureus, Zhibiao Fu, Niles P. Donegan, Guido Memmi, Ambrose L. Cheung
Dartmouth Scholarship
The mazEF homologs of Staphylococcus aureus, designated mazEF(sa), have been shown to cotranscribe with the sigB operon under stress conditions. In this study, we showed that MazEF(Sa), as with their Escherichia coli counterparts, compose a toxin-antitoxin module wherein MazF(Sa) leads to rapid cell growth arrest and loss in viable CFU upon overexpression. MazF(Sa) is a novel sequence-specific endoribonuclease which cleaves mRNA to inhibit protein synthesis. Using ctpA mRNA as the model substrate both in vitro and in vivo, we demonstrated that MazF(Sa) cleaves single-strand RNA preferentially at the 5' side of the first U or 3' side of the second …
Montana Kaimin, October 12, 2007, Students Of The University Of Montana, Missoula
Montana Kaimin, October 12, 2007, Students Of The University Of Montana, Missoula
Montana Kaimin, 1898-present
Student newspaper of the University of Montana, Missoula.
Observer, Central Washington University
Observer, Central Washington University
Student Newspaper
Student newspaper for Central Washington University for October 11, 2007
The Daily Egyptian, October 11, 2007, Daily Egyptian Staff
The Daily Egyptian, October 11, 2007, Daily Egyptian Staff
October 2007
No abstract provided.
The Cord Weekly (October 11, 2007)
Statistical Methods For The Analysis Of Cancer Genome Sequencing Data, Giovanni Parmigiani, J. Lin, Simina Boca, T. Sjoblom, K.W. Kinzler, V.E. Velculescu, B. Vogelstein
Statistical Methods For The Analysis Of Cancer Genome Sequencing Data, Giovanni Parmigiani, J. Lin, Simina Boca, T. Sjoblom, K.W. Kinzler, V.E. Velculescu, B. Vogelstein
Johns Hopkins University, Dept. of Biostatistics Working Papers
The purpose of cancer genome sequencing studies is to determine the nature and types of alterations present in a typical cancer and to discover genes mutated at high frequencies. In this article we discuss statistical methods for the analysis of data generated in these studies. We place special emphasis on a two-stage study design introduced by Sjoblom et al.[1]. In this context, we describe statistical methods for constructing scores that can be used to prioritize candidate genes for further investigation and to assess the statistical signicance of the candidates thus identfied.
Lanthorn, Vol. 42, No. 15, October 11, 2007, Grand Valley State University
Lanthorn, Vol. 42, No. 15, October 11, 2007, Grand Valley State University
Volume 42, July 12, 2007 - June 12, 2008
Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.
Sga Minutes - October 11, 2007, Fhsu Student Government Association
Sga Minutes - October 11, 2007, Fhsu Student Government Association
SGA - Meeting Minutes
Minutes from an SGA meeting in October 2007, covering a variety of topics and announcements.
Deafdigest: Deaf Sports News October 11, 2007, Barry Strassler
Deafdigest: Deaf Sports News October 11, 2007, Barry Strassler
DeafDigest Sports 2007
No abstract provided.
The Pacifican October 11, 2007, University Of The Pacific
The Pacifican October 11, 2007, University Of The Pacific
All Issues - Student Newspaper, The Pacifican, Pacific Weekly
No abstract provided.
Academic Affairs Committee, October 11, 2007, Coastal Carolina University
Academic Affairs Committee, October 11, 2007, Coastal Carolina University
Board of Trustees Committee Minutes
No abstract provided.
Minutes Staff Senate Meeting, October 11, 2007, University Of Arkansas, Fayetteville. Staff Senate
Minutes Staff Senate Meeting, October 11, 2007, University Of Arkansas, Fayetteville. Staff Senate
Staff Senate Meeting Minutes
No abstract provided.
Mustang Daily, October 11, 2007
Mustang Daily, October 11, 2007
Cal Poly Student Newspaper
Student newspaper of California Polytechnic State University, San Luis Obispo, CA.
Analysis, Selection, And Implementation Of A Case Management System For Local City Government Attorney's Office, Patricia D. Hughes
Analysis, Selection, And Implementation Of A Case Management System For Local City Government Attorney's Office, Patricia D. Hughes
Regis University Student Publications (comprehensive collection)
This paper focuses on the business analysis, selection, and implementation of a case management system for a local government City Attorney's Office which is a document management system in addition to calendaring, notes, tasks, and billing. Their current system relies on paper document organization and as well as some electronic documentation in a simple file folder structure on a windows network file server. A business analysis review demonstrated the need for a cost effective automated business system to support and manage daily business processes, automate document creation and filing, track deadlines and tasks, and comply with new document retention and …
Ua12/2/1 College Heights Herald, Vol. 83, No. 12, Wku Student Affairs
Ua12/2/1 College Heights Herald, Vol. 83, No. 12, Wku Student Affairs
WKU Administration Documents
WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news.
Inter- And Intra-Subject Variability: A Palatometric Study, Marybeth Corey Sanders
Inter- And Intra-Subject Variability: A Palatometric Study, Marybeth Corey Sanders
Theses and Dissertations
Electropalatometry (EPM) has proven to be a useful clinical and research tool for measuring tongue-to-palate contact. The goal of this study was to determine whether the development of a database of standardized palatometric articulation files is feasible by examining the variability which exists within and between speakers. Twenty standard American English dialect speakers were fitted with palatometer pseudopalates. Test stimuli were VCV nonsense words using a schwa in the initial position, the 15 palatal consonants, and three corner vowels, /a/, /i/, /u/. From these palatometric recordings a variability index was created to examine intra- and interspeaker variability. Different aspects of …
Prospectus, October 11, 2007, Beth Voigt, Chuck Shepherd, Amanda Robinson, Cindy Brewer, Judy Seyb, Michael Laird
Prospectus, October 11, 2007, Beth Voigt, Chuck Shepherd, Amanda Robinson, Cindy Brewer, Judy Seyb, Michael Laird
Prospectus 2007
No abstract provided.
The Lumberjack, October 11, 2007
The Lumberjack, October 11, 2007
Cal Poly Humboldt's Student Newspaper
The student newspaper of Humboldt State University.
The Weekly Challenger, October 11, 2007, The Weekly Challenger, Et Al
The Weekly Challenger, October 11, 2007, The Weekly Challenger, Et Al
Weekly Challenger Newspaper Collection
The October 11, 2007, issue of The Weekly Challenger.
Daily Eastern News: October 11, 2007, Eastern Illinois University
Daily Eastern News: October 11, 2007, Eastern Illinois University
October
No abstract provided.
Chanticleer | Vol 56, Issue 7, Jacksonville State University
Chanticleer | Vol 56, Issue 7, Jacksonville State University
Chanticleer
No abstract provided.