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Articles 17191 - 17220 of 24806
Full-Text Articles in Entire DC Network
William Eugene Davis - Biography, William E. Davis
William Eugene Davis - Biography, William E. Davis
Biographies of UNM Presidents
William Davis served as the eleventh University President from 1975-1982.
Gerald May - Biography, William E. Davis
Gerald May - Biography, William E. Davis
Biographies of UNM Presidents
Gerald May served as the fourteenth University President from 1986-1990.
Harding Magazine Winter 2006 (Vol. 14, No. 1), Harding University
Harding Magazine Winter 2006 (Vol. 14, No. 1), Harding University
Harding Magazines
Publication distributed to alumni and friends of the university.
2005-2006 Scientific Report, The Jackson Laboratory
2005-2006 Scientific Report, The Jackson Laboratory
Scientific Reports
No abstract provided.
Achieving The American Dream: Facilitators And Barriers To Homeownership Among Immigrants, Lutchmie Narine, Marcia A. Shobe
Achieving The American Dream: Facilitators And Barriers To Homeownership Among Immigrants, Lutchmie Narine, Marcia A. Shobe
Public Health, Food Studies, and Nutrition
As of March 2003, the immigrant population in the United States (US) has reached 33.5 million individuals. Finding a way out of poverty is very difficult for many immigrants due to both individual and institutional barriers to savings and asset accumulation. Given that the primary sources of wealth among native-born households is through homeownership, it is only fitting that foreign-born households would also wish to achieve the “American Dream.” This paper outlines significant supports and barriers to savings and, more importantly, homeownership among US immigrants. Several suggestions for asset-based policy development for immigrants are also included in the discussion. By …
Review Of Quick Reference Dictionary For Massage Therapy And Bodywork, John Brantley
Review Of Quick Reference Dictionary For Massage Therapy And Bodywork, John Brantley
Faculty & Staff Research & Creative Activity
No abstract provided.
Resisting Regulation With Blue Ribbon Panels, Thomas O. Mcgarity
Resisting Regulation With Blue Ribbon Panels, Thomas O. Mcgarity
Fordham Urban Law Journal
The Article analyzes the use of blue ribbon panels to resolve complicated scientific issues that frequently arise during regulatory proceedings. In particular, it looks at the case of beryllium in order to illustrate how blue ribbon panels appointed and paid for by industry often lend scientific legitimacy to policy advocacy. It concludes that agencies should partially discount scientific evidence provided by industry appointed blue ribbon panels due to expected bias. However, it finds the agency will confront some difficulty convincing the public of the adequacy of regulations that are in conflict with a well-financed campaign by a regulated entity armed …
Department Of Veterinary And Biomedical Sciences: 2006 Annual Report
Department Of Veterinary And Biomedical Sciences: 2006 Annual Report
School of Veterinary and Biomedical Sciences: Information and History
Department of Veterinary and Biomedical Sciences Personnel . 9-16
Faculty .. 9
VBMS Researchers, Postdoctoral and Senior Research Associates . 10
VBMS Adjunct and Courtesy Faculty .... 11
Emeriti Faculty .. 11
VBMS Faculty and Staff by Function and Unit .. 9-16
VBMS Honors, Awards and Recognitions, 2006 17-19
VBMS Committee Assignments, 2006/2007 . 20-22
Faculty Profiles . 23-45
Raul G. Barletta, BS, MS, PhD .. 23
Bruce W. Brodersen, BS, DVM, MS, PhD .... 24
Michael P. Carlson, BS, MS, PhD ... 25
Subash Das, BSV c, MVSc, PhD .... 26
Alan R. Doster, DVM, MS, PhD, ACVP . …
Delineating Women’S Historical Lives Through Textiles: A Latvian Knitter’S Narrative Of Memory, Eileen Wheeler
Delineating Women’S Historical Lives Through Textiles: A Latvian Knitter’S Narrative Of Memory, Eileen Wheeler
Textile Society of America: Symposium Proceedings
In presenting and analyzing the narrative of a woman who knitted for survival, I engage two continuing marginalizations in mainstream history; that the lives of ‘everyday’ women are poorly delineated and that the realm of textiles is undervalued as a source of knowledge.
Outside the visual art domain the status and potential of textile study, with its associations of domesticity and craft, is little valued. Yet textiles have a history of being associated with many other aspects of women’s lives, a relationship that is slowly being probed for the knowledge it may hold (Parker, 1984; Tickner, 1988; Ulrich, 2001). Through …
High Style And Cleanliness: Oriental Rugs In Toronto Homes 1880 - 1940, Neil Brochu
High Style And Cleanliness: Oriental Rugs In Toronto Homes 1880 - 1940, Neil Brochu
Textile Society of America: Symposium Proceedings
Academic scholarship pertaining to Oriental rugs, which began at the end of the nineteenthcentury, has concentrated mainly on connoisseurship and the study of the cultures of origin and the peoples that have produced these items with a particular bias for items produced without the taint of Western influence. Little attention has been paid to the actual consumption of Oriental rugs in the West and the general influence of this trade on the evolution of decorative taste or how they may reflect changes in cultural and social attitudes. Oriental rugs within the Canada have received even less attention leading to assumptions …
Designing For Future Textiles – Challenges Of Hybrid Practices, Zane Berzina
Designing For Future Textiles – Challenges Of Hybrid Practices, Zane Berzina
Textile Society of America: Symposium Proceedings
The potential of the future for both science and design lies in a multidisciplinary approach. Disciplines are merging, boundaries are melting and “many […] technologies are not significant when looked at in isolation, but become of critical importance when coupled with other technologies.”
Introduction
This paper offers a condensed case study of a cross-disciplinary practice led Ph.D. research “Skin Stories :: Charting and Mapping the Skin” which dealt with issues across the fields of design, art, textiles technology, electronics, biology, material science and psychology in an attempt to bridge the gap between aesthetics and technology. The artistic investigation examines skin …
Sustainability Of Handwoven Carpets In Turkey: The Context Of The Weaver, Kimberly Berman, Charlotte Jirousek
Sustainability Of Handwoven Carpets In Turkey: The Context Of The Weaver, Kimberly Berman, Charlotte Jirousek
Textile Society of America: Symposium Proceedings
Forms of Production
Past research, conducted mainly in the 1970s and 1980s, has identified three forms of production in which carpets are woven as commodities. These are petty-commodity production, the putting-out system, and workshop production.
Petty-commodity production involves weaving in the home, with the male head of the household or other male relatives selling the finished product to a carpet dealer or at a local or regional market (fig. 1). The family owns the loom and other weaving supplies, and family members purchase or prepare the yarn themselves. Under the putting-out system, the yarn, rug patterns and perhaps the loom …
Contemporary Hemp Weaving In Korea, Min-Sun Hwang
Contemporary Hemp Weaving In Korea, Min-Sun Hwang
Textile Society of America: Symposium Proceedings
Until the 1900s, hemp was one of four traditional textile fibers in Korea, the others being cotton, ramie, and silk. The production of hemp fabrics had traditionally been for family use, but since the 1950s, that tradition has ceased to exist. The present status of hemp production is, therefore, extremely limited to the rural regions, and practiced by only a small number of the elderly (fig. 1). Of the approximately thirteen hemp cultivation regions (fig. 2), the city of Andong developed a different technique in hemp fiber-making from the rest of the regions and this paper will cover hemp fabric …
Abstracts
Textile Society of America: Symposium Proceedings
Textile Society of America
10th Biennial Symposium 2006
October 11–14, 2006
Harbourfront Centre
Toronto, Ontario
A-Z
Rapid Onset Of Transmission-Reducing Antibodies In Javanese Migrants Exposed To Malaria In Papua, Indonesia, J. Teun Bousema, Will Roeffen, Mike Van Der Kolk, Sake J. De Vlas, Marga Van De Vegte-Bolmer, Michael J. Bangs, Karina Teelen, Liliana Kurniawan, Jason D. Maguire, J. Kevin Baird, Robert W. Sauerwein
Rapid Onset Of Transmission-Reducing Antibodies In Javanese Migrants Exposed To Malaria In Papua, Indonesia, J. Teun Bousema, Will Roeffen, Mike Van Der Kolk, Sake J. De Vlas, Marga Van De Vegte-Bolmer, Michael J. Bangs, Karina Teelen, Liliana Kurniawan, Jason D. Maguire, J. Kevin Baird, Robert W. Sauerwein
United States Public Health Resources
Transmission of Plasmodium falciparum malaria is initiated by sexual stages in the mosquito. Anti-Pfs48/45 and anti-Pfs230 sexual stage antibodies that are ingested together with parasites can reduce parasite development and subsequently malaria transmission. Acquisition of sexual stage immunity was studied in a cohort of 102 non-immune Javanese individuals migrating to hyperendemic Papua Indonesia. Seroprevalence of antibodies against Pfs48/45 and Pfs230 and functional transmission-reducing activity (TRA) were measured upon arrival and at 6, 12, and 24 months. Asexual parasitemia and gametocytemia were assessed every two weeks. The TRA and seroreactivity increased with the number of P. falciparum infections. The longitudinally sustained …
Survey Of Community Knowledge, Attitudes, And Practices During A Malaria Epidemic In Central Java, Indonesia, Parsa Sanjana, Mazie J. Barcus, Michael J. Bangs, Sahat Ompusunggu, Iqbal Elyazar, Harijani Marwoto, Sekar Tuti, Mohammed Sururi, Soesanto Tjokrosonto, J. Kevin Baird
Survey Of Community Knowledge, Attitudes, And Practices During A Malaria Epidemic In Central Java, Indonesia, Parsa Sanjana, Mazie J. Barcus, Michael J. Bangs, Sahat Ompusunggu, Iqbal Elyazar, Harijani Marwoto, Sekar Tuti, Mohammed Sururi, Soesanto Tjokrosonto, J. Kevin Baird
United States Public Health Resources
We surveyed adults in a randomly selected sample of 1,000 households in 50 villages in nine malarial sub-districts in Purworejo, central Java, Indonesia from May to July 2001. The survey assessed malaria knowledge, attitudes, and practices in communities experiencing epidemic malaria to begin exploring broad strategies for controlling the disease in the region. A pre-tested survey instrument consisting of 93 questions addressed demographic characteristics, socioeconomic factors, knowledge and perceptions of malaria, burden and severity of disease, treatment-seeking behavior, malaria prevention practices, and perceptions of government malaria control efforts. The survey was taken by in-person interview of all subjects. Most (97%) …
Influenza Vaccination Coverage Of Children Aged 6 To 23 Months: The 2002–2003 And 2003–2004 Influenza Seasons, Tammy A. Santibanez, Jeanne M. Santoli, Carolyn B. Bridges, Gary L. Euler
Influenza Vaccination Coverage Of Children Aged 6 To 23 Months: The 2002–2003 And 2003–2004 Influenza Seasons, Tammy A. Santibanez, Jeanne M. Santoli, Carolyn B. Bridges, Gary L. Euler
United States Public Health Resources
BACKGROUND. Beginning in 2002 the Advisory Committee on Immunization Practices
encouraged, when feasible, annual influenza vaccination of all children aged 6 to
23 months and household contacts and out-of-home caregivers of children <2
years of age.
OBJECTIVE.We sought to report influenza vaccination coverage for the 2002–2003
and 2003–2004 influenza seasons among children aged 6 to 23 months according
to demographic and immunization-provider characteristics.
METHODS. Data from the 2003 and 2004 National Immunization Survey were analyzed.
Two measures of childhood influenza vaccination are reported: receipt of
>1 influenza vaccination and full vaccination (ie, receipt of the appropriate
number of doses on the …
2Deficiency Of Tnf Receptors Suppresses Microglial Activation And Alters The Susceptibility Of Brain Regions To Mptp-Induced Neurotoxicity: Role Of Tnf-Α, Krishnan Sriram, Joanna M. Matheson, Stanley A. Benkovic, Diane B. Miller, Michael I. Luster, James P. O'Callaghan
Deficiency Of Tnf Receptors Suppresses Microglial Activation And Alters The Susceptibility Of Brain Regions To Mptp-Induced Neurotoxicity: Role Of Tnf-Α, Krishnan Sriram, Joanna M. Matheson, Stanley A. Benkovic, Diane B. Miller, Michael I. Luster, James P. O'Callaghan
United States Public Health Resources
Enhanced expression of tumor necrosis
factor (TNF) -α, is associated with the neuropathological
effects underlying disease-, trauma- and chemically
induced neurodegeneration. Previously, we have shown
that deficiency of TNF receptors protects against
MPTP-induced striatal dopaminergic neurotoxicity,
findings suggestive of a role for TNF-α in neurodegeneration.
Here, we demonstrate that deficiency of TNF
receptors suppresses microglial activation and alters
the susceptibility of brain regions to MPTP. MPTPinduced
expression of microglia-derived factors,
TNF-α, MCP-1, and IL-1α, preceded the degeneration
of striatal dopaminergic nerve terminals and astrogliosis,
as assessed by loss of striatal dopamine and TH, …
Implication Of A Retrovirus-Like Glycoprotein Peptide In The Immunopathogenesis Of Ebola And Marburg Viruses, Kavitha Yaddanapudi, Gustavo F. Palacios, Jonathan S. Towner, Ivy Chen, Carlos A. Sariol, Stuart T. Nichol, W. Ian Lipkin
Implication Of A Retrovirus-Like Glycoprotein Peptide In The Immunopathogenesis Of Ebola And Marburg Viruses, Kavitha Yaddanapudi, Gustavo F. Palacios, Jonathan S. Towner, Ivy Chen, Carlos A. Sariol, Stuart T. Nichol, W. Ian Lipkin
United States Public Health Resources
Ebola and Marburg viruses can cause hemorrhagic fever (HF) outbreaks with high mortality in primates. Whereas Marburg (MARV), Ebola Zaire (ZEBOV), and Ebola Sudan (SEBOV) viruses are pathogenic in humans, apes, and monkeys, Ebola Reston (REBOV) is pathogenic only in monkeys (1–3). Early immunosuppression may contribute to pathogenesis by facilitating viral replication (4–6). Lymphocyte depletion, intravascular apoptosis, and cytokine dysregulation are prominent in fatal cases (7). Here we functionally characterize a 17 amino acid domain in filoviral glycoproteins that resembles an immunosuppressive motif in retroviral envelope proteins (8, 9). Activated human or rhesus peripheral blood mononuclear cells (PBMC) were exposed …
Norovirus Classification And Proposed Strain Nomenclature, Du-Ping Zheng, Tamie Ando, Rebecca L. Fankhauser, R. Suzanne Beard, Roger I. Glass, Stephan S. Monroe
Norovirus Classification And Proposed Strain Nomenclature, Du-Ping Zheng, Tamie Ando, Rebecca L. Fankhauser, R. Suzanne Beard, Roger I. Glass, Stephan S. Monroe
United States Public Health Resources
Without a virus culture system, genetic analysis becomes the principal method to classify norovirus (NoV) strains. Currently, classification of NoV strains beneath the species level has been based on sequences from different regions of the viral genome. As a result, the phylogenetic insights of some virus were not appropriately interpreted, and no consensus has been reached to establish a uniform classification scheme. To provide a consistent and reliable scientific basis for classifying NoVs, we analyzed the amino acid sequences for the major capsid protein of 164 NoV strains by first using an alignment based on the predicted 3D structures. A …
Agroterrorism—Why We’Re Not Ready: A Look At The Role Of Law Enforcement, Alberto R. Gonzales, Regina B. Schofield, Glenn R. Schmitt
Agroterrorism—Why We’Re Not Ready: A Look At The Role Of Law Enforcement, Alberto R. Gonzales, Regina B. Schofield, Glenn R. Schmitt
United States Public Health Resources
Terrorists seeking to strike a blow at the U.S. economy need look no further than the Nation’s heartland for a “soft” target. An agroterrorist attack could dramatically impact many aspects of American life, including local law enforcement, which— especially in rural areas—is financially and strategically unprepared to respond.
Agricultural experts say that today they are most concerned about the intentional introduction of foot-and-mouth disease (FMD) into the food supply. Twenty times more infectious than smallpox, FMD causes painful blisters on the tongues, hooves, and teats of cloven-hoofed animals (like cows, pigs, goats, and deer), rendering them unable to walk, be …
Presence And Regulation Of Messenger Ribonucleic Acids Encoding Components Of The Class Ii Major Histocompatibility Complex-Associated Antigen Processing Pathway In The Bovine Corpus Luteum, Matthew J. Cannon, John S. Davis, Joy L. Pate
Presence And Regulation Of Messenger Ribonucleic Acids Encoding Components Of The Class Ii Major Histocompatibility Complex-Associated Antigen Processing Pathway In The Bovine Corpus Luteum, Matthew J. Cannon, John S. Davis, Joy L. Pate
United States Public Health Resources
Luteal cells express class II major histocompatibility complex (MHC) molecules and can stimulate T lymphocyte proliferation in vitro. However, it is unknown whether luteal cells express the intracellular components necessary to process the peptides presented by class II MHC molecules. The objective of the present study was to examine the expression and regulation of three major class II-associated antigen processing components – class II MHC-associated invariant chain (Ii), DMa and DMb – in luteal tissue. Corpora lutea were collected early in the estrous cycle, during midcycle and late in the estrous cycle, and at various times following administration of a …
Hla Alleles Associated With Delayed Progression To Aids Contribute Strongly To The Initial Cd8+ T Cell Response Against Hiv-1, Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathais Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, Bruce D. Walker
Hla Alleles Associated With Delayed Progression To Aids Contribute Strongly To The Initial Cd8+ T Cell Response Against Hiv-1, Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathais Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, Bruce D. Walker
United States Public Health Resources
Background
Very little is known about the immunodominance patterns of HIV-1-specific T cell responses during primary HIV-1 infection and the reasons for human lymphocyte antigen (HLA) modulation of disease progression.
Methods and Findings
In a cohort of 104 individuals with primary HIV-1 infection, we demonstrate that a subset of CD8+ T cell epitopes within HIV-1 are consistently targeted early after infection, while other epitopes subsequently targeted through the same HLA class I alleles are rarely recognized. Certain HLA alleles consistently contributed more than others to the total virus-specific CD8+ T cell response during primary infection, and also reduced …
Rural/Nonrural Differences In Colorectal Cancer Incidence In The United States, 1998--2001, Steven S. Coughlin, Thomas B. Richards, Trevor Thompson, Barry A. Miller, Juliet Van Eenwyk, Marc T. Goodman, Recinda L. Sherman
Rural/Nonrural Differences In Colorectal Cancer Incidence In The United States, 1998--2001, Steven S. Coughlin, Thomas B. Richards, Trevor Thompson, Barry A. Miller, Juliet Van Eenwyk, Marc T. Goodman, Recinda L. Sherman
United States Public Health Resources
BACKGROUND. Few studies of colorectal cancer incidence by rural, suburban, and metropolitan residence have been published.
METHODS. The authors examined colorectal cancer incidence among men and women in U.S. counties classified as rural, suburban, and metropolitan for the period 1998–2001. They examined rural/suburban/metropolitan differences in incidence by age, race, Hispanic ethnicity, stage at diagnosis, histology, and percentage of the total county population below the poverty level, using data from the CDC’s National Program of Cancer Registries, the NCI’s Surveillance, Epidemiology, and End Results Program, and the 2000 U.S. Census.
RESULTS. A total of 495,770 newly diagnosed or …
Colorectal Cancer In U.S. Adults Younger Than 50 Years Of Age, 1998--2001, Temeika L. Fairley, Cheryll J. Cardinez, Jim Martin, Linda Alley, Carol Friedman, Brenda K. Edwards, Patricia Jamison
Colorectal Cancer In U.S. Adults Younger Than 50 Years Of Age, 1998--2001, Temeika L. Fairley, Cheryll J. Cardinez, Jim Martin, Linda Alley, Carol Friedman, Brenda K. Edwards, Patricia Jamison
United States Public Health Resources
BACKGROUND. Colorectal cancer (CRC) incidence rates are increasing among persons younger than 50 years of age, a population routinely not screened unless an individual has a high risk of CRC. This population-based study focuses primarily on describing the CRC burden for persons in this age group.
METHODS. The data used for this study were derived from the National Program of Cancer Registries (NPCR) and Surveillance, Epidemiology, and End Results (SEER) surveillance systems. Age-adjusted incidence rates, rate ratios, and their corresponding 95% confidence intervals were calculated.
RESULTS. CRC is ranked among the top 10 cancers occurring in males …
Transfusion-Associated Transmission Of West Nile Virus, United States 2003 Through 2005, Susan P. Montgomery, Jennifer A. Brown, Matthew Kuehnert, Theresa L. Smith, Nicholas Crall, Robert S. Lanciotti, Alexandre Macedo De Oliveira, Thomas Boo, Anthony A. Marfin
Transfusion-Associated Transmission Of West Nile Virus, United States 2003 Through 2005, Susan P. Montgomery, Jennifer A. Brown, Matthew Kuehnert, Theresa L. Smith, Nicholas Crall, Robert S. Lanciotti, Alexandre Macedo De Oliveira, Thomas Boo, Anthony A. Marfin
United States Public Health Resources
BACKGROUND: National blood donation screening for West Nile virus (WNV) started in June 2003, after the documentation of WNV transfusion-associated transmission (TAT) in 2002.
STUDY DESIGN AND METHODS: Blood donations were screened with investigational nucleic acid amplification assays in minipool formats. Blood collection agencies (BCAs) reported screening results to state and local public health authorities. Donor test results and demographic information were forwarded to CDC via ArboNET, the national electronic arbovirus surveillance system. State health departments and BCAs also reported suspect WNV TATs to CDC, which investigated these reports to confirm WNV infection in blood transfusion recipients in …
Severe Acute Respiratory Syndrome (Sars): Knowledge, Attitudes, Practices And Sources Of Information Among Physicians Answering A Sars Fever Hotline Service, J.-F. Deng, B. Olowokure, S.C. Kaydos-Daniels, H.-J. Chang, R.S. Barwick, M.-L. Lee, C.-Y. Deng, S.H. Factor, C.-E. Chiang, S.A. Maloney, The Sars International Field Team
Severe Acute Respiratory Syndrome (Sars): Knowledge, Attitudes, Practices And Sources Of Information Among Physicians Answering A Sars Fever Hotline Service, J.-F. Deng, B. Olowokure, S.C. Kaydos-Daniels, H.-J. Chang, R.S. Barwick, M.-L. Lee, C.-Y. Deng, S.H. Factor, C.-E. Chiang, S.A. Maloney, The Sars International Field Team
United States Public Health Resources
In June 2003, Taiwan introduced a severe acute respiratory syndrome (SARS) telephone hotline service to provide concerned callers with rapid access to information, advice and appropriate referral where necessary. This paper reports an evaluation of the knowledge, attitude, practices and sources of information relating to SARS among physicians who staffed the SARS fever hotline service. A retrospective survey was conducted using a self-administered postal questionnaire. Participants were physicians who staffed a SARS hotline during the SARS epidemic in Taipei, Taiwan from June 1 to 10, 2003. A response rate of 83% was obtained. All respondents knew the causative agent of …
Temperament In Context: Infant Temperament Moderates The Relationship Between Perceived Neighborhood Quality And Behavior Problems, Craig R. Colder, Liliana J. Lengua, Paula J. Fite, Joshua A. Mott, Nicole R. Bush
Temperament In Context: Infant Temperament Moderates The Relationship Between Perceived Neighborhood Quality And Behavior Problems, Craig R. Colder, Liliana J. Lengua, Paula J. Fite, Joshua A. Mott, Nicole R. Bush
United States Public Health Resources
Hypotheses that positive affect and fear in infancy moderate later relationships between neighborhood quality and behavior problems were examined in a sample of children from the National Longitudinal Survey of Youth. Results suggested that poor neighborhood quality was associated with antisocial behavior at age 6 for children who in infancy were characterized by either high positive affect and low fear or by low positive affect and high fear. Depression/anxiety increased from age 6 to age 12 for children in poor quality neighborhoods who were characterized in infancy by low positive affect. A combination of low fear and high positive affect …
Identification Of An Epithelial-Specific Enhancer Regulating Esx Expression, Richard M. Neve, Hema Parmar, Cliff Amend, Chira Chen, Angie Rizzino, Christopher C. Benz
Identification Of An Epithelial-Specific Enhancer Regulating Esx Expression, Richard M. Neve, Hema Parmar, Cliff Amend, Chira Chen, Angie Rizzino, Christopher C. Benz
United States Public Health Resources
The Ets transcription factor, ESX, exhibits a unique pattern of epithelial-restricted expression and transactivates genes involved in epithelial differentiation and cancer. The aim of this study was to determine the underlying genetic basis for epithelial-specific expression of ESX. We have identified a 30bp ESX enhancer sequence (EES) approximately 3 kb upstream of the proximal promoter. This region displays enhancer activity in an epithelial-specific manner and deletion of this region abrogates ESX gene transcription. An EES binding protein complex (EBC) was identified through electrophoretic mobility shift assays whose degree of EES binding correlated well with endogenous ESX levels in …