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Office Of Research -- Annual Report 2005-2006

Office of Research and Economic Development: Publications

Table of Contents

Physical Sciences & Engineering
Exploring the final frontier – extreme light . . . . . . . . . . . 2
Nano discovery is golden . . . . . . . . . . . . . . . . . . . . . . . . 4
New center fuels energy research . . . . . . . . . . . .. . . . . . 6
Imparting the human touch . . . . . . . . . . . . . . . . . . …

Design And Construction Of A Misse-6 Payload: State Of Utah Space Environment & Contamination Study (Suspecs), Joshua L. Hodges, Jeff Duce, John R. Dennison

All Physics Faculty Publications

No abstract provided.

A View From The Sun Parlor: A History Of Pediatrics In Portland, Maine, J Daniel Miller

Histories

Publication includes a written history, posters, photographs, and charts pertaining to the early years of pediatrics in Portland, Maine.

What's Happening: January, 2006, Maine Medical Center

What's Happening

No abstract provided.

The Breeding Ecology And Natural History Of Ambystomatid Salamanders In An Ephemeral Wetland In Mason County, West Virginia, S. Douglas Kaylor

Theses, Dissertations and Capstones

A forested ephemeral wetland in Mason County, WV, documented to contain 4 of 5 Ambystoma species found in the state, was studied to learn about population sizes, breeding cycles, and habitat use. Minnow traps were placed along three drift fences with additional traps placed throughout the study area. From February 5 to March 27, 2005, 85 captured adults were identified to species, marked by elastomer injection for mark-recapture analysis, and measured for morphometrics. Larval salamanders were identified, staged, measured, and returned. Egg clutches were mapped and counted. Mark-recapture analysis suggests the A. texanum population size is between 635 and 735 …

Survey Of The Great Kanawha River, West Virginia, For Virulence Related Gene Markers Stx1, Stx2, And Eaea, Christina Carole Johnson

Theses, Dissertations and Capstones

Microbial surveying using antibiotic resistant bacteria, fecal coliforms, and virulence genes is an approach not previously tested on the Great Kanawha River. Research objectives were to test antibiotic resistant and fecal coliform bacteria as bioindicators of water quality, and develop a multiplex- polymerase chain reaction (mPCR) system for identification of stx1, stx2, and eaeA DNA sequences in isolated fecal coliforms (FC). Fecal indicator populations and antibiotic resistant populations were demonstrated to be independent. Bacterial populations were assigned impact score(s) (IS) values for each sample site based on data set percent ranks. Population scores were summed per sample site to generate …

Diverse Roles Of Pkcα In Vascular Smooth Muscle Contraction, Ava Caudill Dykes

Theses, Dissertations and Capstones

A complete understanding of the mechanisms underlying smooth muscle contractility has proven elusive due to the many interacting factors thought to influence contractile behavior in this muscle type. One such factor, protein kinase Cα (PKCα), is proposed to play a central role in both the activation and modulation of smooth muscle contraction. PKCα is activated through a G-protein coupled receptor and is subsequently translocated to its site of action. Although the mechanisms regulating PKCα site specific translocation are not completely understood, it is thought that this process is essential for PKCα specificity of action within the cell. In chapter II …

Satellite Image Based Classification Mapping For Spatially Analyzing West Virginia Corridor H Urban Development, Chandra L. Inglis-Smith

Theses, Dissertations and Capstones

The study area for this project is Corridor H, a designated Appalachian Development Highway located in Lewis, Upshur, Barbour Counties which are part of the Appalachian Plateau Province, and Randolph, Tucker, Grant and Hardy Counties which are Part of the Ridge and Valley Province in West Virginia. The region has a long history of occupation and a traditional economic structure consisting of mainly agriculture, timbering and coal mining. The final objective of the study was to perform change detection, using two Landsat datasets obtained from the USGS of the study area from 1987 and 2005 to determine if economic development, …

Northeast Ohio Citizens Speak: Individual Citizen Interviews Data Analysis Final Report, Mark Chupp

All Maxine Goodman Levin School of Urban Affairs Publications

Voices & Choices is an 18-month public engagement process that has involved tens of thousands of citizens and leaders across Northeast Ohio in creating a shared action agenda for revitalizing the region’s economy. In this process, Voices & Choices offered the opportunity for citizens to interview each other, and capture in writing their opinions, values and vision of a better future. This document captures some of the essence of those citizen interviews.

Report Of The President 2006-2007, Indiana State University. Office Of The President; Benjamin, Lloyd W.

Office of the President

No abstract provided.

Comprehensive Annual Financial Report, 2005, City Of Chesterfield

UMSLCAB - UMSL’s Political Science Millennial Era Saint Louis Local Curated Area Budgets

This resource is one among many in the UMSLCAB open dataset at IRL.UMSL.edu/CAB

Financial Report, 2005, Village Of Cedar Hill Lakes

UMSLCAB - UMSL’s Political Science Millennial Era Saint Louis Local Curated Area Budgets

This resource is one among many in the UMSLCAB open dataset at IRL.UMSL.edu/CAB

Report To The Board Of Aldermen, 2005, City Of Ladue

UMSLCAB - UMSL’s Political Science Millennial Era Saint Louis Local Curated Area Budgets

This resource is one among many in the UMSLCAB open dataset at IRL.UMSL.edu/CAB

Cyclin D1 And P16 Expression In Recurrent Nasopharyngeal Carcinoma, Ho-Sheng Lin, Gerald J. Berry, Zijie Sun, Willard E. Fee Jr

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Cyclin D1 and p16 are involved in the regulation of G1 checkpoint and may play an important role in the tumorigenesis of nasopharyngeal carcinoma (NPC). Previous studies have examined the level of expression of cyclin D1 and p16 in primary untreated NPC but no such information is available for recurrent NPC. We set out in this study to examine the expression level of cyclin D1 and p16 in recurrent NPC that have failed previous treatment with radiation +/- chemotherapy.

Patients and methods

A total of 42 patients underwent salvage nasopharyngectomy from 1984 to 2001 for recurrent NPC after …

Effect Of Changes In Contractility On The Index Of Myocardial Performance In The Dysfunctional Left Ventricle, Steven J. Lavine

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

The index of myocardial performance has prognostic power in patients with cardiomyopathy and following myocardial infarction. As the index of myocardial performance has been shown to be preload and afterload dependent, the effect of altering contractility on IMP and its components with left ventricular dysfunction has been incompletely delineated.

Methods

Chronic left ventricular dysfunction was induced in 10 canines using coronary microsphere embolization. Each dog was instrumented and imaged with 2D echo and Doppler. At the same atrially paced rate, contractility was increased with a dobutamine infusion and then following 4 weeks of oral digoxin.

Results

With chronic …

Genistein Inhibits Radiation-Induced Activation Of Nf-Κb In Prostate Cancer Cells Promoting Apoptosis And G2/M Cell Cycle Arrest, Julian J. Raffoul, Yu Wang, Omer Kucuk, Jeffrey D. Forman, Fazlul H. Sarkar, Gilda G. Hillman

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

New cancer therapeutic strategies must be investigated that enhance prostate cancer treatment while minimizing associated toxicities. We have previously shown that genistein, the major isoflavone found in soy, enhanced prostate cancer radiotherapy in vitro and in vivo. In this study, we investigated the cellular and molecular interaction between genistein and radiation using PC-3 human prostate cancer cells.

Methods

Tumor cell survival and progression was determined by clonogenic analysis, flow cytometry, EMSA analysis of NF-κB, and western blot analysis of cyclin B1, p21^WAF1/Cip1, and cleaved PARP protein.

Results

Genistein combined with radiation caused greater inhibition in PC-3 …

Hydroxyurea And Sickle Cell Anemia: Effect On Quality Of Life, Samir K. Ballas, Franca B. Barton, Myron A. Waclawiw, Paul Swerdlow, James R. Eckman, Charles H. Pegelow, Mabel Koshy, Bruce A. Barton, Duane R. Bonds

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

The Multicenter Study of Hydroxyurea (HU) in Sickle Cell Anemia (MSH) previously showed that daily oral HU reduces painful sickle cell (SS) crises by 50% in patients with moderate to severe disease. The morbidity associated with this disease is known to have serious negative impact on the overall quality of life(QOL) of affected individuals.

Methods

The data in this report were collected from the 299 patients enrolled in the MSH. Health quality of llife (HQOL) measures were assessed in the MSH as a secondary endpoint to determine if the clinical benefit of HU could translate into a measurable …

Fast Drying Of Fine Needle Aspiration Slides Using A Hand Held Fan: Impact On Turn Around Time And Staining Quality, Mirza A. Baig, Lamia Fathallah, Jining Feng, Mujtaba Husain, David G. Grignon, Mousa A. Al-Abbadi

Wayne State University Associated BioMed Central Scholarship

Abstract

To analyze the impact of using a hand held fan to speed the air-drying process during immediate adequacy evaluation of Fine Needle Aspirations. The effect on turn around time and staining quality is evaluated.

Two mirror image air-dried smears for each pass were prepared. One was subjected to a small hand-held fan with a fan diameter of 7 cm held an average distance of 3 to 5 cm from the slide. The other smear was left to dry without a fan. A total of 93 consecutive pairs were evaluated over a 2-month duration.

The average time needed for air-drying …

Arterial Blood Pressure Monitoring In Overweight Critically Ill Patients: Invasive Or Noninvasive?, Ali Araghi, Joseph J. Bander, Jorge A. Guzman

Wayne State University Associated BioMed Central Scholarship

Abstract

Introduction

Blood pressure measurements frequently guide management in critical care. Direct readings, commonly from a major artery, are considered to be the gold standard. Because arterial cannulation is associated with risks, alternative noninvasive blood pressure (NIBP) measurements are routinely used. However, the accuracy of NIBP determinations in overweight patients in the outpatient setting is variable, and little is known about critically ill patients. This prospective, observational study was performed to compare direct intra-arterial blood pressure (IABP) with NIBP measurements obtained using auscultatory and oscillometric methods in overweight patients admitted to our medical intensive care unit.

Method

Adult critically ill …

Recall Of Age Of Weaning And Other Breastfeeding Variables, Brenda Gillespie, Hannah D'Arcy, Kendra Schwartz, Janet Bobo, Betsy Foxman

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Many studies of the impact of breastfeeding on child or maternal health have relied on data reported retrospectively. The goal of this study was to assess recall accuracy among breastfeeding mothers of retrospectively collected data on age of weaning, reasons for cessation, breast pain, lactation mastitis, and pumping.

Methods

Women in Michigan and Nebraska, U.S.A. were interviewed by telephone every 3 weeks during the first 3 months after the birth of their child, and mailed a questionnaire at 6 months. A subset was interviewed again by telephone approximately 1–3.5 years after the birth. The results for the three …

Characterization Of Pancreatic Lesions From Mt-Tgfα, Ela-Myc And Mt-Tgfα/Ela-Myc Single And Double Transgenic Mice, Dezhong Liao, Yong Wang, Jiusheng Wu, Nazmi Adsay, David Grignon, Fayyaz Khanani, Fazlul H. Sarkar

Wayne State University Associated BioMed Central Scholarship

Abstract

In order to identify good animal models for investigating therapeutic and preventive strategies for pancreatic cancer, we analyzed pancreatic lesions from several transgenic models and made a series of novel findings. Female MT-tgfα mice of the MT100 line developed pancreatic proliferation, acinar-ductal metaplasia, multilocular cystic neoplasms, ductal adenocarcinomas and prominent fibrosis, while the lesions in males were less severe. MT-tgfα-ES transgenic lines of both sexes developed slowly progressing lesions that were similar to what was seen in MT100 males. In both MT100 and MT-tgfα-ES lines, TGFα transgene was expressed mainly in proliferating ductal cells. Ela-myc transgenic mice with a …

Incidence Of Post Myocardial Infarction Left Ventricular Thrombus Formation In The Era Of Primary Percutaneous Intervention And Glycoprotein Iib/Iiia Inhibitors. A Prospective Observational Study, Arshad Rehan, Manpreet Kanwar, Howard Rosman, Sujood Ahmed, Arshad Ali, Julius Gardin, Gerald Cohen

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Before the widespread use of primary percutaneous coronary intervention (PCI) and glycoprotein IIb/IIIa inhibitors (GP IIb/IIIa) left ventricular (LV) thrombus formation had been reported to complicate up to 20% of acute myocardial infarctions (AMI). The incidence of LV thrombus formation with these treatment modalities is not well known.

Methods

92 consecutive patients with ST-elevation AMI treated with PCI and GP IIb/IIIa inhibitors underwent 2-D echocardiograms, with and without echo contrast agent, within 24–72 hours.

Results

Only 4/92 (4.3%) had an LV thrombus, representing a significantly lower incidence than that reported in the pre-PCI era. Use of contrast agents …

Peroxisomal Proliferator Activated Receptor-Γ Deficiency In A Canadian Kindred With Familial Partial Lipodystrophy Type 3 (Fpld3), Gordon A. Francis, Gang Li, Robin Casey, Jian Wang, Henian Cao, Todd Leff, Robert A. Hegele

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Familial partial lipodystrophy (Dunnigan) type 3 (FPLD3, Mendelian Inheritance in Man [MIM] 604367) results from heterozygous mutations in PPARG encoding peroxisomal proliferator-activated receptor-γ. Both dominant-negative and haploinsufficiency mechanisms have been suggested for this condition.

Methods

We present a Canadian FPLD3 kindred with an affected mother who had loss of fat on arms and legs, but no increase in facial, neck, suprascapular or abdominal fat. She had profound insulin resistance, diabetes, severe hypertriglyceridemia and relapsing pancreatitis, while her pre-pubescent daughter had normal fat distribution but elevated plasma triglycerides and C-peptide and depressed high-density lipoprotein cholesterol.

Results

The mother and …

Increased Therapeutic Potential Of An Experimental Anti-Mitotic Inhibitor Sb715992 By Genistein In Pc-3 Human Prostate Cancer Cell Line, David A. Davis, Sarah H. Sarkar, Maha Hussain, Yiwei Li, Fazlul H. Sarkar

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Kinesin spindle proteins (KSP) are motor proteins that play an essential role in mitotic spindle formation. HsEg5, a KSP, is responsible for the formation of the bipolar spindle, which is critical for proper cell division during mitosis. The function of HsEg5 provides a novel target for the manipulation of the cell cycle and the induction of apoptosis. SB715992, an experimental KSP inhibitor, has been shown to perturb bipolar spindle formation, thus making it an excellent candidate for anti-cancer agent. Our major objective was a) to investigate the cell growth inhibitory effects of SB715992 on PC-3 human prostate cancer …

A Database And Tool, Im Browser, For Exploring And Integrating Emerging Gene And Protein Interaction Data For Drosophila, Svetlana Pacifico, Guozhen Liu, Stephen Guest, Jodi R. Parrish, Farshad Fotouhi, Russell L. Finley Jr

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Biological processes are mediated by networks of interacting genes and proteins. Efforts to map and understand these networks are resulting in the proliferation of interaction data derived from both experimental and computational techniques for a number of organisms. The volume of this data combined with the variety of specific forms it can take has created a need for comprehensive databases that include all of the available data sets, and for exploration tools to facilitate data integration and analysis. One powerful paradigm for the navigation and analysis of interaction data is an interaction graph or map that represents proteins …

Production Of Il-16 Correlates With Cd4+ Th1 Inflammation And Phosphorylation Of Axonal Cytoskeleton In Multiple Sclerosis Lesions, Dusanka S. Skundric, Juan Cai, William W. Cruikshank, Djordje Gveric

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Multiple sclerosis (MS) is a central nervous system-specific autoimmune, demyelinating and neurodegenerative disease. Infiltration of lesions by autoaggressive, myelin-specific CD4+Th1 cells correlates with clinical manifestations of disease. The cytokine IL-16 is a CD4+ T cell-specific chemoattractant that is biased towards CD4+ Th1 cells. IL-16 precursor is constitutively expressed in lymphocytes and during CD4+ T cell activation; active caspase-3 cleaves and releases C-terminal bioactive IL-16. Previously, we used an animal model of MS to demonstrate an important role for IL-16 in regulation of autoimmune inflammation and subsequent axonal damage. This role of IL-16 in MS is largely unexplored. Here …

The Pursuit Of Higher Levels Ofeducational Attainment By Licensed Practical Nurses, Charlene C. Gyurko

All-Inclusive List of Electronic Theses and Dissertations

In the United States, there are 2.7 million persons employed in the field of nursing, a figure that ranks this country as the largest single group of health care professionals in the nation (Kennedy, 2003). However, for a variety of demographic, technical training requirement, and capacity reasons, the demand for nurses has outpaced supply for a number of years. By 2010, it is estimated that there will be a need for over one million new and/or replacement registered nurses (RNs). Furthermore, by 2008, it is projected that the need for RNs will increase by 21% nationwide to its highest level …

Phonological Awareness Instruction: Opinions And Practices Of Educators And Speech-Language Pathologists In West Virginia, Melinda J. Daniel

Theses, Dissertations and Capstones

Research has shown phonological awareness to be a strong predictor of literacy. To support literacy development, a phonological awareness project was piloted in several West Virginia schools in 2001. This study compared WV educators based on employment setting (schools participating and those not participating in the phonological awareness project) and professional category (classroom teacher, reading specialist, speech-language pathologist) on answers to survey questions related to phonological awareness. Results showed no significant relationships between employment setting and responses. However, reading specialists reported spending more minutes per week providing phonological awareness instruction to children at risk for reading difficulty than did speech-language …

Regulatory Reform: The New Lochnerism?, David M. Driesen

College of Law - Faculty Scholarship

This article explores the question of whether contemporary regulatory reformers' attitudes toward government regulation have anything in common with those of the Lochner-era Court. It finds that both groups tend to favor value-neutral law guided by cost-benefit analysis over legislative value choices. Their skepticism toward redistributive legislation reflects shared beliefs that regulation often proves counterproductive in terms of its own objectives, fails demanding tests for rationality, and violates the natural order. This parallelism raises fresh questions about claims of neutrality and heightened rationality that serve as important justifications for modern regulatory reform.

David Spence Hill - Biography, William E. Davis

Biographies of UNM Presidents

David Spence Hill served as the sixth University President from 1919-1927.