Digital Commons Network^™

Identification And Role Of The Mta1 Complex In Small Intestinal Carcinoids Malignancy, Michelle Zikusoka

Yale Medicine Thesis Digital Library

Background: Carcinoid tumors are rare tumors that, despite advances in medical research, have remained enigmatic. Carcinoid tumors can be categorized using gross pathological, histological, and biochemical profiles. While of some utility, this classification method fails to enable accurate determination of malignant potential. Incorporation of molecular analysis of carcinoids will create a paradigm shift in classification. To this end, high throughput technologies such as Quantitative RT PCR, Tissue Microarray, and cDNA Microarray will facilitate such changes. In our investigations, cDNA microarray analysis identified Metastasis-associated protein-1 (MTA1), Histone Deacetylase 2 (HDAC2), and aberrant transcriptional regulation as factors involved in the molecular pathogenesis …

Cardinal Red, Kent Hiatt

Westview

No abstract provided.

Mother Knows Best: Maternal Experience And Choice Of Infant Sleep Position, Meghan Lane

Yale Medicine Thesis Digital Library

Purpose: The purpose of this project was to examine the associations between maternal child-rearing experience, choice of infant sleeping position, and the source, nature and trust of advice received about infant sleeping position in a high-risk, primarily African-American population. Background: The number of deaths attributed to Sudden Infant Death Syndrome (SIDS) has decreased since the initiation of the Back to Sleep campaign in 1994. Although this change has benefited all ethnic groups, African-American infants are still twice as likely to succumb to SIDS as Caucasian infants. Design/Methods: We conducted 668 face-to-face standardized interviews with mothers of infants in Connecticut, Georgia …

Montana Kaimin, November 15, 2006, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula. Page 3 is missing.

The Narrative Of Lieutenant Colonel L.R. Stacy, C.B., Bengal Native Infantry, Whilst In The Brahooe Camp, Inducing The Submission Of Nasseer Khan, Only Son Of The Late Meer Meerab Khan, Khan Of Khelat; And In The Subsequent Operations Of General Nott's Army In Its March To And Its Return From Kabul. (1884) , Lewis Robert Stacy

Digitized Afghanistan Materials in English from the Arthur Paul Afghanistan Collection

19th century history of Afghanistan and the relationship between Afghanistan and Britain.

Mega-Doses Of L-Ascorbic Acid Alter The Antineoplastic Effects Of Ionizing Radiation In Emt6 Cells In Vitro, Karina Lund

Yale Medicine Thesis Digital Library

Despite the common usage of high-dose vitamin C among breast cancer patients, the published medical literature is not in agreement as to how mega-dose vitamin C may interact with conventional therapy to affect clinical outcomes. The purpose of this study was to investigate the interaction of mega-dose vitamin C with radiation therapy and with doxorubicin in the treatment of breast cancer. Cultures of EMT6 mouse mammary tumor cells were treated concurrently with varying dose of vitamin C and either radiation or doxorubicin. A clonogenic assay was then performed to determine the surviving fraction of the cells. The surviving fractions of …

The Role Of Ectopic Lymphoid Tissue In Allograft Rejection, Michael Reel

Yale Medicine Thesis Digital Library

The location of the immunologic response to an allograft is not known with certainty. However, organized collections of T cells, B cells and antigen presenting cells have been found in peripheral tissue, in close proximity to organs undergoing rejection. It is hypothesized that this tertiary lymphoid tissue may be a location in which activation of lymphocytes can occur, leading to rejection of an allograft. We report here that in a splenectomized aly/aly mouse, which is devoid of secondary lymphoid organs and will normally fail to reject an allograft, the presence of tertiary lymphoid organs is associated with graft rejection. We …

Small Interfering Rna Decreases Vegf Mrna Expression And Proliferation Of Colorectal Cancer Cells, Stephen Ward

Yale Medicine Thesis Digital Library

Vascular endothelial growth factor (VEGF-A) was first described in 1989 for its angiogenic and mitogenic properties. Early studies indicated that VEGF-A acts primarily in a paracrine pathway which is limited to vascular endothelium. Further investigation showed that VEGF-A and VEGF receptor-2 (VEGFR-2) are expressed by many solid tumors and improve cell growth and survival. Therefore, VEGF-A may act via an autocrine pathway that effects tumor cellular proliferation by binding VEGFR-2 at the cell surface. This study utilizes small interfering RNA (siRNA) technology to investigate the presence of an autocrine loop in human RKO colorectal cancer cells. RT-PCR demonstrated the expression …

The Effect Of General Anesthesia On Acupuncture: A Functional Mri Study, Dana Weiss

Yale Medicine Thesis Digital Library

We performed a study to examine brain activity as assessed by functional-MRI when acupuncture is administered to awake volunteers as compared to acupuncture administered to volunteers under general anesthesia. Healthy, acupuncture-naive volunteers were recruited for this cross-over study. Volunteers underwent two experimental sessions that included a sequence of 4-20 seconds of on and off manual acupuncture stimulation for a period of 3 minutes while awake and while under propofol general anesthesia. The acupuncture intervention was performed at left stomach 36. General anesthesia was induced and maintained with propofol. BOLD signal images were obtained in a 1.5 T MRI scanner in …

Trapping Phyllophaga Spp. (Coleoptera: Scarabaeidae: Melolonthinae) In The United States And Canada Using Sex Attractants, Paul S. Robbins, Steven R. Alm, Charles D. Armstrong, Anne L. Averill, Thomas C. Baker, Robert J. Bauernfiend, Frederick P. Baxendale, S. Kris Braman, Rick L. Brandenburg, Daniel B. Cash, Gary J. Couch, Richard S. Cowles, Robert L. Crocker, Zandra D. Delamar, Timothy G. Dittl, Sheila M. Fitzpatrick, Kathy L. Flanders, Tom Forgatsch, Timothy J. Gibb, Bruce D. Gill, Daniel O. Gilrein, Clyde S. Gorsuch, Abner M. Hammond, Patricia D. Hastings, David W. Held, Paul R. Heller, Rose T. Hiskes, James L. Holliman, William G. Hudson, Michael G. Klein, Vera L. Krischik, David J. Lee, Charles E. Linn

Faculty Publications

The sex pheromone of the scarab beetle, Phyllophaga anxia, is a blend of the methyl esters of two amino acids, L-valine and L-isoleucine. A field trapping study was conducted, deploying different blends of the two compounds at 59 locations in the United States and Canada. More than 57,000 males of 61 Phyllophaga species (Coleoptera: Scarabaeidae: Melolonthinae) were captured and identified. Three major findings included: (1) widespread use of the two compounds [of the 147 Phyllophaga (sensu stricto) species found in the United States and Canada, males of nearly 40% were captured]; (2) in most species intraspecific male response to the …

Panther- November 2006 - Vol. Lxxxv No. 11, Prairie View A&M University

PV Panther Newspapers

No abstract provided.

Anti-Capsular Antibodies Activate Killing Of Escherichia Coli O8:K87 By The Alternate Complement Pathway In Porcine Serum, N. M. Clark, E. M. Berberov, M. Wang, Rodney A. Moxley

School of Veterinary and Biomedical Sciences: Faculty Publications

Enterotoxigenic Escherichia coli (ETEC) strains that produce K88 (F4) ⁺ fimbria are important causes of diarrhea and post-diarrheal septicemia in swine. ETEC O8:K87, a serotype represented by a number of these strains, is typically serum resistant. Strain-specific antibodies are known to activate alternative C pathway-mediated killing of other serum-resistant E. coli [Hill, A.W., Shears, A.L., Hibbitt, K.G., 1978. The requirement of specific antibody for the killing of E. coli by the alternate complement pathway in bovine serum. Immunology 34, 131–136], but their antigenic targets have not been determined. We tested the hypothesis that anti-K87 antibodies activate alternative pathway-mediated killing of …

Ke Alakai, Vol. 76, No. 12 (2006-11-15), Brigham Young University Hawaii

Ke Alaka'i

No abstract provided.

Gmeiner, Jayne Interview For The Miami Valley College Of Nursing And Health Oral History Project, Carol Holdcraft, Jayne Gmeiner

Wright State University - Miami Valley College of Nursing and Health Oral History Project

Carol Holdcraft interviewed Jayne Gmeiner on November 15, 2006 about the founding of the Wright State University College of Nursing and Health. In the interview, Gmeiner discusses her career and her decision to come to Wright State as a student with the College of Nursing and Health.

Herd Mentality, Hannah Craig

Westview

No abstract provided.

Effect Of Prebiotic Oligosaccharides On Enteropathogenic Escherichia Coli Adherence, Kari Shoaf

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Antiadhesion therapy has been found to be a very promising means to prevent and treat infections in the respiratory, urinary, and gastrointestinal tract. Despite the considerable research interest in antiadhesives, relatively little is known about the ability of commercial dietary oligosaccharides, such as prebiotics, to inhibit pathogen adherence. The goal of this research was to determine if commercially available prebiotic oligosaccharides could function as antiadhesive agents against enteropathogenic E. coli (EPEC).

To investigate the ability of prebiotics to inhibit EPEC adherence, inhibition assays were performed by comparing adherence rates of EPEC on HEp-2 and Caco-2 cells in the presence of …

Intracranial Aneurysm As A Paradigm For The Genetic Analysis Of Complex Human Traits, Ali Ozturk

Yale Medicine Thesis Digital Library

The genetic analysis of complex human traits is hampered by its multifactorial nature, since potentially many genes are imparting a relatively small effect on the disease trait. This makes it considerably more difficult to identify these genes as compared to single-gene diseases, whereby the disease trait is attributable to only one locus, due mostly to the difficulties of carrying out robust linkage analyses. Several strategies have been employed in order to overcome the obstacles of complex human traits, including the candidate gene, non-parametric, and parametric linkage approaches. Of these, the latter two enjoy the benefit of being genome-wide, while carrying …

Éclairs To Derriéres, Elizabeth Gallu

Westview

No abstract provided.

Night-Piece In Cork At The Ambassador Hotel, Matthew Brennan

Westview

No abstract provided.

Identification Of Micrornas And Other Small Rnas From The Adult Newt Eye, Evgeny Makarev, Jason R. Spence, Katia Del Rio-Tsonis, Panagiotis A. Tsonis

Biology Faculty Publications

MicroRNAs (miRNAs) are capable of controlling gene expression by targeting complimentary sequences in many mRNAs. Thus, a small number of miRNAs are capable of regulating expression of many different genes. miRNAs have been found in all animals from Drosophila to human and they are highly conserved. This work was undertaken in order to identify such RNAs in the newt eye.

The George-Anne, Georgia Southern University

The George-Anne

• Waiting for the Smoke to Clear
• Campus News
• News Briefs
• Opinion
• News
• Classifieds
• Sports

Robot Rescue, Hui Yu Ruan

Theses

Recently, it is very common in Asia that people put little toys on their office desks. It doesn’t mean they sometimes have their kids visiting them nor they are not grown up yet. These are toys, which can soothe their stress from work. I am always attracted by toys and also animations designed or directed by many artists and designers. In this fantasy world of toys, there may not be only human beings. As in Hayao Miyazaki’s animation “Spirited Away,” where there was a magic world ruled by a witch; and there was also an old spider man, a frog …

Trapping Phyllophaga Spp. (Coleoptera: Scarabaeidae: Melolonthinae) In The United States And Canada Using Sex Attractants., Paul S. Robbins, Steven R. Alm, Charles D. Armstrong, Anne L. Averille, Thomas C. Baker, Robert J. Bauernfiend, Frederick P. Baxendale, S. Kris Braman, Rick L. Brandenburg, Daniel B. Cash, Gary J. Couch, Richard S. Cowles, Robert L. Crocker, Zandra D. Delamar, Timothy G. Dittl, Sheila M. Fitzpatrick, Kathy L. Flanders, Tom Forgatsch, Timothy J. Gibb, Bruce D. Gill, Daniel O. Gilrein, Clyde Gorsuch, Abner M. Hammond, Patricia D. Hastings, David W. Held, James L. Holliman, William G. Hudson, Michael G. Klein, Vera L. Krischik, David J. Lee, Charles E. Linn Jr., Nancy J. Luce, Kenna Mackenzie, Catherine M. Mannion, Sridhar Polavarapu, Daniel A. Potter, Daniel A. Potter, Wendell Roelofs, Brian M. Royals, Glenn A. Salsbury, Nathan M. Schiff, David J. Shetlar, Margaret Skinner, Beverly L. Sparks, Jessica A. Sutschek, Timothy P. Sutschek, Stanley R. Swier, Martha M. Sylvia, Neil J. Vickers, Patricia A. Vittum, Richard Weidman, Donald C. Weber, R. Chris Williamson, Michael G. Villani

Department of Entomology: Faculty Publications

The sex pheromone of the scarab beetle, Phyllophaga anxia, is a blend of the methyl esters of two amino acids, L-valine and L-isoleucine. A field trapping study was conducted, deploying different blends of the two compounds at 59 locations in the United States and Canada. More than 57,000 males of 61 Phyllophaga species (Coleoptera: Scarabaeidae: Melolonthinae) were captured and identified. Three major findings included: (1) widespread use of the two compounds [of the 147 Phyllophaga (sensu stricto) species found in the United States and Canada, males of nearly 40% were captured]; (2) in most species intraspecific male …

The Eastern Echo, November 15, 2006, Eastern Michigan University

EMU Student Newspaper: The Normal News & The Eastern Echo

No abstract provided.

Proteomic Identification Of In Vivo Substrates For Matrix Metalloproteinases 2 And 9 Reveals A Mechanism For Resolution Of Inflammation, Kendra J Greenlee, David B Corry, David A Engler, Risë K Matsunami, Philippe Tessier, Richard G Cook, Zena Werb, Farrah Kheradmand

Faculty, Staff and Student Publications

Clearance of allergic inflammatory cells from the lung through matrix metalloproteinases (MMPs) is necessary to prevent lethal asphyxiation, but mechanistic insight into this essential homeostatic process is lacking. In this study, we have used a proteomics approach to determine how MMPs promote egression of lung inflammatory cells through the airway. MMP2- and MMP9-dependent cleavage of individual Th2 chemokines modulated their chemotactic activity; however, the net effect of complementing bronchoalveolar lavage fluid of allergen-challenged MMP2(-/-)/MMP9(-/-) mice with active MMP2 and MMP9 was to markedly enhance its overall chemotactic activity. In the bronchoalveolar fluid of MMP2(-/-)/MMP9(-/-) allergic mice, we identified several chemotactic …

Hypoxic Regulation Of Vegf And Pai-1 Expression By Hif-1Α And Hif-2Α In First Trimester Trophoblasts, Eliza Meade

Yale Medicine Thesis Digital Library

Preeclampsia results from incomplete trophoblast invasion of the spiral arteries during early pregnancy. Vascular endothelial growth factor (VEGF) and plasminogen activator inhibitor-1 (PAI-1) are critical factors involved in angiogenesis, invasion and hemostasis at the maternal-fetal interface. Both factors are transcriptionally regulated by hypoxia inducible factor (HIF), a heterodimeric complex consisting of HIF-1β and either HIF-1α or -2α whose specificity or redundancy in gene regulation is cell-type specific. This study uses siRNA technology to dissect the mechanisms of hypoxia-mediated regulation of PAI-1 and VEGF expression in first trimester trophoblasts. Immortalized first trimester human extravillous trophoblasts (HTR8/SVneo cells) were maintained in serum-free …

Differential Endogenous Estrogen Exposure Influences Prefrontal Cortex Response To Acute Stress, Katya Rubinow

Yale Medicine Thesis Digital Library

The present study was conducted to determine the effect of differential endogenous estrogen exposure in rats on stress-induced changes in spatial working memory. Subjects comprised male (n=8) and female (n=10) Sprague-Dawley rats, which were trained to complete a T maze, delayed alternation task. Performance was scored as a percentage of trials during which the correct maze arm was selected. Subjects scores were recorded after 1 and 2 hours of restraint stress, as well as after 1 hour of unimpeded movement in a cage placed in the testing room. Restraint stress was effected through physical confinement within plastic, cylindrical tubing. Female …

Minutes November 14, 2006

Agendas and Minutes

No abstract provided.

The Bates Student - Volume 136 Number 08 - November 14, 2006, Bates College

The Bates Student

No abstract provided.

Volume 44, Number 25: November 14, 2006, University Of North Dakota

University Letter Archive

No abstract provided.