Digital Commons Network^™

Lead Optimization Of 7-Benzyloxy 2-(4′-Pyridylmethyl)Thio Isoflavone Aromatase Inhibitors, Bin Su, John C. Hackett, Edgar S. Diaz-Cruz, Young Woo Kim, Robert W. Brueggemeier

Chemistry Faculty Publications

Aromatase, the enzyme responsible for estrogen biosynthesis, is a particularly attractive target in the treatment of hormone-dependent breast cancer. The synthesis and biological evaluation of a series of 2-(4′-pyridylmethyl)thio, 7-alkyl- or aryl-substituted isoflavones as potential aromatase inhibitors are described. The isoflavone derivatives demonstrate IC50 values from 79 to 553 nM and compete with the endogenous substrate, androstenedione. Data supporting the ability of these analogs to suppress aromatase enzyme activity in the SK-BR-3 breast cancer cell line are also presented.

How The Justice System Responds To Juvenile Victims: A Comprehensive Model., David Finkelhor, Theodore P. Cross, Elise N. Cantor

Crimes Against Children Research Center

The justice system handles thousands of cases involving juvenile victims each year. These victims are served by a complex set of agencies and institutions, including police, prosecutors, courts, and child protection agencies. Despite the many cases involving juvenile victims and the structure in place for responding to them, the juvenile victim justice system model presented in this Bulletin is a new concept. Although the juvenile victim justice system has a distinct structure and sequence, its operation is not very well understood. Unlike the more familiar juvenile offender justice system, the juvenile victim justice system has not been conceptualized as a …

Summary Of Coastal And Estuarine Monitoring Programs In New Hampshire (2005), Phil Trowbridge

PREP Reports & Publications

The New Hampshire Estuaries Project (NHEP) compiles data from many coastal and estuarine monitoring programs to assess the status and trends of environmental indicators in the Great Bay and Hampton/Seabrook Harbor. The full list of NHEP environmental indicators has been published in the NHEP Monitoring Plan. The following catalog is a summary of the coastal and estuarine monitoring programs that provide data for NHEP indicators or for State water quality assessments. This list is limited to long-term monitoring programs that do not have an end date.

0541 Economic Development Committee, Colorado Legislative Council

All Publications (Colorado Legislative Council)

No abstract provided.

0551 The Continuing Examination Of The Treatment Of Persons With Mental Illness Who Are Involved In The Justice System, Colorado Legislative Council

All Publications (Colorado Legislative Council)

No abstract provided.

Spartan Daily, December 1, 2005, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 125, Issue 53

Wandering Wheels Newsletter, December 2005, Wandering Wheels

Wandering Wheels Newsletter

No abstract provided.

Nurturing Joint Forest Management Through Microfinance: A Case From India, K. K. Kaushal, J. C. Kala

Journal of Microfinance / ESR Review

India has embarked upon a community involvement process to restock the state-owned forests through a recent approach called Joint Forest Management. But the success of the Joint Forest Management program lies in the provision of alternative livelihoods to woodcutters and grazers. This article presents how the forest department of a southern state of India devised a potent tool of microfinance promotion for weaning those who are dependent on the forest by implementing a massive externally aided Joint Forest Management Project. Based on a study of 27 program villages in the Tamilnadu state, this paper proves that the success of Joint …

Practicing Cpa, Vol. 29 No. 10, December 2005, American Institute Of Certified Public Accountants (Aicpa)

Newsletters

No abstract provided.

Cpa Client Bulletin, December 2005, American Institute Of Certified Public Accountants (Aicpa)

Newsletters

No abstract provided.

0540 Interim Committee On Auto Insurance, Colorado Legislative Council

All Publications (Colorado Legislative Council)

No abstract provided.

Issues Of Processing And Multiple Testing Of Seldi-Tof Ms Proteomic Data, Merrill D. Birkner, Alan E. Hubbard, Mark J. Van Der Laan, Christine F. Skibola, Christine M. Hegedus, Martyn T. Smith

U.C. Berkeley Division of Biostatistics Working Paper Series

A new data filtering method for SELDI-TOF MS proteomic spectra data is described. We examined technical repeats (2 per subject) of intensity versus m/z (mass/charge) of bone marrow cell lysate for two groups of childhood leukemia patients: acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). As others have noted, the type of data processing as well as experimental variability can have a disproportionate impact on the list of "interesting" proteins (see Baggerly et al. (2004)). We propose a list of processing and multiple testing techniques to correct for 1) background drift; 2) filtering using smooth regression and cross-validated bandwidth …

Distinct Roles Of Different Homer1 Isoforms In Behaviors And Associated Prefrontal Cortex Function, Kevin D. Lominac, Erik B. Oleson, Matthew Pava, Matthias Klugmann, Martin K. Schwarz, Peter H. Seeburg, Matthew J. During, Paul F. Worley, Peter W. Kalivas, Karen K. Szumlinski

MUSC Faculty Journal Articles

Homer1 mutant mice exhibit behavioral and neurochemical abnormalities that are consistent with an animal model of schizophrenia. Because the Homer1 gene encodes both immediate early gene (IEG) and constitutively expressed (CC) gene products, we used the local infusion of adeno-associated viral vectors carrying different Homer1 transcriptional variants into the prefrontal cortex (PFC) to distinguish between the roles for IEG and CC Homer1 isoforms in the “schizophrenia-like” phenotype of Homer1 mutant mice. PFC overexpression of the IEG Homer1 isoform Homer1a reversed the genotypic differences in behavioral adaptation to repeated stress, whereas overexpression of the constitutively expressed Homer1 isoform Homer1c reversed the …

Gender And Women's Studies Newsletter For December 2005, Uri Gender And Women's Studies Department

Gender and Women's Studies Publications

The December 2005 issue of Gender and Women’s Studies Newsletter, a periodical with articles written by faculty members and some related to events within the Gender and Women’s Studies program.

0543 Interim Committee On Health Insurance, Colorado Legislative Council

All Publications (Colorado Legislative Council)

No abstract provided.

Commonwealth Times 2005-12-01

Commonwealth Times, 1969-

No abstract provided.

Atlantic Intersections: Early American Commerce And The Rise Of The Spanish West Indies (Cuba), Linda K. Salvucci

History Faculty Research

An Atlantic approach to the history of early American trade challenges traditional British opinions and, indeed, much Anglo-American scholarship regarding the commercial prospects of the new United States. Contemporary Spanish observations, in contrast to the more familiar and widely cited ones in English, correctly predicted the post-Revolutionary War integration of American and Spanish imperial markets. As political, diplomatic, and economic upheavals broke down the old mercantilist system, U.S. merchants quickly succeeded in exploiting their comparative advantage in the expanding Atlantic economy. The debate over the "decline" of the British West Indies is amplified by examining the concurrent "rise" of the …

The Relationship Between The Number Of Shots And The Quality Of Gamma Knife Radiosurgeries, D Cheek, Allen G. Holder, M Fuss, B Salter

Mathematics Faculty Research

Radiosurgery is a non-invasive alternative to brain surgery that uses a single focused application of high radiation to destroy intracerebral target tissues. A Gamma Knife delivers such treatments by using 201 cylindrically collimated cobalt-60 sources that are arranged in a hemispherical pattern and aimed to a common focal point. The accumulation of radiation at the focal point, called a \shot" due to the spherical nature of the dose distribution, is used to ablate (or destroy) target tissue in the brain. If the target is small and spherical, it is easily treated by choosing one of four available collimators (4, 8, …

Public Sociology, Hot Dogs, Apple Pie, And Chevrolet, Mathieu Deflem

The Journal of Public and Professional Sociology

Public sociology is neither public nor sociology. Public sociology does not and cannot have an epistemology. Speaking only for and to itself, public sociology has no public. There is no debate with public sociology. Instead, public sociology has been successfully advertised and widely embraced among sociologists. Public sociology has consumers. Public sociology is the fast-food of social science. The influence of public sociology is visible and real as it has been institutionalized in various ways. I analyze the conditions of the institutionalization of public sociology and critically evaluate its dynamics and consequences.

Western News, Dec. 1, 2005, Western Michigan University

Western News (1972-2018)

Story highlights: Center puts focus on electronic portfolios; Engineering management program lauded; Obituaries for Henry Beukema, Thomas Slaughter, Carol Voytas; On Campus with Kathleen Keckler.

Vol. 07 No. 2 Journal Of Microfinance, Journal Of Microfinance

Journal of Microfinance / ESR Review

No abstract provided.

Building Economic Self-Reliance: Trickle Up's Microenterprise Seed Capital For The Extreme Poor In Rural India, Jan Maes, Malika Basu

Journal of Microfinance / ESR Review

The Trickle Up Program is a US-based organization engaged in microenterprise development for very poor households in 14 core countries, including India. Because it targets the most vulnerable sections of the population, such as the rural landless, women-led households, people with disabilities, and economically disadvantaged minorities, TUP employs a seed capital grant strategy to facilitate its clients' movement from absolute poverty toward economic self-reliance. TUP clients cannot risk taking a loan because they have no spare income to make payments if their enterprises do not generate an immediate profit. A conditional grant, in contrast to credit, exposes its recipients to …

Insights, Fall, 2005, Utah State University

Discovery Magazine

Bi-annual alumni newsletter for the College of Science of Utah State University in Logan.

Boots On The Ground: Use And Implications Of War Metaphors In A Top Team, Jo L. Longnecker

Organization Management Journal

This paper describes the use and implications of war and military metaphors shared by a top management team working in the defense industry. The team used war metaphors pervasively to make meaning of the ambiguity and uncertainty in its environment. Five categories of war metaphors and action verbs were found. Findings from this study suggest the team used metaphors to structure and communicate abstract ideas and experiences, highlight or hide aspects of the work environment, unite team members, lead their organization, and maintain their warlike culture. Further findings demonstrate how the team constructed and maintained metaphors individually, intersubjectively, unreflectively, and …

Select Listeria Monocytogenes Subtypes Commonly Found In Foods Carry Distinct Nonsense Mutations In Inla, Leading To Expression Of Truncated And Secreted Internalin A, And Are Associated With A Reduced Invasion Phenotype For Human Intestinal Epithelial Cells, K. K. Nightingale, K. Windham, K. E. Martin, M. Yeung, M. Wiedmann

Biological Sciences

The surface protein internalin A (InlA) contributes to the invasion of human intestinal epithelial cells by Listeria monocytogenes. Screening of L. monocytogenes strains isolated from human clinical cases (n=46), foods (n=118), and healthy animals (n=58) in the United States revealed mutations in inlA leading to premature stop codons (PMSCs) in L. monocytogenes ribotypes DUP-1052A and DUP-16635A (PMSC mutation type 1), DUP-1025A and DUP-1031A (PMSC mutation type 2), and DUP-1046B and DUP-1062A (PMSC mutation type 3). While all DUP-1046B, DUP-1062A, DUP-16635A, and DUP-1031A isolates (n=76) contained inlA PMSCs, ribotypes DUP-1052A and DUP-1025A ( …

Protecting Our Nation's Political Duopoly: The Supremes Spoil The Libertarians' Party, Gary D. Allison

Tulsa Law Review

No abstract provided.

Takings And Threes: The Supreme Court's 2004-2005 Term, Marla E. Mansfield

Tulsa Law Review

No abstract provided.

Dayton Business Leader, Winter 2005-06, University Of Dayton

Dayton Business Leader

The Dayton Business Leader, published out of the Office of Public Relations, later University Communications, then University Marketing and Communications, provided news from the University of Dayton School of Business Administration to alumni and friends. It was published from the late 1990s to about 2010.

Promises, Expectations, And Rights, Eduardo Rivera-Lopez

Chicago-Kent Law Review

I address the problem of why promises create obligations. First, I spell out and object the so-called "expectational account" according to which the duty to keep our promises arises from the fact that, when we promise to do something, we create an expectation in the promisee, which we have the duty not to disappoint. It has been claimed that this account is circular since we can only raise the expectation, in the appropriate sense, if we already have the moral duty to keep our promise. I argue, against Scanlon and others, that such circularity is unavoidable. In the second section, …

Ephatha, Winter 2005

Ephatha

A newsletter published for Deaf Catholics in Newark, NJ

Ephatha Finding Aid